Abstract：
:Drug hypersensitivity reactions (DHR) are clinically and functionally heterogeneous. Different subclassifications based on timing of symptom appearance or type of immune mechanism have been proposed. Here, we show that the mode of action of drugs leading to immune/inflammatory cell stimulation is a further decisive factor in understanding and managing DHR. Three mechanisms can be delineated: (a) some drugs have or gain the ability to bind covalently to proteins, form new antigens, and thus elicit immune reactions to hapten-carrier complexes (allergic/immune reaction); (b) a substantial part of immune-mediated DHR is due to a typical off-target activity of drugs on immune receptors like HLA and TCR (pharmacological interaction with immune receptors, p-i reactions); such p-i reactions are linked to severe DHR; and (c) symptoms of DHR can also appear if the drug stimulates or inhibits receptors or enzymes of inflammatory cells (pseudo-allergy). These three distinct ways of stimulations of immune or inflammatory cells differ substantially in clinical manifestations, time of appearance, dose dependence, predictability, and cross-reactivity, and thus need to be differentiated.
journal_name
Int Arch Allergy Immunoljournal_title
International archives of allergy and immunologyauthors
Pichler WJ,Hausmann Odoi
10.1159/000453265subject
Has Abstractpub_date
2016-01-01 00:00:00pages
166-179issue
3-4eissn
1018-2438issn
1423-0097pii
000453265journal_volume
171pub_type
杂志文章,评审abstract：BACKGROUND:Shrimp sensitization is common in the general population, but the presence of symptoms is only moderately related to sensitization. A point still at issue is which in vivo and/or in vitro tests (food challenge, component-resolved diagnosis, house dust mite [HDM] sensitization) can help in distinguishing shri...
journal_title：International archives of allergy and immunology
pub_type： 杂志文章
doi：10.1159/000481985
更新日期：2017-01-01 00:00:00
abstract：:We evaluated whether c-myc and ras P-21 oncogene expression could identify familial polyposis coli/Gardner's syndrome patients at risk for colon cancer. Monoclonal antibodies recognizing c-myc and ras P-21 proteins were used in immunohistochemistry to stain 26 paraffin-embedded tissue specimens collected over 12 years...
journal_title：International archives of allergy and immunology
pub_type： 杂志文章
doi：10.1159/000237351
更新日期：1996-09-01 00:00:00
abstract：BACKGROUND:Wheat is known as the most widely consumed food all over the world. Although many types of wheat allergy have been recognized, their treatment still has a long way to go due to the complex pathogenesis. Oral immunotherapy (OIT) is under investigation for the treatment of wheat allergies. Previous studies hav...
journal_title：International archives of allergy and immunology
pub_type： 杂志文章
doi：10.1159/000506945
更新日期：2020-01-01 00:00:00
abstract：:Eosinophils are pleiotropic multi-functional leukocytes involved in initiation and propagation of diverse inflammatory responses. Recent studies examining eosinophil biology have focused on delineating the molecular basis of FIP1L1/PDGRFalpha-fusion gene induced HES, the molecular steps involved in eosinophil recruitm...
journal_title：International archives of allergy and immunology
pub_type： 杂志文章,评审
doi：10.1159/000101398
更新日期：2007-01-01 00:00:00
abstract：:Human foamy virus (HFV) is a recently characterized member of the retrovirus subfamily Spumaretrovirinae. HFV has a complex structure: it encodes the classical three retroviral structural genes gag, pol and env, but also possesses additional regulatory, so-called bel sequences. Foamy viruses have been discussed occasi...
journal_title：International archives of allergy and immunology
pub_type： 杂志文章
doi：10.1159/000236350
更新日期：1992-01-01 00:00:00
abstract：BACKGROUND:The allergenic potential of chicken egg white ovomucoid (OVM) is thought to depend on its stability to heat treatment and digestion. Pepsin-digested fragments have been speculated to continue to exert an allergenic potential. OVM was digested in simulated gastric fluid (SGF) to examine the reactivity of the ...
journal_title：International archives of allergy and immunology
pub_type： 杂志文章
doi：10.1159/000082581
更新日期：2005-01-01 00:00:00
abstract：:Allergens present in the excretory/secretory (ES) products of adult Paragonimus ohirai were biochemically identified. Immunoblot analysis using sera from P. ohirai-infected rats revealed only two allergens to be major proteins in the ES products, with apparent molecular masses (M(r)) of 27 and 29 kD. As the ES product...
journal_title：International archives of allergy and immunology
pub_type： 杂志文章
doi：10.1159/000064251
更新日期：2002-07-01 00:00:00
abstract：BACKGROUND:Segmental allergen challenge is a powerful tool to study inflammatory reactions in asthmatic airways. There is little information on the early events at 5 min and 4 h after allergen challenge with respect to the cell influx and the chemokine interleukin-8 (IL-8). METHODS:Seven mild to moderate allergic asth...
journal_title：International archives of allergy and immunology
pub_type： 杂志文章
doi：10.1159/000024174
更新日期：1999-05-01 00:00:00
abstract：:Epithelial cells line all cavities and surfaces throughout the body and play a substantial role in maintaining tissue homeostasis. Asthma and other atopic diseases are increasing worldwide and allergic disorders are hypothesized to be a consequence of a combination of dysregulation of the epithelial response towards e...
journal_title：International archives of allergy and immunology
pub_type： 杂志文章,评审
doi：10.1159/000445833
更新日期：2016-01-01 00:00:00
abstract：BACKGROUND:Nonsteroidal anti-inflammatory drugs (NSAIDS) are among the most common causes of drug hypersensitivity (HS) reactions. The diagnosis is based on a careful clinical history, and provocation tests are considered the gold standard for diagnosis. Skin tests have some value to study reactions to pyrazolones. Lab...
journal_title：International archives of allergy and immunology
pub_type： 杂志文章
doi：10.1159/000452627
更新日期：2016-01-01 00:00:00
abstract：BACKGROUND:In some subjects, specific foods trigger anaphylaxis when exercise follows ingestion (specific food-dependent exercise-induced anaphylaxis, FDEIAn). Skin test and/or RAST positivity to foods suggest an IgE-mediated pathogenic mechanism. Others suffer from anaphylaxis after all meals followed by exercise, reg...
journal_title：International archives of allergy and immunology
pub_type： 杂志文章
doi：10.1159/000053825
更新日期：2001-07-01 00:00:00
abstract：BACKGROUND:Studies have shown that serum total immunoglobulin E (IgE) levels are higher in asthmatics. However, the role of the serum total IgE level, independently from atopy, in adult asthma is not understood. We studied the associations between serum total IgE, the number of sensitizations and the sum of specific Ig...
journal_title：International archives of allergy and immunology
pub_type： 杂志文章
doi：10.1159/000342464
更新日期：2013-01-01 00:00:00
abstract：:Monocytes and lymphocytes from human blood contain 0.043 +/- 0.007 and 0.053 +/- 0.014 pg histamine/cell, respectively, which can be released by a number of stimulants (A 23187, C5a, substance P, specific allergen). The release process takes 60-120 min to reach its end point, in contrast to tissue mast cells which com...
journal_title：International archives of allergy and immunology
pub_type： 杂志文章
doi：10.1159/000236974
更新日期：1995-05-01 00:00:00
abstract：:Molecular mimicry between streptococci and heart components has been proposed as the triggering factor leading to autoimmunity in rheumatic heart disease (RHD). In this review, we present data from cellular autoimmune responses, focusing on the interactions between HLA class II molecules, streptococcal peptides and he...
journal_title：International archives of allergy and immunology
pub_type： 杂志文章,评审
doi：10.1159/000077915
更新日期：2004-05-01 00:00:00
abstract：:Bed bugs may cause mild to severe cutaneous reactions. We studied the ability of bed bug salivary extract (SGE) to induce inflammatory reactions responsible for cutaneous manifestations and found that SGE stimulated the production of several potent chemokines and cytokines from macrophages. Chemokines induced by SGE i...
journal_title：International archives of allergy and immunology
pub_type： 杂志文章
doi：10.1159/000345134
更新日期：2013-01-01 00:00:00
abstract：BACKGROUND:Exposure and sensitization to pet allergens are associated with allergic asthma in children. Conflicting data have emerged regarding the potential benefit of air cleaners with respect to a reduction of indoor pet allergens and bronchial hyperresponsiveness (BHR). METHODS:In a randomized controlled trial 36 ...
journal_title：International archives of allergy and immunology
pub_type： 杂志文章,随机对照试验
doi：10.1159/000151502
更新日期：2009-01-01 00:00:00
abstract：:Microwave radiation from mobile phones enhanced skin wheal responses induced by house dust mite and Japanese cedar pollen while it had no effect on wheal responses induced by histamine in patients with atopic eczema/dermatitis syndrome (AEDS). Microwave radiation also increased plasma levels of substance P (SP) and va...
journal_title：International archives of allergy and immunology
pub_type： 杂志文章
doi：10.1159/000067592
更新日期：2002-12-01 00:00:00
abstract：BACKGROUND:The precise roles of T helper (Th)1-type and Th2-type cytokine responses in nickel (Ni)-induced allergic contact dermatitis have not yet been clearly defined. We investigated the involvement of Th2 cytokines in Ni-induced contact hypersensitivity reaction using GATA-3 transgenic (Tg) mice. METHODS:A Ni-tita...
journal_title：International archives of allergy and immunology
pub_type： 杂志文章
doi：10.1159/000314372
更新日期：2010-01-01 00:00:00
abstract：OBJECTIVE:To evaluate whether activated partial thromboplastin time (APTT) could be used in the laboratory diagnosis of hereditary or acquired angioedema (HAE or AAE) with and without C1 inhibitor (C1-INH) deficiency. METHODS:In a prospective investigation, APTT and other coagulation parameters were determined in 149 ...
journal_title：International archives of allergy and immunology
pub_type： 杂志文章
doi：10.1159/000447695
更新日期：2016-01-01 00:00:00
abstract：BACKGROUND:Diethylhexyl phthalate (DEHP) and diisononyl phthalate (DINP), two commonly used plasticizers in flexible polyvinylchloride formulations, have potentially adverse effects on human health. However, the influence of these diphthalates on allergic responses remains unclear. In this study we examined the effects...
journal_title：International archives of allergy and immunology
pub_type： 杂志文章
doi：10.1159/000078768
更新日期：2004-07-01 00:00:00
abstract：BACKGROUND:Systemic anaphylaxis is the most severe form of immediate hypersensitivity reaction. The activation of the complement system occurs during anaphylactic shock. The purpose of this study was to determine in a mouse model whether the lectin pathway of complement activation is involved in anaphylaxis. METHODS:T...
journal_title：International archives of allergy and immunology
pub_type： 杂志文章
doi：10.1159/000094177
更新日期：2006-01-01 00:00:00
abstract：:Because of a unique combination of challenges facing human immunodeficiency virus vaccine developers, a number of traditional and novel vaccine designs are being evaluated essentially in parallel. Monomeric proteins, poxvirus vectors, peptides, and particle-based candidate vaccines have entered or will soon enter huma...
journal_title：International archives of allergy and immunology
pub_type： 杂志文章,评审
doi：10.1159/000237173
更新日期：1995-12-01 00:00:00
abstract：BACKGROUND:Allergen molecule-based diagnosis has been suggested to facilitate the identification of disease-causing allergen sources and the prescription of allergen-specific immunotherapy (AIT). The aim of the current study was to compare allergen molecule-based IgE serology with allergen extract-based skin testing fo...
journal_title：International archives of allergy and immunology
pub_type： 杂志文章
doi：10.1159/000477442
更新日期：2017-01-01 00:00:00
abstract：:To determine the variation of antigenic water soluble proteins in white birch (Betula pendula) pollen, extracts of pollen from different sides of individual trees were analyzed by isoelectric focusing (IEF), crossed immunoelectrophoresis, and crossed radioimmunoelectrophoresis. IgE-antibody-binding patterns were also ...
journal_title：International archives of allergy and immunology
pub_type： 杂志文章
doi：10.1159/000237184
更新日期：1995-12-01 00:00:00
abstract：:IgE is a key mediator in allergic diseases. However, in strong contrast to other antibody isotypes, many details of the composition of the human IgE repertoire are poorly defined. The low levels of human IgE in the circulation and the rarity of IgE-producing B cells are important reasons for this lack of knowledge. In...
journal_title：International archives of allergy and immunology
pub_type： 杂志文章,评审
doi：10.1159/000355947
更新日期：2014-01-01 00:00:00
abstract：BACKGROUND:The clinical significance and efficacy of treating patients who have immunoglobulin (Ig) G subclass deficiency and/or antibody deficiency with Ig-replacement therapy has been debated. There are no clear guidelines to recommend intravenous gammaglobulin (IgIV) in these patients as there are few published stud...
journal_title：International archives of allergy and immunology
pub_type： 临床试验,杂志文章
doi：10.1159/000199723
更新日期：2009-01-01 00:00:00
abstract：:The relationship between the IgE load on mast cells and their secretory capacity when challenged with anti-IgE was studied in peritoneal cells obtained from rats of three different strains, Hooded Lister (HL), Wistar Kyoto (WKY) and Sprague-Dawley (SD). IgE was determined cytofluorometrically after labelling with FITC...
journal_title：International archives of allergy and immunology
pub_type： 杂志文章
doi：10.1159/000236849
更新日期：1995-03-01 00:00:00
abstract：RATIONALE:Evidence-based medicine represents the effort to highlight the best intervention for patients, clinicians, and policy makers, each from their respective viewpoint, to solve a particular health condition. According to a recently diffused grading system of evidence and recommendations for medical interventions,...
journal_title：International archives of allergy and immunology
pub_type： 杂志文章,meta分析,评审
doi：10.1159/000321896
更新日期：2011-01-01 00:00:00
abstract：:The antigenic and allergenic characteristics of three bovine epithelial extracts, dander, skin scrapings and whole skin, were compared using IgE-ELISA inhibition and SDS-PAGE with immunoblotting. Cow dander extract was shown to contain more allergenic activity than skin scrapings or whole skin extracts which were need...
journal_title：International archives of allergy and immunology
pub_type： 杂志文章
doi：10.1159/000236343
更新日期：1992-01-01 00:00:00
abstract：BACKGROUND:The development of simple and standardised methods to measure airborne levels of workplace biological allergens is an important step in reducing the incidence of occupational asthma. Such a method would be useful for measuring wheat flour allergens which cause asthma in bakers. Measurement of allergen per se...
journal_title：International archives of allergy and immunology
pub_type： 杂志文章
doi：10.1159/000237680
更新日期：1997-11-01 00:00:00
