Abstract:
BACKGROUND:A number of different molecules are known to be involved in the signal pathway to release histamine from mast cells, among which arachidonic acid (AA) is one of the key mediators. On the other hand, we found that the application of compound 48/80, a typical histamine liberator, generated superoxide in mast cells. In the present study, we investigated the mechanism of superoxide production in mast cells with respect to AA signaling in conjunction with a fine structural analysis. METHODS:Superoxide production was monitored by chemiluminescence in rat peritoneal mast cells and their subfractions after various treatments. For scanning electron micrography, the conditions for fixation and freeze-fracture were optimized to get natural fine images. RESULTS:Compound 48/80 induced superoxide production in the isolated mast cells and some of their subfractions possibly through intracellular increase in Ca(2+) concentration, activation of cytosolic phospholipase A(2), and release of AA. DISCUSSION:The present results indicate the critical role of AA in the signal pathway to generate superoxide from mast cells in response to compound 48/80.
journal_name
Int Arch Allergy Immunoljournal_title
International archives of allergy and immunologyauthors
Sakaguchi M,Fukuishi N,Teramoto K,Miyazaki M,Huh NH,Namba M,Akagi Mdoi
10.1159/000070216keywords:
subject
Has Abstractpub_date
2003-04-01 00:00:00pages
288-99issue
4eissn
1018-2438issn
1423-0097pii
70216journal_volume
130pub_type
杂志文章abstract:BACKGROUND:Hymenoptera venom allergy (HVA) has a prevalence of 3% in adults. Although patients have no ongoing symptoms, they often suffer from an impairment of their psychological well-being and quality of life. OBJECTIVE:The aim of this study was to analyze sex-specific differences regarding the psychological burden...
journal_title:International archives of allergy and immunology
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journal_title:International archives of allergy and immunology
pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:1996-02-01 00:00:00
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pub_type: 杂志文章
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doi:10.1159/000371421
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pub_type: 杂志文章
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journal_title:International archives of allergy and immunology
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更新日期:2005-08-01 00:00:00
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journal_title:International archives of allergy and immunology
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pub_type: 临床试验,杂志文章
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