Oncogene expression in patients with familial polyposis coli/Gardner's syndrome.

Abstract:

:We evaluated whether c-myc and ras P-21 oncogene expression could identify familial polyposis coli/Gardner's syndrome patients at risk for colon cancer. Monoclonal antibodies recognizing c-myc and ras P-21 proteins were used in immunohistochemistry to stain 26 paraffin-embedded tissue specimens collected over 12 years from 5 familial polyposis coli/Gardner's syndrome patients at various stages of their disease. Differences in staining intensity between specimens were noted with each of the two tissues markers; however, c-myc showed also a distinct cellular staining pattern in patients with advanced histologic features. The c-myc oncogene exhibited strong homogeneous cytoplasmic staining in all adenocarcinoma specimens; weak cytoplasmic staining was found in normal biopsies and in 5/10 familial polyposis coli/Gardner's syndrome specimens in the early stage of disease. In contrast, a heterogeneous staining pattern with a strong supranuclear and weak nuclear and cytoplasmic staining was demonstrated in specimens with advanced histologic features of familial polyposis coli/ Gardner's syndrome and also in postoperative ileal specimens. Anti-ras P-21 antibody, on the other hand, demonstrated a homogeneous cytoplasmic staining pattern in all specimens. We feel that the c-myc oncogene expression, in distinction to that of ras P-21, has potential as a genetic tissue marker to distinguish early from more progressive disease.

authors

Yuwono M,Rossi TM,Fisher JE,Tjota A

doi

10.1159/000237351

subject

Has Abstract

pub_date

1996-09-01 00:00:00

pages

89-95

issue

1

eissn

1018-2438

issn

1423-0097

journal_volume

111

pub_type

杂志文章
  • Assessing the efficacy of immunotherapy with a glutaraldehyde-modified house dust mite extract in children by monitoring changes in clinical parameters and inflammatory markers in exhaled breath.

    abstract:INTRODUCTION:The aim of this study was to evaluate the effectiveness of specific immunotherapy (SIT) management with allergoids in children with allergic asthma by monitoring changes in clinical parameters and inflammatory markers in exhaled breath. METHODS:The study population included 43 patients (24 males) of 6-14 ...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000368832

    authors: Lozano J,Cruz MJ,Piquer M,Giner MT,Plaza AM

    更新日期:2014-01-01 00:00:00

  • Increased expression of matrix metalloproteinase-2, matrix metalloproteinase-9 and matrix metalloproteinase-13 in lesional skin of bullous pemphigoid.

    abstract:BACKGROUND:Matrix metalloproteinase (MMP)-2, MMP-9 and MMP-13 can degrade type IV collagen which is the major component of the basement membrane zone (BMZ). In bullous pemphigoid (BP), the separation occurs within the BMZ. OBJECTIVE:To evaluate the involvement of MMPs in the pathogenesis of BP, we examined the express...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000090385

    authors: Niimi Y,Pawankar R,Kawana S

    更新日期:2006-01-01 00:00:00

  • Influence of Omalizumab on Allergen-Specific IgE in Patients with Adult Asthma.

    abstract:BACKGROUND:Omalizumab, an anti-immunoglobulin E (IgE) monoclonal antibody, inhibits the binding of circulating IgE to mast cells and basophils, resulting in fewer episodes of airway inflammation, asthma symptoms and exacerbations in patients with severe allergic asthma. Treatment of patients with asthma using omalizuma...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000442668

    authors: Mizuma H,Tanaka A,Uchida Y,Fujiwara A,Manabe R,Furukawa H,Kuwahara N,Fukuda Y,Kimura T,Jinno M,Ohta S,Yamamoto M,Matsukura S,Adachi M,Sagara H

    更新日期:2015-01-01 00:00:00

  • Bed bug saliva causes release of monocytic inflammatory mediators: plausible cause of cutaneous bite reactions.

    abstract::Bed bugs may cause mild to severe cutaneous reactions. We studied the ability of bed bug salivary extract (SGE) to induce inflammatory reactions responsible for cutaneous manifestations and found that SGE stimulated the production of several potent chemokines and cytokines from macrophages. Chemokines induced by SGE i...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000345134

    authors: Goddard J,Hasenkampf N,Edwards KT,de Shazo R,Embers ME

    更新日期:2013-01-01 00:00:00

  • Regulation of human eotaxin generation by Th1-/Th2-derived cytokines.

    abstract:BACKGROUND:Accumulating evidence indicates that eotaxin is the primary mediator of tissue eosinophilia. In the present study, we analyzed the mechanisms of eotaxin generation by Th1-/Th2-derived cytokines in vitro. METHODS:Human dermal fibroblasts, human umbilical vein endothelial cells and A549 human bronchial epithe...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000053634

    authors: Miyamasu M,Misaki Y,Yamaguchi M,Yamamoto K,Morita Y,Matsushima K,Nakajima T,Hirai K

    更新日期:2000-05-01 00:00:00

  • Defective 'gut processing' of gliadin in mice with graft-versus-host enteropathy.

    abstract::The gut mucosa plays an important role in the induction of oral tolerance. Extending previous observations, we have here shown that serum containing gut-absorbed gliadin induces suppression of the specific systemic immune response in recipient mice parenterally immunized with gliadin. Graft-versus-host reaction (GvHR)...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000237230

    authors: Troncone R,Caputo N,Zibella A,Russo R,Rossi M,Gianfrani C,Stern M,Wieser H,Auricchio S

    更新日期:1996-01-01 00:00:00

  • Baked Tolerance in Cow's Milk Allergy: Quite Frequent, Hard to Predict!

    abstract:INTRODUCTION:Cow's milk protein allergy (CMA) is the most common type of food allergy in childhood and exclusion diet is a challenge for patients. OBJECTIVE:The study aim was to investigate the frequency of tolerance to baked foods containing milk and evaluate immediate skin prick test (SPT) and specific IgEs for diff...

    journal_title:International archives of allergy and immunology

    pub_type: 新闻

    doi:10.1159/000511148

    authors: Vilar LK,Araújo FA,Santos TP,Menezes TT,Cheik MF,Segundo GRS

    更新日期:2020-10-14 00:00:00

  • Correlation between T-cell and mast cell activity in patients with chronic urticaria.

    abstract:BACKGROUND:The presence of autoantibodies reacting with the high affinity IgE receptor (FcepsilonRIalpha) usually indicates a more severe form of chronic urticaria (CU). Previously, we showed an increased lymphocyte reactivity in CU patients; however, the relation between enhanced cellular immunity and the presence of ...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000073719

    authors: Hidvégi B,Nagy E,Szabó T,Temesvári E,Marschalkó M,Kárpáti S,Horváth A,Gergely P

    更新日期:2003-10-01 00:00:00

  • Circadian patterns in histamine concentrations and mast cell number in the rat thyroid gland.

    abstract::We carried out a cross-sectional chronobiological investigation on blood histamine, thyroid histamine and thyroid mast cell number in Wistar rats. Daily, blood histamine varied from 0.38 +/- 0.01 (12.00 h) to 0.60 +/- 0.01 mg/g wet weight (20.00 h) and thyroid histamine from 21.2 +/- 1.19 (04.00 h) to 38.3 +/- 1.54 mg...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000236788

    authors: Catini C,Miliani A,Macchi C

    更新日期:1994-12-01 00:00:00

  • Peripheral blood T lymphocytes and basophils, freshly isolated from house-dust-mite-sensitive patients, produce interleukin-4 in response to allergen-specific stimulation.

    abstract::We examined the capacity of interleukin-4 (IL) production from lymphocytes and basophils, isolated from the peripheral blood of allergic patients sensitive to house dust mite, after stimulation with mite extract. IL-4 production was measured by a sensitive bioassay based on coculture with CT.h4S (a human IL-4-responsi...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000237375

    authors: Ochi H,Tanaka T,Katada Y,Naka T,Aitani M,Hashimoto S,Maeda K,Toyoshima K,Igarashi T,Suemura M,Kishimoto T

    更新日期:1996-11-01 00:00:00

  • An Observational Study of the Diagnosis and Management of Chronic Urticaria in the UK.

    abstract:BACKGROUND:Patients with chronic urticaria (CU) in the UK could be referred to health care professionals (HCPs) with diverse specialties using different guidelines. The aims of the present study were to determine which CU guidelines HCPs in the UK use, which tests they use for the diagnosis of CU, and how they manage C...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000430442

    authors: Wu CH,Ardern-Jones MR,Eren E,Venter C

    更新日期:2015-01-01 00:00:00

  • IgE reactivity to profilin in pollen-sensitized subjects with adverse reactions to banana and pineapple.

    abstract:BACKGROUND:The so-called 'latex-fruit syndrome' is a well-documented phenomenon in cross-reactive allergies. By contrast, there is a lack of information about allergy to exotic fruits in patients with a predominant pollen sensitization. Since the ubiquitous protein profilin has been identified as an allergen in natural...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000059400

    authors: Reindl J,Rihs HP,Scheurer S,Wangorsch A,Haustein D,Vieths S

    更新日期:2002-06-01 00:00:00

  • Suckling reduces allergic skin responses and plasma levels of neuropeptide and neurotrophin in lactating women with atopic eczema/dermatitis syndrome.

    abstract:BACKGROUND:Lactation is associated with an inhibited hypothalamic-pituitary-adrenal axis response to physical and psychological stress in women and female rats. However, suckling also improved mood and calmness in nonatopic lactating women. Relaxation by humor reduced allergen-induced skin wheal responses, while variou...

    journal_title:International archives of allergy and immunology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000074906

    authors: Kimata H

    更新日期:2003-12-01 00:00:00

  • Differential effects of short-acting beta2-agonists on human granulocyte functions.

    abstract:BACKGROUND:beta2-Adrenergic agonists play a pivotal role in the management of bronchial asthma. Although the major effect of short-acting beta2-agonists on the airway is relaxation of smooth muscles, they may also have several effects on surrounding immunomodulatory cells. METHODS:We examined whether widely used short...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000089516

    authors: Yasui K,Kobayashi N,Yamazaki T,Agematsu K,Matsuzaki S,Nakata S,Baba A

    更新日期:2006-01-01 00:00:00

  • Anti-Thy-1 antibody provokes reverse passive cutaneous anaphylaxis-like reactions.

    abstract::Antibodies to rat Thy-1, and also to murine Thy-1, could provoke reverse passive cutaneous anaphylaxis-like (RPCA-like) reactions. The threshold amount of purified anti-Thy-1 antibodies for RPCA-like reactions was 12.5 microg/ml. No RPCA-like reactions were obtained with IgG1 F(ab')2 anti-Thy-1. Cross-linking the muri...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000237662

    authors: Yamaji C,Hirano T,Miyajima H,Hashimoto H,Okumura K,Ovary Z

    更新日期:1997-10-01 00:00:00

  • Enhancement of interleukin-4 production in activated CD4+ T cells by diphthalate plasticizers via increased NF-AT binding activity.

    abstract:BACKGROUND:Diethylhexyl phthalate (DEHP) and diisononyl phthalate (DINP), two commonly used plasticizers in flexible polyvinylchloride formulations, have potentially adverse effects on human health. However, the influence of these diphthalates on allergic responses remains unclear. In this study we examined the effects...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000078768

    authors: Lee MH,Park J,Chung SW,Kang BY,Kim SH,Kim TS

    更新日期:2004-07-01 00:00:00

  • IL-8 and the activation of eosinophils and neutrophils following nasal allergen challenge.

    abstract:BACKGROUND:A growing body of evidence suggests that proinflammatory cytokines play a role in allergic inflammation by attracting and activating inflammatory cells. In this study, we have investigated the relationship between interleukin-8 (IL-8) in nasal lavage fluid and the local activation of eosinophils and neutroph...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000023925

    authors: Jacobi HH,Poulsen LK,Reimert CM,Skov PS,Ulfgren AK,Jones I,Elfman LB,Malling HJ,Mygind N

    更新日期:1998-05-01 00:00:00

  • Detection and quantification of pharaoh ant antigens in household dust samples as newly identified aeroallergens.

    abstract:BACKGROUND:The widespread house ant, Monomorium pharaonis (pharaoh ant, PA), was recently identified as a potential cause of respiratory allergies. However, there are no reports of the distribution of PA allergens in various environments. We developed specific ELISA inhibition assays and measured the distribution and a...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000103999

    authors: Kim CW,Song JS,Choi SY,Park JW,Hong CS

    更新日期:2007-01-01 00:00:00

  • Profilins: mimickers of allergy or relevant allergens?

    abstract::Profilins are ubiquitous proteins, present in all eukaryotic cells and identified as allergens in pollen, latex and plant foods. The highly conserved structure justifies the cross-reactive nature of IgE antibodies against plant profilins and their designation as pan-allergens. Primary sensitization to profilin seems t...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章,评审

    doi:10.1159/000321178

    authors: Santos A,Van Ree R

    更新日期:2011-01-01 00:00:00

  • Allergenic differences among pollens of three Salsola species.

    abstract:BACKGROUND:Sensitivity to Chenopodiaceae is a frequent cause of allergic respiratory diseases in geographic areas where sensitization to Salsola kali and Chenopodium album has been reported. The objective of this study was to evaluate the pattern of sensitization to 3 Salsola species in patients residing on the Mediter...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000242357

    authors: Ferrer A,Larramendi CH,Huertas AJ,Pagán JA,Andreu C,García-Abujeta JL,López-Matas MA,Carnés J

    更新日期:2010-01-01 00:00:00

  • The negative predictive value of typing safe local anesthetics.

    abstract:BACKGROUND:Although allergy to local anesthetics (LA) is rare, patients often report unwanted reactions after their administration. A history of anaphylaxis or an atypical reaction related to LA is an indication for typing a safe anesthetic for future surgical or dental procedures. AIM:The aim of the study was to dete...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000350763

    authors: Specjalski K,Kita-Milczarska K,Jassem E

    更新日期:2013-01-01 00:00:00

  • Vitamin C and E suppress mitogen-stimulated peripheral blood mononuclear cells in vitro.

    abstract:BACKGROUND/AIMS:The antioxidant properties of vitamin C and E are considered to be important for their anti-inflammatory activity. Recently, antioxidant resveratrol was found to suppress neopterin production and tryptophan degradation in mitogen-treated human peripheral blood mononuclear cells. METHODS:In this study, ...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000096438

    authors: Winkler C,Schroecksnadel K,Schennach H,Fuchs D

    更新日期:2007-01-01 00:00:00

  • Tolerability and clinical outcome of coseasonal treatment with Escherichia coli strain Nissle 1917 in grass pollen-allergic subjects.

    abstract:BACKGROUND:Nonpathogenic Escherichia coli strain Nissle 1917 (EcN) has immunomodulatory properties and can act on different cells which are important for the allergic immune response. Herein, we investigated the efficacy and tolerability of EcN in subjects with grass pollen-dependent allergic rhinoconjunctivitis. METH...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章,随机对照试验

    doi:10.1159/000356328

    authors: Dölle S,Berg J,Rasche C,Worm M

    更新日期:2014-01-01 00:00:00

  • Alpha-melanocyte-stimulating hormone plays an important role in the onset of pollinosis in a pollen allergy mouse model.

    abstract:BACKGROUND:alpha-Melanocyte-stimulating hormone (alpha-MSH) is a neuropeptide that controls melanogenesis in pigmentary cells. In addition, its potent immunomodulatory activity has been recently described in cutaneous inflammatory disorders. However the mechanism of such pollen allergies remains to be elucidated. The p...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000301574

    authors: Hiramoto K,Hashimoto M,Orita K,Jikumaru M,Sato EF,Inoue M

    更新日期:2010-01-01 00:00:00

  • Sequential development of airway hyperresponsiveness and acute airway obstruction in a mouse model of allergic inflammation.

    abstract:BACKGROUND:Mouse models have been established mirroring key features of human bronchial asthma including airway hyperresponsiveness (AHR). Acute airway obstruction in response to an allergen challenge, however, remains to be demonstrated in these models. OBJECTIVE:A mouse model of allergic lung inflammation was employ...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000024298

    authors: Neuhaus-Steinmetz U,Glaab T,Daser A,Braun A,Lommatzsch M,Herz U,Kips J,Alarie Y,Renz H

    更新日期:2000-01-01 00:00:00

  • Increased levels of serum-specific immunoglobulin e to staphylococcal enterotoxin a and B in patients with allergic rhinitis and bronchial asthma.

    abstract:BACKGROUND:The association between staphylococcal enterotoxins and atopic dermatitis (AD) is well characterized. We aim to evaluate the association between sensitization to staphylococcal enterotoxin A (SEA) and/or B (SEB) and the development of allergic airway disease. METHODS:Two hundred and seventy-four patients we...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000088868

    authors: Lee JH,Lin YT,Yang YH,Wang LC,Chiang BL

    更新日期:2005-12-01 00:00:00

  • Suppression of murine IgE responses with ovalbumin-pullulan conjugates: comparison of the suppressive effect of different conjugation methods and different molecular weights of pullulan.

    abstract::Ovalbumin (OVA)-pullulan conjugates were made using four different conjugation methods and eight different molecular weights of pullulan ranging from 4,200 to 600,000. Pretreatment of mice by the administration of conjugates made by using cyanulic chloride or cyanogen bromide and pullulan of molecular weight 40,000 or...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000236536

    authors: Uchida T,Ikegami H,Ando S,Kurimoto M,Mitsuhashi M,Naito S,Usui M,Matuhasi T

    更新日期:1993-01-01 00:00:00

  • Signal transduction through interferon-gamma receptor on human eosinophils.

    abstract:BACKGROUND:We reported on the constitutive interferon-gamma receptor (IFN-gammaR) expression on eosinophils. But signal transduction through IFN-gammaR on eosinophils remains to be elucidated. In this study, we examined the involvement of the Jak/Stat pathway in the signaling of eosinophils after IFN-gammaR conjugation...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000024159

    authors: Ochiai K,Ishihara C,Tomioka H

    更新日期:1999-02-01 00:00:00

  • Influence of degraded phosphatidylserine on binding of antiphospholipid antibodies.

    abstract:BACKGROUND:Antiphospholipid antibodies (aPL) show great heterogeneity. Different phospholipids, with or without protein cofactor(s), and phospholipid binding proteins alone have been proposed as the target molecules for aPL. In order to determine the influence of phospholipid degradation products on the binding of aPL,...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000237426

    authors: Bozic B,Kveder T,Stegnar M,Morosini-Berus E,Kos-Golja M,Peternel P,Rozman B

    更新日期:1997-01-01 00:00:00

  • Allergic sensitization to common airborne allergens among adults in Estonia.

    abstract:BACKGROUND:Allergies and asthma exhibit a growing health problem in the world. Sparse data are available about the prevalence of allergic sensitization in Estonia and Eastern Europe as well. We studied the prevalence of allergic sensitization, the associations between respiratory symptoms and allergic sensitization, an...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000097027

    authors: Raukas-Kivioja A,Raukas ES,Meren M,Loit HM,Rönmark E,Lundbäck B

    更新日期:2007-01-01 00:00:00