Abstract:
:A 73-year-old man developed organized pneumonia with severe right-sided eosinophilic pleural effusion (PE). CD69+ and HLA-DR+ eosinophils in PE were 90 and 31%, respectively, but were undetectable in peripheral blood (PB). CD4+, CD45RA+ (naive) and CD4+, CD45RO+ (memory) cells in PB, PE and bronchoalveolar lavage (BAL) were 10.9, 8.4, 2.5 and 22.7, 38.3 and 16.4%, respectively. CD8+, CD45RA+ (naive) and CD8+, CD45RO+ (memory) cells in PB, PE and BAL were 3.5, 4.7, 1.0, and 8.9, 11.3 and 46.0%, respectively. The concentrations of interleukin-5 (IL-5) and IL-6 in PE were 1,680 and 2,797 pg/ml, respectively; however, these cytokines were undetectable in PB. The patient died 1 month after surgery to remove right thickened pleura. Microscopic findings showed right fibrinous pleuritis and organized pneumonia.
journal_name
Int Arch Allergy Immunoljournal_title
International archives of allergy and immunologyauthors
Hossain M,Okubo Y,Yamaguchi S,Horie S,Itoh S,Sugii S,Takatsu K,Oguchi T,Sekiguchi Mdoi
10.1159/000237368subject
Has Abstractpub_date
1996-10-01 00:00:00pages
195-8issue
2eissn
1018-2438issn
1423-0097journal_volume
111pub_type
杂志文章abstract:BACKGROUND:Serum-derived hyaluronan (HA)-associated proteins (SHAPs), the heavy chains of inter-α-trypsin inhibitor, covalently bind to HA to form the SHAP-HA complex. The SHAP-HA complex is involved in the pathophysiology of inflammatory diseases, including rheumatoid arthritis. We investigated whether this complex is...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000314362
更新日期:2010-01-01 00:00:00
abstract::At an international hereditary angioedema (HAE) expert meeting, results from a survey were used to guide discussion on how best to advise patients on self-administering intravenous C1 esterase inhibitor therapy. Treatment differences across Europe were highlighted, together with the practicalities of self-administrati...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000351236
更新日期:2013-01-01 00:00:00
abstract::Serum antibodies reactive with streptococcal cell wall peptidoglycan (PG) and its peptide subunit (synthetic tetra-D-alanine) were measured by enzyme-linked immunosorbent assay (ELISA) in patients with rheumatoid arthritis (RA), juvenile rheumatoid arthritis (JRA), osteoarthritis and acute rheumatic fever (RF) compare...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000236137
更新日期:1992-01-01 00:00:00
abstract::In recent years, the Th1/Th2 concept has become of prime importance in the understanding of heterogeneous responses of the immune system and implications thereof for infectious and autoimmune diseases. Originally established on the basis of different cytokines produced by T cell clones, it is now known that the Th1/Th...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章,评审
doi:10.1159/000023900
更新日期:1998-03-01 00:00:00
abstract:BACKGROUND:Jellyfish stings cause painful, papular-urticarial eruptions due to the immediate allergic, acute toxic and persistent inflammatory responses. In spite of many marine accidents and their economic impact, modes of first-aid treatment remain conventional and specific allergen and medical treatment are not yet ...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000434721
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:ADAM (a disintegrin and metalloprotease) family members, characterized by a metalloprotease and a disintegrin domain, are membrane-anchored glycoproteins involved in proteolysis and cell adhesion. ADAM8 might have an important role in allergic inflammation. It can cleave a variety of substrates and is a shed...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000097359
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Allergic conjunctivitis is characterized by itchy, watery and swollen eyes which occur in response to exposure to seasonal or environmental allergens. The early phase reaction of allergic conjunctivitis is primarily mediated by mast cell degranulation while the late phase reaction is driven by Th2 cells and ...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000328769
更新日期:2012-01-01 00:00:00
abstract::We aimed to evaluate the therapeutic effect of nebulized beclomethasone dipropionate (nBDP) on both allergic asthma and rhinitis. In a randomized, double-blind, placebo-controlled study, 40 children (mean age 10.7 ± 2.1 years) with allergic asthma and rhinitis received either nBDP (daily dose of 800 µg, administered t...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章,随机对照试验
doi:10.1159/000343137
更新日期:2013-01-01 00:00:00
abstract::A case of anaphylaxis following a bite from a Siberian hamster (SH; Phodopus sungorus) is described. Skin prick tests with hair, urine and salivary gland extracts from SH were positive, while the tests were negative for hair extracts from other rodents. IgE immunoblotting with the patient serum revealed 3 IgE-binding ...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000324956
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Recombinant dog allergens, rCan f 1 and rCan f 2, and their antibodies are good tools for the characterization of dog allergens in order to develop modern therapeutic and preventive methods for dog allergy. METHODS:In this study, cDNA was synthesized from the mRNA of dog salivary glands and cloned into the ...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000097498
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:L-selectin (CD62L) and Mac-1 (CD11b/CD18) play a crucial role in the infiltration of eosinophils. However, changes in CD62L and CD11b expression on eosinophils after stimulation with cytokines were little studied. METHODS:Eosinophils in peripheral blood of healthy volunteers were purified and cultured with ...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000053590
更新日期:1999-01-01 00:00:00
abstract:BACKGROUND:Autoimmune disorders are considered to be associated with a Th1 immune response while allergic diseases with a Th2 response. We carried out a study to determine whether there is an inverse relationship between allergic diseases in IgE-sensitized children or positive skin-prick test reactions to allergens and...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000079166
更新日期:2004-08-01 00:00:00
abstract:BACKGROUND:Measurement of fractional exhaled nitric oxide (FENO) is useful in assessing eosinophilic airway inflammation. Smoking may modify airway inflammation and reduce FENO levels, compromising the diagnostic value of FENO in smokers. How smoking influences FENO in atopic versus nonatopic asthmatics is unknown. The...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000283029
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:The lymphocyte transformation test (LTT) is used for in vitro diagnosis of drug hypersensitivity reactions. While its specificity is over 90%, sensitivity is limited and depends on the type of reaction, drug and possibly time interval between the event and analysis. Removal of regulatory T cells (Treg/CD25(h...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000358491
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Modulating early immune response by application of bacteria and their by-products has been suggested as a preventive strategy against the development of allergic diseases. In light of this, the aim of the study was to test the effects of oral administration of bacterial lysates (BL) in a rat model of food al...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000322352
更新日期:2011-01-01 00:00:00
abstract::Immunological suppression is one of the important aspects which govern the regulation of the immune response. Clonal deletion, clonal anergy and the activity of suppressor cells were proposed as mechanisms leading to this phenomenon. In this review we provide evidence for the existence of suppressor (Ts) cells and the...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章,评审
doi:10.1159/000236379
更新日期:1993-01-01 00:00:00
abstract::Microwave radiation from mobile phones enhanced skin wheal responses induced by house dust mite and Japanese cedar pollen while it had no effect on wheal responses induced by histamine in patients with atopic eczema/dermatitis syndrome (AEDS). Microwave radiation also increased plasma levels of substance P (SP) and va...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000067592
更新日期:2002-12-01 00:00:00
abstract:OBJECTIVE:To evaluate whether activated partial thromboplastin time (APTT) could be used in the laboratory diagnosis of hereditary or acquired angioedema (HAE or AAE) with and without C1 inhibitor (C1-INH) deficiency. METHODS:In a prospective investigation, APTT and other coagulation parameters were determined in 149 ...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000447695
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Antiphospholipid antibodies (aPL) show great heterogeneity. Different phospholipids, with or without protein cofactor(s), and phospholipid binding proteins alone have been proposed as the target molecules for aPL. In order to determine the influence of phospholipid degradation products on the binding of aPL,...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000237426
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND:To understand how the high-affinity IgE receptor (FcepsilonRI) communicates with downstream effectors, we focused on exploring the functional importance of the FcepsilonRI-mediated formation and localization of a signaling complex that contains the hematopoietic cell-specific scaffolding protein linker for a...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章,评审
doi:10.1159/000053692
更新日期:2001-01-01 00:00:00
abstract::Drug hypersensitivity reactions (DHR) are clinically and functionally heterogeneous. Different subclassifications based on timing of symptom appearance or type of immune mechanism have been proposed. Here, we show that the mode of action of drugs leading to immune/inflammatory cell stimulation is a further decisive fa...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章,评审
doi:10.1159/000453265
更新日期:2016-01-01 00:00:00
abstract::Mercuric chloride (HgCl(2)) has been proposed to be a mitogen for human blood lymphocytes in vitro. In our previous study, we demonstrated that HgCl(2) preferentially stimulates the CD4+ T cell subset to blast transformation and DNA synthesis and that the reaction is dependent on CD14+ accessory cells. In order to cha...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000024221
更新日期:1999-09-01 00:00:00
abstract::Antibodies to rat Thy-1, and also to murine Thy-1, could provoke reverse passive cutaneous anaphylaxis-like (RPCA-like) reactions. The threshold amount of purified anti-Thy-1 antibodies for RPCA-like reactions was 12.5 microg/ml. No RPCA-like reactions were obtained with IgG1 F(ab')2 anti-Thy-1. Cross-linking the muri...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000237662
更新日期:1997-10-01 00:00:00
abstract::This study concerned the way in which eosinophils adhere to their surroundings. Many fibrils were seen to adhere to the cell membrane of eosinophils migrating into the submucosa. Those eosinophils migrating into the epithelial layer adhered to the epithelial cells in 2 different ways: through the thin filaments bridgi...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000237199
更新日期:1995-01-01 00:00:00
abstract::In this study, we postulated that repeated cycles of IgE passive sensitisation and antigen challenge may play a role in up-regulating eosinophil response in allergic conditions. Antigen-mediated stimulation of the pleural cavity of rats passively sensitised with a single injection of IgE anti-DNP resulted in mast cell...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000049530
更新日期:2001-12-01 00:00:00
abstract:BACKGROUND:Chronic rhinosinusitis (CRS) is a multifaceted disease with a significant genetic component. The importance of taste receptor signaling has recently been highlighted in CRS; single nucleotide polymorphisms (SNPs) of bitter tastant-responsive G-protein-coupled receptors have been linked with CRS and with alte...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000499875
更新日期:2019-01-01 00:00:00
abstract::IL-13 is a relatively novel cytokine produced by activated T cells. IL-13 inhibits the production of proinflammatory cytokines and chemokines by activated monocytes, induces B cell proliferation and differentiation, including IgE production, and the expression of certain adhesion molecules on endothelial cells. All th...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章,评审
doi:10.1159/000236842
更新日期:1995-03-01 00:00:00
abstract:BACKGROUND:The fractional concentration of exhaled nitric oxide (FeNO) is a surrogate biomarker for Th2-dependent bronchial inflammation. The present study investigated whether FeNO may characterize allergic rhinitis (AR) patients. METHODS:A total of 553 AR patients (497 males, mean age 28.8 years) were evaluated. Tho...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000456548
更新日期:2017-01-01 00:00:00
abstract::Penicillium and Aspergillus species have been identified as prevalent indoor airborne fungi that are associated with extrinsic bronchial asthma. We have recently analyzed the IgE-binding components in 8 prevalent Penicillium and Aspergillus species (P. citrinum, P. notatum, P. oxalicum, P. brevicompactum, A. fumigatus...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章,评审
doi:10.1159/000024202
更新日期:1999-08-01 00:00:00
abstract:BACKGROUND:Transforming growth factor-β1 (TGF-β1)-in-duced proliferation of airway smooth muscle cells plays critical roles in the development of airway remodeling. Six1 (sine oculis homeobox homolog 1) has been demonstrated to be involved in airway inflammation and remodeling in asthmatic mice. OBJECTIVES:The aim of ...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000505064
更新日期:2020-01-01 00:00:00