The influence of CpG motifs on a protein or DNA-based Th2-type immune response against major pollen allergens Bet v 1a, Phl p 2 and Escherichia coli-derived beta-galactosidase.

abstract：:IL-3-dependent, murine mast cell lines derived from embryonic yolk sac precursors display a tumoricidal activity that is blocked by antibodies against tumor necrosis factor-alpha, indicating that this cytokine is the major mediator involved in the cytotoxic activity of the cultured mast cell lines. Further, cholera to...

journal_title：International archives of allergy and immunology

authors： Manning JK,Malkovsky M,Meager A

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:Th2 cell infiltration is a characteristic feature of allergic chronic sinusitis. However, the mechanisms that cause the predominance of Th2 cells in this disease have yet to be clarified. The airway is often exposed to not only Th2 cytokines but also bacterial products such as lipopolysaccharides (LPS). A CC...

journal_title：International archives of allergy and immunology

authors： Fukumoto A,Nonaka M,Ogihara N,Pawankar R

更新日期：2008-01-01 00:00:00

abstract：:The relationship between the IgE load on mast cells and their secretory capacity when challenged with anti-IgE was studied in peritoneal cells obtained from rats of three different strains, Hooded Lister (HL), Wistar Kyoto (WKY) and Sprague-Dawley (SD). IgE was determined cytofluorometrically after labelling with FITC...

journal_title：International archives of allergy and immunology

authors： Chen XJ,Enerbäck L

更新日期：1995-03-01 00:00:00

abstract：:A high-dose, accelerated escalation schedule during subcutaneous allergen-specific immunotherapy (AIT) is safe and well-tolerated in adults. However, there are no data in children and adolescents. The aim of the present trial was to assess safety and tolerability of an accelerated dose escalation schedule of an AIT wi...

journal_title：International archives of allergy and immunology

authors： Bovermann X,Ricklefs I,Vogelberg C,Klimek L,Kopp MV

更新日期：2021-01-27 00:00:00

abstract：:Peritoneal mast cells of Syrian hamsters release histamine to the action of concanavalin A (Con A) in dose-dependent fashion. The rate of release was very rapid in the first seconds of cell activation and completed in 60 s after the challenge. Morphological changes concomitant to the lectin treatment, followed by elec...

journal_title：International archives of allergy and immunology

authors： Wyczolkowska J,Rydzynski K,Prouvost-Danon A

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:Severe refractory atopic dermatitis (AD) is a chronic, debilitating condition that is associated with elevated serum immunoglobulin E (IgE) levels. Thymic stromal lymphopoietin (TSLP), thymus and activation-regulated chemokine (TARC) and OX40 ligand (OX40L) are important immunologic factors involved in the p...

journal_title：International archives of allergy and immunology

authors： Iyengar SR,Hoyte EG,Loza A,Bonaccorso S,Chiang D,Umetsu DT,Nadeau KC

更新日期：2013-01-01 00:00:00

abstract：:The modulatory role of hormones in the regulation of the immune response has been well documented. Here, we present some thoughts on how sex hormones affect immunity, particularly at mucosal sites. We further discuss the possible pitfalls and difficulties associated with analysis of the data. ...

journal_title：International archives of allergy and immunology

authors： Stanisz AM,Kataeva G,Bienenstock J

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND:Basophils and mast cells are important initiator/effector cells capable of rapidly responding to IgE-mediated stimulation, but the precise mechanisms regulating their functions in vivo have not been fully identified. In this study, we assessed whether low levels of antigen can modulate activation of basophil...

journal_title：International archives of allergy and immunology

authors： Koketsu R,Yamaguchi M,Suzukawa M,Tanaka Y,Tashimo H,Arai H,Nagase H,Matsumoto K,Saito H,Ra C,Yamamoto K,Ohta K

更新日期：2013-01-01 00:00:00

abstract：:In recent years, the Th1/Th2 concept has become of prime importance in the understanding of heterogeneous responses of the immune system and implications thereof for infectious and autoimmune diseases. Originally established on the basis of different cytokines produced by T cell clones, it is now known that the Th1/Th...

journal_title：International archives of allergy and immunology

authors： Lohoff M,Gessner A,Bogdan C,Röllinghoff M

更新日期：1998-03-01 00:00:00

abstract：:We investigated the in vitro adhesion of 51Cr-labeled lymphocytes to cultured brain endothelial cells and the in vivo expression of intercellular adhesion molecule-1 (ICAM-1) on cerebral endothelial cells in a rat model of experimental allergic encephalomyelitis (EAE) before and after treatment with lipopolysaccharide...

journal_title：International archives of allergy and immunology

authors： Matsuda M,Tsukada N,Miyagi K,Yanagisawa N

更新日期：1995-04-01 00:00:00

abstract：BACKGROUND:Natural rubber latex proteins have been implicated in severe allergy in individuals exposed to latex products, particularly health care workers. Until recently, only crude antigens were available to study the immune response in these patients. In recent years a number of relevant allergens have been purified...

journal_title：International archives of allergy and immunology

authors： Johnson BD,Kurup VP,Sussman GL,Arif SA,Kelly KJ,Beezhold DH,Fink JN

更新日期：1999-12-01 00:00:00

abstract：:Thioredoxin (TRX) is a redox-active protein that regulates reactive oxidative metabolism and plays a crucial role in the antioxidant system in regulating the reduction/oxidation balance by scavenging reactive oxygen species, which is implicated in the mechanism of asthma. As for the mechanisms by which TRX exerts its ...

journal_title：International archives of allergy and immunology

authors： Ito W,Kobayashi N,Takeda M,Ueki S,Kayaba H,Nakamura H,Yodoi J,Chihara J

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:In some subjects, specific foods trigger anaphylaxis when exercise follows ingestion (specific food-dependent exercise-induced anaphylaxis, FDEIAn). Skin test and/or RAST positivity to foods suggest an IgE-mediated pathogenic mechanism. Others suffer from anaphylaxis after all meals followed by exercise, reg...

journal_title：International archives of allergy and immunology

authors： Romano A,Di Fonso M,Giuffreda F,Papa G,Artesani MC,Viola M,Venuti A,Palmieri V,Zeppilli P

更新日期：2001-07-01 00:00:00

abstract：BACKGROUND:Immunoglobulin G4-related disease (IgG4-RD) is a systemic immunological disorder characterized by fibro-inflammatory conditions; however, the pathobiology of IgG4-RD has not been fully identified. OBJECTIVE:This study aimed to analyze systemic differences of innate and adaptive immune cells from healthy con...

journal_title：International archives of allergy and immunology

authors： Sohn KH,Ham J,Chung SJ,Kang HR,Kim HY

更新日期：2020-01-01 00:00:00

abstract：:IgE responsiveness to Dermatophagoides farinae body extract was compared by immunoblotting among four groups of mite-sensitive asthmatic children: group I aged 0-3, group II aged 4-7, group III aged 8-11 and group IV aged 12-15. In the group I subjects, the 15-kD component was bound by 88% of sera and strongly by 56% ...

journal_title：International archives of allergy and immunology

authors： Shibasaki M,Isoyama S,Takita H

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND:beta2-Adrenergic agonists play a pivotal role in the management of bronchial asthma. Although the major effect of short-acting beta2-agonists on the airway is relaxation of smooth muscles, they may also have several effects on surrounding immunomodulatory cells. METHODS:We examined whether widely used short...

journal_title：International archives of allergy and immunology

authors： Yasui K,Kobayashi N,Yamazaki T,Agematsu K,Matsuzaki S,Nakata S,Baba A

更新日期：2006-01-01 00:00:00

abstract：AIM:We evaluated the effect of the 45-kD protein of Trichinella spiralis (gp45), purified by affinity chromatography, on random migration and chemotaxis, the oxidative metabolism of human neutrophils and on the CD11b upregulation induced by formyl-methionyl-leucyl-phenylalanine (f-MLP). METHODS:Donor neutrophils incub...

journal_title：International archives of allergy and immunology

authors： Bruschi F,Carulli G,Azzarà A,Homan W,Minnucci S,Rizzuti-Gullaci A,Sbrana S,Angiolini C

更新日期：2000-05-01 00:00:00

abstract：BACKGROUND:We reported on the constitutive interferon-gamma receptor (IFN-gammaR) expression on eosinophils. But signal transduction through IFN-gammaR on eosinophils remains to be elucidated. In this study, we examined the involvement of the Jak/Stat pathway in the signaling of eosinophils after IFN-gammaR conjugation...

journal_title：International archives of allergy and immunology

authors： Ochiai K,Ishihara C,Tomioka H

更新日期：1999-02-01 00:00:00

abstract：BACKGROUND:The clinical significance and efficacy of treating patients who have immunoglobulin (Ig) G subclass deficiency and/or antibody deficiency with Ig-replacement therapy has been debated. There are no clear guidelines to recommend intravenous gammaglobulin (IgIV) in these patients as there are few published stud...

journal_title：International archives of allergy and immunology

authors： Abdou NI,Greenwell CA,Mehta R,Narra M,Hester JD,Halsey JF

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Common variable immunodeficiency (CVID) is characterized by hypogammaglobulinemia and a defect in antibody production. Herein we describe 3 patients diagnosed with CVID in whom vitamin D deficiency was detected in the absence of enteropathy. METHODS:Biochemical and immunological analysis, serum osteocalcin,...

journal_title：International archives of allergy and immunology

authors： Ardeniz O,Avci CB,Sin A,Ozgen G,Gunsar F,Mete N,Gulbahar O,Kokuludag A

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:In vivo, all blood vessels are lined by a single layer of flattened noncycling endothelial cells. We tested the hypothesis that the maintenance of such a quiescent endothelial monolayer depends on homotypic contacts between not yet defined growth-inhibitory molecules located at interendothelial junctions. M...

journal_title：International archives of allergy and immunology

authors： Halama T,Staffler G,Hoch S,Stockinger H,Wolff K,Petzelbauer P

更新日期：1999-11-01 00:00:00

abstract：BACKGROUND:The aetiological factors underlying the worldwide increase in the prevalence of asthma and the international patterns of the prevalence of asthma are not well understood. This has led to consideration of factors such as fetomaternal health which may programme the initial susceptibility to allergic sensitisat...

journal_title：International archives of allergy and immunology

authors： Beasley R,Leadbitter P,Pearce N,Crane J

更新日期：1999-02-01 00:00:00

abstract：BACKGROUND:Antiphospholipid antibodies (aPL) show great heterogeneity. Different phospholipids, with or without protein cofactor(s), and phospholipid binding proteins alone have been proposed as the target molecules for aPL. In order to determine the influence of phospholipid degradation products on the binding of aPL,...

journal_title：International archives of allergy and immunology

authors： Bozic B,Kveder T,Stegnar M,Morosini-Berus E,Kos-Golja M,Peternel P,Rozman B

更新日期：1997-01-01 00:00:00

abstract：:Homogenates of bovine iris were fractionated by gel filtration chromatography, and the column-eluted proteins were probed with pooled sera obtained from patients with pauciarticular juvenile rheumatoid arthritis (JRA). The serum pool prepared from patients with pauciarticular JRA and a history of anterior uveitis, but...

journal_title：International archives of allergy and immunology

authors： Hunt DW,Petty RE,Millar F

更新日期：1993-01-01 00:00:00

abstract：:Adhesion molecules of microvascular endothelial cells play a key role in the inflammatory processes involved in nonallergic sinusitis. We investigated the cytokine-regulated expression of intercellular adhesion molecule-1 (ICAM-1), E-selectin and vascular cell adhesion molecule-1 (VCAM-1), and the effect of dexamethas...

journal_title：International archives of allergy and immunology

authors： Yamamoto Y,Ikeda K,Watanabe M,Shimomura A,Suzuki H,Oshima T,Imamura Y,Ohuchi K,Takasaka T

更新日期：1998-09-01 00:00:00

abstract：BACKGROUND:Patients with allergic rhinoconjunctivitis are susceptible to both nasal and ocular symptoms. The conjunctival provocation test (CPT) is an established diagnostic procedure used in allergic rhinoconjunctivitis, particularly to document a patient's current reactivity to allergens. To date, there are no intern...

journal_title：International archives of allergy and immunology

authors： Dogan S,Astvatsatourov A,Deserno TM,Bock F,Shah-Hosseini K,Michels A,Mösges R

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Nitrosative and acid stress play an important role in the pathogenesis of asthma. The aim of this study was to evaluate whether, in asthmatics, a link exists between the concentrations of nitrite/nitrate, ammonia and pH values in exhaled breath condensate (EBC) and asthma severity, lung function, exhaled nit...

journal_title：International archives of allergy and immunology

authors： Tomasiak-Lozowska MM,Zietkowski Z,Przeslaw K,Tomasiak M,Skiepko R,Bodzenta-Lukaszyk A

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Segmental allergen challenge is a powerful tool to study inflammatory reactions in asthmatic airways. There is little information on the early events at 5 min and 4 h after allergen challenge with respect to the cell influx and the chemokine interleukin-8 (IL-8). METHODS:Seven mild to moderate allergic asth...

journal_title：International archives of allergy and immunology

authors： Nocker RE,Out TA,Weller FR,Mul EP,Jansen HM,van der Zee JS

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND:Th17 is a subset of T-helper lymphocytes that produce proinflammatory cytokines, mainly IL-17. Serum IL-17 is increased in allergic patients and relates to clinical severity. Recently, it has been reported that CD161 is a highly upregulated gene in Th17 clones and all IL-17-producing cells are contained in C...

journal_title：International archives of allergy and immunology

authors： Poggi A,Canevali P,Contatore M,Ciprandi G

更新日期：2012-01-01 00:00:00

abstract：:Peritoneal eosinophilia was induced in rats using Ascaris suum extract as an antigen, and characteristics of granule proteins of eosinophils collected from the peritoneal cavity were investigated. Peritoneal eosinophilia was induced by injection of the antigen solution into the peritoneal cavity of the immunized rats ...

journal_title：International archives of allergy and immunology

authors： Watanabe M,Nittoh T,Suzuki T,Kitoh A,Mue S,Ohuchi K

更新日期：1995-09-01 00:00:00