Abstract:
OBJECTIVE:To evaluate whether activated partial thromboplastin time (APTT) could be used in the laboratory diagnosis of hereditary or acquired angioedema (HAE or AAE) with and without C1 inhibitor (C1-INH) deficiency. METHODS:In a prospective investigation, APTT and other coagulation parameters were determined in 149 adult patients with various types of angioedema and in 26 healthy participants (HP). RESULTS:Mean APTT was significantly shortened in HAE-C1-INH type I (p < 0.0001) and type II (p = 0.0017) and in AAE-C1-INH (p < 0.0001) compared to the HP. APTT was shortened under the reference range (26-36 s) in 33/45 (73.3%) patients with HAE-C1-INH, 10/15 (66.7%) patients with AAE-C1-INH, 4/27 (14.8%) patients with HAE with normal C1-INH, 1/32 (3.1%) patients with histaminergic angioedema, 4/30 (13.3%) patients with nonhistaminergic angioedema and in 2/26 (7.7%) HP. Thus, a shortened APTT was obtained in 8-9 times more patients with angioedema due to C1-INH deficiency when compared to patients with various forms of angioedema with normal C1-INH and also to HP. CONCLUSIONS:A shortened APTT may help to diagnose HAE-C1-INH and AAE-C1-INH when determination of C1-INH is not yet available.
journal_name
Int Arch Allergy Immunoljournal_title
International archives of allergy and immunologyauthors
Bork K,Witzke Gdoi
10.1159/000447695subject
Has Abstractpub_date
2016-01-01 00:00:00pages
101-7issue
2eissn
1018-2438issn
1423-0097pii
000447695journal_volume
170pub_type
杂志文章abstract:BACKGROUND:Data regarding the prevalence of chronic spontaneous urticaria (CSU) in childhood-onset systemic lupus erythematosus (cSLE) patients and possible associated factors are limited to a few case reports. The objectives of this study were to assess CSU in a large cSLE population, in order to evaluate the demograp...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章,多中心研究
doi:10.1159/000438723
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Chronic rhinosinusitis (CRS) is a multifaceted disease with a significant genetic component. The importance of taste receptor signaling has recently been highlighted in CRS; single nucleotide polymorphisms (SNPs) of bitter tastant-responsive G-protein-coupled receptors have been linked with CRS and with alte...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000499875
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Grape allergy is considered rare; grape lipid transfer protein (LTP; Vit v 1), an endochitinase and a thaumatin-like protein (TLP) have been reported as grape allergens. A considerable number of patients have referred to our department for severe reactions to grapes, and several IgE binding proteins were det...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000098657
更新日期:2007-01-01 00:00:00
abstract::T cells are central regulators and mediators of allergic sensitisation and disease. The house dust mite allergens are a biochemically diverse group of proteins which are present in extracts and the environment in a wide range of concentrations. Here the importance of ascertaining the contribution of the different alle...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章,评审
doi:10.1159/000023824
更新日期:1998-01-01 00:00:00
abstract::To determine the variation of antigenic water soluble proteins in white birch (Betula pendula) pollen, extracts of pollen from different sides of individual trees were analyzed by isoelectric focusing (IEF), crossed immunoelectrophoresis, and crossed radioimmunoelectrophoresis. IgE-antibody-binding patterns were also ...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000237184
更新日期:1995-12-01 00:00:00
abstract:BACKGROUND:The implementation of allergen immunotherapy (AIT) requires extensive knowledge of allergen distribution in the region to identify high-risk regions for AIT utilization. However, the geographical distribution patterns of the major Dermatophagoides allergens in China remain unclear despite the increasing prev...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000499409
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Hypersensitivity to contrast media (CMs) may be common and serious. AIM:To evaluate the prevalence of CM hypersensitivity, risk factors associated with it and the role of skin testing in its diagnosis. METHODS:A structured questionnaire was administered to patients who underwent computed tomography during ...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000320760
更新日期:2011-01-01 00:00:00
abstract::CD40 is a surface antigen expressed on B cells. The CD40 ligand (CD40L) is expressed on activated T cells. Interaction between CD40 and CD40L is critical for proliferation and isotype switching in the context of a response to a T-cell-dependent antigen. Patients with X-linked hyper-IgM syndrome (HIGMX-1) in their CD40...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章,评审
doi:10.1159/000236923
更新日期:1995-05-01 00:00:00
abstract::Anti-cyclic citrullinated peptide antibodies (anti-CCP) are a new diagnostic marker for rheumatoid arthritis (RA), which shows a specificity of 97% and a sensitivity of 81% in the second generation assay. About 61% of RA patients express HLA-DRB1*0401. In a cohort of patients with RA we investigated whether the expres...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000086463
更新日期:2005-08-01 00:00:00
abstract::Psoriasis (Ps) is a chronic, immune-mediated, skin inflammatory disease affecting up to 3% of the population worldwide. Different environmental triggers initiate this complex multifactorial syndrome. Many individuals affected by Ps (6-26%) develop inflammatory disease in other organs, often in the joints as in psorias...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章,评审
doi:10.1159/000375401
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Nonpathogenic Escherichia coli strain Nissle 1917 (EcN) has immunomodulatory properties and can act on different cells which are important for the allergic immune response. Herein, we investigated the efficacy and tolerability of EcN in subjects with grass pollen-dependent allergic rhinoconjunctivitis. METH...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章,随机对照试验
doi:10.1159/000356328
更新日期:2014-01-01 00:00:00
abstract::A prospective study was conducted on 73 allergic patients and 14 normal volunteers in order to measure the IgE concentration in both serum and saliva, and analyze salivary IgE according to the characteristics of the allergic disease. IgE was more frequently detected in saliva from allergic patients than from normal su...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000236715
更新日期:1994-05-01 00:00:00
abstract:BACKGROUND:The hemagglutinin (HA) of influenza viruses is one of the major targets of the humoral response. The role of serum antibody to HA in the protection against infection has been demonstrated by long-standing observation. In previous studies, we suggested that an epitope vaccine might be a new strategy against t...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000053869
更新日期:2002-03-01 00:00:00
abstract:BACKGROUND:Prostaglandin D(2) (PGD(2)), a major prostanoid produced by activated mast cells, has long been implicated in allergic diseases. PGD(2) demonstrates its effects through two G-protein-coupled receptors, DP and CRTH2. The PGD(2)/CRTH2 system mediates chemotaxis of eosinophils, basophils, and Th2 cells, which a...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000095436
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:Microbial components in the environment are potent activators of the immune system with capacity to shift the active immune response towards priming of Th1 and/or Th2 cells. Lipopolysaccharide (LPS), a cell-wall component of Gram-negative bacteria, is extensively present in food products like cow's milk. It ...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000081306
更新日期:2004-11-01 00:00:00
abstract::Thymulin is a nonapeptide hormone isolated from the thymus gland. It has immunomodulatory effects which have not yet been well defined. Its major actions have been shown to be on T-cells and their immature precursors. In this study, thymulin was tested in vitro for its effect on the release of IL-1 alpha, IL-2, IL-6 a...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000236509
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND:Recently, the high affinity receptor for IgE (Fc epsilonRI), which plays a major role in allergies, has been identified on a number of different antigen-presenting cell types, including human monocytes from atopic and nonatopic donors. In this report human monocytic cell lines were used to test for the expre...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000237621
更新日期:1997-08-01 00:00:00
abstract::The gut mucosa plays an important role in the induction of oral tolerance. Extending previous observations, we have here shown that serum containing gut-absorbed gliadin induces suppression of the specific systemic immune response in recipient mice parenterally immunized with gliadin. Graft-versus-host reaction (GvHR)...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000237230
更新日期:1996-01-01 00:00:00
abstract::Increased serum IgE and enhanced susceptibility to viral infections, decreased levels of interferons, lymphocytic skin infiltrates and IgE-bearing epidermal Langerhans cells are striking features in patients with atopic eczema (AE). Since the hyper-IgE syndrome is known to improve under alpha-interferon (alpha-IFN) th...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000236494
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND:The development of simple and standardised methods to measure airborne levels of workplace biological allergens is an important step in reducing the incidence of occupational asthma. Such a method would be useful for measuring wheat flour allergens which cause asthma in bakers. Measurement of allergen per se...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000237680
更新日期:1997-11-01 00:00:00
abstract:BACKGROUND:The importance of fungal allergens in the development of allergic diseases in a desert environment is uncertain. This study evaluated the prevalence of IgE sensitization to moulds among patients with allergic respiratory diseases in Kuwait - a desert country. METHODS:A total of 810 patients (male:female rat...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000024343
更新日期:2000-04-01 00:00:00
abstract::Sera of 54 symptomatic workers showing sensitization to isocyanate-human serum albumin (HSA) conjugates were subjected to parallel enzyme allergosorbent test (EAST) and CAP measurements to determine IgE antibodies to diphenyl-methane diisocyanate-HSA, toluene diisocyanate-HSA and hexamethylene diisocyanate-HSA. Result...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000237325
更新日期:1996-08-01 00:00:00
abstract::Long-term birth cohort studies are essential to understanding the life course and childhood predictors of allergy and the complex interplay between genes and the environment (including lifestyle and socioeconomic determinants). Over 100 cohorts focusing on asthma and allergy have been initiated in the world over the p...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章,评审
doi:10.1159/000343018
更新日期:2013-01-01 00:00:00
abstract:AIM:To investigate the potential risk factors in patients who have experienced anaphylaxis from drugs. METHOD:The study included 281 adult patients (median age 40 years; 76.5% female) who experienced immediate types of hypersensitivity reaction to a drug. The patients were divided into an anaphylaxis group and a nonan...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000494130
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Clinically it is recognized that tree nut allergies such as hazelnut allergy are not usually outgrown. Specific mechanisms underlying the persistence of such food allergies are incompletely understood. Here we studied the natural history and the long-term immune and clinical characteristics of hazelnut aller...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000283028
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:Sensitivity to Chenopodiaceae is a frequent cause of allergic respiratory diseases in geographic areas where sensitization to Salsola kali and Chenopodium album has been reported. The objective of this study was to evaluate the pattern of sensitization to 3 Salsola species in patients residing on the Mediter...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000242357
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:The aetiology of chronic urticaria is heterogeneous. Physical urticaria (PU) is estimated at around 35%, autoimmune urticaria (AIU) at 25% and chronic idiopathic urticaria (CIU) at 35% of all chronic urticaria cases. METHODS:Differences in clinical and laboratory parameters among AIU, PU and CIU groups were...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000103995
更新日期:2007-01-01 00:00:00
abstract::The prevalence of IgE myeloma is 0.01% in all plasmocytomas. Although signs and symptoms are similar, it is generally accepted that IgE myeloma has a more malignant clinical course than other forms of plasmocytoma with monoclonal gammopathy. The disease has widely variable presentation. Most of the reported cases were...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章,评审
doi:10.1159/000237490
更新日期:1997-04-01 00:00:00
abstract::Human colostrum and a high molecular weight colostrum fraction (HMWF; > 14,000 D) prevented the adhesion of localized adherent (LA+) O111:H-enteropathogenic Escherichia coli (EPEC) to HeLa cells. This effect was abolished after absorption with an O111:H-LA + EPEC strain, but absorption with a LA- strain of same seroty...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000236645
更新日期:1994-01-01 00:00:00
abstract:INTRODUCTION:House dust mite contains several allergen components and causes perennial allergy. Lately, a new major allergen, Der p 23, was described with relatively high sensitization rates in different European Countries. In addition, Der p 23 is supposed to cause asthmatic disease. OBJECTIVE:We would like to questi...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000508522
更新日期:2020-01-01 00:00:00