Abstract:
:There is a great need to develop a method for making an accurate and reliable in vitro diagnosis of adverse hypersensitivity reactions to drugs. We measured the amount of sulfidoleukotriene (sLT) released from the peripheral blood leukocytes obtained from 25 patients who developed hypersensitivity reactions following the administration of nonsteroidal anti-inflammatory drugs (NSAIDs); 12 patients demonstrated reactions to Voltaren, 8 patients to Bufferin, and 5 patients to Sedes G. The stimulation index, the ratio of the amounts of sLT (pg/ml) incubated with and without drugs, was considerably higher in the patients than in the controls, which consisted of 5 nonallergic healthy subjects. The sensitivity of the CAST (cellular antigen stimulation test) was evaluated to range from 62.5 to 80%, while the specificity was 70-100%. The CAST may thus be useful as a novel in vitro test system in order to screen for possible hypersensitive reactions to NSAIDs with both reliability and safety.
journal_name
Int Arch Allergy Immunoljournal_title
International archives of allergy and immunologyauthors
Kubota Y,Imayama S,Toshitani A,Miyahara H,Tanahashi T,Uemura Y,Koga T,Sugawara N,Kurimoto F,Hata Kdoi
10.1159/000237695subject
Has Abstractpub_date
1997-12-01 00:00:00pages
361-6issue
4eissn
1018-2438issn
1423-0097journal_volume
114pub_type
杂志文章abstract:BACKGROUND:Sweating can worsen atopic dermatitis (AD). The purpose of this work was to study the associations between reactivity to autologous sweat and the clinical severity of AD as well as investigate the possible wheal-inducing factors of sweat. METHODS:Intracutaneous skin tests with autologous sweat were performe...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000447638
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Flavonoids exert antiallergic and antioxidant effects. We investigated the efficacy of enzymatically modified isoquercitrin (EMIQ), a flavonoid, to relieve symptoms of pollinosis. METHODS:In a parallel-group, double-blind placebo-controlled study design, 20 subjects with Japanese cedar pollinosis took two c...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章,随机对照试验
doi:10.1159/000205582
更新日期:2009-01-01 00:00:00
abstract::It has been well documented that environmental factors such as antigen-presenting cells and related cytokines can affect the development of T-helper cells. The purpose of this study was to investigate the role of different antigen-presenting cells on T-cell development. Ovalbumin (OVA) combined with complete Freud's a...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000237394
更新日期:1996-12-01 00:00:00
abstract:BACKGROUND:It is important to understand that allergic rhinitis, whether seasonal or perennial, may be difficult to distinguish clinically from the nonallergic forms of rhinitis. OBJECTIVE:This study aimed to investigate the presence of local allergic rhinitis (LAR) in children who have allergic rhinitis symptoms in t...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000447635
更新日期:2016-01-01 00:00:00
abstract::Peritoneal eosinophilia was induced in rats using Ascaris suum extract as an antigen, and characteristics of granule proteins of eosinophils collected from the peritoneal cavity were investigated. Peritoneal eosinophilia was induced by injection of the antigen solution into the peritoneal cavity of the immunized rats ...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000237111
更新日期:1995-09-01 00:00:00
abstract:UNLABELLED:T-bet is crucially implicated in Th1 differentiation due to its strong promoting activity for IFN-gamma gene transcription. However, the regulatory role of T-bet in Th2 cytokines is not fully delineated. METHODS:The effect of T-bet on mRNA expression as well as the promoter activity of IL-4 in human T cells...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000101408
更新日期:2007-01-01 00:00:00
abstract::Based on in vitro findings with mouse mast cells and in vivo findings in mice, we report that dexamethasone or cyclosporin A can have at least three actions which interfere with the pathogenesis IgE-, mast-cell-, and cytokine-dependent inflammatory reactions: suppression of the IgE-dependent increase in tumor necrosis...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章,评审
doi:10.1159/000237015
更新日期:1995-05-01 00:00:00
abstract:BACKGROUND:Allergic reactions occur rarely in patients with chronic helminth infections, although FcepsilonRI-bearing cells are sensitized with anti-parasite IgE and are exposed to antigen. The inhibition of allergic reactivity is due to 'blocking antibodies', predominantly IgG4. IgG4 antibodies represent 50-95% of ant...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000024099
更新日期:1999-02-01 00:00:00
abstract::Elevated levels of ovine reaginic antibody were induced by immunization with Ascaris suum antigens. The PCA activity of this antibody persisted in the skin of sheep for 20 days and was abolished by heating to 56 degrees C, suggesting that it was immunoglobulin E. Attempts to isolate IgE from this hyperimmune serum by ...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000236479
更新日期:1993-01-01 00:00:00
abstract::The inhibitory effects of a novel compound, 6-hydroxy-2-(4-sulfamoylbenzylamino)-4,5,7-trimethylbenzothiazo le hydrochloride (E6080) on IgE-mediated reactions in vitro and in vivo were determined in rhesus monkeys. E6080 inhibited both antigen- and anti-human IgE-induced leukotriene C4 generations from lung fragments ...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000236406
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND:Depression and smoking contribute to the prognosis of autoimmune rheumatoid arthritis (RA). Advanced glycation end products (AGEs) are also detected in RA patients. This study correlates RA in patients with various levels of depression and a history of smoking through the detection of antibodies against AGEs...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000489896
更新日期:2018-01-01 00:00:00
abstract:INTRODUCTION:House dust mite contains several allergen components and causes perennial allergy. Lately, a new major allergen, Der p 23, was described with relatively high sensitization rates in different European Countries. In addition, Der p 23 is supposed to cause asthmatic disease. OBJECTIVE:We would like to questi...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000508522
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Basophils and mast cells are important initiator/effector cells capable of rapidly responding to IgE-mediated stimulation, but the precise mechanisms regulating their functions in vivo have not been fully identified. In this study, we assessed whether low levels of antigen can modulate activation of basophil...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000350339
更新日期:2013-01-01 00:00:00
abstract::Allergic granulomatosis and angiitis was first reported as a disease entity separate from polyarteritis nodosa in 1951 by Churg and Strauss. It is characterized by bronchial asthma, eosinophilia, and vasculitis and is especially rare in women of reproductive age, though, when present, may be associated with fetal mort...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000237140
更新日期:1995-10-01 00:00:00
abstract:BACKGROUND:Natural rubber latex (NRL) products are complex mixtures consisting of different allergenic components. Among them, Hev b 1 belongs to the important and well-characterized ones. To quantify the relevant allergen Hev b 1 in NRL products, a two-site monoclonal antibody (mAb)-based assay was developed. METHODS...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000024449
更新日期:2000-11-01 00:00:00
abstract::Studies in migrant populations provide vital opportunities to investigate the role of environmental factors in the pathogenesis of allergic disorders. Differences in allergy prevalence have been observed between migrants and native-born subjects living in the same geographical location. Immigrants who migrate from les...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章,评审
doi:10.1159/000494129
更新日期:2019-01-01 00:00:00
abstract::Antiphospholipid antibody syndrome (APS) is characterized by autoantibodies against negatively charged phospholipids in the serum, and clinically by multiple thromboses, thrombocytopenia, and recurrent fetal loss. The mechanism(s) by which the antibodies cause the clinical picture are not clear. We review the possible...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章,评审
doi:10.1159/000236883
更新日期:1995-01-01 00:00:00
abstract::Fourteen Brown-Norway rats were pretreated with physiological saline (n = 7) or 500 micrograms Sephadex (n = 7) intratracheally. 24 h later, a bronchial provocation test was performed under pentobarbital anaesthesia using increasing doses of acetylcholine aerosol and the degree of bronchospasm was measured using a mod...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000236196
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:IgE mediates immediate-type hypersensitivity reactions responsible for various allergic symptoms. It is secreted by IgE-producing plasma cells, which differentiate from B cells expressing membrane-bound IgE (mIgE) on their surface. The epsilon-chain of human mIgE contains a membrane-anchoring peptide and an ...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000063860
更新日期:2002-08-01 00:00:00
abstract::Immunological suppression is one of the important aspects which govern the regulation of the immune response. Clonal deletion, clonal anergy and the activity of suppressor cells were proposed as mechanisms leading to this phenomenon. In this review we provide evidence for the existence of suppressor (Ts) cells and the...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章,评审
doi:10.1159/000236379
更新日期:1993-01-01 00:00:00
abstract::The modulatory role of hormones in the regulation of the immune response has been well documented. Here, we present some thoughts on how sex hormones affect immunity, particularly at mucosal sites. We further discuss the possible pitfalls and difficulties associated with analysis of the data. ...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章,评审
doi:10.1159/000236631
更新日期:1994-01-01 00:00:00
abstract::Profilins are ubiquitous proteins, present in all eukaryotic cells and identified as allergens in pollen, latex and plant foods. The highly conserved structure justifies the cross-reactive nature of IgE antibodies against plant profilins and their designation as pan-allergens. Primary sensitization to profilin seems t...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章,评审
doi:10.1159/000321178
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:In some subjects, specific foods trigger anaphylaxis when exercise follows ingestion (specific food-dependent exercise-induced anaphylaxis, FDEIAn). Skin test and/or RAST positivity to foods suggest an IgE-mediated pathogenic mechanism. Others suffer from anaphylaxis after all meals followed by exercise, reg...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000053825
更新日期:2001-07-01 00:00:00
abstract:BACKGROUND:IgE-mediated hypersensitivity to latex has been recognized as an increasing health problem with far-reaching consequences for patients, regarding both their occupational situation and safety in medical care. Therefore, a correct diagnosis of natural rubber latex (NRL) allergy is essential. The purpose of the...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000049518
更新日期:2001-11-01 00:00:00
abstract:BACKGROUND:Activated eosinophils are thought to play an important role in allergic inflammation. Prior reports suggest that eosinophils have receptors recognizing IgA, IgG and IgE; however, little is known regarding the direct effects of antigens and antigen-specific immunoglobulins on the functions of eosinophils. ME...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000320226
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Nonsteroidal anti-inflammatory drugs (NSAIDS) are among the most common causes of drug hypersensitivity (HS) reactions. The diagnosis is based on a careful clinical history, and provocation tests are considered the gold standard for diagnosis. Skin tests have some value to study reactions to pyrazolones. Lab...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000452627
更新日期:2016-01-01 00:00:00
abstract::Interaction between vascular cell adhesion molecule-1 (VCAM-1) on endothelial cells and CD49d molecules on eosinophils is thought to mediate the selective infiltration of eosinophils into inflamed tissues in allergic disease. IL-4 and TNF-alpha are associated with allergic conditions, and they have been shown to selec...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000237357
更新日期:1996-10-01 00:00:00
abstract:BACKGROUND:Allergies and asthma exhibit a growing health problem in the world. Sparse data are available about the prevalence of allergic sensitization in Estonia and Eastern Europe as well. We studied the prevalence of allergic sensitization, the associations between respiratory symptoms and allergic sensitization, an...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000097027
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:ADAM (a disintegrin and metalloprotease) family members, characterized by a metalloprotease and a disintegrin domain, are membrane-anchored glycoproteins involved in proteolysis and cell adhesion. ADAM8 might have an important role in allergic inflammation. It can cleave a variety of substrates and is a shed...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000097359
更新日期:2007-01-01 00:00:00
abstract::Contact sensitivity to para-phenylenediamine (PPD) is a frequent delayed-type hypersensitivity resulting in contact dermatitis. The aim of the present study, conducted in 16 patients allergic to PPD (as assessed by a positive patch test), was to get better insight into the mechanism of T-cell activation in PPD contact...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000236573
更新日期:1993-01-01 00:00:00