Modulation of anti-tumor cytotoxicity of cultured mast cells by metabolic inhibitors.

abstract：BACKGROUND:Asthma, allergic conditions, and COPD overlap, but the effect of them and their combinations on disease severity, need for drugs, use of healthcare, and costs is poorly known. OBJECTIVE:To study how different allergic diseases co-occur in asthma and allergy patients and evaluate the use of medication well a...

journal_title：International archives of allergy and immunology

authors： Jantunen J,Haahtela T,Salimäki J,Linna M,Mäkelä M,Pelkonen A,Kauppi P

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Endogenous IL-17 is needed for the Ag sensitization that results in murine allergic asthma, a Th2-mediated disease. Here, we aimed to investigate the role IL-17 plays in the development of murine experimental allergic conjunctivitis (EC) which is also a Th2-mediated disease. METHODS:To induce EC, wild-type ...

journal_title：International archives of allergy and immunology

authors： Fukushima A,Sumi T,Ishida W,Yamada J,Iwakura Y,Ueno H

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Aspirin-intolerant asthma (AIA) is a clinical syndrome characterized by acute bronchoconstriction following the ingestion of aspirin. Solute carrier family 22, member 2 (SLC22A2), also known as organic cation transporter 2 (OCT2), is predominantly expressed in the luminal membrane of airway epithelial cells ...

journal_title：International archives of allergy and immunology

authors： Park TJ,Kim JH,Bae JS,Park BL,Cheong HS,Chun JY,Lee JS,Kim JY,Pasaje CF,Cho SH,Uh ST,Kim MK,Choi IS,Koh IS,Park CS,Shin HD

更新日期：2011-01-01 00:00:00

abstract：:Mast cells are recognized not only as the major effector cells of type I hypersensitivity reactions but also as an important player of innate immune response against bacterial infection. Type I IFNs are also involved in the response against bacterial infection. However, the role of type I IFNs and their associated Jan...

journal_title：International archives of allergy and immunology

authors： Mori Y,Hirose K,Suzuki K,Nakajima H,Seto Y,Ikeda K,Shimoda K,Nakayama K,Saito Y,Iwamoto I

更新日期：2004-06-01 00:00:00

abstract：:The inhibitory effects of a novel compound, 6-hydroxy-2-(4-sulfamoylbenzylamino)-4,5,7-trimethylbenzothiazo le hydrochloride (E6080) on IgE-mediated reactions in vitro and in vivo were determined in rhesus monkeys. E6080 inhibited both antigen- and anti-human IgE-induced leukotriene C4 generations from lung fragments ...

journal_title：International archives of allergy and immunology

authors： Katayama S,Sakuma Y,Abe S,Tsunoda H,Yamatsu I,Katayama K

更新日期：1993-01-01 00:00:00

abstract：:The allergic pig can be used as a large-animal model for studies of allergic reactions in the airways and the role of eosinophils in such reactions. To measure the activation of eosinophils, the release of eosinophil-derived cationic proteins can be used. The purpose of this study was to isolate and characterize catio...

journal_title：International archives of allergy and immunology

authors： Fornhem C,Peterson CG,Alving K

更新日期：1996-06-01 00:00:00

abstract：BACKGROUND:Secretory phospholipases A(2) (sPLA(2)) are an emerging class of mediators of inflammation. These enzymes are released in vivo in patients with systemic inflammatory diseases and allergic disorders. sPLA(2)s may activate inflammatory cells by both enzymatic and nonenzymatic mechanisms. The aim of this study ...

journal_title：International archives of allergy and immunology

authors： Triggiani M,Granata F,Petraroli A,Loffredo S,Frattini A,Staiano RI,Monaco G,Marone G

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Exposure to Aspergillus fumigatus allergens results in the sensitization and the development of allergic bronchopulmonary aspergillosis in susceptible individuals. Aspergillus antigen consists of a number of chemically diverse components and their cumulative or synergistic effect may result in disease. When ...

journal_title：International archives of allergy and immunology

authors： Kurup VP,Xia JQ,Shen HD,Rickaby DA,Henderson JD Jr,Fink JN,Chou H,Kelly KJ,Dawson CA

更新日期：2002-10-01 00:00:00

abstract：BACKGROUND:The Notch signaling pathway plays an important role in regulating human immune function, but the relationship between allergic rhinitis (AR) and Notch signaling remains unclear. OBJECTIVE:To investigate the role of Notch signaling in the pathogenesis of AR and its regulation on Foxp3-Treg cells. METHOD:The...

journal_title：International archives of allergy and immunology

authors： Jiao WE,Wei JF,Kong YG,Xu Y,Tao ZZ,Chen SM

更新日期：2019-01-01 00:00:00

abstract：:We aimed to evaluate the therapeutic effect of nebulized beclomethasone dipropionate (nBDP) on both allergic asthma and rhinitis. In a randomized, double-blind, placebo-controlled study, 40 children (mean age 10.7 ± 2.1 years) with allergic asthma and rhinitis received either nBDP (daily dose of 800 µg, administered t...

journal_title：International archives of allergy and immunology

authors： Profita M,Riccobono L,Bonanno A,Chanez P,Gagliardo R,Montalbano AM,Albano GD,Liotta G,Gjomarkaj M,La Grutta S

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Ultra-rush regimens for administering sublingual immunotherapy to patients with allergies are becoming more widespread. We aimed to assess treatment safety for patients with allergic rhinitis with or without asthma caused by Dermatophagoides house dust mites. METHODS:This observational study at 5 Spanish ce...

journal_title：International archives of allergy and immunology

authors： Roger A,Justicia JL,Navarro LÁ,Eseverri JL,Ferrès J,Malet A,Alvà V

更新日期：2011-01-01 00:00:00

abstract：:The aim of this study was to assess the relevance of immunoinflammatory markers on the response to short acting beta(2)-agonist in acute asthma exacerbation. Thus, we measured serum eosinophil cationic protein (ECP) levels and sIL-2R at acute exacerbation in 52 adult patients with atopic asthma, and assessed forced ex...

journal_title：International archives of allergy and immunology

authors： Di Lorenzo G,Pacor ML,Morici G,Drago A,Esposito-Pellitteri M,Candore G,Lo Bianco C,Caruso C

更新日期：2002-04-01 00:00:00

abstract：BACKGROUND:METHODS for predicting the clinical outcome of specific oral immunotherapy (OIT) would improve the safety of the therapy. METHODS:We investigated 40 children aged 6-17 years with IgE-mediated cow's milk allergy (CMA) who either successfully completed OIT (n = 32) or discontinued the therapy due to adverse r...

journal_title：International archives of allergy and immunology

authors： Savilahti EM,Kuitunen M,Savilahti E,Mäkelä MJ

更新日期：2014-01-01 00:00:00

abstract：:Serum antibodies reactive with streptococcal cell wall peptidoglycan (PG) and its peptide subunit (synthetic tetra-D-alanine) were measured by enzyme-linked immunosorbent assay (ELISA) in patients with rheumatoid arthritis (RA), juvenile rheumatoid arthritis (JRA), osteoarthritis and acute rheumatic fever (RF) compare...

journal_title：International archives of allergy and immunology

authors： Todome Y,Ohkuni H,Mizuse M,Furuya M,Fujikawa S,Tanaka S,Watanabe N,Fujii K,Zabriskie JB

更新日期：1992-01-01 00:00:00

abstract：:Elevated levels of ovine reaginic antibody were induced by immunization with Ascaris suum antigens. The PCA activity of this antibody persisted in the skin of sheep for 20 days and was abolished by heating to 56 degrees C, suggesting that it was immunoglobulin E. Attempts to isolate IgE from this hyperimmune serum by ...

journal_title：International archives of allergy and immunology

authors： Yilmaz H,Roe JM,Morgan KL

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND:Accumulating evidence indicates that eotaxin is the primary mediator of tissue eosinophilia. In the present study, we analyzed the mechanisms of eotaxin generation by Th1-/Th2-derived cytokines in vitro. METHODS:Human dermal fibroblasts, human umbilical vein endothelial cells and A549 human bronchial epithe...

journal_title：International archives of allergy and immunology

authors： Miyamasu M,Misaki Y,Yamaguchi M,Yamamoto K,Morita Y,Matsushima K,Nakajima T,Hirai K

更新日期：2000-05-01 00:00:00

abstract：BACKGROUND:The development of simple and standardised methods to measure airborne levels of workplace biological allergens is an important step in reducing the incidence of occupational asthma. Such a method would be useful for measuring wheat flour allergens which cause asthma in bakers. Measurement of allergen per se...

journal_title：International archives of allergy and immunology

authors： Wiley K,Smith MM,Allan LJ,Griffin P

更新日期：1997-11-01 00:00:00

abstract：:The effect of ibudilast on anaphylactic bronchoconstriction was studied in guinea pigs sensitized actively with ovalbumin (OA). Animals were treated with indomethacin, tripelennamine and propranolol prior to the antigen challenge. Anaphylactic bronchoconstriction was prevented by ibudilast (1-4 mg/kg i.v. and 5-20 mg/...

journal_title：International archives of allergy and immunology

authors： Ohashi M,Uno T,Nishino K

更新日期：1993-01-01 00:00:00

abstract：INTRODUCTION:Unique gut microbial colonisation patterns are associated with the onset of allergic disease in infants; however, there is insufficient evidence to determine if aberrant microbial composition patterns persist in adult allergic rhinitis (AR) sufferers. OBJECTIVE:To compare the gut microbiome composition be...

journal_title：International archives of allergy and immunology

authors： Watts AM,West NP,Zhang P,Smith PK,Cripps AW,Cox AJ

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:Cat allergens are ubiquitous because the clothing of cat owners constitutes an important source of distribution of Fel d 1 in cat-free environments. Since Fel d 1 can adhere to a variety of surfaces, we sought to verify if human hair belonging to individuals with or without a cat at home might represent a re...

journal_title：International archives of allergy and immunology

authors： Liccardi G,Barber D,Russo M,D'Amato M,D'Amato G

更新日期：2005-06-01 00:00:00

abstract：BACKGROUND:Intravenous immunoglobulin (IVIG) is the mainstay therapy in human immune deficiency states characterized by qualitative and quantitative reductions in B cells. In addition, however, there is widespread use of IVIG in a number of other areas, including neuroimmunologic, infectious, dermatologic, hematologic,...

journal_title：International archives of allergy and immunology

authors： Kumar A,Teuber SS,Gershwin ME

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:The clinical significance and efficacy of treating patients who have immunoglobulin (Ig) G subclass deficiency and/or antibody deficiency with Ig-replacement therapy has been debated. There are no clear guidelines to recommend intravenous gammaglobulin (IgIV) in these patients as there are few published stud...

journal_title：International archives of allergy and immunology

authors： Abdou NI,Greenwell CA,Mehta R,Narra M,Hester JD,Halsey JF

更新日期：2009-01-01 00:00:00

abstract：:The perchloric-acid-soluble Bacille bilié de Calmette-Guérin (BCG) antigen (BCG-P) was investigated for the diagnosis of tuberculosis. Monoclonal antibodies against BCG-P were produced. After SDS-PAGE, silver staining and immunoblotting were done. Pathological specimens of pulmonary tuberculosis, BCG organism itself a...

journal_title：International archives of allergy and immunology

authors： Kim DS,Kim KH

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND:Cross-sectional epidemiological studies have demonstrated that farm milk from traditional farm settings possesses allergoprotective properties. Up to now, it has not been clarified which milk ingredient is responsible for protection against allergic diseases. As farm milk is rich in conjugated linoleic acids...

journal_title：International archives of allergy and immunology

authors： Böcking C,Harb H,Ege MJ,Zehethofer N,Fischer K,Krauß J,Holst O,Nüsing RM,Lindner B,von Mutius E,Renz H,Garn H,Pfefferle PI

更新日期：2014-01-01 00:00:00

abstract：:The case of a 46-year-old man with a chronic cough with sputum eosinophilia (atopic cough) caused by Trichosporon cutaneum serotype II (Trichosporon asahii) is reported. The diagnosis was made with the inhalation challenge test with T. asahii antigen. He was admitted for the diagnosis and treatment of a severe nonprod...

journal_title：International archives of allergy and immunology

authors： Ogawa H,Fujimura M,Amaike S,Nishiura Y,Nakagawa-Yoshida K,Suga M,Ando M,Matsuda T

更新日期：1998-06-01 00:00:00

abstract：BACKGROUND:Shellfish allergy is one of the major causes of life-threatening allergic reactions to food. The shrimp species Pandalus borealis is the commercially most important coldwater shrimp species, and its protein extract is commonly used in shrimp allergy diagnostics. However, the DNA sequence of its major allerge...

journal_title：International archives of allergy and immunology

authors： Myrset HR,Barletta B,Di Felice G,Egaas E,Dooper MM

更新日期：2013-01-01 00:00:00

abstract：:There is increasing evidence that the asthma process is 'driven' and maintained by persistence of a subset of chronically activated T memory cells, sensitized against allergenic, occupational or viral antigens which 'home' to the lung after antigen exposure or viral infection. In general, allergens induce a CD4 T help...

journal_title：International archives of allergy and immunology

authors： Kon OM,Kay AB

更新日期：1999-02-01 00:00:00

abstract：:The downstream signaling components of high-affinity IgE receptor (FcepsilonRI) were studied using yeast two-hybrid screening of the cDNA library constructed from RBL-2H3 cells. The cytoplasmic part of the gamma-chain but not that of the beta-chain was found to interact with pyruvate kinase in the yeast. The in-vitro-...

journal_title：International archives of allergy and immunology

authors： Oak MH,Cheong H,Kim KM

更新日期：1999-06-01 00:00:00

abstract：:Recently, the induction of T cell anergy has been considered as a sophisticated form of immunotherapy. However, the multiplicity of T cell allergen epitopes discourages the practical use of this method. Since orally administered antigen proteins are digested to peptides and absorbed into the circulation, oral administ...

journal_title：International archives of allergy and immunology

authors： Suko M,Mori A,Ito K,Okudaira H

更新日期：1995-05-01 00:00:00

abstract：OBJECTIVE:To evaluate whether activated partial thromboplastin time (APTT) could be used in the laboratory diagnosis of hereditary or acquired angioedema (HAE or AAE) with and without C1 inhibitor (C1-INH) deficiency. METHODS:In a prospective investigation, APTT and other coagulation parameters were determined in 149 ...

journal_title：International archives of allergy and immunology

authors： Bork K,Witzke G

更新日期：2016-01-01 00:00:00