Measurement of inflammatory mediators of eosinophils and lymphocytes in blood in acute asthma: serum levels of ECP influence the bronchodilator response.


:The aim of this study was to assess the relevance of immunoinflammatory markers on the response to short acting beta(2)-agonist in acute asthma exacerbation. Thus, we measured serum eosinophil cationic protein (ECP) levels and sIL-2R at acute exacerbation in 52 adult patients with atopic asthma, and assessed forced expiratory volume in 1 s (FEV(1)) before and after the administration of aerosolized salbutamol. After a cumulative dose of salbutamol causing a 10% improvement in FEV(1) from baseline [CD10, i.e. cumulative doses of salbutamol (800 microg) causing an improvement in FEV(1) from baseline to 10%] the patients were divided into two groups: group A with CD <10 and group B with CD >10. The bronchodilator response, as defined by a DeltaFEV(1) (percentage of predictive value of FEV(1)) of > or =10 predictive value, was shown by 40% of the patients. After 200, 400 and 800 microg of salbutamol, significant differences of FEV(1) with respect to baseline values were, respectively, p = 0.049, 0.0039 and 0.0014. In contrast, no significant difference of the means of FEV(1) between the doses of salbutamol was observed. Significant differences of DeltaFEV(1) between 200 and 400 microg (p = 0.0002) and between 200 and 800 microg (p < 0.0001) were observed, but not between 400 and 800 microg of salbutamol. There were significant correlations between baseline values of predictive FEV(1) and serum ECP levels (rho = -0.60, p < 0.0001) and sIL-2R levels (rho = -0.35, p = 0.01) respectively. Besides, a correlation between DeltaFEV(1) and serum ECP levels (rho = -0.53, p < 0.0001) was observed, whereas no correlation was found between DeltaFEV(1) and sIL-2R. By analyzing differences between the two groups (A and B) for serum ECP levels, sIL-2R and blood eosinophil count, a significant difference was found for serum ECP levels. We conclude that subjects with acute exacerbation of asthma show high serum levels of ECP and sIL-2R and, more interestingly, that the response to brochodilator was higher in patients with lower serum ECP levels.


Di Lorenzo G,Pacor ML,Morici G,Drago A,Esposito-Pellitteri M,Candore G,Lo Bianco C,Caruso C





Has Abstract


2002-04-01 00:00:00














  • Skin testing correlates negatively with high-activity ACP1 *B/*C genotype.

    abstract:BACKGROUND:Previous studies have shown a negative association between ACP1 *B/*C genotype and total IgE level. ACP1 (acid phosphatase locus 1) is a polymorphic phosphotyrosine phosphatase that interacts with IL4-RA and is involved in T cell receptor signaling. METHODS:In the present paper, we have studied the relation...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章


    authors: Greco E,Bottini N,Canu G,Maccari AM,Saccucci P,Gloria-Bottini F,Fontana L

    更新日期:2008-01-01 00:00:00

  • Intravenous immunoglobulin: striving for appropriate use.

    abstract:BACKGROUND:Intravenous immunoglobulin (IVIG) is the mainstay therapy in human immune deficiency states characterized by qualitative and quantitative reductions in B cells. In addition, however, there is widespread use of IVIG in a number of other areas, including neuroimmunologic, infectious, dermatologic, hematologic,...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章,评审


    authors: Kumar A,Teuber SS,Gershwin ME

    更新日期:2006-01-01 00:00:00

  • Food allergy in Ghanaian schoolchildren: data on sensitization and reported food allergy.

    abstract:BACKGROUND:Epidemiological data on food allergy are scarce in African countries. We studied the prevalence of food sensitization in Ghanaian schoolchildren. METHODS:Children (5-16 years; n = 1,714) from 9 Ghanaian schools were given parental consent to participate in the study. Adverse reactions and food consumption w...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章


    authors: Obeng BB,Amoah AS,Larbi IA,Yazdanbakhsh M,van Ree R,Boakye DA,Hartgers FC

    更新日期:2011-01-01 00:00:00

  • A rapid and simple photometric assay for quantification of eosinophil chemotaxis.

    abstract::Various methods have been devised to assay eosinophil chemotaxis. In this review, we introduced a rapid and sensitive eosinophil chemotactic assay system based on eosinophil peroxidase (EPO) determination. Eosinophils were semipurified by dextran sedimentation followed by Percoll gradient centrifugation. Eosinophil mi...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章


    authors: Nagase H,Yamaguchi M,Jibiki S,Yamada H,Ohta K,Kawasaki H,Yoshie O,Yamamoto K,Morita Y,Hirai K

    更新日期:2000-05-01 00:00:00

  • Early DNA synthesis and cytokine expression in the nickel activation of peripheral blood mononuclear cells in nickel-allergic subjects.

    abstract:BACKGROUND AND OBJECTIVE:Nickel sulphate stimulates the proliferation of lymphocytes in nickel-allergic subjects. However, nickel-induced stimulation of lymphocytes from control persons without clinical symptoms of nickel allergy has also been reported. The aim of the present study was to correlate T cell activity, mea...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章


    authors: Falsafi-Amin H,Lundeberg L,Bakhiet M,Nordlind K

    更新日期:2000-10-01 00:00:00

  • Inhibition of enteropathogenic Escherichia coli (EPEC) adhesion to HeLa cells by human colostrum: detection of specific sIgA related to EPEC outer-membrane proteins.

    abstract::Human colostrum and a high molecular weight colostrum fraction (HMWF; > 14,000 D) prevented the adhesion of localized adherent (LA+) O111:H-enteropathogenic Escherichia coli (EPEC) to HeLa cells. This effect was abolished after absorption with an O111:H-LA + EPEC strain, but absorption with a LA- strain of same seroty...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章


    authors: Camara LM,Carbonare SB,Silva ML,Carneiro-Sampaio MM

    更新日期:1994-01-01 00:00:00

  • Chlorhexidine Anaphylaxis Masquerading as Septic Shock.

    abstract::Chlorhexidine is a commonly used antiseptic and disinfectant in the health-care setting. Its usage has increased in recent years with intensive campaigns and infection control guidelines to combat hospital-acquired infections. As a result, patients and health-care workers (HCW) are exposed to increasing chlorhexidine ...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章


    authors: Hong CC,Wang SM,Nather A,Tan JH,Tay SH,Poon KH

    更新日期:2015-01-01 00:00:00

  • Thioredoxin in allergic inflammation.

    abstract::Thioredoxin (TRX) is a redox-active protein that regulates reactive oxidative metabolism and plays a crucial role in the antioxidant system in regulating the reduction/oxidation balance by scavenging reactive oxygen species, which is implicated in the mechanism of asthma. As for the mechanisms by which TRX exerts its ...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章,评审


    authors: Ito W,Kobayashi N,Takeda M,Ueki S,Kayaba H,Nakamura H,Yodoi J,Chihara J

    更新日期:2011-01-01 00:00:00

  • Effect of ibudilast, a novel antiasthmatic agent, on anaphylactic bronchoconstriction: predominant involvement of endogenous slow reacting substance of anaphylaxis.

    abstract::The effect of ibudilast on anaphylactic bronchoconstriction was studied in guinea pigs sensitized actively with ovalbumin (OA). Animals were treated with indomethacin, tripelennamine and propranolol prior to the antigen challenge. Anaphylactic bronchoconstriction was prevented by ibudilast (1-4 mg/kg i.v. and 5-20 mg/...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章


    authors: Ohashi M,Uno T,Nishino K

    更新日期:1993-01-01 00:00:00

  • IgE lambda monoclonal gammopathy and amyloidosis.

    abstract::The prevalence of IgE myeloma is 0.01% in all plasmocytomas. Although signs and symptoms are similar, it is generally accepted that IgE myeloma has a more malignant clinical course than other forms of plasmocytoma with monoclonal gammopathy. The disease has widely variable presentation. Most of the reported cases were...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章,评审


    authors: Jako JM,Gesztesi T,Kaszas I

    更新日期:1997-04-01 00:00:00

  • Induction of Oral Tolerance by Pepsin-Digested Gliadin Retaining T Cell Reactivity in a Mouse Model of Wheat Allergy.

    abstract:BACKGROUND:Wheat is known as the most widely consumed food all over the world. Although many types of wheat allergy have been recognized, their treatment still has a long way to go due to the complex pathogenesis. Oral immunotherapy (OIT) is under investigation for the treatment of wheat allergies. Previous studies hav...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章


    authors: Li X,Miyakawa T,Takano T,Nakajima-Adachi H,Tanokura M,Hachimura S

    更新日期:2020-01-01 00:00:00

  • Smoking attenuates increase in exhaled nitric oxide in atopic but not in nonatopic young adults with asthma.

    abstract:BACKGROUND:Measurement of fractional exhaled nitric oxide (FENO) is useful in assessing eosinophilic airway inflammation. Smoking may modify airway inflammation and reduce FENO levels, compromising the diagnostic value of FENO in smokers. How smoking influences FENO in atopic versus nonatopic asthmatics is unknown. The...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章


    authors: Rouhos A,Ekroos H,Karjalainen J,Sarna S,Haahtela T,Sovijärvi AR

    更新日期:2010-01-01 00:00:00

  • Regulatory T cells participate in 4-1BB-mediated suppression of experimental allergic conjunctivitis.

    abstract:BACKGROUND:We showed previously that treatment with an agonistic anti-4-1BB Ab during the induction phase of murine experimental allergic conjunctivitis (EC) suppresses the development of this model disease. It was reported that 4-1BB promotes the expansion of regulatory T cells. Here we asked whether the suppression o...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章


    authors: Sumi T,Ishida W,Mittler RS,Yagita H,Taguchi O,Fukushima A

    更新日期:2009-01-01 00:00:00

  • Profilins: mimickers of allergy or relevant allergens?

    abstract::Profilins are ubiquitous proteins, present in all eukaryotic cells and identified as allergens in pollen, latex and plant foods. The highly conserved structure justifies the cross-reactive nature of IgE antibodies against plant profilins and their designation as pan-allergens. Primary sensitization to profilin seems t...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章,评审


    authors: Santos A,Van Ree R

    更新日期:2011-01-01 00:00:00

  • Alpha-melanocyte-stimulating hormone plays an important role in the onset of pollinosis in a pollen allergy mouse model.

    abstract:BACKGROUND:alpha-Melanocyte-stimulating hormone (alpha-MSH) is a neuropeptide that controls melanogenesis in pigmentary cells. In addition, its potent immunomodulatory activity has been recently described in cutaneous inflammatory disorders. However the mechanism of such pollen allergies remains to be elucidated. The p...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章


    authors: Hiramoto K,Hashimoto M,Orita K,Jikumaru M,Sato EF,Inoue M

    更新日期:2010-01-01 00:00:00

  • Participation of platelets in protection against larval Taenia taeniaeformis infection in mice.

    abstract::The participation of platelets in the protection against larval Taenia taeniaeformis was studied. CB-17 SCID mice, susceptible to T. taeniaeformis, were protected against a challenge infection with T. taeniaeformis by the passive transfer of platelets from T. taeniaeformis-infected normal CB-17 mice, resistant to T. t...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章


    authors: Kakuda T,Ooi HK,Oku Y,Kamiya M

    更新日期:1996-03-01 00:00:00

  • Seasonal chronic cough with sputum eosinophilia caused by Trichosporon cutaneum (Trichosporon asahii).

    abstract::The case of a 46-year-old man with a chronic cough with sputum eosinophilia (atopic cough) caused by Trichosporon cutaneum serotype II (Trichosporon asahii) is reported. The diagnosis was made with the inhalation challenge test with T. asahii antigen. He was admitted for the diagnosis and treatment of a severe nonprod...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章


    authors: Ogawa H,Fujimura M,Amaike S,Nishiura Y,Nakagawa-Yoshida K,Suga M,Ando M,Matsuda T

    更新日期:1998-06-01 00:00:00

  • Detection of Dermatophagoides farinae in the dust of air conditioning filters.

    abstract:BACKGROUND:The allergenic dust mite species Dermatophagoides pteronyssinus and Dermatophagoides farinae generally inhabit warm moist environments. This study tested the hypothesis that these allergenic species may thrive in air conditioner filters. METHODS:A year-long investigation of the dust mite population densitie...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章


    authors: Liu Z,Bai Y,Ji K,Liu X,Cai C,Yu H,Li M,Bao Y,Lian Y,Gao B

    更新日期:2007-01-01 00:00:00

  • Measurement of airborne flour exposure with a monoclonal antibody-based immunoassay.

    abstract:BACKGROUND:The development of simple and standardised methods to measure airborne levels of workplace biological allergens is an important step in reducing the incidence of occupational asthma. Such a method would be useful for measuring wheat flour allergens which cause asthma in bakers. Measurement of allergen per se...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章


    authors: Wiley K,Smith MM,Allan LJ,Griffin P

    更新日期:1997-11-01 00:00:00

  • Oral immunotherapy may induce T cell anergy.

    abstract::Recently, the induction of T cell anergy has been considered as a sophisticated form of immunotherapy. However, the multiplicity of T cell allergen epitopes discourages the practical use of this method. Since orally administered antigen proteins are digested to peptides and absorbed into the circulation, oral administ...

    journal_title:International archives of allergy and immunology

    pub_type: 临床试验,杂志文章


    authors: Suko M,Mori A,Ito K,Okudaira H

    更新日期:1995-05-01 00:00:00

  • A perspective: regulation of IgE receptor-mediated mast cell responses by a LAT-organized plasma membrane-localized signaling complex.

    abstract:BACKGROUND:To understand how the high-affinity IgE receptor (FcepsilonRI) communicates with downstream effectors, we focused on exploring the functional importance of the FcepsilonRI-mediated formation and localization of a signaling complex that contains the hematopoietic cell-specific scaffolding protein linker for a...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章,评审


    authors: Rivera J,Arudchandran R,Gonzalez-Espinosa C,Manetz TS,Xirasagar S

    更新日期:2001-01-01 00:00:00

  • The nonionic radiocontrast medium iopromide does not release endothelin-1 or activate cardiac mast cells during coronary angiography.

    abstract:BACKGROUND:High osmolal ionic radiocontrast media (RCM) cause vascular release of endothelin-1 (ET-1) and activate mast cells. Iomeprol, a nonionic RCM, has recently been reported not to activate cardiac mast cells. This coronary angiography study was performed to extend those findings using another nonionic RCM, iopro...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章


    authors: Simon MR,Reher RL,Long PM,Yellayi K

    更新日期:2003-05-01 00:00:00

  • Monoclonal antibodies against the C(epsilon)mX domain of human membrane-bound IgE and their potential use for targeting IgE-expressing B cells.

    abstract:BACKGROUND:IgE mediates immediate-type hypersensitivity reactions responsible for various allergic symptoms. It is secreted by IgE-producing plasma cells, which differentiate from B cells expressing membrane-bound IgE (mIgE) on their surface. The epsilon-chain of human mIgE contains a membrane-anchoring peptide and an ...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章


    authors: Chen HY,Liu FT,Hou CM,Huang JS,Sharma BB,Chang TW

    更新日期:2002-08-01 00:00:00

  • Enhancement of interleukin-4 production in activated CD4+ T cells by diphthalate plasticizers via increased NF-AT binding activity.

    abstract:BACKGROUND:Diethylhexyl phthalate (DEHP) and diisononyl phthalate (DINP), two commonly used plasticizers in flexible polyvinylchloride formulations, have potentially adverse effects on human health. However, the influence of these diphthalates on allergic responses remains unclear. In this study we examined the effects...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章


    authors: Lee MH,Park J,Chung SW,Kang BY,Kim SH,Kim TS

    更新日期:2004-07-01 00:00:00

  • Modulation of immunological histamine release from human lung fragments by stem cell factor, IL-3, IL-5 and GM-CSF: comparison with human leukocytes.

    abstract::Because of the importance of cytokines in the regulation of allergic inflammation, we investigated the effects of SCF, IL-3, IL-5 and GM-CSF on immunological histamine release from sensitized human lung fragments as well as human leukocytes. SCF (0.2-20 ng/ml) caused a concentration-related enhancement of anti-IgE (1/...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章


    authors: Louis R,Dowlati A,Weber T,Bury T,Corhay JL,Radermecker MF

    更新日期:1994-09-01 00:00:00

  • Chemotaxis of human peripheral blood eosinophils to 2-arachidonoylglycerol: comparison with other eosinophil chemoattractants.

    abstract:BACKGROUND:2-Arachidonoylglycerol (2-AG), an endogenous ligand for the cannabinoid receptors (CB1 and CB2), has been shown to exhibit a variety of cannabimimetic activities in vitro and in vivo. Recently, we found that human eosinophilic leukemia EoL-1 cells and human peripheral blood eosinophils express the CB2 recept...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章


    authors: Kishimoto S,Oka S,Gokoh M,Sugiura T

    更新日期:2006-01-01 00:00:00

  • Lack of detectable alterations in immune responses during sublingual immunotherapy in children with seasonal allergic rhinoconjunctivitis to grass pollen.

    abstract:BACKGROUND:Recent work indicates that subcutaneous specific immunotherapy induces specific T-cell anergy, a shift in the TH1/TH2 ratio, and antibody production in favor of IgG4. There are few data on sublingual immunotherapy (SLIT), especially in children. METHODS:We assessed the proliferation of peripheral blood mono...

    journal_title:International archives of allergy and immunology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Rolinck-Werninghaus C,Kopp M,Liebke C,Lange J,Wahn U,Niggemann B

    更新日期:2005-02-01 00:00:00

  • Oncogene expression in patients with familial polyposis coli/Gardner's syndrome.

    abstract::We evaluated whether c-myc and ras P-21 oncogene expression could identify familial polyposis coli/Gardner's syndrome patients at risk for colon cancer. Monoclonal antibodies recognizing c-myc and ras P-21 proteins were used in immunohistochemistry to stain 26 paraffin-embedded tissue specimens collected over 12 years...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章


    authors: Yuwono M,Rossi TM,Fisher JE,Tjota A

    更新日期:1996-09-01 00:00:00

  • Constipation and cow's milk allergy: a review of the literature.

    abstract::The causal association between cow's milk allergy (CMA) and constipation is not well established. Some guidelines describe constipation as a possible symptom of CMA, while others do not mention it. We conducted a literature review and found 10 prospective clinical trials. In all of them, an oral food challenge was per...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章,评审


    authors: Miceli Sopo S,Arena R,Greco M,Bergamini M,Monaco S

    更新日期:2014-01-01 00:00:00

  • Objectifying the conjunctival provocation test: photography-based rating and digital analysis.

    abstract:BACKGROUND:Patients with allergic rhinoconjunctivitis are susceptible to both nasal and ocular symptoms. The conjunctival provocation test (CPT) is an established diagnostic procedure used in allergic rhinoconjunctivitis, particularly to document a patient's current reactivity to allergens. To date, there are no intern...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章


    authors: Dogan S,Astvatsatourov A,Deserno TM,Bock F,Shah-Hosseini K,Michels A,Mösges R

    更新日期:2014-01-01 00:00:00