当前位置： SCI文献检索 > INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY期刊下所有文献 > Aerosolized anti-T-cell-receptor antibodies are effective against airway inflammation and hyperreactivity.

Aerosolized anti-T-cell-receptor antibodies are effective against airway inflammation and hyperreactivity.

Abstract：

:Aerosolized monoclonal antibodies (mAbs) specific for T-cell receptors (TCR) were used to manipulate T-cell function in airways of ovalbumin (OVA)-sensitized and -challenged mice with airway hyperresponsiveness (AHR). The inhaled mAbs were found to be effective at low doses, had little or no systemic effect and specifically abrogated both effector and regulatory functions of the targeted T cells. Specific mAbs targeting alphabeta T cells suppressed and those targeting gammadelta T cells enhanced AHR. Moreover, specific mAbs directed against subsets of gammadelta T cells varied in their effect on AHR. Using this approach of targeting either alphabeta or gammadelta T cells reduced airway eosinophila, although the effect of mAbs specific for alphabeta T cells was stronger. The use of aerosolized anti-TCR mAbs may offer an effective approach for the treatment of airway inflammation and AHR.

journal_name

Int Arch Allergy Immunol

journal_title

International archives of allergy and immunology

authors

Lahn M,Kanehiro A,Hahn YS,Wands JM,Aydintug MK,O'Brien RL,Gelfand EW,Born WK

doi

10.1159/000077533

keywords:

subject

Has Abstract

pub_date

2004-05-01 00:00:00

pages

49-55

issue

1

eissn

1018-2438

issn

1423-0097

pii

77533

journal_volume

134

pub_type

杂志文章

相关文献

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY文献大全
  • Specific activation of human mast cells by the ligand for c-kit: comparison between lung, uterus and heart mast cells.

    abstract：:Recent data suggest that stem cell factor (SCF or c-kit ligand, KL) is a major regulator of human mast cells (MCs). In the present study, MCs derived from the lung (n = 8), uterus (n = 14) and heart (n = 4) were analyzed for expression of c-kit receptor and for responses to recombinant SCF. MCs of all organs tested we...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000236568

    authors： Sperr WR,Czerwenka K,Mundigler G,Müller MR,Semper H,Klappacher G,Glogar HD,Lechner K,Valent P

    更新日期：1993-01-01 00:00:00

  • Association of galectin-9 with eosinophil apoptosis.

    abstract：BACKGROUND:There is no information whether galectin-9 (a novel eosinophil chemoattractant) was associated with pathogenesis of eosinophilic disorders. METHODS:We assessed the expression of galectin-9 with imunostaining and in situ hybridization both in the lesion of angiolymphoid hyperplasia with eosinophilia, and per...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000058002

    authors： Saita N,Goto E,Yamamoto T,Cho I,Tsumori K,Kohrogi H,Maruo K,Ono T,Takeya M,Kashio Y,Nakamura K,Hirashima M

    更新日期：2002-05-01 00:00:00

  • Identification and characterization of major allergens in excretory/secretory products of the worm Paragonimus ohirai.

    abstract：:Allergens present in the excretory/secretory (ES) products of adult Paragonimus ohirai were biochemically identified. Immunoblot analysis using sera from P. ohirai-infected rats revealed only two allergens to be major proteins in the ES products, with apparent molecular masses (M(r)) of 27 and 29 kD. As the ES product...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000064251

    authors： Ikeda T

    更新日期：2002-07-01 00:00:00

  • Classification of Drug Hypersensitivity into Allergic, p-i, and Pseudo-Allergic Forms.

    abstract：:Drug hypersensitivity reactions (DHR) are clinically and functionally heterogeneous. Different subclassifications based on timing of symptom appearance or type of immune mechanism have been proposed. Here, we show that the mode of action of drugs leading to immune/inflammatory cell stimulation is a further decisive fa...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章,评审

    doi：10.1159/000453265

    authors： Pichler WJ,Hausmann O

    更新日期：2016-01-01 00:00:00

  • Progress in AIDS vaccine development.

    abstract：:Because of a unique combination of challenges facing human immunodeficiency virus vaccine developers, a number of traditional and novel vaccine designs are being evaluated essentially in parallel. Monomeric proteins, poxvirus vectors, peptides, and particle-based candidate vaccines have entered or will soon enter huma...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章,评审

    doi：10.1159/000237173

    authors： Johnston MI

    更新日期：1995-12-01 00:00:00

  • Fractional Exhaled Nitric Oxide: A Potential Biomarker in Allergic Rhinitis?

    abstract：BACKGROUND:The fractional concentration of exhaled nitric oxide (FeNO) is a surrogate biomarker for Th2-dependent bronchial inflammation. The present study investigated whether FeNO may characterize allergic rhinitis (AR) patients. METHODS:A total of 553 AR patients (497 males, mean age 28.8 years) were evaluated. Tho...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000456548

    authors： Ciprandi G,Gallo F,Ricciardolo FL,Cirillo I

    更新日期：2017-01-01 00:00:00

  • Immunological analysis of organized pneumonia with eosinophilic pleural effusion.

    abstract：:A 73-year-old man developed organized pneumonia with severe right-sided eosinophilic pleural effusion (PE). CD69+ and HLA-DR+ eosinophils in PE were 90 and 31%, respectively, but were undetectable in peripheral blood (PB). CD4+, CD45RA+ (naive) and CD4+, CD45RO+ (memory) cells in PB, PE and bronchoalveolar lavage (BAL...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000237368

    authors： Hossain M,Okubo Y,Yamaguchi S,Horie S,Itoh S,Sugii S,Takatsu K,Oguchi T,Sekiguchi M

    更新日期：1996-10-01 00:00:00

  • Use of immunoglobulin variable-region genes by normal subjects and patients with systemic lupus erythematosus.

    abstract：:Antibodies to specific autoantigens are serological hallmarks of systemic autoimmune diseases. These autoantibodies are thought to represent a consequence of immune dysregulation in these conditions, and, in part, have been shown to be involved in their pathologic consequences. However, the mechanisms that lead to the...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章,评审

    doi：10.1159/000024422

    authors： Hansen A,Dörner T,Lipsky PE

    更新日期：2000-09-01 00:00:00

  • Inhibitory effects of human neutrophil functions by the 45-kD glycoprotein derived from the parasitic nematode Trichinella spiralis.

    abstract：AIM:We evaluated the effect of the 45-kD protein of Trichinella spiralis (gp45), purified by affinity chromatography, on random migration and chemotaxis, the oxidative metabolism of human neutrophils and on the CD11b upregulation induced by formyl-methionyl-leucyl-phenylalanine (f-MLP). METHODS:Donor neutrophils incub...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000024359

    authors： Bruschi F,Carulli G,Azzarà A,Homan W,Minnucci S,Rizzuti-Gullaci A,Sbrana S,Angiolini C

    更新日期：2000-05-01 00:00:00

  • Investigations on the involvement of the lectin pathway of complement activation in anaphylaxis.

    abstract：BACKGROUND:Systemic anaphylaxis is the most severe form of immediate hypersensitivity reaction. The activation of the complement system occurs during anaphylactic shock. The purpose of this study was to determine in a mouse model whether the lectin pathway of complement activation is involved in anaphylaxis. METHODS:T...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000094177

    authors： Windbichler M,Echtenacher B,Takahashi K,Ezekowitz RA,Schwaeble WJ,Jenseniuis JC,Männel DN

    更新日期：2006-01-01 00:00:00

  • Oncogene expression in patients with familial polyposis coli/Gardner's syndrome.

    abstract：:We evaluated whether c-myc and ras P-21 oncogene expression could identify familial polyposis coli/Gardner's syndrome patients at risk for colon cancer. Monoclonal antibodies recognizing c-myc and ras P-21 proteins were used in immunohistochemistry to stain 26 paraffin-embedded tissue specimens collected over 12 years...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000237351

    authors： Yuwono M,Rossi TM,Fisher JE,Tjota A

    更新日期：1996-09-01 00:00:00

  • Activation of Fc epsilon RI inhibits the pyruvate kinase through direct interaction with the gamma-chain.

    abstract：:The downstream signaling components of high-affinity IgE receptor (FcepsilonRI) were studied using yeast two-hybrid screening of the cDNA library constructed from RBL-2H3 cells. The cytoplasmic part of the gamma-chain but not that of the beta-chain was found to interact with pyruvate kinase in the yeast. The in-vitro-...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000024183

    authors： Oak MH,Cheong H,Kim KM

    更新日期：1999-06-01 00:00:00

  • Selective regulation of T cell IL-5 synthesis by OM-01, JTE-711 and p38 MAP kinase inhibitor: independent control of Th2 cytokines, IL-4 and IL-5.

    abstract：BACKGROUND:Helper T cells are involved in chronic eosinophilic inflammation. Control of cytokine production seems to be an effective management. METHODS:The effect of nonactin, SB203580, a p38 MAP kinase inhibitor, and JTE-711 on the cytokine production of allergen-specific T cell clones was determined. The effect of ...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000053702

    authors： Mori A,Okudaira H,Kobayashi N,Akiyama K

    更新日期：2001-01-01 00:00:00

  • Interleukin-4 and interleukin-13 enhance human bronchial smooth muscle cell proliferation.

    abstract：BACKGROUND:T(H)2 inflammation and bronchial smooth muscle cell (BSMC) hyperplasia are characteristic features of asthma, but whether these phenomena are linked remains unknown. This study aims to define the effect of the T(H)2 cytokines IL-4 and IL-13 on human BSMC proliferation when administered alone or in combinatio...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000113517

    authors： Bossé Y,Thompson C,Audette K,Stankova J,Rola-Pleszczynski M

    更新日期：2008-01-01 00:00:00

  • Early DNA synthesis and cytokine expression in the nickel activation of peripheral blood mononuclear cells in nickel-allergic subjects.

    abstract：BACKGROUND AND OBJECTIVE:Nickel sulphate stimulates the proliferation of lymphocytes in nickel-allergic subjects. However, nickel-induced stimulation of lymphocytes from control persons without clinical symptoms of nickel allergy has also been reported. The aim of the present study was to correlate T cell activity, mea...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000024437

    authors： Falsafi-Amin H,Lundeberg L,Bakhiet M,Nordlind K

    更新日期：2000-10-01 00:00:00

  • Induction of Oral Tolerance by Pepsin-Digested Gliadin Retaining T Cell Reactivity in a Mouse Model of Wheat Allergy.

    abstract：BACKGROUND:Wheat is known as the most widely consumed food all over the world. Although many types of wheat allergy have been recognized, their treatment still has a long way to go due to the complex pathogenesis. Oral immunotherapy (OIT) is under investigation for the treatment of wheat allergies. Previous studies hav...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000506945

    authors： Li X,Miyakawa T,Takano T,Nakajima-Adachi H,Tanokura M,Hachimura S

    更新日期：2020-01-01 00:00:00

  • 100 years of immunotherapy: the Monaco charter. under the high patronage of His Serene Highness Prince Albert II of Monaco.

    abstract：:Aims of the Monaco Charter: (1) to present the current evidence on the efficacy and safety of allergen-specific immunotherapy (SIT) and to address the reasons for its underuse in clinical practice; (2) to develop strategies to increase the awareness about the benefits and the hazards of SIT in allergic patients, lay p...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000343883

    authors： Canonica GW,Baena-Cagnani CE,Compalati E,Bohle B,Bonini S,Bousquet J,Cox L,Fink-Wagner AH,González Díaz S,Jacobsen L,Passalacqua G,Pawankar R,Vieths S,Yusuf O,Zuberbier T

    更新日期：2013-01-01 00:00:00

  • Genetic Characteristics, Infectious, and Noninfectious Manifestations of 32 Patients with Chronic Granulomatous Disease.

    abstract：BACKGROUND:Chronic granulomatous disease (CGD) is a rare genetic disorder characterized by failure of phagocytic leukocytes to destroy certain microbes. We present a study on CGD patients enrolled at a single medical center concerning the infectious and noninfectious complications and genetic properties of the disease....

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000507366

    authors： Aygun D,Koker MY,Nepesov S,Koker N,van Leeuwen K,de Boer M,Kıykım A,Ozsoy S,Cokugras H,Kuijpers T,Roos D,Camcıoglu Y

    更新日期：2020-01-01 00:00:00

  • Engineering, characterization and in vitro efficacy of the major peanut allergens for use in immunotherapy.

    abstract：BACKGROUND:Numerous strategies have been proposed for the treatment of peanut allergies, but despite the steady advancement in our understanding of atopic immune responses and the increasing number of deaths each year from peanut anaphylaxis, there is still no safe, effective, specific therapy for the peanut-sensitive ...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000053672

    authors： Bannon GA,Cockrell G,Connaughton C,West CM,Helm R,Stanley JS,King N,Rabjohn P,Sampson HA,Burks AW

    更新日期：2001-01-01 00:00:00

  • Hypersensitivity pneumonitis associated with mushroom worker's lung: an update on the clinical significance of the importation of exotic mushroom varieties.

    abstract：:Hypersensitivity pneumonitis remains an important industrial disease in mushroom workers. It has a significant morbidity, and early diagnosis and removal from exposure to the antigen are critically important in its management. Recently, several new allergens have been described, particularly those from mushroom specie...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章,评审

    doi：10.1159/000083298

    authors： Moore JE,Convery RP,Millar BC,Rao JR,Elborn JS

    更新日期：2005-01-01 00:00:00

  • Pavlovian conditioning of the immune system.

    abstract：:In the classical Pavlovian conditioning paradigm, a stimulus that unconditionally elicits a physiological response is repeatedly paired with a neutral stimulus that does not elicit that same response. Eventually, the neutral stimulus becomes a conditioned stimulus in that it elicits the physiological response in the a...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章,评审

    doi：10.1159/000236811

    authors： Cohen N,Moynihan JA,Ader R

    更新日期：1994-10-01 00:00:00

  • Participation of platelets in protection against larval Taenia taeniaeformis infection in mice.

    abstract：:The participation of platelets in the protection against larval Taenia taeniaeformis was studied. CB-17 SCID mice, susceptible to T. taeniaeformis, were protected against a challenge infection with T. taeniaeformis by the passive transfer of platelets from T. taeniaeformis-infected normal CB-17 mice, resistant to T. t...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000237253

    authors： Kakuda T,Ooi HK,Oku Y,Kamiya M

    更新日期：1996-03-01 00:00:00

  • Isolation and preparation of antisera to ovine IgE.

    abstract：:Elevated levels of ovine reaginic antibody were induced by immunization with Ascaris suum antigens. The PCA activity of this antibody persisted in the skin of sheep for 20 days and was abolished by heating to 56 degrees C, suggesting that it was immunoglobulin E. Attempts to isolate IgE from this hyperimmune serum by ...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000236479

    authors： Yilmaz H,Roe JM,Morgan KL

    更新日期：1993-01-01 00:00:00

  • Vascular-endothelial cadherin (CD144)- but not PECAM-1 (CD31)-based cell-to-cell contacts convey the maintenance of a quiescent endothelial monolayer.

    abstract：BACKGROUND:In vivo, all blood vessels are lined by a single layer of flattened noncycling endothelial cells. We tested the hypothesis that the maintenance of such a quiescent endothelial monolayer depends on homotypic contacts between not yet defined growth-inhibitory molecules located at interendothelial junctions. M...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000024273

    authors： Halama T,Staffler G,Hoch S,Stockinger H,Wolff K,Petzelbauer P

    更新日期：1999-11-01 00:00:00

  • Lactose-intolerance may induce severe chronic eczema.

    abstract：:The primary acquired lactase deficiency of the adult is known to cause various disturbances in the gastrointestinal tract while extraintestinal symptoms are unusual. Here we report on a histologically proven chronic eczema requiring corticosteroid treatment for several months. It was obviously induced by a concomitant...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000237632

    authors： Grimbacher B,Peters T,Peter HH

    更新日期：1997-08-01 00:00:00

  • Immunotherapy is allergen-specific: a double-blind trial of mite or timothy extract in mite and grass dual-allergic patients.

    abstract：BACKGROUND:One hundred years ago, Noon [Lancet 1911;1:1572-1573], using conjunctival provocation testing (CPT), was the first to demonstrate the effectiveness of subcutaneous immunotherapy (SCIT) in grass-allergic subjects with hay fever. In this centenary year, we present data that, by use of CPT and allergen-specific...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章,随机对照试验

    doi：10.1159/000330649

    authors： Dreborg S,Lee TH,Kay AB,Durham SR

    更新日期：2012-01-01 00:00:00

  • Hypersensitivity reactions to contrast media: prevalence, risk factors and the role of skin tests in diagnosis--a cross-sectional survey.

    abstract：BACKGROUND:Hypersensitivity to contrast media (CMs) may be common and serious. AIM:To evaluate the prevalence of CM hypersensitivity, risk factors associated with it and the role of skin testing in its diagnosis. METHODS:A structured questionnaire was administered to patients who underwent computed tomography during ...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000320760

    authors： Goksel O,Aydın O,Atasoy C,Akyar S,Demirel YS,Misirligil Z,Bavbek S

    更新日期：2011-01-01 00:00:00

  • High-Sensitivity C-Reactive Protein and Allergic Endpoints in German Adolescents.

    abstract：BACKGROUND:Assessing high-sensitivity C-reactive protein (hs-CRP) in relation to allergic endpoints can shed light on both the mechanisms of allergic disease development and early non-communicable disease prevention. However, only a few epidemiological studies so far have investigated the relationship in children and a...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章,多中心研究

    doi：10.1159/000497320

    authors： Yang BY,Markevych I,Harris C,Standl M,Schikowski T,Koletzko S,Herberth G,Bauer CP,von Berg A,Berdel D,Dong GH,Heinrich J

    更新日期：2019-01-01 00:00:00

  • Role of nucleases in apoptosis.

    abstract：:The last decade has seen the rapid development of research investigating the mechanisms of apoptosis in a variety of experimental systems. Among the multitude of changes observed in apoptotic cells, chromatin cleavage is considered a biochemical hallmark of apoptosis. Chromatin fragmentation is an enzymatic process wh...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章,评审

    doi：10.1159/000236778

    authors： Zhivotovsky B,Wade D,Nicotera P,Orrenius S

    更新日期：1994-12-01 00:00:00

  • Evaluation of the Potential Risk Factors for Drug-Induced Anaphylaxis in Adult Patients.

    abstract：AIM:To investigate the potential risk factors in patients who have experienced anaphylaxis from drugs. METHOD:The study included 281 adult patients (median age 40 years; 76.5% female) who experienced immediate types of hypersensitivity reaction to a drug. The patients were divided into an anaphylaxis group and a nonan...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000494130

    authors： Demir S,Erdenen F,Gelincik A,Unal D,Olgac M,Coskun R,Colakoglu B,Buyukozturk S

    更新日期：2019-01-01 00:00:00