Tyk2 is essential for IFN-alpha-induced gene expression in mast cells.

abstract：BACKGROUND:The fractional concentration of exhaled nitric oxide (FeNO) is a surrogate biomarker for Th2-dependent bronchial inflammation. The present study investigated whether FeNO may characterize allergic rhinitis (AR) patients. METHODS:A total of 553 AR patients (497 males, mean age 28.8 years) were evaluated. Tho...

journal_title：International archives of allergy and immunology

authors： Ciprandi G,Gallo F,Ricciardolo FL,Cirillo I

更新日期：2017-01-01 00:00:00

abstract：:Chlorhexidine is a commonly used antiseptic and disinfectant in the health-care setting. Its usage has increased in recent years with intensive campaigns and infection control guidelines to combat hospital-acquired infections. As a result, patients and health-care workers (HCW) are exposed to increasing chlorhexidine ...

journal_title：International archives of allergy and immunology

authors： Hong CC,Wang SM,Nather A,Tan JH,Tay SH,Poon KH

更新日期：2015-01-01 00:00:00

abstract：:Various methods have been devised to assay eosinophil chemotaxis. In this review, we introduced a rapid and sensitive eosinophil chemotactic assay system based on eosinophil peroxidase (EPO) determination. Eosinophils were semipurified by dextran sedimentation followed by Percoll gradient centrifugation. Eosinophil mi...

journal_title：International archives of allergy and immunology

authors： Nagase H,Yamaguchi M,Jibiki S,Yamada H,Ohta K,Kawasaki H,Yoshie O,Yamamoto K,Morita Y,Hirai K

更新日期：2000-05-01 00:00:00

abstract：BACKGROUND:IgE mediates immediate-type hypersensitivity reactions responsible for various allergic symptoms. It is secreted by IgE-producing plasma cells, which differentiate from B cells expressing membrane-bound IgE (mIgE) on their surface. The epsilon-chain of human mIgE contains a membrane-anchoring peptide and an ...

journal_title：International archives of allergy and immunology

authors： Chen HY,Liu FT,Hou CM,Huang JS,Sharma BB,Chang TW

更新日期：2002-08-01 00:00:00

abstract：BACKGROUND:Clinically it is recognized that tree nut allergies such as hazelnut allergy are not usually outgrown. Specific mechanisms underlying the persistence of such food allergies are incompletely understood. Here we studied the natural history and the long-term immune and clinical characteristics of hazelnut aller...

journal_title：International archives of allergy and immunology

authors： Gonipeta B,Parvataneni S,Paruchuri P,Gangur V

更新日期：2010-01-01 00:00:00

abstract：:Nonspecific hyperreactivity to a number of physical, chemical and pharmacological agents in a common characteristics of allergic subjects, which is strictly related to the inflammatory events consequent to an allergic reaction. Hyperosmolar stimulus has previously been shown to cause an inflammatory response inducing ...

journal_title：International archives of allergy and immunology

authors： Ciprandi G,Buscaglia S,Pesce G,Lotti R,Rolando M,Bagnasco M,Canonica GW

更新日期：1994-05-01 00:00:00

abstract：BACKGROUND:Nitrosative and acid stress play an important role in the pathogenesis of asthma. The aim of this study was to evaluate whether, in asthmatics, a link exists between the concentrations of nitrite/nitrate, ammonia and pH values in exhaled breath condensate (EBC) and asthma severity, lung function, exhaled nit...

journal_title：International archives of allergy and immunology

authors： Tomasiak-Lozowska MM,Zietkowski Z,Przeslaw K,Tomasiak M,Skiepko R,Bodzenta-Lukaszyk A

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Dendritic cells (DC) play a decisive role in the induction of allergen-induced Th1 and Th2 responses. Since the induction of allergen-specific Th1 responses has shown to inhibit allergen-induced Th2-type inflammation, in this study we investigated whether manipulated myeloid-derived DC pulsed with the specif...

journal_title：International archives of allergy and immunology

authors： Trujillo-Vargas CM,Ramirez-Pineda JR,Palmetshofer A,Grunewald S,Moll H,Berberich C,Erb KJ

更新日期：2005-07-01 00:00:00

abstract：BACKGROUND:The association of pollinosis with allergy to plant foods occurs in up to 70% of tree pollen-allergic patients. In recent years, some of the relevant cross-reacting proteins have been characterized at the molecular and immunological level. Api g 1 has been identified as the celery homologue of the major birc...

journal_title：International archives of allergy and immunology

authors： Hoffmann-Sommergruber K,Ferris R,Pec M,Radauer C,O'Riordain G,Laimer Da Camara Machado M,Scheiner O,Breiteneder H

更新日期：2000-06-01 00:00:00

abstract：BACKGROUND:T cells are key regulators of immunologic disease parameters. However, their contribution to the process of tissue remodeling is ill defined. In the present study, we investigated gene expression of allergy-characteristic, IL-4-rich T cell cDNAs to monitor expression of genes that might participate in the pa...

journal_title：International archives of allergy and immunology

authors： Wohlfahrt JG,Kunzmann S,Menz G,Kneist W,Akdis CA,Blaser K,Schmidt-Weber CB

更新日期：2003-08-01 00:00:00

abstract：BACKGROUND:Over the past years, dust of green coffee beans has become known to be a relevant cause for occupational type I allergies. Up to now, allergy diagnostics is based on native green coffee bean extract which exhibits insufficient specificity due to interfering substances as well as batch-to-batch variations. No...

journal_title：International archives of allergy and immunology

authors： Manavski N,Peters U,Brettschneider R,Oldenburg M,Baur X,Bittner C

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:A number of different molecules are known to be involved in the signal pathway to release histamine from mast cells, among which arachidonic acid (AA) is one of the key mediators. On the other hand, we found that the application of compound 48/80, a typical histamine liberator, generated superoxide in mast c...

journal_title：International archives of allergy and immunology

authors： Sakaguchi M,Fukuishi N,Teramoto K,Miyazaki M,Huh NH,Namba M,Akagi M

更新日期：2003-04-01 00:00:00

abstract：BACKGROUND:Orange allergens are virtually unknown, in spite of the large consumption of this fruit. Germin-like proteins, together with vicilins and legumins, form the cupin superfamily of plant proteins, which includes many seed allergens. METHODS:Twenty-nine patients with allergy to oranges were studied. A major IgE...

journal_title：International archives of allergy and immunology

authors： Ahrazem O,Ibáñez MD,López-Torrejón G,Sánchez-Monge R,Sastre J,Lombardero M,Barber D,Salcedo G

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Cytosolic phospholipase A2 (cPLA2) plays a key role in the development of late-phase anaphylaxis. L-Glutamine (Gln), a nonessential amino acid, has anti-inflammatory activity via inhibiting cPLA2. METHODS:We used a penicillin-induced murine model of anaphylaxis, and late-phase anaphylaxis was quantified by ...

journal_title：International archives of allergy and immunology

authors： Kim HK,Song CH,Bae YS,Im SY,Lee HK

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:The lymphocyte transformation test (LTT) is used for in vitro diagnosis of drug hypersensitivity reactions. While its specificity is over 90%, sensitivity is limited and depends on the type of reaction, drug and possibly time interval between the event and analysis. Removal of regulatory T cells (Treg/CD25(h...

journal_title：International archives of allergy and immunology

authors： Srinoulprasert Y,Pichler WJ

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Basophils and mast cells are important initiator/effector cells capable of rapidly responding to IgE-mediated stimulation, but the precise mechanisms regulating their functions in vivo have not been fully identified. In this study, we assessed whether low levels of antigen can modulate activation of basophil...

journal_title：International archives of allergy and immunology

authors： Koketsu R,Yamaguchi M,Suzukawa M,Tanaka Y,Tashimo H,Arai H,Nagase H,Matsumoto K,Saito H,Ra C,Yamamoto K,Ohta K

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:The population of large parts of Africa, South America and travellers to these areas are at risk of yellow fever (YF) with a 50% mortality risk. Yellow fever vaccine (YFV) propagated in hens' eggs confers protection in 95% of the vaccinated. The rate of anaphylaxis for YFV ranges from 0.42 to 1.8/100,000 dos...

journal_title：International archives of allergy and immunology

authors： Rutkowski K,Ewan PW,Nasser SM

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:There is no information whether galectin-9 (a novel eosinophil chemoattractant) was associated with pathogenesis of eosinophilic disorders. METHODS:We assessed the expression of galectin-9 with imunostaining and in situ hybridization both in the lesion of angiolymphoid hyperplasia with eosinophilia, and per...

journal_title：International archives of allergy and immunology

authors： Saita N,Goto E,Yamamoto T,Cho I,Tsumori K,Kohrogi H,Maruo K,Ono T,Takeya M,Kashio Y,Nakamura K,Hirashima M

更新日期：2002-05-01 00:00:00

abstract：BACKGROUND:Diagnosis and immunotherapy of house-dust mite (HDM) allergy is still based on natural allergen extracts. The aim of this study was to analyze commercially available Dermatophagoides pteronyssinus extracts from different manufacturers regarding allergen composition and content and whether variations may affe...

journal_title：International archives of allergy and immunology

authors： Casset A,Mari A,Purohit A,Resch Y,Weghofer M,Ferrara R,Thomas WR,Alessandri C,Chen KW,de Blay F,Valenta R,Vrtala S

更新日期：2012-01-01 00:00:00

abstract：:Psoriasis (Ps) is a chronic, immune-mediated, skin inflammatory disease affecting up to 3% of the population worldwide. Different environmental triggers initiate this complex multifactorial syndrome. Many individuals affected by Ps (6-26%) develop inflammatory disease in other organs, often in the joints as in psorias...

journal_title：International archives of allergy and immunology

authors： Khmaladze Ia,Nandakumar KS,Holmdahl R

更新日期：2015-01-01 00:00:00

abstract：:Eosinophils may play an important role in the pathogenesis of airway remodeling in asthma through the production of various fibrogenic cytokines such as transforming growth factor-beta1 (TGF-beta1). Cysteinyl leukotrienes are also suggested to be involved in remodeling with their potential to induce proliferation of a...

journal_title：International archives of allergy and immunology

authors： Kato Y,Fujisawa T,Nishimori H,Katsumata H,Atsuta J,Iguchi K,Kamiya H

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Endogenous IL-17 is needed for the Ag sensitization that results in murine allergic asthma, a Th2-mediated disease. Here, we aimed to investigate the role IL-17 plays in the development of murine experimental allergic conjunctivitis (EC) which is also a Th2-mediated disease. METHODS:To induce EC, wild-type ...

journal_title：International archives of allergy and immunology

authors： Fukushima A,Sumi T,Ishida W,Yamada J,Iwakura Y,Ueno H

更新日期：2008-01-01 00:00:00

abstract：:CD40 is a surface antigen expressed on B cells. The CD40 ligand (CD40L) is expressed on activated T cells. Interaction between CD40 and CD40L is critical for proliferation and isotype switching in the context of a response to a T-cell-dependent antigen. Patients with X-linked hyper-IgM syndrome (HIGMX-1) in their CD40...

journal_title：International archives of allergy and immunology

authors： Castigli E,Fuleihan R,Ramesh N,Tsitsikov E,Tsytsykova A,Geha RS

更新日期：1995-05-01 00:00:00

abstract：:Human mononuclear leukocytes (MNL), probably OKT4-positive T cells, produced an eosinophil chemotactic factor (ECF) when they were cocultured with irradiated BALL-1, a B cell lymphoma line. Treatment of MNL, with anti-IL-2 antibody failed to suppress BALL-1-induced ECF production. Periodate-lysine-paraformaldehyde-fix...

journal_title：International archives of allergy and immunology

authors： Yoshida N,Ueno M,Saita N,Hirashima M

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND:ADAM (a disintegrin and metalloprotease) family members, characterized by a metalloprotease and a disintegrin domain, are membrane-anchored glycoproteins involved in proteolysis and cell adhesion. ADAM8 might have an important role in allergic inflammation. It can cleave a variety of substrates and is a shed...

journal_title：International archives of allergy and immunology

authors： Matsuno O,Miyazaki E,Nureki S,Ueno T,Ando M,Ito K,Kumamoto T,Higuchi Y

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Subcutaneous immunotherapy for respiratory allergy has shown a long lasting efficacy after its discontinuation, whereas evidence in the case of sublingual immunotherapy (SLIT) is weak. This retrospective study evaluates whether SLIT exerts a long-lasting effect and whether it relates to its duration. METHOD...

journal_title：International archives of allergy and immunology

authors： Marogna M,Bruno M,Massolo A,Falagiani P

更新日期：2007-01-01 00:00:00

abstract：:The participation of platelets in the protection against larval Taenia taeniaeformis was studied. CB-17 SCID mice, susceptible to T. taeniaeformis, were protected against a challenge infection with T. taeniaeformis by the passive transfer of platelets from T. taeniaeformis-infected normal CB-17 mice, resistant to T. t...

journal_title：International archives of allergy and immunology

authors： Kakuda T,Ooi HK,Oku Y,Kamiya M

更新日期：1996-03-01 00:00:00

abstract：BACKGROUND:IgE-mediated hypersensitivity to latex has been recognized as an increasing health problem with far-reaching consequences for patients, regarding both their occupational situation and safety in medical care. Therefore, a correct diagnosis of natural rubber latex (NRL) allergy is essential. The purpose of the...

journal_title：International archives of allergy and immunology

authors： Kütting B,Weber B,Brehler R

更新日期：2001-11-01 00:00:00

abstract：:A significant increase in the incidence of allergy and asthma has been observed during the past decades. The background of this phenomenon has not been well explained, but changes in lifestyle and habits are heavily discussed as contributing factors. Among these is a too clean environment, which may predispose individ...

journal_title：International archives of allergy and immunology

authors： Zaknun D,Schroecksnadel S,Kurz K,Fuchs D

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Although common variable immunodeficiency (CVID) is associated with sinopulmonary disease, there are no previous systematic evaluations comparing computed tomographic (CT) sinus imaging with immunoglobulin measurements in patients with this condition. METHODS:We performed a retrospective review by a blinded...

journal_title：International archives of allergy and immunology

authors： Hagan JB,Park MA,Kita H,Campeau NG

更新日期：2010-01-01 00:00:00