Patients' satisfaction with diagnostic drug provocation tests and perception of its usefulness.

Abstract:

BACKGROUND AND AIM:Although still controversial, drug provocation tests (DPTs) are considered by many as the gold standard for diagnosis of drug hypersensitivity. No studies have addressed the opinion of patients submitted to DPT. We aimed to determine patient satisfaction with diagnostic DPT and their perception of its usefulness. METHODS:Surveys were supplied to patients submitted to diagnostic DPT in 3 different drug allergy clinics which used the same diagnostic protocols for drug hypersensitivity evaluation. Seventy-three patients (33.6%) were enrolled in Porto (Portugal), 102 (47%) in Montpellier (France) and 42 (19.4%) in Vilnius (Lithuania). The patients filled in a written questionnaire within 15 days after the diagnostic procedure, and satisfaction was assessed on a 1 (very unsatisfied) to 5 (very satisfied) score. RESULTS:A total of 217 surveys were collected; 144 female patients (66.4%). The most prevalent studied reactions were cutaneous (70.1%), but 17.9% of the patients had had a systemic reaction. β-Lactam antibiotics were the main culprit drugs (44.3%) tested in all centres and 25.3% of the patients had a positive DPT. No patients were unsatisfied (8.8% were neither unsatisfied nor satisfied and the others were satisfied or very satisfied). The level of satisfaction did not depend on the results of the DPT; 207 (95.4%) believed DPTs were useful and almost all the patients would recommend DPTs to others. CONCLUSIONS:Most patients were satisfied with DPT for diagnostic purposes. Satisfaction with the procedure was independent of the results of the provocation tests and did not depend on the country.

authors

Gomes ER,Kvedariene V,Demoly P,Bousquet PJ

doi

10.1159/000323898

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

333-8

issue

3

eissn

1018-2438

issn

1423-0097

pii

000323898

journal_volume

156

pub_type

杂志文章,多中心研究
  • Human keratinocytes release mast cell differentiation factors other than stem cell factor.

    abstract::Besides stem cell factor (SCF), additional fibroblast-derived mast cell growth factors have previously been described. Since keratinocytes have also been shown to produce SCF, we have studied the ability of culture supernatants from the human HaCaT keratinocyte cell line to induce SCF-independent mast cell differentia...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000236956

    authors: Welker P,Grabbe J,Czarnetzki BM

    更新日期:1995-05-01 00:00:00

  • Sequence analysis of BIRC4/XIAP in male patients with common variable immunodeficiency.

    abstract:BACKGROUND:Common variable immunodeficiency (CVID) is the most common primary antibody deficiency syndrome in humans, but it remains a diagnosis of exclusion in most cases. Several genetically defined primary immunodeficiencies mimic CVID. Among them is the X-linked lymphoproliferative syndrome (XLP) which was shown to...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000135702

    authors: Salzer U,Hagena T,Webster DB,Grimbacher B

    更新日期:2008-01-01 00:00:00

  • Increased levels of serum-specific immunoglobulin e to staphylococcal enterotoxin a and B in patients with allergic rhinitis and bronchial asthma.

    abstract:BACKGROUND:The association between staphylococcal enterotoxins and atopic dermatitis (AD) is well characterized. We aim to evaluate the association between sensitization to staphylococcal enterotoxin A (SEA) and/or B (SEB) and the development of allergic airway disease. METHODS:Two hundred and seventy-four patients we...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000088868

    authors: Lee JH,Lin YT,Yang YH,Wang LC,Chiang BL

    更新日期:2005-12-01 00:00:00

  • Oncogene expression in patients with familial polyposis coli/Gardner's syndrome.

    abstract::We evaluated whether c-myc and ras P-21 oncogene expression could identify familial polyposis coli/Gardner's syndrome patients at risk for colon cancer. Monoclonal antibodies recognizing c-myc and ras P-21 proteins were used in immunohistochemistry to stain 26 paraffin-embedded tissue specimens collected over 12 years...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000237351

    authors: Yuwono M,Rossi TM,Fisher JE,Tjota A

    更新日期:1996-09-01 00:00:00

  • Plant-expressed recombinant mountain cedar allergen Jun a 1 is allergenic and has limited pectate lyase activity.

    abstract:BACKGROUND:Mountain cedar (Juniperus ashei) pollen commonly causes a winter time allergic rhinitis in the central USA. Jun a 1 is the dominant allergenic protein, but biologically active recombinant Jun a 1 has not been successfully expressed, despite numerous attempts with several expression systems. METHOD:Jun a 1 c...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000316345

    authors: Liu Z,Bhattacharyya S,Ning B,Midoro-Horiuti T,Czerwinski EW,Goldblum RM,Mort A,Kearney CM

    更新日期:2010-01-01 00:00:00

  • Presence of bronchoalveolar lavage fluid necessary for platelet activating factor-induced ciliary depression.

    abstract::Many different mediators have been implicated in allergic responses and allergic diseases of the respiratory tract. The influence of several allergic inflammatory mediators on the ciliary activity has been well studied. However, ciliary responsiveness to platelet-activating factor (PAF) is yet to be established conclu...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000236681

    authors: Ohashi Y,Ohno Y,Sugiura Y,Okamoto H,Tanaka A,Kakinoki Y,Sakamoto H,Hayashi M,Nakai Y

    更新日期:1994-07-01 00:00:00

  • T cells and chronic asthma.

    abstract::There is increasing evidence that the asthma process is 'driven' and maintained by persistence of a subset of chronically activated T memory cells, sensitized against allergenic, occupational or viral antigens which 'home' to the lung after antigen exposure or viral infection. In general, allergens induce a CD4 T help...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章,评审

    doi:10.1159/000024049

    authors: Kon OM,Kay AB

    更新日期:1999-02-01 00:00:00

  • IgE-mediated sensitization to mould allergens among patients with allergic respiratory diseases in a desert environment.

    abstract:BACKGROUND:The importance of fungal allergens in the development of allergic diseases in a desert environment is uncertain. This study evaluated the prevalence of IgE sensitization to moulds among patients with allergic respiratory diseases in Kuwait - a desert country. METHODS:A total of 810 patients (male:female rat...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000024343

    authors: Ezeamuzie CI,Al-Ali S,Khan M,Hijazi Z,Dowaisan A,Thomson MS,Georgi J

    更新日期:2000-04-01 00:00:00

  • Pooling birth cohorts in allergy and asthma: European Union-funded initiatives - a MeDALL, CHICOS, ENRIECO, and GA²LEN joint paper.

    abstract::Long-term birth cohort studies are essential to understanding the life course and childhood predictors of allergy and the complex interplay between genes and the environment (including lifestyle and socioeconomic determinants). Over 100 cohorts focusing on asthma and allergy have been initiated in the world over the p...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章,评审

    doi:10.1159/000343018

    authors: Bousquet J,Anto J,Sunyer J,Nieuwenhuijsen M,Vrijheid M,Keil T,MeDALL Study Group.,CHICOS Study Group.,ENRIECO Study Group.,GA²LEN Study Group.

    更新日期:2013-01-01 00:00:00

  • EAST and CAP specificity for the evaluation of IgE and IgG antibodies to diisocyanate-HSA conjugates.

    abstract::Sera of 54 symptomatic workers showing sensitization to isocyanate-human serum albumin (HSA) conjugates were subjected to parallel enzyme allergosorbent test (EAST) and CAP measurements to determine IgE antibodies to diphenyl-methane diisocyanate-HSA, toluene diisocyanate-HSA and hexamethylene diisocyanate-HSA. Result...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000237325

    authors: Baur X,Chen Z,Flagge A,Posch A,Raulf-Heimsoth M

    更新日期:1996-08-01 00:00:00

  • Distribution and Determinants of Dermatophagoides Mites Sensitization ofAllergic Rhinitis and Allergic Asthma in China.

    abstract:BACKGROUND:The implementation of allergen immunotherapy (AIT) requires extensive knowledge of allergen distribution in the region to identify high-risk regions for AIT utilization. However, the geographical distribution patterns of the major Dermatophagoides allergens in China remain unclear despite the increasing prev...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000499409

    authors: Chen ZG,Li YT,Wang WH,Tan KS,Zheng R,Yang LF,Guan WJ,Hong HY,Yang QT

    更新日期:2019-01-01 00:00:00

  • Correlation between T-cell and mast cell activity in patients with chronic urticaria.

    abstract:BACKGROUND:The presence of autoantibodies reacting with the high affinity IgE receptor (FcepsilonRIalpha) usually indicates a more severe form of chronic urticaria (CU). Previously, we showed an increased lymphocyte reactivity in CU patients; however, the relation between enhanced cellular immunity and the presence of ...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000073719

    authors: Hidvégi B,Nagy E,Szabó T,Temesvári E,Marschalkó M,Kárpáti S,Horváth A,Gergely P

    更新日期:2003-10-01 00:00:00

  • Effectiveness and Safety of Omalizumab in Patients with Allergic Bronchopulmonary Aspergillosis Complicated by Chronic Bacterial Infection in the Airways.

    abstract:BACKGROUND:Allergic bronchopulmonary aspergillosis (ABPA) develops in the presence of predisposing conditions such as asthma and cystic fibrosis. Even ABPA accompanied by asthma is often complicated by chronic Pseudomonas aeruginosa or nontuberculous mycobacterial infection of the lower respiratory tract, rendering tre...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000507216

    authors: Tomomatsu K,Oguma T,Baba T,Toyoshima M,Komase Y,Taniguchi M,Asano K,Japan ABPM Research Program.

    更新日期:2020-01-01 00:00:00

  • Aggravation of Food Allergy by Skin Sensitization via Systemic Th2 Enhancement.

    abstract:BACKGROUND:Recently, the relationship between antigen contact via skin (skin sensitization) and the development of food allergies has gained increasing attention. However, few studies have examined the effects of skin sensitization on healthy skin. OBJECTIVE:To examine the effect of sensitization in healthy skin on Ig...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000511239

    authors: Koshiba R,Oba T,Fuwa A,Arai K,Sasaki N,Kitazawa G,Hattori M,Matsuda H,Yoshida T

    更新日期:2020-11-11 00:00:00

  • Modifications of Phleum pratense grass pollen allergens following artificial exposure to gaseous air pollutants (O(3), NO(2), SO(2)).

    abstract:BACKGROUND:Air pollution is frequently proposed as a potential cause of the increased incidence of allergy in industrialised countries. Our objective was to investigate the impact of the major gaseous air pollutants on grass pollen allergens. METHODS:Timothy grass pollen was exposed to ozone (O(3)), nitrogen dioxide (...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000099079

    authors: Rogerieux F,Godfrin D,Sénéchal H,Motta AC,Marlière M,Peltre G,Lacroix G

    更新日期:2007-01-01 00:00:00

  • Association between loss-of-function mutations in the filaggrin gene and self-reported food allergy and alcohol sensitivity.

    abstract:BACKGROUND:Loss-of-function mutations of the filaggrin (FLG) gene cause an impaired skin barrier and increase the risk of atopic dermatitis. Interestingly, FLG mutations have also been found to be associated with a high risk of peanut allergy. OBJECTIVE:We investigated the association of FLG mutations with self-report...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000345949

    authors: Linneberg A,Fenger RV,Husemoen LL,Thuesen BH,Skaaby T,Gonzalez-Quintela A,Vidal C,Carlsen BC,Johansen JD,Menné T,Stender S,Melgaard M,Szecsi PB,Berg ND,Thyssen JP

    更新日期:2013-01-01 00:00:00

  • Coexistence of angioedema alone with impaired glucose tolerance.

    abstract:BACKGROUND:Most patients with chronic spontaneous urticaria (CSU) exhibit recurrent angioedema. As of yet, the pathogenesis of angioedema in CSU is largely unclear, especially when angioedema occurs in patients who do not develop wheals. Over the past years, we and others have repeatedly observed that patients with rec...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000371421

    authors: Rogala B,Bozek A,Glück J,Rymarczyk B,Jarzab J,Maurer M

    更新日期:2014-01-01 00:00:00

  • Analysis of gamma4 germline transcription in human B cells.

    abstract:BACKGROUND:Allergic reactions occur rarely in patients with chronic helminth infections, although FcepsilonRI-bearing cells are sensitized with anti-parasite IgE and are exposed to antigen. The inhibition of allergic reactivity is due to 'blocking antibodies', predominantly IgG4. IgG4 antibodies represent 50-95% of ant...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000024099

    authors: Agresti A,Vercelli D

    更新日期:1999-02-01 00:00:00

  • Histamine augments VCAM-1 expression on IL-4- and TNF-alpha-stimulated human umbilical vein endothelial cells.

    abstract::Interaction between vascular cell adhesion molecule-1 (VCAM-1) on endothelial cells and CD49d molecules on eosinophils is thought to mediate the selective infiltration of eosinophils into inflamed tissues in allergic disease. IL-4 and TNF-alpha are associated with allergic conditions, and they have been shown to selec...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000237357

    authors: Saito H,Shimizu H,Mita H,Maeda Y,Akiyama K

    更新日期:1996-10-01 00:00:00

  • Parietaria profilin shows only limited cross-reactivity with birch and grass profilins.

    abstract:BACKGROUND:In patients showing multiple reactivity to seasonal airborne allergens, a skin prick test (SPT) with Parietaria pollen scores frequently negative, suggesting that profilin from Parietaria might not share IgE-binding epitopes with profilin from botanically unrelated airborne allergens. This study investigated...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000076384

    authors: Asero R,Mistrello G,Roncarolo D,Amato S

    更新日期:2004-02-01 00:00:00

  • Eight Aeroallergen Skin Extracts May Be the Optimal Panel for Allergic Rhinitis Patients in Central China.

    abstract:BACKGROUND:The prevalence of allergic rhinitis (AR) is increasing rapidly in Central China. The skin prick test (SPT) is the standard tool with which to determine the allergen sensitization status in AR patients. Changes in allergen sensitization patterns have been observed within countries and regions due to geographi...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000479429

    authors: Wang J,Wu Y,Li J,Huang X,Zhu R

    更新日期:2017-01-01 00:00:00

  • Correlations between complaints, inflammatory cells and mediator concentrations in nasal secretions after nasal allergen challenge and during natural allergen exposure.

    abstract::A quantitative determination of the inflammatory mediators was performed and correlated with complaints and the measurement of the inflammatory cells in nasal secretions of 18 seasonal allergic rhinitis patients (group 1) outside the pollen season and 40 symptomatic patients (group 2) with seasonal allergic rhinitis d...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000236855

    authors: Wang D,Clement P,Smitz J,De Waele M,Derde MP

    更新日期:1995-03-01 00:00:00

  • Lipopolysaccharides modulate allergen-specific immune regulation in a murine model of mucosal tolerance induction.

    abstract:BACKGROUND:Farming has been widely reported to be associated with decreased risk of developing atopic disorders, but underlying immunomodulatory mechanisms are still not fully defined. We delineated T-cell functions after induction of mucosal tolerance in the context of intranasally delivered organic dust compounds, li...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000128583

    authors: Gerhold K,Avagyan A,Reichert E,Blumchen K,Wahn U,Hamelmann E

    更新日期:2008-01-01 00:00:00

  • Expression and effects of IL-33 and ST2 in allergic bronchial asthma: IL-33 induces eotaxin production in lung fibroblasts.

    abstract:BACKGROUND:Interleukin (IL)-33, a new member of the IL-1 cytokine family, has been recognized as a key cytokine that enhances T helper 2-balanced immune regulation through its receptor ST2; however, the function and relationship of the IL-33 and ST2 pathways in bronchial asthma are still unclear. We investigated the ce...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000327259

    authors: Kurokawa M,Matsukura S,Kawaguchi M,Ieki K,Suzuki S,Odaka M,Watanabe S,Homma T,Sato M,Yamaguchi M,Takeuchi H,Adachi M

    更新日期:2011-01-01 00:00:00

  • Dexamethasone and cyclosporin A suppress mast cell-leukocyte cytokine cascades by multiple mechanisms.

    abstract::Based on in vitro findings with mouse mast cells and in vivo findings in mice, we report that dexamethasone or cyclosporin A can have at least three actions which interfere with the pathogenesis IgE-, mast-cell-, and cytokine-dependent inflammatory reactions: suppression of the IgE-dependent increase in tumor necrosis...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章,评审

    doi:10.1159/000237015

    authors: Wershil BK,Furuta GT,Lavigne JA,Choudhury AR,Wang ZS,Galli SJ

    更新日期:1995-05-01 00:00:00

  • Effect of enzymatically modified isoquercitrin, a flavonoid, on symptoms of Japanese cedar pollinosis: a randomized double-blind placebo-controlled trial.

    abstract:BACKGROUND:Flavonoids exert antiallergic and antioxidant effects. We investigated the efficacy of enzymatically modified isoquercitrin (EMIQ), a flavonoid, to relieve symptoms of pollinosis. METHODS:In a parallel-group, double-blind placebo-controlled study design, 20 subjects with Japanese cedar pollinosis took two c...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章,随机对照试验

    doi:10.1159/000205582

    authors: Kawai M,Hirano T,Arimitsu J,Higa S,Kuwahara Y,Hagihara K,Shima Y,Narazaki M,Ogata A,Koyanagi M,Kai T,Shimizu R,Moriwaki M,Suzuki Y,Ogino S,Kawase I,Tanaka T

    更新日期:2009-01-01 00:00:00

  • Mechanisms of action of antiphospholipid antibodies in the antiphospholipid syndrome.

    abstract::Antiphospholipid antibody syndrome (APS) is characterized by autoantibodies against negatively charged phospholipids in the serum, and clinically by multiple thromboses, thrombocytopenia, and recurrent fetal loss. The mechanism(s) by which the antibodies cause the clinical picture are not clear. We review the possible...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章,评审

    doi:10.1159/000236883

    authors: Aron AL,Gharavi AE,Shoenfeld Y

    更新日期:1995-01-01 00:00:00

  • Increase in reactive oxygen metabolite level in acute exacerbations of asthma.

    abstract:BACKGROUND:Oxidants including reactive oxygen species have been indicated to play an important role in the pathogenesis of asthma. OBJECTIVE:We investigated oxidative status in patients with acute exacerbations of asthma and evaluated the therapeutic response using the D-ROM test which is simple to use and quick. MET...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000126064

    authors: Suzuki S,Matsukura S,Takeuchi H,Kawaguchi M,Ieki K,Odaka M,Watanabe S,Homma T,Dohi K,Aruga T,Sato M,Kurokawa M,Kokubu F,Adachi M

    更新日期:2008-01-01 00:00:00

  • Recent Practice Patterns and Variations in Children Hospitalized for Asthma Exacerbation in Japan.

    abstract:BACKGROUND:High antibiotic prescribing rates for adults with an asthma exacerbation have been reported in developed countries, but few studies have assessed the variation of antibiotic and adjunctive treatment in the routine care of children. OBJECTIVE:We evaluated the trends in health resource utilization for childre...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000507857

    authors: Okubo Y,Horimukai K,Michihata N,Morita K,Matsui H,Fushimi K,Yasunaga H

    更新日期:2020-01-01 00:00:00

  • Inhibition of IgE antibody formation by plasmid DNA immunization is mediated by both CD4+ and CD8+ T cells.

    abstract:BACKGROUND:We previously showed that immunization of mice with plasmid DNA (pDNA) encoding the Escherichia coli beta-galactosidase gene (pCMV-LacZ) induces a Th1 response, whereas beta-galactosidase (beta-gal) in saline or alum induces a Th2 response. Furthermore, the Th1 response dominates over the Th2 response and do...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000237554

    authors: Lee DJ,Tighe H,Corr M,Roman M,Carson DA,Spiegelberg HL,Raz E

    更新日期:1997-05-01 00:00:00