Pooling birth cohorts in allergy and asthma: European Union-funded initiatives - a MeDALL, CHICOS, ENRIECO, and GA²LEN joint paper.

abstract：BACKGROUND:Endogenous IL-17 is needed for the Ag sensitization that results in murine allergic asthma, a Th2-mediated disease. Here, we aimed to investigate the role IL-17 plays in the development of murine experimental allergic conjunctivitis (EC) which is also a Th2-mediated disease. METHODS:To induce EC, wild-type ...

journal_title：International archives of allergy and immunology

authors： Fukushima A,Sumi T,Ishida W,Yamada J,Iwakura Y,Ueno H

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:The cytokine transforming growth factor-beta(TGF-beta) has important regulatory roles in the immune system. To investigate the role of intact TGF-beta signaling during the contact hypersensitivity (CHS) response to a respiratory allergen, we exposed Smad3-/- mice to topical trimellitic anhydride (TMA). METH...

journal_title：International archives of allergy and immunology

authors： Anthoni M,Fyhrquist N,Lehtimäki S,Alenius H,Wolff H,Lauerma A

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Reactive oxygen species (ROS) and eosinophilic granule proteins such as eosinophil-derived neurotoxin (EDN) are known to damage bronchial tissue and cause airway hyperresponsiveness (AHR) in asthma. Hepatocyte growth factor (HGF) regulates various biological activities and is known to be a multifunctional fa...

journal_title：International archives of allergy and immunology

authors： Ito W,Takeda M,Fujita M,Kamada Y,Kato H,Chiba T,Yamaguchi K,Ueki S,Kayaba H,Kanehiro A,Chihara J

更新日期：2008-01-01 00:00:00

abstract：:Increased serum IgE and enhanced susceptibility to viral infections, decreased levels of interferons, lymphocytic skin infiltrates and IgE-bearing epidermal Langerhans cells are striking features in patients with atopic eczema (AE). Since the hyper-IgE syndrome is known to improve under alpha-interferon (alpha-IFN) th...

journal_title：International archives of allergy and immunology

authors： Gruschwitz MS,Peters KP,Heese A,Stosiek N,Koch HU,Hornstein OP

更新日期：1993-01-01 00:00:00

abstract：:A peptide B3144, derived after peptic tryptic digestion of alpha-gliadin and corresponding to residues 3-56 from the coeliac-activating domain I, was previously used to produce monoclonal antibodies. A dot immunobinding assay was developed using these antibodies to detect gluten in wheat, rye, barley and oats. The lim...

journal_title：International archives of allergy and immunology

authors： Ellis HJ,Doyle AP,Day P,Wieser H,Ciclitira PJ

更新日期：1994-07-01 00:00:00

abstract：:The present study was designed to determine if depletion of the complement system in the circulation with cobra venom factor (CVF) prevented the cellular infiltration in a guinea pig model of asthma. Guinea pigs were sensitized with ovalbumin (OA) alone or OA with complete Freund's adjuvant. Animals were pretreated wi...

journal_title：International archives of allergy and immunology

authors： Regal JF,Fraser DG

更新日期：1996-02-01 00:00:00

abstract：:We aimed to evaluate the therapeutic effect of nebulized beclomethasone dipropionate (nBDP) on both allergic asthma and rhinitis. In a randomized, double-blind, placebo-controlled study, 40 children (mean age 10.7 ± 2.1 years) with allergic asthma and rhinitis received either nBDP (daily dose of 800 µg, administered t...

journal_title：International archives of allergy and immunology

authors： Profita M,Riccobono L,Bonanno A,Chanez P,Gagliardo R,Montalbano AM,Albano GD,Liotta G,Gjomarkaj M,La Grutta S

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Prostaglandin D(2) (PGD(2)), a major prostanoid produced by activated mast cells, has long been implicated in allergic diseases. PGD(2) demonstrates its effects through two G-protein-coupled receptors, DP and CRTH2. The PGD(2)/CRTH2 system mediates chemotaxis of eosinophils, basophils, and Th2 cells, which a...

journal_title：International archives of allergy and immunology

authors： Chiba T,Kanda A,Ueki S,Ito W,Kamada Y,Oyamada H,Saito N,Kayaba H,Chihara J

更新日期：2006-01-01 00:00:00

abstract：:CD95 (APO-1) is a member of the TNF/nerve growth factor receptor superfamily, which is expressed on the surface of different types of cells. Cross-linking of CD95 leads to the induction of apoptosis. This may be of importance in many physiological systems, but seems to play a special role for the maintenance of immuno...

journal_title：International archives of allergy and immunology

authors： Lechner H,Amort M,Steger MM,Maczek C,Grubeck-Loebenstein B

更新日期：1996-07-01 00:00:00

abstract：AIM:To investigate the potential risk factors in patients who have experienced anaphylaxis from drugs. METHOD:The study included 281 adult patients (median age 40 years; 76.5% female) who experienced immediate types of hypersensitivity reaction to a drug. The patients were divided into an anaphylaxis group and a nonan...

journal_title：International archives of allergy and immunology

authors： Demir S,Erdenen F,Gelincik A,Unal D,Olgac M,Coskun R,Colakoglu B,Buyukozturk S

更新日期：2019-01-01 00:00:00

abstract：:To determine the variation of antigenic water soluble proteins in white birch (Betula pendula) pollen, extracts of pollen from different sides of individual trees were analyzed by isoelectric focusing (IEF), crossed immunoelectrophoresis, and crossed radioimmunoelectrophoresis. IgE-antibody-binding patterns were also ...

journal_title：International archives of allergy and immunology

authors： Hjelmroos M,Schumacher MJ,Van Hage-Hamsten M

更新日期：1995-12-01 00:00:00

abstract：BACKGROUND:Segmental allergen challenge is a powerful tool to study inflammatory reactions in asthmatic airways. There is little information on the early events at 5 min and 4 h after allergen challenge with respect to the cell influx and the chemokine interleukin-8 (IL-8). METHODS:Seven mild to moderate allergic asth...

journal_title：International archives of allergy and immunology

authors： Nocker RE,Out TA,Weller FR,Mul EP,Jansen HM,van der Zee JS

更新日期：1999-05-01 00:00:00

abstract：:The inhibitory effects of a novel compound, 6-hydroxy-2-(4-sulfamoylbenzylamino)-4,5,7-trimethylbenzothiazo le hydrochloride (E6080) on IgE-mediated reactions in vitro and in vivo were determined in rhesus monkeys. E6080 inhibited both antigen- and anti-human IgE-induced leukotriene C4 generations from lung fragments ...

journal_title：International archives of allergy and immunology

authors： Katayama S,Sakuma Y,Abe S,Tsunoda H,Yamatsu I,Katayama K

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND:Patients with allergic rhinoconjunctivitis are susceptible to both nasal and ocular symptoms. The conjunctival provocation test (CPT) is an established diagnostic procedure used in allergic rhinoconjunctivitis, particularly to document a patient's current reactivity to allergens. To date, there are no intern...

journal_title：International archives of allergy and immunology

authors： Dogan S,Astvatsatourov A,Deserno TM,Bock F,Shah-Hosseini K,Michels A,Mösges R

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Flavonoids exert antiallergic and antioxidant effects. We investigated the efficacy of enzymatically modified isoquercitrin (EMIQ), a flavonoid, to relieve symptoms of pollinosis. METHODS:In a parallel-group, double-blind placebo-controlled study design, 20 subjects with Japanese cedar pollinosis took two c...

journal_title：International archives of allergy and immunology

authors： Kawai M,Hirano T,Arimitsu J,Higa S,Kuwahara Y,Hagihara K,Shima Y,Narazaki M,Ogata A,Koyanagi M,Kai T,Shimizu R,Moriwaki M,Suzuki Y,Ogino S,Kawase I,Tanaka T

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Recent work indicates that subcutaneous specific immunotherapy induces specific T-cell anergy, a shift in the TH1/TH2 ratio, and antibody production in favor of IgG4. There are few data on sublingual immunotherapy (SLIT), especially in children. METHODS:We assessed the proliferation of peripheral blood mono...

journal_title：International archives of allergy and immunology

authors： Rolinck-Werninghaus C,Kopp M,Liebke C,Lange J,Wahn U,Niggemann B

更新日期：2005-02-01 00:00:00

abstract：INTRODUCTION:Obesity-associated asthma is characterized by type 2-low airway inflammation. We previously showed that EM900, which is a 12-membered nonantibiotic macrolide, suppressed airway inflammation in a mouse model of asthma exacerbation. The aim of this study was to clarify the effects of EM900 in obesity-associa...

journal_title：International archives of allergy and immunology

authors： Sadamatsu H,Takahashi K,Tashiro H,Kurihara Y,Kato G,Uchida M,Noguchi Y,Kurata K,Ōmura S,Sunazuka T,Kimura S,Sueoka-Aragane N

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Little information is available on eosinophil activation and the cytokine profile in virus-induced acute exacerbation of bronchial asthma; therefore, we examined the effects of treatments that included systemic corticosteroids on serum eosinophil cationic protein (ECP) and 17 cytokines/chemokines in rhinovir...

journal_title：International archives of allergy and immunology

authors： Kato M,Yamada Y,Maruyama K,Hayashi Y

更新日期：2011-01-01 00:00:00

abstract：:We describe an HLA-B8, DR3-positive patient with localized morphea after silicone gel breast implantation for cosmetic reasons. We believe that this case suggests that a genetic background, i.e. HLA-B8, DR3 haplotype, is involved in the autoimmune response to silicone. ...

journal_title：International archives of allergy and immunology

authors： Di Lorenzo G,Mansueto P,Melluso M,Sangiorgi GB,Cigna D,Candore G,Caruso C

更新日期：1997-01-01 00:00:00

abstract：:In contrast to mast cells and basophils, the high affinity IgE receptor (FcepsilonRI) on antigen-presenting cells (APC) shows structural and functional differences. It consists only of a minimal structure of one alpha- and two gamma-chains and enables APC to efficiently take up and present antigen in IgE-mediated dela...

journal_title：International archives of allergy and immunology

authors： Kraft S,Katoh N,Novak N,Koch S,Bieber T

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:omega-5 gliadin is a major allergen in exercise-induced wheat allergy (EIWA), but it is also implicated in immediate-type reactions to wheat. An ImmunoCAP assay to measure omega-5 gliadin-specific IgE has become available. This study aimed to evaluate this new biological test in wheat allergy diagnosis and t...

journal_title：International archives of allergy and immunology

authors： Jacquenet S,Morisset M,Battais F,Denery-Papini S,Croizier A,Baudouin E,Bihain B,Moneret-Vautrin DA

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Subcutaneous immunotherapy for respiratory allergy has shown a long lasting efficacy after its discontinuation, whereas evidence in the case of sublingual immunotherapy (SLIT) is weak. This retrospective study evaluates whether SLIT exerts a long-lasting effect and whether it relates to its duration. METHOD...

journal_title：International archives of allergy and immunology

authors： Marogna M,Bruno M,Massolo A,Falagiani P

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Microbial components in the environment are potent activators of the immune system with capacity to shift the active immune response towards priming of Th1 and/or Th2 cells. Lipopolysaccharide (LPS), a cell-wall component of Gram-negative bacteria, is extensively present in food products like cow's milk. It ...

journal_title：International archives of allergy and immunology

authors： Brix S,Kjaer TM,Barkholt V,Frøkiaer H

更新日期：2004-11-01 00:00:00

abstract：BACKGROUND:beta2-Adrenergic agonists play a pivotal role in the management of bronchial asthma. Although the major effect of short-acting beta2-agonists on the airway is relaxation of smooth muscles, they may also have several effects on surrounding immunomodulatory cells. METHODS:We examined whether widely used short...

journal_title：International archives of allergy and immunology

authors： Yasui K,Kobayashi N,Yamazaki T,Agematsu K,Matsuzaki S,Nakata S,Baba A

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Although common variable immunodeficiency (CVID) is associated with sinopulmonary disease, there are no previous systematic evaluations comparing computed tomographic (CT) sinus imaging with immunoglobulin measurements in patients with this condition. METHODS:We performed a retrospective review by a blinded...

journal_title：International archives of allergy and immunology

authors： Hagan JB,Park MA,Kita H,Campeau NG

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:The role of food allergens in the induction of allergic reactions in the airways is not completely understood. The aim of the present study was to evaluate fluorocytometric assays of the peripheral blood during food challenge tests in children with asthma and food allergy. PATIENTS AND METHODS:22 children w...

journal_title：International archives of allergy and immunology

authors： Krogulska A,Wasowska-Królikowska K,Polakowska E,Chrul S

更新日期：2009-01-01 00:00:00

abstract：:Reversible airway obstruction and airway inflammation following allergen exposure represent crucial pathophysiological features of allergic asthma. In order to investigate these events, bronchial-specific challenge is commonly employed although it may be complicated and may not be free of possible risks. Therefore, we...

journal_title：International archives of allergy and immunology

authors： Ciprandi G,Buscaglia S,Scordamaglia A,Canonica GW

更新日期：1997-03-01 00:00:00

abstract：:Sera of 54 symptomatic workers showing sensitization to isocyanate-human serum albumin (HSA) conjugates were subjected to parallel enzyme allergosorbent test (EAST) and CAP measurements to determine IgE antibodies to diphenyl-methane diisocyanate-HSA, toluene diisocyanate-HSA and hexamethylene diisocyanate-HSA. Result...

journal_title：International archives of allergy and immunology

authors： Baur X,Chen Z,Flagge A,Posch A,Raulf-Heimsoth M

更新日期：1996-08-01 00:00:00

abstract：BACKGROUND:Elicitation of contact hypersensitivity requires antigen-specific immunoglobulin M (IgM) antibodies that trigger recruitment of effector T cells to the local tissue. These antigen-specific IgM antibodies are produced by B-1-like 'initiator B cells'. In this study, we compared susceptibility to hapten-induced...

journal_title：International archives of allergy and immunology

authors： Itakura A,Ikutani M,Takatsu K,Kikuchi Y

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Grape allergy is considered rare; grape lipid transfer protein (LTP; Vit v 1), an endochitinase and a thaumatin-like protein (TLP) have been reported as grape allergens. A considerable number of patients have referred to our department for severe reactions to grapes, and several IgE binding proteins were det...

journal_title：International archives of allergy and immunology

authors： Vassilopoulou E,Zuidmeer L,Akkerdaas J,Tassios I,Rigby NR,Mills EN,van Ree R,Saxoni-Papageorgiou P,Papadopoulos NG

更新日期：2007-01-01 00:00:00