HLA-DRB1 and anti-cyclic citrullinated peptide antibody production in rheumatoid arthritis.

Abstract:

:Anti-cyclic citrullinated peptide antibodies (anti-CCP) are a new diagnostic marker for rheumatoid arthritis (RA), which shows a specificity of 97% and a sensitivity of 81% in the second generation assay. About 61% of RA patients express HLA-DRB1*0401. In a cohort of patients with RA we investigated whether the expression of anti-CCP correlates with the carriage of certain genes on the HLA-DRB1 locus. Our data reveal a highly significant association between anti-CCP and HLA-DR4, and a weaker but still significant association with HLA-DR1. HLA-DRB1*0401 is not a prerequisite for anti-CCP production, but if HLA-DRB1*0401 was present, 90% of our RA patients were anti-CCP positive.

authors

Senkpiehl I,Marget M,Wedler M,Jenisch S,Georgi J,Kabelitz D,Steinmann J

doi

10.1159/000086463

keywords:

subject

Has Abstract

pub_date

2005-08-01 00:00:00

pages

315-8

issue

4

eissn

1018-2438

issn

1423-0097

pii

86463

journal_volume

137

pub_type

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