Induction of TARC production by lipopolysaccharide and interleukin-4 in nasal fibroblasts.

abstract：BACKGROUND:L-selectin (CD62L) and Mac-1 (CD11b/CD18) play a crucial role in the infiltration of eosinophils. However, changes in CD62L and CD11b expression on eosinophils after stimulation with cytokines were little studied. METHODS:Eosinophils in peripheral blood of healthy volunteers were purified and cultured with ...

journal_title：International archives of allergy and immunology

authors： Momose T,Okubo Y,Horie S,Takashi S,Tsukadaira A,Suzuki J,Isobe M,Sekiguchi M

更新日期：1999-01-01 00:00:00

abstract：:For the identification and characterization of allergen grass group VI we performed two-dimensional immunoblotting of timothy grass pollen (Phleum pratense). Two intense 13-kD protein spots of pI 5.2 and 5.5 were found to be IgE reactive. By N-terminal microsequencing and amino acid analysis we identified them as Phl ...

journal_title：International archives of allergy and immunology

authors： Petersen A,Bufe A,Schlaak M,Becker WM

更新日期：1995-09-01 00:00:00

abstract：BACKGROUND:Subcutaneous immunotherapy for respiratory allergy has shown a long lasting efficacy after its discontinuation, whereas evidence in the case of sublingual immunotherapy (SLIT) is weak. This retrospective study evaluates whether SLIT exerts a long-lasting effect and whether it relates to its duration. METHOD...

journal_title：International archives of allergy and immunology

authors： Marogna M,Bruno M,Massolo A,Falagiani P

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Natural rubber latex (NRL) products are complex mixtures consisting of different allergenic components. Among them, Hev b 1 belongs to the important and well-characterized ones. To quantify the relevant allergen Hev b 1 in NRL products, a two-site monoclonal antibody (mAb)-based assay was developed. METHODS...

journal_title：International archives of allergy and immunology

authors： Raulf-Heimsoth M,Sander I,Chen Z,Borowitzki G,Diewald K,van Kampen V,Baur X

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND:Disturbed cytokine production is thought to govern inflammation in asthma, which, in its turn, may lead to uncontrolled disease. The aim of this study was to assess the relationship between cytokine production from blood leucocytes and the level of asthma control. METHODS:We compared the production of inter...

journal_title：International archives of allergy and immunology

authors： Manise M,Schleich F,Quaedvlieg V,Moermans C,Henket M,Sele J,Corhay JL,Louis R

更新日期：2012-01-01 00:00:00

abstract：:Fourteen Brown-Norway rats were pretreated with physiological saline (n = 7) or 500 micrograms Sephadex (n = 7) intratracheally. 24 h later, a bronchial provocation test was performed under pentobarbital anaesthesia using increasing doses of acetylcholine aerosol and the degree of bronchospasm was measured using a mod...

journal_title：International archives of allergy and immunology

authors： Kubin R,Deschl U,Linssen M,Wilhelms OH

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:Measurement of fractional exhaled nitric oxide (FENO) is useful in assessing eosinophilic airway inflammation. Smoking may modify airway inflammation and reduce FENO levels, compromising the diagnostic value of FENO in smokers. How smoking influences FENO in atopic versus nonatopic asthmatics is unknown. The...

journal_title：International archives of allergy and immunology

authors： Rouhos A,Ekroos H,Karjalainen J,Sarna S,Haahtela T,Sovijärvi AR

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Endogenous IL-17 is needed for the Ag sensitization that results in murine allergic asthma, a Th2-mediated disease. Here, we aimed to investigate the role IL-17 plays in the development of murine experimental allergic conjunctivitis (EC) which is also a Th2-mediated disease. METHODS:To induce EC, wild-type ...

journal_title：International archives of allergy and immunology

authors： Fukushima A,Sumi T,Ishida W,Yamada J,Iwakura Y,Ueno H

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:The 2S albumins are a group of storage proteins that occur widely in seeds of dicotyledonous plants. The widespread distribution and stability to digestion of allergenic 2S albumins raise the question of why some members of this family present in important food sources, such as soybean, are not regarded as m...

journal_title：International archives of allergy and immunology

authors： Lin J,Shewry PR,Archer DB,Beyer K,Niggemann B,Haas H,Wilson P,Alcocer MJ

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Recently, the high affinity receptor for IgE (Fc epsilonRI), which plays a major role in allergies, has been identified on a number of different antigen-presenting cell types, including human monocytes from atopic and nonatopic donors. In this report human monocytic cell lines were used to test for the expre...

journal_title：International archives of allergy and immunology

authors： Reischl IG,Corvaïa N,Unger J,Woisetschläger M,Mudde GC

更新日期：1997-08-01 00:00:00

abstract：:Volumetric air sampling was performed at Corpus Christi, Tex., September 1987 to August 1989. Grass aeropollen during all of 1988 accounted for 15.3% of total pollen captured during two major peaks, one in May and another during September and October. The remaining grass pollen, about one-quarter of the total, was fou...

journal_title：International archives of allergy and immunology

authors： Lewis WH,Dixit AB,Wedner HJ

更新日期：1992-01-01 00:00:00

abstract：:We have systematically investigated the capacity of highly purified human peripheral CD8+ T cells to produce interleukin (IL)-4 and interferon (IFN)-gamma when triggered by different stimuli. CD8+ T cells were isolated from peripheral blood by positive selection to > 99% purity and stimulated with one of three differe...

journal_title：International archives of allergy and immunology

authors： Li Y,Richards D,Noble A,Kemeny DM

更新日期：1995-05-01 00:00:00

abstract：BACKGROUND:Mouse models have been established mirroring key features of human bronchial asthma including airway hyperresponsiveness (AHR). Acute airway obstruction in response to an allergen challenge, however, remains to be demonstrated in these models. OBJECTIVE:A mouse model of allergic lung inflammation was employ...

journal_title：International archives of allergy and immunology

authors： Neuhaus-Steinmetz U,Glaab T,Daser A,Braun A,Lommatzsch M,Herz U,Kips J,Alarie Y,Renz H

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND:Eosinophils develop from bone marrow (BM) progenitors, and interleukin-5 (IL-5) and eotaxin may act in expansion and mobilisation of BM eosinophils in asthma. METHODS:We have examined phenotypic changes as CD34+ cells develop to the eosinophil lineage in vitro, and have evaluated BM eosinophils from asthmat...

journal_title：International archives of allergy and immunology

authors： Robinson DS,North J,Zeibecoglou K,Ying S,Meng Q,Rankin S,Hamid Q,Tavernier J,Kay AB

更新日期：1999-02-01 00:00:00

abstract：:A prospective study was conducted on 73 allergic patients and 14 normal volunteers in order to measure the IgE concentration in both serum and saliva, and analyze salivary IgE according to the characteristics of the allergic disease. IgE was more frequently detected in saliva from allergic patients than from normal su...

journal_title：International archives of allergy and immunology

authors： Vernejoux JM,Tunon de Lara JM,Villanueva P,Vuillemin L,Taytard A

更新日期：1994-05-01 00:00:00

abstract：BACKGROUND:Partially hydrolyzed cow's milk protein-based formula (pHF) possesses low allergenicity. Here, we investigate the safety and efficacy of oral immunotherapy using pHF for children with cow's milk protein allergy (CMPA). OBJECTIVES:A randomized, double-blind, controlled single-center trial was conducted to ev...

journal_title：International archives of allergy and immunology

authors： Inuo C,Tanaka K,Suzuki S,Nakajima Y,Yamawaki K,Tsuge I,Urisu A,Kondo Y

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Five to twenty percent of healthy, nonasthmatic individuals exhibit airway hyperreactivity. Because cytokines are important intermediates in airway responses, we investigated the relationship between serum cytokines and airway responsiveness in a well-characterized population of pregnant women. METHODS:We a...

journal_title：International archives of allergy and immunology

authors： Tsunoda M,Litonjua AA,Kuniak MP,Weiss ST,Satoh T,Guevarra L,Tollerud DJ

更新日期：2003-02-01 00:00:00

abstract：OBJECTIVE:To evaluate whether activated partial thromboplastin time (APTT) could be used in the laboratory diagnosis of hereditary or acquired angioedema (HAE or AAE) with and without C1 inhibitor (C1-INH) deficiency. METHODS:In a prospective investigation, APTT and other coagulation parameters were determined in 149 ...

journal_title：International archives of allergy and immunology

authors： Bork K,Witzke G

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Lactation is associated with an inhibited hypothalamic-pituitary-adrenal axis response to physical and psychological stress in women and female rats. However, suckling also improved mood and calmness in nonatopic lactating women. Relaxation by humor reduced allergen-induced skin wheal responses, while variou...

journal_title：International archives of allergy and immunology

authors： Kimata H

更新日期：2003-12-01 00:00:00

abstract：BACKGROUND:It is assumed that the very late antigen-4 (VLA-4) plays a key role in selective migration and accumulation of eosinophils to the allergic inflammatory focus. The regulatory mechanism for VLA-4 expression is poorly understood, as is its relationship between other adhesion molecules. OBJECTIVE:The aim of the...

journal_title：International archives of allergy and immunology

authors： Kayaba H,Yamada Y,Cui CH,Saito N,Honda K,Kobayashi Y,Urayama O,Chihara J

更新日期：2001-01-01 00:00:00

abstract：:Olive pollen is one of the most important causes of seasonal respiratory allergy in Mediterranean countries, where this tree is intensely cultivated. Among the high number of protein allergens detected in this pollen, 8 - Ole e 1 to Ole e 8 - have been isolated and characterized. Ole e 1 is the most frequent sensitizi...

journal_title：International archives of allergy and immunology

authors： Rodríguez R,Villalba M,Monsalve RI,Batanero E

更新日期：2001-07-01 00:00:00

abstract：:The morbidity and mortality of elderly onset asthma have recently been on the increase. To evaluate the allergic status of the elderly onset asthmatics, we performed skin tests for allergens and estimated serum total IgE levels of the patients. The proportion of the skin-test-positive patients among the elderly onset ...

journal_title：International archives of allergy and immunology

authors： Atsuta R,Akiyama K,Shirasawa T,Okumura K,Fukuchi Y,Ra C

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND:The cervical sympathetic trunk-submandibular gland (CST-SMG) axis plays an important role in inflammation. An immunoregulatory heptapeptide, submandibular gland peptide T (SGP-T), was isolated from submandibular glands, and several of its biological activities have been identified. RESULTS:SGP-T reduced sho...

journal_title：International archives of allergy and immunology

authors： Mathison RD,Davison JS,Befus AD

更新日期：1997-05-01 00:00:00

abstract：:Aerosolized monoclonal antibodies (mAbs) specific for T-cell receptors (TCR) were used to manipulate T-cell function in airways of ovalbumin (OVA)-sensitized and -challenged mice with airway hyperresponsiveness (AHR). The inhaled mAbs were found to be effective at low doses, had little or no systemic effect and specif...

journal_title：International archives of allergy and immunology

authors： Lahn M,Kanehiro A,Hahn YS,Wands JM,Aydintug MK,O'Brien RL,Gelfand EW,Born WK

更新日期：2004-05-01 00:00:00

abstract：:Studies in migrant populations provide vital opportunities to investigate the role of environmental factors in the pathogenesis of allergic disorders. Differences in allergy prevalence have been observed between migrants and native-born subjects living in the same geographical location. Immigrants who migrate from les...

journal_title：International archives of allergy and immunology

authors： Tham EH,Loo EXL,Zhu Y,Shek LP

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:We previously showed that immunization of mice with plasmid DNA (pDNA) encoding the Escherichia coli beta-galactosidase gene (pCMV-LacZ) induces a Th1 response, whereas beta-galactosidase (beta-gal) in saline or alum induces a Th2 response. Furthermore, the Th1 response dominates over the Th2 response and do...

journal_title：International archives of allergy and immunology

authors： Lee DJ,Tighe H,Corr M,Roman M,Carson DA,Spiegelberg HL,Raz E

更新日期：1997-05-01 00:00:00

abstract：BACKGROUND:Asthma, allergic conditions, and COPD overlap, but the effect of them and their combinations on disease severity, need for drugs, use of healthcare, and costs is poorly known. OBJECTIVE:To study how different allergic diseases co-occur in asthma and allergy patients and evaluate the use of medication well a...

journal_title：International archives of allergy and immunology

authors： Jantunen J,Haahtela T,Salimäki J,Linna M,Mäkelä M,Pelkonen A,Kauppi P

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Orange allergens are virtually unknown, in spite of the large consumption of this fruit. Germin-like proteins, together with vicilins and legumins, form the cupin superfamily of plant proteins, which includes many seed allergens. METHODS:Twenty-nine patients with allergy to oranges were studied. A major IgE...

journal_title：International archives of allergy and immunology

authors： Ahrazem O,Ibáñez MD,López-Torrejón G,Sánchez-Monge R,Sastre J,Lombardero M,Barber D,Salcedo G

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:A number of different molecules are known to be involved in the signal pathway to release histamine from mast cells, among which arachidonic acid (AA) is one of the key mediators. On the other hand, we found that the application of compound 48/80, a typical histamine liberator, generated superoxide in mast c...

journal_title：International archives of allergy and immunology

authors： Sakaguchi M,Fukuishi N,Teramoto K,Miyazaki M,Huh NH,Namba M,Akagi M

更新日期：2003-04-01 00:00:00

abstract：:Thioredoxin (TRX) is a redox-active protein that regulates reactive oxidative metabolism and plays a crucial role in the antioxidant system in regulating the reduction/oxidation balance by scavenging reactive oxygen species, which is implicated in the mechanism of asthma. As for the mechanisms by which TRX exerts its ...

journal_title：International archives of allergy and immunology

authors： Ito W,Kobayashi N,Takeda M,Ueki S,Kayaba H,Nakamura H,Yodoi J,Chihara J

更新日期：2011-01-01 00:00:00