Abstract:
INTRODUCTION:House dust mite contains several allergen components and causes perennial allergy. Lately, a new major allergen, Der p 23, was described with relatively high sensitization rates in different European Countries. In addition, Der p 23 is supposed to cause asthmatic disease. OBJECTIVE:We would like to question the prevalence and clinical impact of specific immunoglobulin E to Der p 23 in a large patient sample in southern Bavaria, Germany. METHODS:474 patients from southern Bavaria, who visited the allergy department within the Department of Oto-Rhino-Laryngology of a university hospital, with sensitization to Dermatophagoides pteronyssinus were retrospectively compared regarding their sensitization profile to Der p 1, Der p 2, and Der p 23 and their clinical characteristics. RESULTS:Among D. pteronyssinus-sensitized patients, the overall sensitization rate to Der p 23 was 42% in southern Bavaria. Most likely, patients were simultaneously sensitized to Der p 1, Der p 2, and Der p 23. Der p 23-sensitized patients reported more frequently asthma and showed higher prevalence of poly-sensitization towards 3 additional allergen groups and higher prevalence of double-sensitization to Der p 1 and Der p 2 compared to patients with missing sensitization to Der p 23. Considering the results of allergen provocation tests, neither IgE sensitization against Der p 23 nor levels of specific immunoglobulin E to Der p 23 allow a clear prediction of the clinical relevance of the sensitization. CONCLUSION:With a sensitization rate of 42%, Der p 23 closely misses the criterion of a major allergen in our southern Bavarian patient collective. A higher prevalence of polysensitization and self-reported asthma was the only clinical feature found in Der p 23-sensitized patients.
journal_name
Int Arch Allergy Immunoljournal_title
International archives of allergy and immunologyauthors
Eder K,Becker S,Gellrich D,Zieglmayer P,Gröger Mdoi
10.1159/000508522subject
Has Abstractpub_date
2020-01-01 00:00:00pages
689-698issue
9eissn
1018-2438issn
1423-0097pii
000508522journal_volume
181pub_type
杂志文章abstract::Recent studies have demonstrated that pulmonary surfactant protein (SP)-A plays a potential role in modifying inflammation and immune function. To see whether SP-A could modify IL-8 production and release by eosinophils stimulated with ionomycin, SP-A purified from surfactant recovered from patients with alveolar prot...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000053574
更新日期:1998-09-01 00:00:00
abstract::The morbidity and mortality of elderly onset asthma have recently been on the increase. To evaluate the allergic status of the elderly onset asthmatics, we performed skin tests for allergens and estimated serum total IgE levels of the patients. The proportion of the skin-test-positive patients among the elderly onset ...
journal_title:International archives of allergy and immunology
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journal_title:International archives of allergy and immunology
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journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000237621
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journal_title:International archives of allergy and immunology
pub_type: 杂志文章
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journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000237161
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journal_title:International archives of allergy and immunology
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journal_title:International archives of allergy and immunology
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doi:10.1159/000237394
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journal_title:International archives of allergy and immunology
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journal_title:International archives of allergy and immunology
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journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000237214
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journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000486958
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journal_title:International archives of allergy and immunology
pub_type: 杂志文章,评审
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journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000112501
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journal_title:International archives of allergy and immunology
pub_type: 杂志文章
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journal_title:International archives of allergy and immunology
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journal_title:International archives of allergy and immunology
pub_type: 杂志文章,评审
doi:10.1159/000355947
更新日期:2014-01-01 00:00:00
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journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000024099
更新日期:1999-02-01 00:00:00
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journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000322352
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journal_title:International archives of allergy and immunology
pub_type: 杂志文章
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journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000350367
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journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000345134
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journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000236767
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journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000507857
更新日期:2020-01-01 00:00:00
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journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000236168
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journal_title:International archives of allergy and immunology
pub_type: 杂志文章,多中心研究
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更新日期:2019-01-01 00:00:00
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journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000069458
更新日期:1998-04-01 00:00:00
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journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000049518
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journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000024343
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journal_title:International archives of allergy and immunology
pub_type: 杂志文章,评审
doi:10.1159/000023900
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