Inhibition of stem cell factor dependent formation of human mast cells by interleukin-3 and interleukin-4.

abstract：:For each medicinal product quality, safety and efficacy have to be proven to obtain a marketing authorisation. The national competent health authorities and the European Medicines Agency (EMEA) with support of the Heads of Medicines Agencies (HMA) work together to grant marketing authorisations for medicinal products....

journal_title：International archives of allergy and immunology

authors： Lorenz AR,Luttkopf D,Seitz R,Vieths S

更新日期：2008-01-01 00:00:00

abstract：:Factors are discussed as potential diagnostic parameters of atopic disorders. The amounts of sCD23 in sera from newborn children (n = 4,329) were determined by radioimmunoassay with monoclonal antibodies specific for CD23. The sCD23 levels ranged between 0 and 81.5 ng/ml of CD23-specific mAb. Furthermore, the sera of ...

journal_title：International archives of allergy and immunology

authors： Bujanowski-Weber J,Knöller I,Wahn U,König W

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:Food allergy to wheat-derived foodstuffs is on the rise. Tri a 14, a wheat flour lipid transfer protein (LTP) allergen, has been described as a major allergen associated with baker's asthma and wheat food allergy. Cross-reactivity among LTP allergens leads to the so-called 'LTP syndrome'. METHODS:Eight adul...

journal_title：International archives of allergy and immunology

authors： Palacin A,Bartra J,Muñoz R,Diaz-Perales A,Valero A,Salcedo G

更新日期：2010-01-01 00:00:00

abstract：:This study concerned the way in which eosinophils adhere to their surroundings. Many fibrils were seen to adhere to the cell membrane of eosinophils migrating into the submucosa. Those eosinophils migrating into the epithelial layer adhered to the epithelial cells in 2 different ways: through the thin filaments bridgi...

journal_title：International archives of allergy and immunology

authors： Watanabe K

更新日期：1995-01-01 00:00:00

abstract：BACKGROUND:Shellfish allergy is one of the major causes of life-threatening allergic reactions to food. The shrimp species Pandalus borealis is the commercially most important coldwater shrimp species, and its protein extract is commonly used in shrimp allergy diagnostics. However, the DNA sequence of its major allerge...

journal_title：International archives of allergy and immunology

authors： Myrset HR,Barletta B,Di Felice G,Egaas E,Dooper MM

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Helper T cells are involved in chronic eosinophilic inflammation. Control of cytokine production seems to be an effective management. METHODS:The effect of nonactin, SB203580, a p38 MAP kinase inhibitor, and JTE-711 on the cytokine production of allergen-specific T cell clones was determined. The effect of ...

journal_title：International archives of allergy and immunology

authors： Mori A,Okudaira H,Kobayashi N,Akiyama K

更新日期：2001-01-01 00:00:00

abstract：:The effect of ibudilast on anaphylactic bronchoconstriction was studied in guinea pigs sensitized actively with ovalbumin (OA). Animals were treated with indomethacin, tripelennamine and propranolol prior to the antigen challenge. Anaphylactic bronchoconstriction was prevented by ibudilast (1-4 mg/kg i.v. and 5-20 mg/...

journal_title：International archives of allergy and immunology

authors： Ohashi M,Uno T,Nishino K

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND:Transforming growth factor-β1 (TGF-β1)-in-duced proliferation of airway smooth muscle cells plays critical roles in the development of airway remodeling. Six1 (sine oculis homeobox homolog 1) has been demonstrated to be involved in airway inflammation and remodeling in asthmatic mice. OBJECTIVES:The aim of ...

journal_title：International archives of allergy and immunology

authors： Yang Z,Qu Z,Yi M,Lv Z,Wang Y,Shan Y,Ran N,Liu X

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Nitrosative and acid stress play an important role in the pathogenesis of asthma. The aim of this study was to evaluate whether, in asthmatics, a link exists between the concentrations of nitrite/nitrate, ammonia and pH values in exhaled breath condensate (EBC) and asthma severity, lung function, exhaled nit...

journal_title：International archives of allergy and immunology

authors： Tomasiak-Lozowska MM,Zietkowski Z,Przeslaw K,Tomasiak M,Skiepko R,Bodzenta-Lukaszyk A

更新日期：2012-01-01 00:00:00

abstract：:Adhesion molecules of microvascular endothelial cells play a key role in the inflammatory processes involved in nonallergic sinusitis. We investigated the cytokine-regulated expression of intercellular adhesion molecule-1 (ICAM-1), E-selectin and vascular cell adhesion molecule-1 (VCAM-1), and the effect of dexamethas...

journal_title：International archives of allergy and immunology

authors： Yamamoto Y,Ikeda K,Watanabe M,Shimomura A,Suzuki H,Oshima T,Imamura Y,Ohuchi K,Takasaka T

更新日期：1998-09-01 00:00:00

abstract：BACKGROUND:The importance of fungal allergens in the development of allergic diseases in a desert environment is uncertain. This study evaluated the prevalence of IgE sensitization to moulds among patients with allergic respiratory diseases in Kuwait - a desert country. METHODS:A total of 810 patients (male:female rat...

journal_title：International archives of allergy and immunology

authors： Ezeamuzie CI,Al-Ali S,Khan M,Hijazi Z,Dowaisan A,Thomson MS,Georgi J

更新日期：2000-04-01 00:00:00

abstract：BACKGROUND:The role of food allergens in the induction of allergic reactions in the airways is not completely understood. The aim of the present study was to evaluate fluorocytometric assays of the peripheral blood during food challenge tests in children with asthma and food allergy. PATIENTS AND METHODS:22 children w...

journal_title：International archives of allergy and immunology

authors： Krogulska A,Wasowska-Królikowska K,Polakowska E,Chrul S

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:We previously showed that immunization of mice with plasmid DNA (pDNA) encoding the Escherichia coli beta-galactosidase gene (pCMV-LacZ) induces a Th1 response, whereas beta-galactosidase (beta-gal) in saline or alum induces a Th2 response. Furthermore, the Th1 response dominates over the Th2 response and do...

journal_title：International archives of allergy and immunology

authors： Lee DJ,Tighe H,Corr M,Roman M,Carson DA,Spiegelberg HL,Raz E

更新日期：1997-05-01 00:00:00

abstract：:Nitric oxide (NO) is a potent biological mediator, and has a regulatory role in a wide variety of cellular and tissue functions. In the upper and lower airways, NO has been suggested to be involved in different functions with regulatory, protective, defensive or damaging effects. It is obvious that NO plays an importa...

journal_title：International archives of allergy and immunology

authors： Sahin G,Klimek L,Mullol J,Hörmann K,Walther LE,Pfaar O

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Ultra-rush regimens for administering sublingual immunotherapy to patients with allergies are becoming more widespread. We aimed to assess treatment safety for patients with allergic rhinitis with or without asthma caused by Dermatophagoides house dust mites. METHODS:This observational study at 5 Spanish ce...

journal_title：International archives of allergy and immunology

authors： Roger A,Justicia JL,Navarro LÁ,Eseverri JL,Ferrès J,Malet A,Alvà V

更新日期：2011-01-01 00:00:00

abstract：:Peritoneal eosinophilia was induced in rats using Ascaris suum extract as an antigen, and characteristics of granule proteins of eosinophils collected from the peritoneal cavity were investigated. Peritoneal eosinophilia was induced by injection of the antigen solution into the peritoneal cavity of the immunized rats ...

journal_title：International archives of allergy and immunology

authors： Watanabe M,Nittoh T,Suzuki T,Kitoh A,Mue S,Ohuchi K

更新日期：1995-09-01 00:00:00

abstract：BACKGROUND:Recombinant dog allergens, rCan f 1 and rCan f 2, and their antibodies are good tools for the characterization of dog allergens in order to develop modern therapeutic and preventive methods for dog allergy. METHODS:In this study, cDNA was synthesized from the mRNA of dog salivary glands and cloned into the ...

journal_title：International archives of allergy and immunology

authors： Kamata Y,Miyanomae A,Nakayama E,Miyanomae T,Tajima T,Hoshi H

更新日期：2007-01-01 00:00:00

abstract：:Red soft coral (RSC; Dendronephthya nipponica, a marine coelenterate) causes spiny lobster fishermen living along the Pacific coast of Miyazaki Prefecture in Japan to develop occupational allergies, such as conjunctivitis, rhinitis, dermatitis and bronchial asthma. The aim of this study was to purify and to characteri...

journal_title：International archives of allergy and immunology

authors： Onizuka R,Kamiya H,Muramoto K,Goto R,Inoue K,Kumamoto K,Nakajima Y,Iida S,Ishigami F

更新日期：2001-06-01 00:00:00

abstract：BACKGROUND:DNA immunization and protein immunization with CpG motifs as adjuvants represent promising approaches in allergen-specific immunotherapy. OBJECTIVE:We investigated the effect of coinjection or prepriming with CpG-ODN on Th2-type responses induced by gene gun and protein immunization. METHODS:BALB/c mice we...

journal_title：International archives of allergy and immunology

authors： Hochreiter R,Hartl A,Freund J,Valenta R,Ferreira F,Thalhamer J

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:Serum-derived hyaluronan (HA)-associated proteins (SHAPs), the heavy chains of inter-α-trypsin inhibitor, covalently bind to HA to form the SHAP-HA complex. The SHAP-HA complex is involved in the pathophysiology of inflammatory diseases, including rheumatoid arthritis. We investigated whether this complex is...

journal_title：International archives of allergy and immunology

authors： Zhu L,Zhuo L,Kimata K,Yamaguchi E,Watanabe H,Aronica MA,Hascall VC,Baba K

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Farming has been widely reported to be associated with decreased risk of developing atopic disorders, but underlying immunomodulatory mechanisms are still not fully defined. We delineated T-cell functions after induction of mucosal tolerance in the context of intranasally delivered organic dust compounds, li...

journal_title：International archives of allergy and immunology

authors： Gerhold K,Avagyan A,Reichert E,Blumchen K,Wahn U,Hamelmann E

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:To understand how the high-affinity IgE receptor (FcepsilonRI) communicates with downstream effectors, we focused on exploring the functional importance of the FcepsilonRI-mediated formation and localization of a signaling complex that contains the hematopoietic cell-specific scaffolding protein linker for a...

journal_title：International archives of allergy and immunology

authors： Rivera J,Arudchandran R,Gonzalez-Espinosa C,Manetz TS,Xirasagar S

更新日期：2001-01-01 00:00:00

abstract：:Cross-linking of FcepsilonRI on mast cells elicits positive signal transduction cascades that lead to the release of a variety of proinflammatory mediators. Mouse mast cells also express gp49B1 on their surface, an immunoglobulin superfamily member that bears two immunoreceptor tyrosine-based inhibitory motifs in its ...

journal_title：International archives of allergy and immunology

authors： Katz HR

更新日期：1999-02-01 00:00:00

abstract：:Recently, the induction of T cell anergy has been considered as a sophisticated form of immunotherapy. However, the multiplicity of T cell allergen epitopes discourages the practical use of this method. Since orally administered antigen proteins are digested to peptides and absorbed into the circulation, oral administ...

journal_title：International archives of allergy and immunology

authors： Suko M,Mori A,Ito K,Okudaira H

更新日期：1995-05-01 00:00:00

abstract：BACKGROUND:Cat allergens are ubiquitous because the clothing of cat owners constitutes an important source of distribution of Fel d 1 in cat-free environments. Since Fel d 1 can adhere to a variety of surfaces, we sought to verify if human hair belonging to individuals with or without a cat at home might represent a re...

journal_title：International archives of allergy and immunology

authors： Liccardi G,Barber D,Russo M,D'Amato M,D'Amato G

更新日期：2005-06-01 00:00:00

abstract：BACKGROUND:Nonpathogenic Escherichia coli strain Nissle 1917 (EcN) has immunomodulatory properties and can act on different cells which are important for the allergic immune response. Herein, we investigated the efficacy and tolerability of EcN in subjects with grass pollen-dependent allergic rhinoconjunctivitis. METH...

journal_title：International archives of allergy and immunology

authors： Dölle S,Berg J,Rasche C,Worm M

更新日期：2014-01-01 00:00:00

abstract：:Bronchial asthma, characterized by eosinophilic inflammation in airways, may involve Th2-type cytokines such as interleukin-5 (IL-5). IL-12, a newly established cytokine, induces IFN-gamma production, which may have a regulatory effect on the production of Th2-type cytokines. We examined the effects of IL-12 on the pr...

journal_title：International archives of allergy and immunology

authors： Okano Y,Nakamura Y,Sano T,Azuma M,Sone S

更新日期：1998-01-01 00:00:00

abstract：:In the classical Pavlovian conditioning paradigm, a stimulus that unconditionally elicits a physiological response is repeatedly paired with a neutral stimulus that does not elicit that same response. Eventually, the neutral stimulus becomes a conditioned stimulus in that it elicits the physiological response in the a...

journal_title：International archives of allergy and immunology

authors： Cohen N,Moynihan JA,Ader R

更新日期：1994-10-01 00:00:00

abstract：RATIONALE:Evidence-based medicine represents the effort to highlight the best intervention for patients, clinicians, and policy makers, each from their respective viewpoint, to solve a particular health condition. According to a recently diffused grading system of evidence and recommendations for medical interventions,...

journal_title：International archives of allergy and immunology

authors： Compalati E,Baena-Cagnani R,Penagos M,Badellino H,Braido F,Gómez RM,Canonica GW,Baena-Cagnani CE

更新日期：2011-01-01 00:00:00

abstract：:Allergens present in the excretory/secretory (ES) products of adult Paragonimus ohirai were biochemically identified. Immunoblot analysis using sera from P. ohirai-infected rats revealed only two allergens to be major proteins in the ES products, with apparent molecular masses (M(r)) of 27 and 29 kD. As the ES product...

journal_title：International archives of allergy and immunology

authors： Ikeda T

更新日期：2002-07-01 00:00:00