Abstract:
:The objective of this study was to investigate the role of progesterone in modulating electrophysiological responses to antigenic challenge that are reflective of immune functions in uterine and jejunal mucosae. In the rat-Trichinella spiralis, host-parasite system, an enteric infection with a microscopic nematode sensitizes both the jejunum and uterus. Electrophysiological correlates of local anaphylaxis or type I hypersensitivity were monitored in vitro throughout the estrus cycle and during pregnancy. The magnitude of the anaphylactic response was correlated with serum levels of progesterone. Functional immunity was measured directly in the intestine by assessing the development of acquired resistance to reinfection with T. spiralis. Results support the conclusion that high progesterone output, as occurs during metestrus and pregnancy, and exogenously administered hormone suppress uterine responsiveness. However, the reduced uterine sensitivity to challenge could be attributed to nonspecific physiological effects of progesterone rather than direct effects on immunological components involved in the transduction of the antigenic signal. The electrophysiological response to antigen in the intestine was relatively refractory to effects of progesterone. These observations add to our understanding of endocrine control of mucosal responses to antigenic challenge and underscore site selectively of hormonal action.
journal_name
Int Arch Allergy Immunoljournal_title
International archives of allergy and immunologyauthors
Harari Y,Castro GAdoi
10.1159/000237130subject
Has Abstractpub_date
1995-10-01 00:00:00pages
134-41issue
2eissn
1018-2438issn
1423-0097journal_volume
108pub_type
杂志文章abstract:BACKGROUND:Patients with chronic urticaria (CU) in the UK could be referred to health care professionals (HCPs) with diverse specialties using different guidelines. The aims of the present study were to determine which CU guidelines HCPs in the UK use, which tests they use for the diagnosis of CU, and how they manage C...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000430442
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Sensitivity to Chenopodiaceae is a frequent cause of allergic respiratory diseases in geographic areas where sensitization to Salsola kali and Chenopodium album has been reported. The objective of this study was to evaluate the pattern of sensitization to 3 Salsola species in patients residing on the Mediter...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000242357
更新日期:2010-01-01 00:00:00
abstract::The present study has extended histochemical and functional investigations into rat mast cell heterogeneity using isolated mast cells from four connective tissue locations; the peritoneum, mesentery, lung and skin. On histological examination, mast cells from these locations displayed a range of phenotypes following f...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000236161
更新日期:1992-01-01 00:00:00
abstract::At an international hereditary angioedema (HAE) expert meeting, results from a survey were used to guide discussion on how best to advise patients on self-administering intravenous C1 esterase inhibitor therapy. Treatment differences across Europe were highlighted, together with the practicalities of self-administrati...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000351236
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Cat allergens are ubiquitous because the clothing of cat owners constitutes an important source of distribution of Fel d 1 in cat-free environments. Since Fel d 1 can adhere to a variety of surfaces, we sought to verify if human hair belonging to individuals with or without a cat at home might represent a re...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000085793
更新日期:2005-06-01 00:00:00
abstract::Owing to the proposed role of Fc epsilon RII/CD23 in allergic diseases, we analyzed the expression of this receptor on peripheral blood lymphocytes (pan-B, pan-T and CD4+ or CD8+ T cells) and its autoproteolytic product sCD23 in serum. This was done in 10 asthmatic children allergic to Dermatophagoides pteronyssinus (...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000236520
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND:Previous studies have shown a negative association between ACP1 *B/*C genotype and total IgE level. ACP1 (acid phosphatase locus 1) is a polymorphic phosphotyrosine phosphatase that interacts with IL4-RA and is involved in T cell receptor signaling. METHODS:In the present paper, we have studied the relation...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000107466
更新日期:2008-01-01 00:00:00
abstract::Antibodies to specific autoantigens are serological hallmarks of systemic autoimmune diseases. These autoantibodies are thought to represent a consequence of immune dysregulation in these conditions, and, in part, have been shown to be involved in their pathologic consequences. However, the mechanisms that lead to the...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章,评审
doi:10.1159/000024422
更新日期:2000-09-01 00:00:00
abstract::Hypersensitivity pneumonitis remains an important industrial disease in mushroom workers. It has a significant morbidity, and early diagnosis and removal from exposure to the antigen are critically important in its management. Recently, several new allergens have been described, particularly those from mushroom specie...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章,评审
doi:10.1159/000083298
更新日期:2005-01-01 00:00:00
abstract:INTRODUCTION:One of the most frequent abnormalities of B cells in common variable immunodeficiency (CVID) is reduced number of class-switched memory B cells, suggesting an impaired germinal center response. Therefore, due to its pivotal role in regulating the development of humoral immunity, the objective of this study...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000507995
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Shellfish hypersensitivity is amongst the most common food allergies. The major shellfish allergen was identified as tropomyosin. Here, we investigated the immediate hypersensitivity responses, IgE and cell-mediated immune response in mice sensitized with recombinant shrimp tropomyosin. METHODS:Shrimp tropo...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000144038
更新日期:2008-01-01 00:00:00
abstract::Effects of mature T lymphocytes on thymic colonization by lymphohemopoietic cells were investigated in an in vitro experimental model, using a variety of experimental strategies. Lymphoid-depleted fetal thymus (FT) explants (C57BL/Ka, Thy1.1, H-2b) were incubated with bone marrow (BM) cells from syngeneic (C57BL/Ka; S...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000236884
更新日期:1995-01-01 00:00:00
abstract:BACKGROUND:Shrimp sensitization is common in the general population, but the presence of symptoms is only moderately related to sensitization. A point still at issue is which in vivo and/or in vitro tests (food challenge, component-resolved diagnosis, house dust mite [HDM] sensitization) can help in distinguishing shri...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000481985
更新日期:2017-01-01 00:00:00
abstract::The causal association between cow's milk allergy (CMA) and constipation is not well established. Some guidelines describe constipation as a possible symptom of CMA, while others do not mention it. We conducted a literature review and found 10 prospective clinical trials. In all of them, an oral food challenge was per...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章,评审
doi:10.1159/000362365
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Mugwort (Artemisia vulgaris) represents an important source of weed pollen allergens. The objectives of the present study were (i) to analyze the IgE binding profiles in a group of mugwort-allergic patients, (ii) to identify individual marker allergens crucial for the diagnosis of mugwort allergy and (iii) t...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000108134
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Lactation is associated with an inhibited hypothalamic-pituitary-adrenal axis response to physical and psychological stress in women and female rats. However, suckling also improved mood and calmness in nonatopic lactating women. Relaxation by humor reduced allergen-induced skin wheal responses, while variou...
journal_title:International archives of allergy and immunology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000074906
更新日期:2003-12-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to investigate lymphocyte adhesion to Kupffer cells as a component of an immune-mediated mechanism for halothane hepatitis. METHODS:Kupffer cells were isolated from guinea pigs exposed to 1.0% halothane/40% oxygen and cultured with various synthetic antigens (trifluoroacetyl-pr...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000237642
更新日期:1997-09-01 00:00:00
abstract:BACKGROUND:Prostaglandin D(2) (PGD(2)), a major prostanoid produced by activated mast cells, has long been implicated in allergic diseases. PGD(2) demonstrates its effects through two G-protein-coupled receptors, DP and CRTH2. The PGD(2)/CRTH2 system mediates chemotaxis of eosinophils, basophils, and Th2 cells, which a...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000095436
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:Accumulating evidence indicates that eotaxin is the primary mediator of tissue eosinophilia. In the present study, we analyzed the mechanisms of eotaxin generation by Th1-/Th2-derived cytokines in vitro. METHODS:Human dermal fibroblasts, human umbilical vein endothelial cells and A549 human bronchial epithe...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000053634
更新日期:2000-05-01 00:00:00
abstract:BACKGROUND:Volatile monoisocyanates are formed through thermal degradation when products containing polyurethane are heated. Repeated exposure to diisocyanates, such as toluene diisocyanate (TDI) are a well-known cause of occupational asthma. However, although monoisocyanates are abundant in occupational settings, ther...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000222675
更新日期:2009-01-01 00:00:00
abstract::Aims of the Monaco Charter: (1) to present the current evidence on the efficacy and safety of allergen-specific immunotherapy (SIT) and to address the reasons for its underuse in clinical practice; (2) to develop strategies to increase the awareness about the benefits and the hazards of SIT in allergic patients, lay p...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000343883
更新日期:2013-01-01 00:00:00
abstract::The relationship between the IgE load on mast cells and their secretory capacity when challenged with anti-IgE was studied in peritoneal cells obtained from rats of three different strains, Hooded Lister (HL), Wistar Kyoto (WKY) and Sprague-Dawley (SD). IgE was determined cytofluorometrically after labelling with FITC...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000236849
更新日期:1995-03-01 00:00:00
abstract:BACKGROUND:IgE mediates immediate-type hypersensitivity reactions responsible for various allergic symptoms. It is secreted by IgE-producing plasma cells, which differentiate from B cells expressing membrane-bound IgE (mIgE) on their surface. The epsilon-chain of human mIgE contains a membrane-anchoring peptide and an ...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000063860
更新日期:2002-08-01 00:00:00
abstract:BACKGROUND:It has been reported that protein tyrosine phosphorylation is essential for cytokine production in mouse Th1 cells but not in Th2 cells. However, little is known about the difference of signal transduction between human antigen-specific Th1 and Th2 cell clones. METHODS:Purified protein derivative-specific T...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000024028
更新日期:1999-01-01 00:00:00
abstract::Most subjects without IgE to Dermatophagoides pteronyssinus do not have IgG to Der p 1 or Der p 2 (as measured by RIA). However, by immunoblot or ELISA, IgG reactivity (mostly IgG1) to mite components is easily detectable. This discrepancy is caused largely by immune reactivity to mite components with a high molecular...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000053712
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND/AIMS:The antioxidant properties of vitamin C and E are considered to be important for their anti-inflammatory activity. Recently, antioxidant resveratrol was found to suppress neopterin production and tryptophan degradation in mitogen-treated human peripheral blood mononuclear cells. METHODS:In this study, ...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000096438
更新日期:2007-01-01 00:00:00
abstract::Preferential eosinophil accumulation is characteristic of airway inflammation in asthma. Although little is known about its mechanism, the effect of a sialyl Lewis X analog on airway eosinophilia was examined in a guinea-pig model of asthma. Guinea-pigs were sensitized by repeated inhalation of ovalbumin. After a sing...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000237412
更新日期:1996-01-01 00:00:00
abstract:BACKGROUND:Epidemiological data on food allergy are scarce in African countries. We studied the prevalence of food sensitization in Ghanaian schoolchildren. METHODS:Children (5-16 years; n = 1,714) from 9 Ghanaian schools were given parental consent to participate in the study. Adverse reactions and food consumption w...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000318704
更新日期:2011-01-01 00:00:00
abstract::The time course of the development of airway hyperresponsiveness (AHR) to inhaled acetylcholine (ACh) and the associated inflammatory cell recovery in bronchoalveolar lavage fluid (BAL) in actively sensitised Brown-Norway rats was studied following challenge with inhaled ovalbumin (OA). IgE for OA was detected in seru...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000236340
更新日期:1992-01-01 00:00:00
abstract::We have systematically investigated the capacity of highly purified human peripheral CD8+ T cells to produce interleukin (IL)-4 and interferon (IFN)-gamma when triggered by different stimuli. CD8+ T cells were isolated from peripheral blood by positive selection to > 99% purity and stimulated with one of three differe...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000237030
更新日期:1995-05-01 00:00:00