Rats repeatedly exposed to toluene diisocyanate exhibit immune reactivity against methyl isocyanate-protein conjugates.

abstract：BACKGROUND:The implementation of allergen immunotherapy (AIT) requires extensive knowledge of allergen distribution in the region to identify high-risk regions for AIT utilization. However, the geographical distribution patterns of the major Dermatophagoides allergens in China remain unclear despite the increasing prev...

journal_title：International archives of allergy and immunology

authors： Chen ZG,Li YT,Wang WH,Tan KS,Zheng R,Yang LF,Guan WJ,Hong HY,Yang QT

更新日期：2019-01-01 00:00:00

abstract：:The JAK (Janus kinase) family of protein tyrosine kinases and the STATs (signal transducers and activators of transcription) have been shown to be activated in response to a number of cytokines and growth factors. In this study, we evaluated the activation of JAK/STAT pathway upon human interleukin-5 (hIL-5) stimulati...

journal_title：International archives of allergy and immunology

authors： Ogata N,Kikuchi Y,Kouro T,Tomonaga M,Takatsu K

更新日期：1997-10-01 00:00:00

abstract：BACKGROUND:Recent studies have demonstrated that eosinophils from allergic patients express low levels of FcepsilonRI on their surface, but the regulatory mechanisms of eosinophil surface FcepsilonRI expression are not fully understood. We investigated whether IL-4 and IgE, which are reported to regulate surface Fcepsi...

journal_title：International archives of allergy and immunology

authors： Iikura M,Yamaguchi M,Hirai K,Miyamasu M,Yamada H,Nakajima T,Fujisawa T,Ra C,Morita Y,Yamamoto K

更新日期：2001-04-01 00:00:00

abstract：:This study concerned the way in which eosinophils adhere to their surroundings. Many fibrils were seen to adhere to the cell membrane of eosinophils migrating into the submucosa. Those eosinophils migrating into the epithelial layer adhered to the epithelial cells in 2 different ways: through the thin filaments bridgi...

journal_title：International archives of allergy and immunology

authors： Watanabe K

更新日期：1995-01-01 00:00:00

abstract：BACKGROUND:Patients with atopic dermatitis (AD) are frequently colonized with α-toxin-producing Staphylococcus aureus which is in turn positively correlated with the severity of eczema. METHODS:IN this study we addressed T cell proliferation and T cell as well as monocyte cytokine secretion upon α-toxin stimulation in...

journal_title：International archives of allergy and immunology

authors： Niebuhr M,Mamerow D,Heratizadeh A,Satzger I,Werfel T

更新日期：2011-01-01 00:00:00

abstract：:Allergens from the pollen of Parthenium hysterophorus (American feverfew), responsible for high incidence of allergic rhinitis, were found by immunoprint analysis to be localized on the surface of the pollen grains. The allergens were released very rapidly when extracted in vitro. The allergenic activity of the rapid ...

journal_title：International archives of allergy and immunology

authors： Gupta N,Sriramarao P,Kori R,Rao PV

更新日期：1995-08-01 00:00:00

abstract：:The time course of the development of airway hyperresponsiveness (AHR) to inhaled acetylcholine (ACh) and the associated inflammatory cell recovery in bronchoalveolar lavage fluid (BAL) in actively sensitised Brown-Norway rats was studied following challenge with inhaled ovalbumin (OA). IgE for OA was detected in seru...

journal_title：International archives of allergy and immunology

authors： Elwood W,Barnes PJ,Chung KF

更新日期：1992-01-01 00:00:00

abstract：:The modulatory role of hormones in the regulation of the immune response has been well documented. Here, we present some thoughts on how sex hormones affect immunity, particularly at mucosal sites. We further discuss the possible pitfalls and difficulties associated with analysis of the data. ...

journal_title：International archives of allergy and immunology

authors： Stanisz AM,Kataeva G,Bienenstock J

更新日期：1994-01-01 00:00:00

abstract：:In the present study, we investigated the role of resident peritoneal cells as well as the mediators involved in the eosinophil migration induced by large volumes of physiological saline. Two consecutive intraperitoneal injections of saline given 48 h apart, induced a selective recruitment of eosinophils into the cavi...

journal_title：International archives of allergy and immunology

authors： Oliveira SH,Faccioli LH,Cunha FQ,Ferreira SH

更新日期：1994-08-01 00:00:00

abstract：BACKGROUND:The production of house dust mite (HDM) allergen products for allergy immunotherapy has traditionally been based on purified mite bodies or whole-mite culture, which are quite different source materials with a limited possibility for adjusting the chemical composition. The SQ HDM SLIT-tablet is a fast-dissol...

journal_title：International archives of allergy and immunology

authors： Henmar H,Frisenette SM,Grosch K,Nielsen K,Smith G,Sønderkær S,Larsen JN

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Little is known about the relation between allergic rhinitis severity and airborne pollen in combination with air pollutants. OBJECTIVE:To model the risk of suffering from severe seasonal allergic rhinitis (SAR) as a function of both pollen count and air pollution levels in a large nationwide sample of pati...

journal_title：International archives of allergy and immunology

authors： Annesi-Maesano I,Rouve S,Desqueyroux H,Jankovski R,Klossek JM,Thibaudon M,Demoly P,Didier A

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:The cysteinyl leukotrienes (CysLTs) mediate their biological actions through two receptors: CysLT(1) receptor and CysLT(2) receptor. OBJECTIVE:This study was undertaken to examine the direct effects of CysLTs on eosinophils, such as chemotaxis and degranulation, focusing on CysLT(1). METHODS:Eosinophils we...

journal_title：International archives of allergy and immunology

authors： Ohshima N,Nagase H,Koshino T,Miyamasu M,Yamaguchi M,Hirai K,Yamamoto K,Fujisawa T,Nakagawa N,Kishikawa K,Morita Y

更新日期：2002-09-01 00:00:00

abstract：:Interaction between vascular cell adhesion molecule-1 (VCAM-1) on endothelial cells and CD49d molecules on eosinophils is thought to mediate the selective infiltration of eosinophils into inflamed tissues in allergic disease. IL-4 and TNF-alpha are associated with allergic conditions, and they have been shown to selec...

journal_title：International archives of allergy and immunology

authors： Saito H,Shimizu H,Mita H,Maeda Y,Akiyama K

更新日期：1996-10-01 00:00:00

abstract：:In the last 40 years, the pathogenesis of transmissible spongiform encephalopathies of humans and animals have been the subject of exciting discoveries and also of passionate controversies. Although the human forms of these diseases are rare, the recent epidemics of bovine spongiform encephalopathy has most dramatical...

journal_title：International archives of allergy and immunology

authors： Aguzzi A

更新日期：1996-06-01 00:00:00

abstract：BACKGROUND:In vivo, all blood vessels are lined by a single layer of flattened noncycling endothelial cells. We tested the hypothesis that the maintenance of such a quiescent endothelial monolayer depends on homotypic contacts between not yet defined growth-inhibitory molecules located at interendothelial junctions. M...

journal_title：International archives of allergy and immunology

authors： Halama T,Staffler G,Hoch S,Stockinger H,Wolff K,Petzelbauer P

更新日期：1999-11-01 00:00:00

abstract：:A peptide B3144, derived after peptic tryptic digestion of alpha-gliadin and corresponding to residues 3-56 from the coeliac-activating domain I, was previously used to produce monoclonal antibodies. A dot immunobinding assay was developed using these antibodies to detect gluten in wheat, rye, barley and oats. The lim...

journal_title：International archives of allergy and immunology

authors： Ellis HJ,Doyle AP,Day P,Wieser H,Ciclitira PJ

更新日期：1994-07-01 00:00:00

abstract：BACKGROUND:A number of different molecules are known to be involved in the signal pathway to release histamine from mast cells, among which arachidonic acid (AA) is one of the key mediators. On the other hand, we found that the application of compound 48/80, a typical histamine liberator, generated superoxide in mast c...

journal_title：International archives of allergy and immunology

authors： Sakaguchi M,Fukuishi N,Teramoto K,Miyazaki M,Huh NH,Namba M,Akagi M

更新日期：2003-04-01 00:00:00

abstract：BACKGROUND:There seems to be an association between paracetamol consumption during late pregnancy and the prevalence of wheezing in infancy and childhood. The aim of the present study is to determine whether the aforementioned association is modified by the presence of asthma in the mother. METHODS:A total of 1,741 ch...

journal_title：International archives of allergy and immunology

authors： Garcia-Marcos L,Sanchez-Solis M,Perez-Fernandez V,Pastor-Vivero MD,Mondejar-Lopez P,Valverde-Molina J

更新日期：2009-01-01 00:00:00

abstract：:The low responsiveness of contact sensitivity (CS) in sensitized and challenged mice was induced by using hapten-amino acid derivatives. Subcutaneous injection of trinitrophenyl (TNP)-lysine or oxazolone-glycine inhibited ear swelling responses in mice that received rechallenge. The inhibitory effect was long-lasting ...

journal_title：International archives of allergy and immunology

authors： Satoh T,Yokozeki H,Katayama I,Nishioka K

更新日期：1993-01-01 00:00:00

abstract：:Aerosolized monoclonal antibodies (mAbs) specific for T-cell receptors (TCR) were used to manipulate T-cell function in airways of ovalbumin (OVA)-sensitized and -challenged mice with airway hyperresponsiveness (AHR). The inhaled mAbs were found to be effective at low doses, had little or no systemic effect and specif...

journal_title：International archives of allergy and immunology

authors： Lahn M,Kanehiro A,Hahn YS,Wands JM,Aydintug MK,O'Brien RL,Gelfand EW,Born WK

更新日期：2004-05-01 00:00:00

abstract：BACKGROUND:House dust mite (HDM)-sensitive allergic rhinitis is a perennial rhinitis with persistent nasal inflammation. Currently, there are no reliable parameters to monitor the severity of perennial allergic rhinitis. The purpose of this study was to evaluate correlations between clinical and laboratory parameters i...

journal_title：International archives of allergy and immunology

authors： Klaewsongkram J,Ruxrungtham K,Wannakrairot P,Ruangvejvorachai P,Phanupak P

更新日期：2003-09-01 00:00:00

abstract：BACKGROUND:Orange allergens are virtually unknown, in spite of the large consumption of this fruit. Germin-like proteins, together with vicilins and legumins, form the cupin superfamily of plant proteins, which includes many seed allergens. METHODS:Twenty-nine patients with allergy to oranges were studied. A major IgE...

journal_title：International archives of allergy and immunology

authors： Ahrazem O,Ibáñez MD,López-Torrejón G,Sánchez-Monge R,Sastre J,Lombardero M,Barber D,Salcedo G

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Five to twenty percent of healthy, nonasthmatic individuals exhibit airway hyperreactivity. Because cytokines are important intermediates in airway responses, we investigated the relationship between serum cytokines and airway responsiveness in a well-characterized population of pregnant women. METHODS:We a...

journal_title：International archives of allergy and immunology

authors： Tsunoda M,Litonjua AA,Kuniak MP,Weiss ST,Satoh T,Guevarra L,Tollerud DJ

更新日期：2003-02-01 00:00:00

abstract：BACKGROUND:Sensitivity to Chenopodiaceae is a frequent cause of allergic respiratory diseases in geographic areas where sensitization to Salsola kali and Chenopodium album has been reported. The objective of this study was to evaluate the pattern of sensitization to 3 Salsola species in patients residing on the Mediter...

journal_title：International archives of allergy and immunology

authors： Ferrer A,Larramendi CH,Huertas AJ,Pagán JA,Andreu C,García-Abujeta JL,López-Matas MA,Carnés J

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Elicitation of contact hypersensitivity requires antigen-specific immunoglobulin M (IgM) antibodies that trigger recruitment of effector T cells to the local tissue. These antigen-specific IgM antibodies are produced by B-1-like 'initiator B cells'. In this study, we compared susceptibility to hapten-induced...

journal_title：International archives of allergy and immunology

authors： Itakura A,Ikutani M,Takatsu K,Kikuchi Y

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by the interplay between multiple genetic and environmental factors. The pathogenesis of AD remains incompletely understood. Treatment with topical steroids for chronic AD symptoms has severe side effects and so a new treatment is re...

journal_title：International archives of allergy and immunology

authors： Li Y,Yu H,Jin Y,Li M,Qu C

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:T cells are key regulators of immunologic disease parameters. However, their contribution to the process of tissue remodeling is ill defined. In the present study, we investigated gene expression of allergy-characteristic, IL-4-rich T cell cDNAs to monitor expression of genes that might participate in the pa...

journal_title：International archives of allergy and immunology

authors： Wohlfahrt JG,Kunzmann S,Menz G,Kneist W,Akdis CA,Blaser K,Schmidt-Weber CB

更新日期：2003-08-01 00:00:00

abstract：:We studied the effect of NZ-107 in a number of animal models of anaphylactic bronchoconstriction. In conscious guinea pigs, pretreated with indomethacin, pyrilamine and propranolol, passively sensitized with heterologous anti serum, NZ-107 in doses of 10-30 mg/kg per os inhibited the aerosolized antigen-induced cough ...

journal_title：International archives of allergy and immunology

authors： Iwama T,Shikada K,Yamamoto A,Sakashita M,Hibi M,Tanaka S

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:Nonpathogenic Escherichia coli strain Nissle 1917 (EcN) has immunomodulatory properties and can act on different cells which are important for the allergic immune response. Herein, we investigated the efficacy and tolerability of EcN in subjects with grass pollen-dependent allergic rhinoconjunctivitis. METH...

journal_title：International archives of allergy and immunology

authors： Dölle S,Berg J,Rasche C,Worm M

更新日期：2014-01-01 00:00:00

abstract：:The case of a 46-year-old man with a chronic cough with sputum eosinophilia (atopic cough) caused by Trichosporon cutaneum serotype II (Trichosporon asahii) is reported. The diagnosis was made with the inhalation challenge test with T. asahii antigen. He was admitted for the diagnosis and treatment of a severe nonprod...

journal_title：International archives of allergy and immunology

authors： Ogawa H,Fujimura M,Amaike S,Nishiura Y,Nakagawa-Yoshida K,Suga M,Ando M,Matsuda T

更新日期：1998-06-01 00:00:00