Long-term characteristics of hazelnut allergy in an adjuvant-free mouse model.

abstract：BACKGROUND:Pseudomonas aeruginosa phospholipase C (PLC) is a critical component in the pathogenesis of severe P. aeruginosa infections. However, P. aeruginosa can produce a hemolytic (PLC-H) as well as a nonhemolytic (PLC-N) variant, both having a MW of about 77 kD. In the past, studies did not distinguish between both...

journal_title：International archives of allergy and immunology

authors： König B,Vasil ML,König W

更新日期：1997-02-01 00:00:00

abstract：BACKGROUND:Cry j 1 and Cry j 2 are thought to be the major allergens of Japanese cedar pollen. HLA class II types capable of presenting T-cell epitopes in both allergens and their role in induction of T-cell subsets are not well known. METHODS:CD4+ T (Th)-cell clones (TCCs) specific to either Cry j 1 or Cry j 2 were g...

journal_title：International archives of allergy and immunology

authors： Sone T,Morikubo K,Shimizu K,Komiyama N,Tsunoo H,Kino K

更新日期：1999-07-01 00:00:00

abstract：BACKGROUND:Accumulating evidence indicates that eotaxin is the primary mediator of tissue eosinophilia. In the present study, we analyzed the mechanisms of eotaxin generation by Th1-/Th2-derived cytokines in vitro. METHODS:Human dermal fibroblasts, human umbilical vein endothelial cells and A549 human bronchial epithe...

journal_title：International archives of allergy and immunology

authors： Miyamasu M,Misaki Y,Yamaguchi M,Yamamoto K,Morita Y,Matsushima K,Nakajima T,Hirai K

更新日期：2000-05-01 00:00:00

abstract：:Eosinophils used to be thought of as regulators of allergic inflammation, but there is now evidence to the contrary; eosinophils have been found to be the major effector cells responsible for the late asthmatic response (LAR), airway hyperresponsiveness (AHR) and, at least in part, airway remodeling by releasing leuko...

journal_title：International archives of allergy and immunology

authors： Matsumoto K,Saito H

更新日期：2001-08-01 00:00:00

abstract：BACKGROUND:Endogenous IL-17 is needed for the Ag sensitization that results in murine allergic asthma, a Th2-mediated disease. Here, we aimed to investigate the role IL-17 plays in the development of murine experimental allergic conjunctivitis (EC) which is also a Th2-mediated disease. METHODS:To induce EC, wild-type ...

journal_title：International archives of allergy and immunology

authors： Fukushima A,Sumi T,Ishida W,Yamada J,Iwakura Y,Ueno H

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:A number of different molecules are known to be involved in the signal pathway to release histamine from mast cells, among which arachidonic acid (AA) is one of the key mediators. On the other hand, we found that the application of compound 48/80, a typical histamine liberator, generated superoxide in mast c...

journal_title：International archives of allergy and immunology

authors： Sakaguchi M,Fukuishi N,Teramoto K,Miyazaki M,Huh NH,Namba M,Akagi M

更新日期：2003-04-01 00:00:00

abstract：BACKGROUND:Nasal polyps are a common health problem that can significantly impact the quality of life. OBJECTIVE:To analyze the impact of allergy and peripheral eosinophils (EOS) on the morbidity of chronic rhinosinusitis with nasal polyps (CRSwNP) in Northwest China. METHODS:A retrospective cohort of 323 patients wh...

journal_title：International archives of allergy and immunology

authors： Chen F,Wen L,Qiao L,Shi Z,Xue T,Chen X,Li X

更新日期：2019-01-01 00:00:00

abstract：:Elevated levels of ovine reaginic antibody were induced by immunization with Ascaris suum antigens. The PCA activity of this antibody persisted in the skin of sheep for 20 days and was abolished by heating to 56 degrees C, suggesting that it was immunoglobulin E. Attempts to isolate IgE from this hyperimmune serum by ...

journal_title：International archives of allergy and immunology

authors： Yilmaz H,Roe JM,Morgan KL

更新日期：1993-01-01 00:00:00

abstract：:To determine the variation of antigenic water soluble proteins in white birch (Betula pendula) pollen, extracts of pollen from different sides of individual trees were analyzed by isoelectric focusing (IEF), crossed immunoelectrophoresis, and crossed radioimmunoelectrophoresis. IgE-antibody-binding patterns were also ...

journal_title：International archives of allergy and immunology

authors： Hjelmroos M,Schumacher MJ,Van Hage-Hamsten M

更新日期：1995-12-01 00:00:00

abstract：BACKGROUND:Systemic anaphylaxis is the most severe form of immediate hypersensitivity reaction. The activation of the complement system occurs during anaphylactic shock. The purpose of this study was to determine in a mouse model whether the lectin pathway of complement activation is involved in anaphylaxis. METHODS:T...

journal_title：International archives of allergy and immunology

authors： Windbichler M,Echtenacher B,Takahashi K,Ezekowitz RA,Schwaeble WJ,Jenseniuis JC,Männel DN

更新日期：2006-01-01 00:00:00

abstract：:Increased serum IgE and enhanced susceptibility to viral infections, decreased levels of interferons, lymphocytic skin infiltrates and IgE-bearing epidermal Langerhans cells are striking features in patients with atopic eczema (AE). Since the hyper-IgE syndrome is known to improve under alpha-interferon (alpha-IFN) th...

journal_title：International archives of allergy and immunology

authors： Gruschwitz MS,Peters KP,Heese A,Stosiek N,Koch HU,Hornstein OP

更新日期：1993-01-01 00:00:00

abstract：:T cells are central regulators and mediators of allergic sensitisation and disease. The house dust mite allergens are a biochemically diverse group of proteins which are present in extracts and the environment in a wide range of concentrations. Here the importance of ascertaining the contribution of the different alle...

journal_title：International archives of allergy and immunology

authors： Thomas WR,Smith W,Hales BJ

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND:Loss-of-function mutations of the filaggrin (FLG) gene cause an impaired skin barrier and increase the risk of atopic dermatitis. Interestingly, FLG mutations have also been found to be associated with a high risk of peanut allergy. OBJECTIVE:We investigated the association of FLG mutations with self-report...

journal_title：International archives of allergy and immunology

authors： Linneberg A,Fenger RV,Husemoen LL,Thuesen BH,Skaaby T,Gonzalez-Quintela A,Vidal C,Carlsen BC,Johansen JD,Menné T,Stender S,Melgaard M,Szecsi PB,Berg ND,Thyssen JP

更新日期：2013-01-01 00:00:00

abstract：:Studies in migrant populations provide vital opportunities to investigate the role of environmental factors in the pathogenesis of allergic disorders. Differences in allergy prevalence have been observed between migrants and native-born subjects living in the same geographical location. Immigrants who migrate from les...

journal_title：International archives of allergy and immunology

authors： Tham EH,Loo EXL,Zhu Y,Shek LP

更新日期：2019-01-01 00:00:00

abstract：:Kimura disease is a rare disorder of unknown etiology, characterized by the presence of benign subcutaneous granuloma, marked peripheral blood eosinophilia and elevation of the immunglobulin E (IgE) serum level. Here, we present a case of a 12-year-old boy with Kimura disease who had a history of repeated severe influ...

journal_title：International archives of allergy and immunology

authors： Hosoki K,Hirayama M,Kephart GM,Kita H,Nagao M,Uchizono H,Toyoda H,Senba Y,Imai Y,Komada Y,Ihara T,Fujisawa T

更新日期：2012-01-01 00:00:00

abstract：:Glycosphingolipids (GSLs) are physiological membrane components known to modulate various cellular functions. In order to study their influence on basophil mediator release washed leukocytes obtained from allergic asthmatics and nonatopics were preincubated with varying concentrations of different GSLs. Cells were was...

journal_title：International archives of allergy and immunology

authors： Lichey J,Zuberbier T,Luck W,Lau S,Wahn U

更新日期：1994-01-01 00:00:00

abstract：:Fourteen Brown-Norway rats were pretreated with physiological saline (n = 7) or 500 micrograms Sephadex (n = 7) intratracheally. 24 h later, a bronchial provocation test was performed under pentobarbital anaesthesia using increasing doses of acetylcholine aerosol and the degree of bronchospasm was measured using a mod...

journal_title：International archives of allergy and immunology

authors： Kubin R,Deschl U,Linssen M,Wilhelms OH

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:ADAM (a disintegrin and metalloprotease) family members, characterized by a metalloprotease and a disintegrin domain, are membrane-anchored glycoproteins involved in proteolysis and cell adhesion. ADAM8 might have an important role in allergic inflammation. It can cleave a variety of substrates and is a shed...

journal_title：International archives of allergy and immunology

authors： Matsuno O,Miyazaki E,Nureki S,Ueno T,Ando M,Ito K,Kumamoto T,Higuchi Y

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Antiphospholipid antibodies (aPL) show great heterogeneity. Different phospholipids, with or without protein cofactor(s), and phospholipid binding proteins alone have been proposed as the target molecules for aPL. In order to determine the influence of phospholipid degradation products on the binding of aPL,...

journal_title：International archives of allergy and immunology

authors： Bozic B,Kveder T,Stegnar M,Morosini-Berus E,Kos-Golja M,Peternel P,Rozman B

更新日期：1997-01-01 00:00:00

abstract：:Because of a unique combination of challenges facing human immunodeficiency virus vaccine developers, a number of traditional and novel vaccine designs are being evaluated essentially in parallel. Monomeric proteins, poxvirus vectors, peptides, and particle-based candidate vaccines have entered or will soon enter huma...

journal_title：International archives of allergy and immunology

authors： Johnston MI

更新日期：1995-12-01 00:00:00

abstract：:Cross-linking of FcepsilonRI on mast cells elicits positive signal transduction cascades that lead to the release of a variety of proinflammatory mediators. Mouse mast cells also express gp49B1 on their surface, an immunoglobulin superfamily member that bears two immunoreceptor tyrosine-based inhibitory motifs in its ...

journal_title：International archives of allergy and immunology

authors： Katz HR

更新日期：1999-02-01 00:00:00

abstract：:Preferential eosinophil accumulation is characteristic of airway inflammation in asthma. Although little is known about its mechanism, the effect of a sialyl Lewis X analog on airway eosinophilia was examined in a guinea-pig model of asthma. Guinea-pigs were sensitized by repeated inhalation of ovalbumin. After a sing...

journal_title：International archives of allergy and immunology

authors： Sagara H,Ra C,Okada T,Shinohara S,Fukuda T,Okumura K,Makino S

更新日期：1996-01-01 00:00:00

abstract：:Nitric oxide (NO) is a potent biological mediator, and has a regulatory role in a wide variety of cellular and tissue functions. In the upper and lower airways, NO has been suggested to be involved in different functions with regulatory, protective, defensive or damaging effects. It is obvious that NO plays an importa...

journal_title：International archives of allergy and immunology

authors： Sahin G,Klimek L,Mullol J,Hörmann K,Walther LE,Pfaar O

更新日期：2011-01-01 00:00:00

abstract：:Long-term birth cohort studies are essential to understanding the life course and childhood predictors of allergy and the complex interplay between genes and the environment (including lifestyle and socioeconomic determinants). Over 100 cohorts focusing on asthma and allergy have been initiated in the world over the p...

journal_title：International archives of allergy and immunology

authors： Bousquet J,Anto J,Sunyer J,Nieuwenhuijsen M,Vrijheid M,Keil T,MeDALL Study Group.,CHICOS Study Group.,ENRIECO Study Group.,GA²LEN Study Group.

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Shellfish hypersensitivity is amongst the most common food allergies. The major shellfish allergen was identified as tropomyosin. Here, we investigated the immediate hypersensitivity responses, IgE and cell-mediated immune response in mice sensitized with recombinant shrimp tropomyosin. METHODS:Shrimp tropo...

journal_title：International archives of allergy and immunology

authors： Leung PS,Lee YS,Tang CY,Kung WY,Chuang YH,Chiang BL,Fung MC,Chu KH

更新日期：2008-01-01 00:00:00

abstract：:CD95 (APO-1) is a member of the TNF/nerve growth factor receptor superfamily, which is expressed on the surface of different types of cells. Cross-linking of CD95 leads to the induction of apoptosis. This may be of importance in many physiological systems, but seems to play a special role for the maintenance of immuno...

journal_title：International archives of allergy and immunology

authors： Lechner H,Amort M,Steger MM,Maczek C,Grubeck-Loebenstein B

更新日期：1996-07-01 00:00:00

abstract：BACKGROUND:Orange allergens are virtually unknown, in spite of the large consumption of this fruit. Germin-like proteins, together with vicilins and legumins, form the cupin superfamily of plant proteins, which includes many seed allergens. METHODS:Twenty-nine patients with allergy to oranges were studied. A major IgE...

journal_title：International archives of allergy and immunology

authors： Ahrazem O,Ibáñez MD,López-Torrejón G,Sánchez-Monge R,Sastre J,Lombardero M,Barber D,Salcedo G

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:beta2-Adrenergic agonists play a pivotal role in the management of bronchial asthma. Although the major effect of short-acting beta2-agonists on the airway is relaxation of smooth muscles, they may also have several effects on surrounding immunomodulatory cells. METHODS:We examined whether widely used short...

journal_title：International archives of allergy and immunology

authors： Yasui K,Kobayashi N,Yamazaki T,Agematsu K,Matsuzaki S,Nakata S,Baba A

更新日期：2006-01-01 00:00:00

abstract：:There is a great need to develop a method for making an accurate and reliable in vitro diagnosis of adverse hypersensitivity reactions to drugs. We measured the amount of sulfidoleukotriene (sLT) released from the peripheral blood leukocytes obtained from 25 patients who developed hypersensitivity reactions following ...

journal_title：International archives of allergy and immunology

authors： Kubota Y,Imayama S,Toshitani A,Miyahara H,Tanahashi T,Uemura Y,Koga T,Sugawara N,Kurimoto F,Hata K

更新日期：1997-12-01 00:00:00

abstract：:A 20mer peptide representing the N-terminus of a major allergen, Alt a I, of Alternaria alternata was synthesized and examined for its antibody binding and antibody induction activities. Alt a I peptide-BSA conjugate reacted with both human IgE and rabbit anti-Alt a I IgG in ELISA, albeit the binding of the peptide to...

journal_title：International archives of allergy and immunology

authors： Zhang L,Curran IH,Muradia G,De Vouge MW,Rode H,Vijay HM

更新日期：1995-11-01 00:00:00