An Observational Study of the Diagnosis and Management of Chronic Urticaria in the UK.

Abstract:

BACKGROUND:Patients with chronic urticaria (CU) in the UK could be referred to health care professionals (HCPs) with diverse specialties using different guidelines. The aims of the present study were to determine which CU guidelines HCPs in the UK use, which tests they use for the diagnosis of CU, and how they manage CU. METHODS:In this UK-wide survey, we designed a questionnaire covering the diagnosis and management of CU based on current guidelines. The link to the questionnaire was sent to the British Society for Allergy and Clinical Immunology (BSACI), the British Association of Dermatologists (BAD), the British Society of Immunology (BSI), and the Food Allergy and Intolerance Specialist Group (FAISG) of the British Dietetic Association (BDA), who distributed the link to their members. RESULTS:The questionnaire was completed by 55 allergists/immunologists, 64 dermatologists, and 43 dietitians. More dermatologists used the BAD guidelines in comparison with allergists and immunologists (93.6 vs. 12.5%; p < 0.001). On the other hand, the BSACI guidelines (83.3 vs. 14.9%; p < 0.001) and the European Academy of Allergy and Clinical Immunology (EAACI)/Global Allergy and Asthma European Network (GA(2)LEN)/European Dermatology Forum (EDF)/World Allergy Organization (WAO) guidelines (2013) (52.1 vs. 10.6%; p < 0.001) were used by more allergists and immunologists compared to dermatologists. Differences were found between allergists/immunologists and dermatologists with regard to guidelines used, investigations performed, preference of first-line antihistamine, and prescription of alternative treatment methods. CONCLUSION:In conclusion, differences in the diagnosis and management of CU between HCPs of diverse specialties were identified, which reflected differences among the guidelines used.

authors

Wu CH,Ardern-Jones MR,Eren E,Venter C

doi

10.1159/000430442

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

1-8

issue

1

eissn

1018-2438

issn

1423-0097

pii

000430442

journal_volume

167

pub_type

杂志文章
  • Baked Tolerance in Cow's Milk Allergy: Quite Frequent, Hard to Predict!

    abstract:INTRODUCTION:Cow's milk protein allergy (CMA) is the most common type of food allergy in childhood and exclusion diet is a challenge for patients. OBJECTIVE:The study aim was to investigate the frequency of tolerance to baked foods containing milk and evaluate immediate skin prick test (SPT) and specific IgEs for diff...

    journal_title:International archives of allergy and immunology

    pub_type: 新闻

    doi:10.1159/000511148

    authors: Vilar LK,Araújo FA,Santos TP,Menezes TT,Cheik MF,Segundo GRS

    更新日期:2020-10-14 00:00:00

  • Sera from patients with multiple drug allergy syndrome contain circulating histamine-releasing factors.

    abstract:BACKGROUND:A subset of drug-intolerant patients show a marked propensity to react to several chemically unrelated antibacterial drugs. This condition is termed multiple drug allergy syndrome (MDAS). The pathogenesis of MDAS is still unclear. A possible mechanism is that a nonspecific patient-related factor leading to d...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000071486

    authors: Asero R,Tedeschi A,Lorini M,Caldironi G,Barocci F

    更新日期:2003-07-01 00:00:00

  • HLA-DRB1 and anti-cyclic citrullinated peptide antibody production in rheumatoid arthritis.

    abstract::Anti-cyclic citrullinated peptide antibodies (anti-CCP) are a new diagnostic marker for rheumatoid arthritis (RA), which shows a specificity of 97% and a sensitivity of 81% in the second generation assay. About 61% of RA patients express HLA-DRB1*0401. In a cohort of patients with RA we investigated whether the expres...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000086463

    authors: Senkpiehl I,Marget M,Wedler M,Jenisch S,Georgi J,Kabelitz D,Steinmann J

    更新日期:2005-08-01 00:00:00

  • Specific antibodies in oral immunotherapy for cow's milk allergy: kinetics and prediction of clinical outcome.

    abstract:BACKGROUND:METHODS for predicting the clinical outcome of specific oral immunotherapy (OIT) would improve the safety of the therapy. METHODS:We investigated 40 children aged 6-17 years with IgE-mediated cow's milk allergy (CMA) who either successfully completed OIT (n = 32) or discontinued the therapy due to adverse r...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000361023

    authors: Savilahti EM,Kuitunen M,Savilahti E,Mäkelä MJ

    更新日期:2014-01-01 00:00:00

  • Modifications of Phleum pratense grass pollen allergens following artificial exposure to gaseous air pollutants (O(3), NO(2), SO(2)).

    abstract:BACKGROUND:Air pollution is frequently proposed as a potential cause of the increased incidence of allergy in industrialised countries. Our objective was to investigate the impact of the major gaseous air pollutants on grass pollen allergens. METHODS:Timothy grass pollen was exposed to ozone (O(3)), nitrogen dioxide (...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000099079

    authors: Rogerieux F,Godfrin D,Sénéchal H,Motta AC,Marlière M,Peltre G,Lacroix G

    更新日期:2007-01-01 00:00:00

  • The Th1/Th2 paradigm and experimental murine leishmaniasis.

    abstract::In recent years, the Th1/Th2 concept has become of prime importance in the understanding of heterogeneous responses of the immune system and implications thereof for infectious and autoimmune diseases. Originally established on the basis of different cytokines produced by T cell clones, it is now known that the Th1/Th...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章,评审

    doi:10.1159/000023900

    authors: Lohoff M,Gessner A,Bogdan C,Röllinghoff M

    更新日期:1998-03-01 00:00:00

  • Antiallergic and anti-inflammatory effects of a novel I kappaB kinase beta inhibitor, IMD-0354, in a mouse model of allergic inflammation.

    abstract:BACKGROUND:Nuclear factor (NF)-kappaB is a transcription factor known to regulate allergy-associated cytokine and chemokine production related to the induction of inflammation. I kappaB kinase beta (IKK beta), which is responsible for activation of the NF-kappaB pathway, may be an ideal molecular target to inhibit this...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000161579

    authors: Sugita A,Ogawa H,Azuma M,Muto S,Honjo A,Yanagawa H,Nishioka Y,Tani K,Itai A,Sone S

    更新日期:2009-01-01 00:00:00

  • Respiratory responses of asthmatics to ozone.

    abstract::Asthmatic individuals in the general population appear to be susceptible to disease exacerbation during summertime 'smog' episodes (ambient air pollution containing other pollutants in addition to ozone). Although controlled exposure to ozone causes acute decrements in lung function, asthmatic subjects are only margin...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章,评审

    doi:10.1159/000236989

    authors: Koren HS,Bromberg PA

    更新日期:1995-05-01 00:00:00

  • Lactose-intolerance may induce severe chronic eczema.

    abstract::The primary acquired lactase deficiency of the adult is known to cause various disturbances in the gastrointestinal tract while extraintestinal symptoms are unusual. Here we report on a histologically proven chronic eczema requiring corticosteroid treatment for several months. It was obviously induced by a concomitant...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000237632

    authors: Grimbacher B,Peters T,Peter HH

    更新日期:1997-08-01 00:00:00

  • Leukotriene D4 induces production of transforming growth factor-beta1 by eosinophils.

    abstract::Eosinophils may play an important role in the pathogenesis of airway remodeling in asthma through the production of various fibrogenic cytokines such as transforming growth factor-beta1 (TGF-beta1). Cysteinyl leukotrienes are also suggested to be involved in remodeling with their potential to induce proliferation of a...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000085427

    authors: Kato Y,Fujisawa T,Nishimori H,Katsumata H,Atsuta J,Iguchi K,Kamiya H

    更新日期:2005-01-01 00:00:00

  • Blockade of CD28/B7 interaction suppresses allergic eosinophilic inflammation in mice.

    abstract::To determine whether the costimulatory signal via CD28/B7 interaction is required for causing allergic inflammation, we examined the effect of administration of CTLA4-Ig, a fusion protein of the extracellular domain of CTLA4 and human IgG1-constant region, at the time of sensitization, on antigen-induced eosinophil in...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000053564

    authors: Kasai M,Kumano K,Kurasawa K,Nakao A,Saito Y,Iwamoto I

    更新日期:1998-09-01 00:00:00

  • Progesterone modulation of anaphylactically induced ion transport in uterus and intestine.

    abstract::The objective of this study was to investigate the role of progesterone in modulating electrophysiological responses to antigenic challenge that are reflective of immune functions in uterine and jejunal mucosae. In the rat-Trichinella spiralis, host-parasite system, an enteric infection with a microscopic nematode sen...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000237130

    authors: Harari Y,Castro GA

    更新日期:1995-10-01 00:00:00

  • Histamine augments VCAM-1 expression on IL-4- and TNF-alpha-stimulated human umbilical vein endothelial cells.

    abstract::Interaction between vascular cell adhesion molecule-1 (VCAM-1) on endothelial cells and CD49d molecules on eosinophils is thought to mediate the selective infiltration of eosinophils into inflamed tissues in allergic disease. IL-4 and TNF-alpha are associated with allergic conditions, and they have been shown to selec...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000237357

    authors: Saito H,Shimizu H,Mita H,Maeda Y,Akiyama K

    更新日期:1996-10-01 00:00:00

  • Tolerability and clinical outcome of coseasonal treatment with Escherichia coli strain Nissle 1917 in grass pollen-allergic subjects.

    abstract:BACKGROUND:Nonpathogenic Escherichia coli strain Nissle 1917 (EcN) has immunomodulatory properties and can act on different cells which are important for the allergic immune response. Herein, we investigated the efficacy and tolerability of EcN in subjects with grass pollen-dependent allergic rhinoconjunctivitis. METH...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章,随机对照试验

    doi:10.1159/000356328

    authors: Dölle S,Berg J,Rasche C,Worm M

    更新日期:2014-01-01 00:00:00

  • Changes in the production of nitric oxide and superoxide by inflammatory cells in liver cirrhosis.

    abstract::Superoxide (O2-) and nitric oxide (NO) production by polymorphonuclear leukocyte (PMNs) and monocytes in patients with liver cirrhosis were evaluated. PMNs obtained from cirrhotic patients were less effective than those from controls in producing O2- after stimulation with opsonized zymosan, while they were more effec...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000236975

    authors: Masini E,Mugnai L,Foschi M,Laffi G,Gentilini P,Mannaioni PF

    更新日期:1995-05-01 00:00:00

  • Eosinophil granulocyte interaction with serum-opsonized particles: binding and degranulation are enhanced by tumor necrosis factor alpha.

    abstract::Eosinophils participate in the inflammatory response seen in allergy and helminthic infestation. Their release of granule-bound cationic proteins may play a role in these diseases. Therefore, we investigated mechanisms involved in the release of eosinophil cationic protein (ECP). Serum-opsonized zymosan was phagocytos...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000023891

    authors: Egesten A,Blom M,Calafat J,Janssen H,Knol EF

    更新日期:1998-02-01 00:00:00

  • Activation of human mast cells through stem cell factor receptor (KIT) is associated with expression of bcl-2.

    abstract:BACKGROUND:Mast cells (MCs) are multifunctional effector cells of the immune system. These cells originate from pluripotent hemopoietic progenitors. In contrast to basophils and other leukocytes, MCs exhibit a remarkably long life span (years) in vivo. Although a role for stem cell factor (SCF) and SCF receptor (KIT) i...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000066773

    authors: Baghestanian M,Jordan JH,Kiener HP,Bevec D,Agis H,Fritsch G,Müller MR,Bankl HC,Schernthaner GH,Lechner K,Valent P

    更新日期:2002-11-01 00:00:00

  • Nitric oxide: a promising methodological approach in airway diseases.

    abstract::Nitric oxide (NO) is a potent biological mediator, and has a regulatory role in a wide variety of cellular and tissue functions. In the upper and lower airways, NO has been suggested to be involved in different functions with regulatory, protective, defensive or damaging effects. It is obvious that NO plays an importa...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章,评审

    doi:10.1159/000324678

    authors: Sahin G,Klimek L,Mullol J,Hörmann K,Walther LE,Pfaar O

    更新日期:2011-01-01 00:00:00

  • 100 years of immunotherapy: the Monaco charter. under the high patronage of His Serene Highness Prince Albert II of Monaco.

    abstract::Aims of the Monaco Charter: (1) to present the current evidence on the efficacy and safety of allergen-specific immunotherapy (SIT) and to address the reasons for its underuse in clinical practice; (2) to develop strategies to increase the awareness about the benefits and the hazards of SIT in allergic patients, lay p...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000343883

    authors: Canonica GW,Baena-Cagnani CE,Compalati E,Bohle B,Bonini S,Bousquet J,Cox L,Fink-Wagner AH,González Díaz S,Jacobsen L,Passalacqua G,Pawankar R,Vieths S,Yusuf O,Zuberbier T

    更新日期:2013-01-01 00:00:00

  • Genetic and environmental influences on airway inflammation in asthma.

    abstract::The clear recognition that asthma has an inflammatory basis has led to a search for genetic and environmental causes. Genetic linkage studies provide evidence for allelic association between polymorphic markers of interleukin-9 on chromosome 5 and a principal component of the allergic phenotype, log IgE. Further studi...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章,评审

    doi:10.1159/000236921

    authors: Holgate ST,Church MK,Howarth PH,Morton EN,Frew AJ,Djukanović R

    更新日期:1995-05-01 00:00:00

  • Immune reactivity to mite allergens in nonatopic subjects: immune deviation or immune ignorance.

    abstract::Most subjects without IgE to Dermatophagoides pteronyssinus do not have IgG to Der p 1 or Der p 2 (as measured by RIA). However, by immunoblot or ELISA, IgG reactivity (mostly IgG1) to mite components is easily detectable. This discrepancy is caused largely by immune reactivity to mite components with a high molecular...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000053712

    authors: Aalberse RC,Vermeulen E

    更新日期:2001-01-01 00:00:00

  • Interleukin-12 inhibits production of interleukin-5 but not of granulocyte/macrophage colony-stimulating factor by antigen-stimulated blood mononuclear cells in allergic bronchial asthmatics.

    abstract::Bronchial asthma, characterized by eosinophilic inflammation in airways, may involve Th2-type cytokines such as interleukin-5 (IL-5). IL-12, a newly established cytokine, induces IFN-gamma production, which may have a regulatory effect on the production of Th2-type cytokines. We examined the effects of IL-12 on the pr...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000023834

    authors: Okano Y,Nakamura Y,Sano T,Azuma M,Sone S

    更新日期:1998-01-01 00:00:00

  • Specific activation of human mast cells by the ligand for c-kit: comparison between lung, uterus and heart mast cells.

    abstract::Recent data suggest that stem cell factor (SCF or c-kit ligand, KL) is a major regulator of human mast cells (MCs). In the present study, MCs derived from the lung (n = 8), uterus (n = 14) and heart (n = 4) were analyzed for expression of c-kit receptor and for responses to recombinant SCF. MCs of all organs tested we...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000236568

    authors: Sperr WR,Czerwenka K,Mundigler G,Müller MR,Semper H,Klappacher G,Glogar HD,Lechner K,Valent P

    更新日期:1993-01-01 00:00:00

  • Increased expression of matrix metalloproteinase-2, matrix metalloproteinase-9 and matrix metalloproteinase-13 in lesional skin of bullous pemphigoid.

    abstract:BACKGROUND:Matrix metalloproteinase (MMP)-2, MMP-9 and MMP-13 can degrade type IV collagen which is the major component of the basement membrane zone (BMZ). In bullous pemphigoid (BP), the separation occurs within the BMZ. OBJECTIVE:To evaluate the involvement of MMPs in the pathogenesis of BP, we examined the express...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000090385

    authors: Niimi Y,Pawankar R,Kawana S

    更新日期:2006-01-01 00:00:00

  • Eight Aeroallergen Skin Extracts May Be the Optimal Panel for Allergic Rhinitis Patients in Central China.

    abstract:BACKGROUND:The prevalence of allergic rhinitis (AR) is increasing rapidly in Central China. The skin prick test (SPT) is the standard tool with which to determine the allergen sensitization status in AR patients. Changes in allergen sensitization patterns have been observed within countries and regions due to geographi...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000479429

    authors: Wang J,Wu Y,Li J,Huang X,Zhu R

    更新日期:2017-01-01 00:00:00

  • Lipopolysaccharides modulate allergen-specific immune regulation in a murine model of mucosal tolerance induction.

    abstract:BACKGROUND:Farming has been widely reported to be associated with decreased risk of developing atopic disorders, but underlying immunomodulatory mechanisms are still not fully defined. We delineated T-cell functions after induction of mucosal tolerance in the context of intranasally delivered organic dust compounds, li...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000128583

    authors: Gerhold K,Avagyan A,Reichert E,Blumchen K,Wahn U,Hamelmann E

    更新日期:2008-01-01 00:00:00

  • Interleukin-4 and interleukin-13 enhance human bronchial smooth muscle cell proliferation.

    abstract:BACKGROUND:T(H)2 inflammation and bronchial smooth muscle cell (BSMC) hyperplasia are characteristic features of asthma, but whether these phenomena are linked remains unknown. This study aims to define the effect of the T(H)2 cytokines IL-4 and IL-13 on human BSMC proliferation when administered alone or in combinatio...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000113517

    authors: Bossé Y,Thompson C,Audette K,Stankova J,Rola-Pleszczynski M

    更新日期:2008-01-01 00:00:00

  • Practical approach to self-administration of intravenous C1-INH concentrate: a nursing perspective.

    abstract::At an international hereditary angioedema (HAE) expert meeting, results from a survey were used to guide discussion on how best to advise patients on self-administering intravenous C1 esterase inhibitor therapy. Treatment differences across Europe were highlighted, together with the practicalities of self-administrati...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000351236

    authors: Symons C,Rossi O,Magerl M,Andritschke K

    更新日期:2013-01-01 00:00:00

  • Orange germin-like glycoprotein Cit s 1: an equivocal allergen.

    abstract:BACKGROUND:Orange allergens are virtually unknown, in spite of the large consumption of this fruit. Germin-like proteins, together with vicilins and legumins, form the cupin superfamily of plant proteins, which includes many seed allergens. METHODS:Twenty-nine patients with allergy to oranges were studied. A major IgE...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000090384

    authors: Ahrazem O,Ibáñez MD,López-Torrejón G,Sánchez-Monge R,Sastre J,Lombardero M,Barber D,Salcedo G

    更新日期:2006-01-01 00:00:00

  • Suppression of murine IgE responses with ovalbumin-pullulan conjugates: comparison of the suppressive effect of different conjugation methods and different molecular weights of pullulan.

    abstract::Ovalbumin (OVA)-pullulan conjugates were made using four different conjugation methods and eight different molecular weights of pullulan ranging from 4,200 to 600,000. Pretreatment of mice by the administration of conjugates made by using cyanulic chloride or cyanogen bromide and pullulan of molecular weight 40,000 or...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000236536

    authors: Uchida T,Ikegami H,Ando S,Kurimoto M,Mitsuhashi M,Naito S,Usui M,Matuhasi T

    更新日期:1993-01-01 00:00:00