Progress in AIDS vaccine development.

Abstract:

:Because of a unique combination of challenges facing human immunodeficiency virus vaccine developers, a number of traditional and novel vaccine designs are being evaluated essentially in parallel. Monomeric proteins, poxvirus vectors, peptides, and particle-based candidate vaccines have entered or will soon enter human trials. Other designs are at earlier stages of development. All candidates evaluated to date in phase I/II human trials have proven safe and immunogenic. One or more of the most promising designs will soon progress to 'test of concept' clinical trials to determine efficacy.

authors

Johnston MI

doi

10.1159/000237173

subject

Has Abstract

pub_date

1995-12-01 00:00:00

pages

313-7

issue

4

eissn

1018-2438

issn

1423-0097

journal_volume

108

pub_type

杂志文章,评审
  • Allergic sensitisation in tuberculosis and leprosy patients.

    abstract:BACKGROUND:A negative association has been observed between infections and allergy in several studies. The aim of the present study was to examine whether tuberculosis and leprosy patients have more or fewer allergies than healthy individuals. METHOD:Sera from tuberculosis patients, leprosy patients and healthy contro...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000088722

    authors: Ellertsen LK,Wiker HG,Egeberg NT,Hetland G

    更新日期:2005-11-01 00:00:00

  • Degranulation from human eosinophils stimulated with C3a and C5a.

    abstract::It is unclear what actually induces eosinophil degranulation in vivo. We examined eosinophil cationic protein (ECP) release from normal human eosinophils (Eos) in response to C3a and C5a. C3a and C5a induced remarkable ECP release when Eos were preincubated with cytochalasin B. ECP release induced by C3a or C5a was gr...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000236743

    authors: Takafuji S,Tadokoro K,Ito K,Dahinden CA

    更新日期:1994-01-01 00:00:00

  • Immunotherapy is allergen-specific: a double-blind trial of mite or timothy extract in mite and grass dual-allergic patients.

    abstract:BACKGROUND:One hundred years ago, Noon [Lancet 1911;1:1572-1573], using conjunctival provocation testing (CPT), was the first to demonstrate the effectiveness of subcutaneous immunotherapy (SCIT) in grass-allergic subjects with hay fever. In this centenary year, we present data that, by use of CPT and allergen-specific...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章,随机对照试验

    doi:10.1159/000330649

    authors: Dreborg S,Lee TH,Kay AB,Durham SR

    更新日期:2012-01-01 00:00:00

  • Can the use of HEPA cleaners in homes of asthmatic children and adolescents sensitized to cat and dog allergens decrease bronchial hyperresponsiveness and allergen contents in solid dust?

    abstract:BACKGROUND:Exposure and sensitization to pet allergens are associated with allergic asthma in children. Conflicting data have emerged regarding the potential benefit of air cleaners with respect to a reduction of indoor pet allergens and bronchial hyperresponsiveness (BHR). METHODS:In a randomized controlled trial 36 ...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章,随机对照试验

    doi:10.1159/000151502

    authors: Sulser C,Schulz G,Wagner P,Sommerfeld C,Keil T,Reich A,Wahn U,Lau S

    更新日期:2009-01-01 00:00:00

  • Low-allergenic hydrolyzed egg induces oral tolerance in mice.

    abstract:BACKGROUND:Egg allergy is one of the most common food allergies in children. The standard therapy for egg allergy is strict avoidance. Yet, there is considerable clinical and scientific interest in primary or secondary prevention. A major drawback of oral tolerance (OT) induction protocols, however, is the possibility ...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000363110

    authors: Hacini-Rachinel F,Vissers YM,Doucet-Ladevéze R,Blanchard C,Demont A,Perrot M,Panchaud A,Prioult G,Mercenier A,Nutten S

    更新日期:2014-01-01 00:00:00

  • Induction of Oral Tolerance by Pepsin-Digested Gliadin Retaining T Cell Reactivity in a Mouse Model of Wheat Allergy.

    abstract:BACKGROUND:Wheat is known as the most widely consumed food all over the world. Although many types of wheat allergy have been recognized, their treatment still has a long way to go due to the complex pathogenesis. Oral immunotherapy (OIT) is under investigation for the treatment of wheat allergies. Previous studies hav...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000506945

    authors: Li X,Miyakawa T,Takano T,Nakajima-Adachi H,Tanokura M,Hachimura S

    更新日期:2020-01-01 00:00:00

  • Lipopolysaccharide contamination of beta-lactoglobulin affects the immune response against intraperitoneally and orally administered antigen.

    abstract:BACKGROUND:Microbial components in the environment are potent activators of the immune system with capacity to shift the active immune response towards priming of Th1 and/or Th2 cells. Lipopolysaccharide (LPS), a cell-wall component of Gram-negative bacteria, is extensively present in food products like cow's milk. It ...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000081306

    authors: Brix S,Kjaer TM,Barkholt V,Frøkiaer H

    更新日期:2004-11-01 00:00:00

  • Orange germin-like glycoprotein Cit s 1: an equivocal allergen.

    abstract:BACKGROUND:Orange allergens are virtually unknown, in spite of the large consumption of this fruit. Germin-like proteins, together with vicilins and legumins, form the cupin superfamily of plant proteins, which includes many seed allergens. METHODS:Twenty-nine patients with allergy to oranges were studied. A major IgE...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000090384

    authors: Ahrazem O,Ibáñez MD,López-Torrejón G,Sánchez-Monge R,Sastre J,Lombardero M,Barber D,Salcedo G

    更新日期:2006-01-01 00:00:00

  • Th2 immune response plays a critical role in the development of nickel-induced allergic contact dermatitis.

    abstract:BACKGROUND:The precise roles of T helper (Th)1-type and Th2-type cytokine responses in nickel (Ni)-induced allergic contact dermatitis have not yet been clearly defined. We investigated the involvement of Th2 cytokines in Ni-induced contact hypersensitivity reaction using GATA-3 transgenic (Tg) mice. METHODS:A Ni-tita...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000314372

    authors: Niiyama S,Tamauchi H,Amoh Y,Terashima M,Matsumura Y,Kanoh M,Habu S,Komotori J,Katsuoka K

    更新日期:2010-01-01 00:00:00

  • Single Nucleotide Polymorphisms in Chemosensory Pathway Genes GNB3, TAS2R19, and TAS2R38 Are Associated with Chronic Rhinosinusitis.

    abstract:BACKGROUND:Chronic rhinosinusitis (CRS) is a multifaceted disease with a significant genetic component. The importance of taste receptor signaling has recently been highlighted in CRS; single nucleotide polymorphisms (SNPs) of bitter tastant-responsive G-protein-coupled receptors have been linked with CRS and with alte...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000499875

    authors: Purnell PR,Addicks BL,Zalzal HG,Shapiro S,Wen S,Ramadan HH,Setola V,Siderovski DP

    更新日期:2019-01-01 00:00:00

  • Interest of ImmunoCAP system to recombinant omega-5 gliadin for the diagnosis of exercise-induced wheat allergy.

    abstract:BACKGROUND:omega-5 gliadin is a major allergen in exercise-induced wheat allergy (EIWA), but it is also implicated in immediate-type reactions to wheat. An ImmunoCAP assay to measure omega-5 gliadin-specific IgE has become available. This study aimed to evaluate this new biological test in wheat allergy diagnosis and t...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000176309

    authors: Jacquenet S,Morisset M,Battais F,Denery-Papini S,Croizier A,Baudouin E,Bihain B,Moneret-Vautrin DA

    更新日期:2009-01-01 00:00:00

  • Glutamine Prevents Late-Phase Anaphylaxis via MAPK Phosphatase 1-Dependent Cytosolic Phospholipase A2 Deactivation.

    abstract:BACKGROUND:Cytosolic phospholipase A2 (cPLA2) plays a key role in the development of late-phase anaphylaxis. L-Glutamine (Gln), a nonessential amino acid, has anti-inflammatory activity via inhibiting cPLA2. METHODS:We used a penicillin-induced murine model of anaphylaxis, and late-phase anaphylaxis was quantified by ...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000452103

    authors: Kim HK,Song CH,Bae YS,Im SY,Lee HK

    更新日期:2016-01-01 00:00:00

  • N-terminus of a major allergen, Alt a I, of Alternaria alternata defined to be an epitope.

    abstract::A 20mer peptide representing the N-terminus of a major allergen, Alt a I, of Alternaria alternata was synthesized and examined for its antibody binding and antibody induction activities. Alt a I peptide-BSA conjugate reacted with both human IgE and rabbit anti-Alt a I IgG in ELISA, albeit the binding of the peptide to...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000237161

    authors: Zhang L,Curran IH,Muradia G,De Vouge MW,Rode H,Vijay HM

    更新日期:1995-11-01 00:00:00

  • Mice vaccinated with allergen-pulsed myeloid dendritic cells are not protected from developing allergen-induced Th2 responses.

    abstract:BACKGROUND:Dendritic cells (DC) play a decisive role in the induction of allergen-induced Th1 and Th2 responses. Since the induction of allergen-specific Th1 responses has shown to inhibit allergen-induced Th2-type inflammation, in this study we investigated whether manipulated myeloid-derived DC pulsed with the specif...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000086334

    authors: Trujillo-Vargas CM,Ramirez-Pineda JR,Palmetshofer A,Grunewald S,Moll H,Berberich C,Erb KJ

    更新日期:2005-07-01 00:00:00

  • Asthma: the role of low high-density-lipoprotein cholesterol in childhood and adolescence.

    abstract:BACKGROUND:Several studies have examined the relationship of asthma with serum dyslipidemia and reported positive, negative or no association. Most studies were limited by their cross-sectional design and the wide age range of the participants. In a cohort of children in Cyprus, we explored the association of asthma wi...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000368405

    authors: Yiallouros PK,Savva SC,Kolokotroni O,Dima K,Zerva A,Kouis P,Bousquet J,Middleton N

    更新日期:2014-01-01 00:00:00

  • The human IgE repertoire.

    abstract::IgE is a key mediator in allergic diseases. However, in strong contrast to other antibody isotypes, many details of the composition of the human IgE repertoire are poorly defined. The low levels of human IgE in the circulation and the rarity of IgE-producing B cells are important reasons for this lack of knowledge. In...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章,评审

    doi:10.1159/000355947

    authors: Gadermaier E,Levin M,Flicker S,Ohlin M

    更新日期:2014-01-01 00:00:00

  • Practical approach to self-administration of intravenous C1-INH concentrate: a nursing perspective.

    abstract::At an international hereditary angioedema (HAE) expert meeting, results from a survey were used to guide discussion on how best to advise patients on self-administering intravenous C1 esterase inhibitor therapy. Treatment differences across Europe were highlighted, together with the practicalities of self-administrati...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000351236

    authors: Symons C,Rossi O,Magerl M,Andritschke K

    更新日期:2013-01-01 00:00:00

  • The negative predictive value of typing safe local anesthetics.

    abstract:BACKGROUND:Although allergy to local anesthetics (LA) is rare, patients often report unwanted reactions after their administration. A history of anaphylaxis or an atypical reaction related to LA is an indication for typing a safe anesthetic for future surgical or dental procedures. AIM:The aim of the study was to dete...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000350763

    authors: Specjalski K,Kita-Milczarska K,Jassem E

    更新日期:2013-01-01 00:00:00

  • Oral Immunotherapy Using Partially Hydrolyzed Formula for Cow's Milk Protein Allergy: A Randomized, Controlled Trial.

    abstract:BACKGROUND:Partially hydrolyzed cow's milk protein-based formula (pHF) possesses low allergenicity. Here, we investigate the safety and efficacy of oral immunotherapy using pHF for children with cow's milk protein allergy (CMPA). OBJECTIVES:A randomized, double-blind, controlled single-center trial was conducted to ev...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章,随机对照试验

    doi:10.1159/000490804

    authors: Inuo C,Tanaka K,Suzuki S,Nakajima Y,Yamawaki K,Tsuge I,Urisu A,Kondo Y

    更新日期:2018-01-01 00:00:00

  • Characterization of the allergen group VI in timothy grass pollen (Phl p 6). I. Immunological and biochemical studies.

    abstract::For the identification and characterization of allergen grass group VI we performed two-dimensional immunoblotting of timothy grass pollen (Phleum pratense). Two intense 13-kD protein spots of pI 5.2 and 5.5 were found to be IgE reactive. By N-terminal microsequencing and amino acid analysis we identified them as Phl ...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000237117

    authors: Petersen A,Bufe A,Schlaak M,Becker WM

    更新日期:1995-09-01 00:00:00

  • Sialyl Lewis X analog inhibits eosinophil accumulation and late asthmatic response in a guinea-pig model of asthma.

    abstract::Preferential eosinophil accumulation is characteristic of airway inflammation in asthma. Although little is known about its mechanism, the effect of a sialyl Lewis X analog on airway eosinophilia was examined in a guinea-pig model of asthma. Guinea-pigs were sensitized by repeated inhalation of ovalbumin. After a sing...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000237412

    authors: Sagara H,Ra C,Okada T,Shinohara S,Fukuda T,Okumura K,Makino S

    更新日期:1996-01-01 00:00:00

  • The spectrum of olive pollen allergens.

    abstract::Olive pollen is one of the most important causes of seasonal respiratory allergy in Mediterranean countries, where this tree is intensely cultivated. Among the high number of protein allergens detected in this pollen, 8 - Ole e 1 to Ole e 8 - have been isolated and characterized. Ole e 1 is the most frequent sensitizi...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章,评审

    doi:10.1159/000053815

    authors: Rodríguez R,Villalba M,Monsalve RI,Batanero E

    更新日期:2001-07-01 00:00:00

  • Modifications of Phleum pratense grass pollen allergens following artificial exposure to gaseous air pollutants (O(3), NO(2), SO(2)).

    abstract:BACKGROUND:Air pollution is frequently proposed as a potential cause of the increased incidence of allergy in industrialised countries. Our objective was to investigate the impact of the major gaseous air pollutants on grass pollen allergens. METHODS:Timothy grass pollen was exposed to ozone (O(3)), nitrogen dioxide (...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000099079

    authors: Rogerieux F,Godfrin D,Sénéchal H,Motta AC,Marlière M,Peltre G,Lacroix G

    更新日期:2007-01-01 00:00:00

  • Immediate Wheal Reactivity to Autologous Sweat in Atopic Dermatitis Is Associated with Clinical Severity, Serum Total and Specific IgE and Sweat Tryptase Activity.

    abstract:BACKGROUND:Sweating can worsen atopic dermatitis (AD). The purpose of this work was to study the associations between reactivity to autologous sweat and the clinical severity of AD as well as investigate the possible wheal-inducing factors of sweat. METHODS:Intracutaneous skin tests with autologous sweat were performe...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000447638

    authors: Ilves T,Virolainen A,Harvima IT

    更新日期:2016-01-01 00:00:00

  • Recent advances in eosinophil biology.

    abstract::Eosinophils are pleiotropic multi-functional leukocytes involved in initiation and propagation of diverse inflammatory responses. Recent studies examining eosinophil biology have focused on delineating the molecular basis of FIP1L1/PDGRFalpha-fusion gene induced HES, the molecular steps involved in eosinophil recruitm...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章,评审

    doi:10.1159/000101398

    authors: Hogan SP

    更新日期:2007-01-01 00:00:00

  • IgE lambda monoclonal gammopathy and amyloidosis.

    abstract::The prevalence of IgE myeloma is 0.01% in all plasmocytomas. Although signs and symptoms are similar, it is generally accepted that IgE myeloma has a more malignant clinical course than other forms of plasmocytoma with monoclonal gammopathy. The disease has widely variable presentation. Most of the reported cases were...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章,评审

    doi:10.1159/000237490

    authors: Jako JM,Gesztesi T,Kaszas I

    更新日期:1997-04-01 00:00:00

  • Characterization of candidate anti-allergic probiotic strains in a model of th2-skewed human peripheral blood mononuclear cells.

    abstract:BACKGROUND:Pre-clinical and clinical studies have evaluated the efficacy of probiotics in allergy. However, predictive in vitro systems for rational strain selection are still missing. METHODS:We developed a novel in vitro screening system for the characterization of probiotics with anti-allergic potential. In this mo...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000343703

    authors: Holvoet S,Zuercher AW,Julien-Javaux F,Perrot M,Mercenier A

    更新日期:2013-01-01 00:00:00

  • Bed bug saliva causes release of monocytic inflammatory mediators: plausible cause of cutaneous bite reactions.

    abstract::Bed bugs may cause mild to severe cutaneous reactions. We studied the ability of bed bug salivary extract (SGE) to induce inflammatory reactions responsible for cutaneous manifestations and found that SGE stimulated the production of several potent chemokines and cytokines from macrophages. Chemokines induced by SGE i...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000345134

    authors: Goddard J,Hasenkampf N,Edwards KT,de Shazo R,Embers ME

    更新日期:2013-01-01 00:00:00

  • Impact of Allergy and Eosinophils on the Morbidity of Chronic Rhinosinusitis with Nasal Polyps in Northwest China.

    abstract:BACKGROUND:Nasal polyps are a common health problem that can significantly impact the quality of life. OBJECTIVE:To analyze the impact of allergy and peripheral eosinophils (EOS) on the morbidity of chronic rhinosinusitis with nasal polyps (CRSwNP) in Northwest China. METHODS:A retrospective cohort of 323 patients wh...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000497384

    authors: Chen F,Wen L,Qiao L,Shi Z,Xue T,Chen X,Li X

    更新日期:2019-01-01 00:00:00

  • Structural and immunological characterization of recombinant Pan b 1, a major allergen of northern shrimp, Pandalus borealis.

    abstract:BACKGROUND:Shellfish allergy is one of the major causes of life-threatening allergic reactions to food. The shrimp species Pandalus borealis is the commercially most important coldwater shrimp species, and its protein extract is commonly used in shrimp allergy diagnostics. However, the DNA sequence of its major allerge...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000339740

    authors: Myrset HR,Barletta B,Di Felice G,Egaas E,Dooper MM

    更新日期:2013-01-01 00:00:00