Effectiveness and Safety of Omalizumab in Patients with Allergic Bronchopulmonary Aspergillosis Complicated by Chronic Bacterial Infection in the Airways.

abstract：BACKGROUND:It has been reported that protein tyrosine phosphorylation is essential for cytokine production in mouse Th1 cells but not in Th2 cells. However, little is known about the difference of signal transduction between human antigen-specific Th1 and Th2 cell clones. METHODS:Purified protein derivative-specific T...

journal_title：International archives of allergy and immunology

authors： Minoguchi K,Yamashita N,Oda N,Takeno M,Kaneoka H,Sakane T

更新日期：1999-01-01 00:00:00

abstract：:Tyrosine phosphorylation of STAT1alpha in eosinophils after IFN-gamma stimulation has been shown, but the biological significance of eosinophil STAT1alpha activation in transmitting the signals through the IFN-gamma receptor remains unknown. The purpose of this study is to determine whether STAT1 is involved in the re...

journal_title：International archives of allergy and immunology

authors： Ochiai K,Otaka K,Ito M,Tomioka H

更新日期：2001-01-01 00:00:00

abstract：:Because of a unique combination of challenges facing human immunodeficiency virus vaccine developers, a number of traditional and novel vaccine designs are being evaluated essentially in parallel. Monomeric proteins, poxvirus vectors, peptides, and particle-based candidate vaccines have entered or will soon enter huma...

journal_title：International archives of allergy and immunology

authors： Johnston MI

更新日期：1995-12-01 00:00:00

abstract：:Superoxide (O2-) and nitric oxide (NO) production by polymorphonuclear leukocyte (PMNs) and monocytes in patients with liver cirrhosis were evaluated. PMNs obtained from cirrhotic patients were less effective than those from controls in producing O2- after stimulation with opsonized zymosan, while they were more effec...

journal_title：International archives of allergy and immunology

authors： Masini E,Mugnai L,Foschi M,Laffi G,Gentilini P,Mannaioni PF

更新日期：1995-05-01 00:00:00

abstract：:Peritoneal eosinophilia was induced in rats using Ascaris suum extract as an antigen, and characteristics of granule proteins of eosinophils collected from the peritoneal cavity were investigated. Peritoneal eosinophilia was induced by injection of the antigen solution into the peritoneal cavity of the immunized rats ...

journal_title：International archives of allergy and immunology

authors： Watanabe M,Nittoh T,Suzuki T,Kitoh A,Mue S,Ohuchi K

更新日期：1995-09-01 00:00:00

abstract：BACKGROUND:We reported on the constitutive interferon-gamma receptor (IFN-gammaR) expression on eosinophils. But signal transduction through IFN-gammaR on eosinophils remains to be elucidated. In this study, we examined the involvement of the Jak/Stat pathway in the signaling of eosinophils after IFN-gammaR conjugation...

journal_title：International archives of allergy and immunology

authors： Ochiai K,Ishihara C,Tomioka H

更新日期：1999-02-01 00:00:00

abstract：:Patients with atopic dermatitis (AD) are frequently colonized with Staphylococcus aureus strains secreting exotoxins such as the staphylococcal enterotoxin B (SEB) and A (SEA). Nonetheless the role of SEB and SEA in AD is yet unknown. We analyzed the responsiveness of peripheral blood mononuclear cells (PBMCs) and iso...

journal_title：International archives of allergy and immunology

authors： König B,Neuber K,König W

更新日期：1995-02-01 00:00:00

abstract：BACKGROUND:Asthma is a major health problem worldwide, and the morbidity and mortality caused by asthma are on the rise. Corticosteroid therapies for asthma treatment frequently induce many side effects. Therefore, the development of new medicines that have both high efficacy and fewer side effects has been a scientifi...

journal_title：International archives of allergy and immunology

authors： Lim YJ,Na HS,Yun YS,Choi IS,Oh JS,Rhee JH,Cho BH,Lee HC

更新日期：2009-01-01 00:00:00

abstract：:Phosphoinositide 3-kinases (PI3Ks) are known to be involved in a variety of cellular responses such as cell survival, proliferation, differentiation and cell migration. Recently, PI3Ks have been associated with the pathogenesis of asthma because various immune cells regulate allergic responses. Among the three classes...

journal_title：International archives of allergy and immunology

authors： Takeda M,Ito W,Tanabe M,Ueki S,Kihara J,Kato H,Tanigai T,Kayaba H,Sasaki T,Chihara J

更新日期：2010-01-01 00:00:00

abstract：:HIV-1 RNA has become the standard for monitoring antiretroviral therapies. Dogma predicts, however, that a viral protein like p24 should be at least as good a marker of HIV disease activity, provided that it is measured with sufficient sensitivity and accuracy. Simple modifications including use of a more efficient vi...

journal_title：International archives of allergy and immunology

authors： Schüpbach J

更新日期：2003-11-01 00:00:00

abstract：BACKGROUND:Nuclear factor (NF)-kappaB is a transcription factor known to regulate allergy-associated cytokine and chemokine production related to the induction of inflammation. I kappaB kinase beta (IKK beta), which is responsible for activation of the NF-kappaB pathway, may be an ideal molecular target to inhibit this...

journal_title：International archives of allergy and immunology

authors： Sugita A,Ogawa H,Azuma M,Muto S,Honjo A,Yanagawa H,Nishioka Y,Tani K,Itai A,Sone S

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Serum-derived hyaluronan (HA)-associated proteins (SHAPs), the heavy chains of inter-α-trypsin inhibitor, covalently bind to HA to form the SHAP-HA complex. The SHAP-HA complex is involved in the pathophysiology of inflammatory diseases, including rheumatoid arthritis. We investigated whether this complex is...

journal_title：International archives of allergy and immunology

authors： Zhu L,Zhuo L,Kimata K,Yamaguchi E,Watanabe H,Aronica MA,Hascall VC,Baba K

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Jellyfish stings cause painful, papular-urticarial eruptions due to the immediate allergic, acute toxic and persistent inflammatory responses. In spite of many marine accidents and their economic impact, modes of first-aid treatment remain conventional and specific allergen and medical treatment are not yet ...

journal_title：International archives of allergy and immunology

authors： Horiike T,Nagai H,Kitani S

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:A growing body of evidence suggests that proinflammatory cytokines play a role in allergic inflammation by attracting and activating inflammatory cells. In this study, we have investigated the relationship between interleukin-8 (IL-8) in nasal lavage fluid and the local activation of eosinophils and neutroph...

journal_title：International archives of allergy and immunology

authors： Jacobi HH,Poulsen LK,Reimert CM,Skov PS,Ulfgren AK,Jones I,Elfman LB,Malling HJ,Mygind N

更新日期：1998-05-01 00:00:00

abstract：BACKGROUND:Recombinant dog allergens, rCan f 1 and rCan f 2, and their antibodies are good tools for the characterization of dog allergens in order to develop modern therapeutic and preventive methods for dog allergy. METHODS:In this study, cDNA was synthesized from the mRNA of dog salivary glands and cloned into the ...

journal_title：International archives of allergy and immunology

authors： Kamata Y,Miyanomae A,Nakayama E,Miyanomae T,Tajima T,Hoshi H

更新日期：2007-01-01 00:00:00

abstract：:Toll-like receptors have a critical role in innate immunity and host defence. However their role in allergic disease has not been studied in great detail. The presence of these receptors on mast cells opens up new possibilities concerning the role of Toll-like receptors in the pathogenesis of asthma and atopic dermati...

journal_title：International archives of allergy and immunology

authors： Marshall JS,McCurdy JD,Olynych T

更新日期：2003-10-01 00:00:00

abstract：:The antigenic and allergenic characteristics of three bovine epithelial extracts, dander, skin scrapings and whole skin, were compared using IgE-ELISA inhibition and SDS-PAGE with immunoblotting. Cow dander extract was shown to contain more allergenic activity than skin scrapings or whole skin extracts which were need...

journal_title：International archives of allergy and immunology

authors： Ylönen J,Mäntyjärvi R,Taivainen A,Virtanen T

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:The prevalence of allergic rhinitis (AR) is increasing rapidly in Central China. The skin prick test (SPT) is the standard tool with which to determine the allergen sensitization status in AR patients. Changes in allergen sensitization patterns have been observed within countries and regions due to geographi...

journal_title：International archives of allergy and immunology

authors： Wang J,Wu Y,Li J,Huang X,Zhu R

更新日期：2017-01-01 00:00:00

abstract：:Aims of the Monaco Charter: (1) to present the current evidence on the efficacy and safety of allergen-specific immunotherapy (SIT) and to address the reasons for its underuse in clinical practice; (2) to develop strategies to increase the awareness about the benefits and the hazards of SIT in allergic patients, lay p...

journal_title：International archives of allergy and immunology

authors： Canonica GW,Baena-Cagnani CE,Compalati E,Bohle B,Bonini S,Bousquet J,Cox L,Fink-Wagner AH,González Díaz S,Jacobsen L,Passalacqua G,Pawankar R,Vieths S,Yusuf O,Zuberbier T

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Allergen molecule-based diagnosis has been suggested to facilitate the identification of disease-causing allergen sources and the prescription of allergen-specific immunotherapy (AIT). The aim of the current study was to compare allergen molecule-based IgE serology with allergen extract-based skin testing fo...

journal_title：International archives of allergy and immunology

authors： Saltabayeva U,Garib V,Morenko M,Rosenson R,Ispayeva Z,Gatauova M,Zulus L,Karaulov A,Gastager F,Valenta R

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:It has been shown that antigen presentation by resting B cells can induce tolerance to intravenously administered protein antigens, but the role of resting B cells in the induction of oral tolerance is unclear. METHODS:Mice continuously treated since birth with rabbit anti-mouse IgM serum for 5 weeks were d...

journal_title：International archives of allergy and immunology

authors： Peng HJ,Chang ZN,Kuo SW,Lee CC,Tzau YY

更新日期：2000-07-01 00:00:00

abstract：:T cells are central regulators and mediators of allergic sensitisation and disease. The house dust mite allergens are a biochemically diverse group of proteins which are present in extracts and the environment in a wide range of concentrations. Here the importance of ascertaining the contribution of the different alle...

journal_title：International archives of allergy and immunology

authors： Thomas WR,Smith W,Hales BJ

更新日期：1998-01-01 00:00:00

abstract：:A 73-year-old man developed organized pneumonia with severe right-sided eosinophilic pleural effusion (PE). CD69+ and HLA-DR+ eosinophils in PE were 90 and 31%, respectively, but were undetectable in peripheral blood (PB). CD4+, CD45RA+ (naive) and CD4+, CD45RO+ (memory) cells in PB, PE and bronchoalveolar lavage (BAL...

journal_title：International archives of allergy and immunology

authors： Hossain M,Okubo Y,Yamaguchi S,Horie S,Itoh S,Sugii S,Takatsu K,Oguchi T,Sekiguchi M

更新日期：1996-10-01 00:00:00

abstract：:Reversible airway obstruction and airway inflammation following allergen exposure represent crucial pathophysiological features of allergic asthma. In order to investigate these events, bronchial-specific challenge is commonly employed although it may be complicated and may not be free of possible risks. Therefore, we...

journal_title：International archives of allergy and immunology

authors： Ciprandi G,Buscaglia S,Scordamaglia A,Canonica GW

更新日期：1997-03-01 00:00:00

abstract：:IL-3-dependent, murine mast cell lines derived from embryonic yolk sac precursors display a tumoricidal activity that is blocked by antibodies against tumor necrosis factor-alpha, indicating that this cytokine is the major mediator involved in the cytotoxic activity of the cultured mast cell lines. Further, cholera to...

journal_title：International archives of allergy and immunology

authors： Manning JK,Malkovsky M,Meager A

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:Aspirin-intolerant asthma (AIA) is a clinical syndrome characterized by acute bronchoconstriction following the ingestion of aspirin. Solute carrier family 22, member 2 (SLC22A2), also known as organic cation transporter 2 (OCT2), is predominantly expressed in the luminal membrane of airway epithelial cells ...

journal_title：International archives of allergy and immunology

authors： Park TJ,Kim JH,Bae JS,Park BL,Cheong HS,Chun JY,Lee JS,Kim JY,Pasaje CF,Cho SH,Uh ST,Kim MK,Choi IS,Koh IS,Park CS,Shin HD

更新日期：2011-01-01 00:00:00

abstract：:A 20mer peptide representing the N-terminus of a major allergen, Alt a I, of Alternaria alternata was synthesized and examined for its antibody binding and antibody induction activities. Alt a I peptide-BSA conjugate reacted with both human IgE and rabbit anti-Alt a I IgG in ELISA, albeit the binding of the peptide to...

journal_title：International archives of allergy and immunology

authors： Zhang L,Curran IH,Muradia G,De Vouge MW,Rode H,Vijay HM

更新日期：1995-11-01 00:00:00

abstract：BACKGROUND:Systemic anaphylaxis is the most severe form of immediate hypersensitivity reaction. The activation of the complement system occurs during anaphylactic shock. The purpose of this study was to determine in a mouse model whether the lectin pathway of complement activation is involved in anaphylaxis. METHODS:T...

journal_title：International archives of allergy and immunology

authors： Windbichler M,Echtenacher B,Takahashi K,Ezekowitz RA,Schwaeble WJ,Jenseniuis JC,Männel DN

更新日期：2006-01-01 00:00:00

abstract：:For each medicinal product quality, safety and efficacy have to be proven to obtain a marketing authorisation. The national competent health authorities and the European Medicines Agency (EMEA) with support of the Heads of Medicines Agencies (HMA) work together to grant marketing authorisations for medicinal products....

journal_title：International archives of allergy and immunology

authors： Lorenz AR,Luttkopf D,Seitz R,Vieths S

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Prostaglandin D(2) (PGD(2)), a major prostanoid produced by activated mast cells, has long been implicated in allergic diseases. PGD(2) demonstrates its effects through two G-protein-coupled receptors, DP and CRTH2. The PGD(2)/CRTH2 system mediates chemotaxis of eosinophils, basophils, and Th2 cells, which a...

journal_title：International archives of allergy and immunology

authors： Chiba T,Kanda A,Ueki S,Ito W,Kamada Y,Oyamada H,Saito N,Kayaba H,Chihara J

更新日期：2006-01-01 00:00:00