Reactive oxygen species in psoriasis and psoriasis arthritis: relevance to human disease.

Abstract:

:Psoriasis (Ps) is a chronic, immune-mediated, skin inflammatory disease affecting up to 3% of the population worldwide. Different environmental triggers initiate this complex multifactorial syndrome. Many individuals affected by Ps (6-26%) develop inflammatory disease in other organs, often in the joints as in psoriasis arthritis (PsA). Animal models that reflect the typical Ps syndrome, including both skin and joint pathology as in Ps and PsA, are valuable tools for dissecting disease pathways leading to clinical manifestations. In this context, we developed a new acute Ps and PsA-like disease model that appears after exposure to Saccharomyces cerevisiae mannan in certain mouse strains. The disease was found to be triggered by mannan-activated macrophages, leading to the activation of a pathogenic interleukin-17 pathway involving innate lymphocytes. Interestingly, the production of reactive oxygen species protected the mice from the triggering of this pathway and ameliorated Ps and PsA development.

authors

Khmaladze Ia,Nandakumar KS,Holmdahl R

doi

10.1159/000375401

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

135-49

issue

2

eissn

1018-2438

issn

1423-0097

pii

000375401

journal_volume

166

pub_type

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