Immune reactivity to mite allergens in nonatopic subjects: immune deviation or immune ignorance.

Abstract:

:Most subjects without IgE to Dermatophagoides pteronyssinus do not have IgG to Der p 1 or Der p 2 (as measured by RIA). However, by immunoblot or ELISA, IgG reactivity (mostly IgG1) to mite components is easily detectable. This discrepancy is caused largely by immune reactivity to mite components with a high molecular weight under native conditions (possibly mite gut flora cross-reactive with human gut flora) and partially by the presence of IgG with low affinity for fluid-phase antigen. We conclude that the pattern of IgG antibody in subjects without IgE to mites does not support the notion of immune deviation, but rather indicates a lack of a mite-induced high-affinity immune response.

authors

Aalberse RC,Vermeulen E

doi

10.1159/000053712

keywords:

subject

Has Abstract

pub_date

2001-01-01 00:00:00

pages

208-9

issue

1-3

eissn

1018-2438

issn

1423-0097

pii

53712

journal_volume

124

pub_type

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