Variability of Ole e 9 allergen in olive pollen extracts: relevance of minor allergens in immunotherapy treatments.

Abstract:

BACKGROUND:Clustered severe adverse reactions to immunotherapy with olive pollen extracts have been occasionally reported in areas where olive trees are extensively grown. Allergic patients from these areas, in addition to the major olive pollen allergen Ole e 1, frequently recognize a recently described allergen, Ole e 9. OBJECTIVE:We aimed to develop an immunoassay to measure Ole e 9 concentration and to study the variability of this allergen in olive pollen extracts. METHODS:Monoclonal antibodies (mAb) to Ole e 9 were produced from mice immunized with the pure allergen. One of these mAbs was used to develop a sandwich ELISA with an anti-olive pollen extract rabbit serum as the tracer. Olive pollen batches from several suppliers were analyzed using this method. These batches were also analyzed for Ole e 1 content and biological activity. RESULTS:A 10-fold variation between the extreme values was found for the biological activity of the batches analyzed. Ole e 1 concentration showed a 25-fold variation. Variability of Ole e 9 concentration was extremely high, up to 161 times. The ratio Ole e 1/Ole e 9 varied in a range from 0.6 to 390.4. CONCLUSION:The availability of a mAb-based ELISA for Ole e 9 made it possible for us to detect an important source of variability in olive pollen batches. This variability may be the cause of outbreaks of adverse reactions in the course of immunotherapy treatments, which have sometimes been observed among olive-allergic patients living in areas with very high levels of airborne olive pollen.

authors

Duffort O,Palomares O,Lombardero M,Villalba M,Barber D,Rodríguez R,Polo F

doi

10.1159/000092532

subject

Has Abstract

pub_date

2006-01-01 00:00:00

pages

131-8

issue

2

eissn

1018-2438

issn

1423-0097

pii

92532

journal_volume

140

pub_type

杂志文章
  • Characterization of dog allergens Can f 1 and Can f 2. 1. Preparation of their recombinant proteins and antibodies.

    abstract:BACKGROUND:Recombinant dog allergens, rCan f 1 and rCan f 2, and their antibodies are good tools for the characterization of dog allergens in order to develop modern therapeutic and preventive methods for dog allergy. METHODS:In this study, cDNA was synthesized from the mRNA of dog salivary glands and cloned into the ...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000097498

    authors: Kamata Y,Miyanomae A,Nakayama E,Miyanomae T,Tajima T,Hoshi H

    更新日期:2007-01-01 00:00:00

  • Polarized Airway Epithelial Models for Immunological Co-Culture Studies.

    abstract::Epithelial cells line all cavities and surfaces throughout the body and play a substantial role in maintaining tissue homeostasis. Asthma and other atopic diseases are increasing worldwide and allergic disorders are hypothesized to be a consequence of a combination of dysregulation of the epithelial response towards e...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章,评审

    doi:10.1159/000445833

    authors: Papazian D,Würtzen PA,Hansen SW

    更新日期:2016-01-01 00:00:00

  • Resting B cells are not antigen-presenting cells in the induction of oral tolerance of specific Th2 immune responses in mice.

    abstract:BACKGROUND:It has been shown that antigen presentation by resting B cells can induce tolerance to intravenously administered protein antigens, but the role of resting B cells in the induction of oral tolerance is unclear. METHODS:Mice continuously treated since birth with rabbit anti-mouse IgM serum for 5 weeks were d...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000024394

    authors: Peng HJ,Chang ZN,Kuo SW,Lee CC,Tzau YY

    更新日期:2000-07-01 00:00:00

  • Analysis of IgE-binding factors (sCD23) within newborn sera.

    abstract::Factors are discussed as potential diagnostic parameters of atopic disorders. The amounts of sCD23 in sera from newborn children (n = 4,329) were determined by radioimmunoassay with monoclonal antibodies specific for CD23. The sCD23 levels ranged between 0 and 81.5 ng/ml of CD23-specific mAb. Furthermore, the sera of ...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000236346

    authors: Bujanowski-Weber J,Knöller I,Wahn U,König W

    更新日期:1992-01-01 00:00:00

  • The Ability to Use Epinephrine Autoinjector in Patients Who Receive Prescription Immediately after Anaphylaxis.

    abstract:BACKGROUND:Epinephrine autoinjector (EAI) is prescribed to prevent a fatal outcome in the case of a repeated anaphylactic reactions. We wanted to determine how adult patients who received their first prescription as part of an urgent treatment of an anaphylactic reaction or at their family physician were instructed on ...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000513421

    authors: Kadivec S,Košnik M

    更新日期:2021-01-22 00:00:00

  • Orange germin-like glycoprotein Cit s 1: an equivocal allergen.

    abstract:BACKGROUND:Orange allergens are virtually unknown, in spite of the large consumption of this fruit. Germin-like proteins, together with vicilins and legumins, form the cupin superfamily of plant proteins, which includes many seed allergens. METHODS:Twenty-nine patients with allergy to oranges were studied. A major IgE...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000090384

    authors: Ahrazem O,Ibáñez MD,López-Torrejón G,Sánchez-Monge R,Sastre J,Lombardero M,Barber D,Salcedo G

    更新日期:2006-01-01 00:00:00

  • Serum total immunoglobulin E is a surrogate of atopy in adult-onset asthma: a longitudinal study.

    abstract:BACKGROUND:Studies have shown that serum total immunoglobulin E (IgE) levels are higher in asthmatics. However, the role of the serum total IgE level, independently from atopy, in adult asthma is not understood. We studied the associations between serum total IgE, the number of sensitizations and the sum of specific Ig...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000342464

    authors: Carsin AE,Zock JP,Jarvis D,Basagaña X,Heinrich J,Toren K,Janson C,Anto JM,Sunyer J

    更新日期:2013-01-01 00:00:00

  • Mast cell hyperplasia: role of cytokines.

    abstract::Mast cell hyperplasia is found in different pathologies such as chronic inflammatory processes, fibrotic disorders, wound healing or neoplastic tissue transformation. The functional significance of the accumulation of mast cells in these processes is largely unknown. It is now established that bone marrow-derived mast...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章,评审

    doi:10.1159/000048181

    authors: Bischoff SC,Sellge G

    更新日期:2002-02-01 00:00:00

  • Bioavailability and allergoprotective capacity of milk-associated conjugated linoleic acid in a murine model of allergic airway inflammation.

    abstract:BACKGROUND:Cross-sectional epidemiological studies have demonstrated that farm milk from traditional farm settings possesses allergoprotective properties. Up to now, it has not been clarified which milk ingredient is responsible for protection against allergic diseases. As farm milk is rich in conjugated linoleic acids...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000358523

    authors: Böcking C,Harb H,Ege MJ,Zehethofer N,Fischer K,Krauß J,Holst O,Nüsing RM,Lindner B,von Mutius E,Renz H,Garn H,Pfefferle PI

    更新日期:2014-01-01 00:00:00

  • Grass aeropollen of the western United States Gulf Coast.

    abstract::Volumetric air sampling was performed at Corpus Christi, Tex., September 1987 to August 1989. Grass aeropollen during all of 1988 accounted for 15.3% of total pollen captured during two major peaks, one in May and another during September and October. The remaining grass pollen, about one-quarter of the total, was fou...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000236168

    authors: Lewis WH,Dixit AB,Wedner HJ

    更新日期:1992-01-01 00:00:00

  • Antigen-induced reduction in mast cell and basophil functional responses due to reduced Syk protein levels.

    abstract:BACKGROUND:The high-affinity IgE receptor, FcepsilonRI, is unresponsive on mast cells and basophils from people in several populations through an unknown mechanism. Similarly, FcepsilonRI-positive basophils from 'nonreleasers' are IgE-unresponsive and are deficient in the tyrosine kinase Syk. OBJECTIVE:To test the hyp...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000087355

    authors: Kepley CL

    更新日期:2005-09-01 00:00:00

  • Morphology and three-dimensional reconstruction of the digestive system of Dermatophagoides farinae.

    abstract:BACKGROUND:The digestive system of Dermatophagoides farinae remains poorly documented. METHODS:In this study, a three-dimensional (3-D) model of the alimentary canal of D. farinae was built for the first time based on hematoxylin-eosin staining, 76 cross-sections of the adult mite and 3-D reconstruction technology. R...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000115890

    authors: Zhang YY,Sun X,Liu ZG

    更新日期:2008-01-01 00:00:00

  • The Gut Microbiome of Adults with Allergic Rhinitis Is Characterised by Reduced Diversity and an Altered Abundance of Key Microbial Taxa Compared to Controls.

    abstract:INTRODUCTION:Unique gut microbial colonisation patterns are associated with the onset of allergic disease in infants; however, there is insufficient evidence to determine if aberrant microbial composition patterns persist in adult allergic rhinitis (AR) sufferers. OBJECTIVE:To compare the gut microbiome composition be...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000510536

    authors: Watts AM,West NP,Zhang P,Smith PK,Cripps AW,Cox AJ

    更新日期:2021-01-01 00:00:00

  • 100 years of immunotherapy: the Monaco charter. under the high patronage of His Serene Highness Prince Albert II of Monaco.

    abstract::Aims of the Monaco Charter: (1) to present the current evidence on the efficacy and safety of allergen-specific immunotherapy (SIT) and to address the reasons for its underuse in clinical practice; (2) to develop strategies to increase the awareness about the benefits and the hazards of SIT in allergic patients, lay p...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000343883

    authors: Canonica GW,Baena-Cagnani CE,Compalati E,Bohle B,Bonini S,Bousquet J,Cox L,Fink-Wagner AH,González Díaz S,Jacobsen L,Passalacqua G,Pawankar R,Vieths S,Yusuf O,Zuberbier T

    更新日期:2013-01-01 00:00:00

  • Enhancement of allergic skin wheal responses by microwave radiation from mobile phones in patients with atopic eczema/dermatitis syndrome.

    abstract::Microwave radiation from mobile phones enhanced skin wheal responses induced by house dust mite and Japanese cedar pollen while it had no effect on wheal responses induced by histamine in patients with atopic eczema/dermatitis syndrome (AEDS). Microwave radiation also increased plasma levels of substance P (SP) and va...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000067592

    authors: Kimata H

    更新日期:2002-12-01 00:00:00

  • Evaluation of receptor expression on immune system cells in the peripheral blood of asthmatic children undergoing food challenges.

    abstract:BACKGROUND:The role of food allergens in the induction of allergic reactions in the airways is not completely understood. The aim of the present study was to evaluate fluorocytometric assays of the peripheral blood during food challenge tests in children with asthma and food allergy. PATIENTS AND METHODS:22 children w...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000226239

    authors: Krogulska A,Wasowska-Królikowska K,Polakowska E,Chrul S

    更新日期:2009-01-01 00:00:00

  • Cytokine production by highly purified human CD8+ T cells.

    abstract::We have systematically investigated the capacity of highly purified human peripheral CD8+ T cells to produce interleukin (IL)-4 and interferon (IFN)-gamma when triggered by different stimuli. CD8+ T cells were isolated from peripheral blood by positive selection to > 99% purity and stimulated with one of three differe...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000237030

    authors: Li Y,Richards D,Noble A,Kemeny DM

    更新日期:1995-05-01 00:00:00

  • Adjuvant effect of pertussis toxin on the production of anti-ovalbumin IgE in mice and lack of direct correlation between PCA and ELISA.

    abstract::In studies designed to optimize the production and detection of anti-ovalbumin (anti-Oa) IgE in Ham/ICR mice, a range of doses of both Oa and pertussis toxin as the IgE adjuvant was explored. As determined by 48-hour passive cutaneous anaphylaxis (PCA) tests, the highest titre of anti-Oa IgE was obtained in a three-in...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000236770

    authors: Lindsay DS,Parton R,Wardlaw AC

    更新日期:1994-11-01 00:00:00

  • Optimizing the use of a skin prick test device on children.

    abstract:BACKGROUND:Studies comparing skin prick test (SPT) devices have revealed varying results in performance and there is little known about their use on children. METHODS:We performed 2 complementary studies to test the sensitivity, reproducibility and acceptability of commercially available SPT devices (Stallerpoint, Ant...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000350788

    authors: Buyuktiryaki B,Sahiner UM,Karabulut E,Cavkaytar O,Tuncer A,Sekerel BE

    更新日期:2013-01-01 00:00:00

  • Circadian patterns in histamine concentrations and mast cell number in the rat thyroid gland.

    abstract::We carried out a cross-sectional chronobiological investigation on blood histamine, thyroid histamine and thyroid mast cell number in Wistar rats. Daily, blood histamine varied from 0.38 +/- 0.01 (12.00 h) to 0.60 +/- 0.01 mg/g wet weight (20.00 h) and thyroid histamine from 21.2 +/- 1.19 (04.00 h) to 38.3 +/- 1.54 mg...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000236788

    authors: Catini C,Miliani A,Macchi C

    更新日期:1994-12-01 00:00:00

  • Immediate-Type Hypersensitivity Cross-Reactions to Proton Pump Inhibitors: A Descriptive Study of Data from the French National Pharmacovigilance Database.

    abstract:BACKGROUND:Proton pump inhibitors (PPIs) can trigger immediate-type hypersensitivity reactions (HSRs). Three main patterns of cross-reactivity have been identified: reactions to a single PPI, selective cross-reactions, and cross-reactions with all PPIs. Several hypotheses have been advanced, but no consensus has been r...

    journal_title:International archives of allergy and immunology

    pub_type:

    doi:10.1159/000493581

    authors: Tourillon C,Mahe J,Baron A,Lambert A,Yélehé-Okouma M,Veyrac G,Jolliet P

    更新日期:2019-01-01 00:00:00

  • Anaphylaxis to wheat flour-derived foodstuffs and the lipid transfer protein syndrome: a potential role of wheat lipid transfer protein Tri a 14.

    abstract:BACKGROUND:Food allergy to wheat-derived foodstuffs is on the rise. Tri a 14, a wheat flour lipid transfer protein (LTP) allergen, has been described as a major allergen associated with baker's asthma and wheat food allergy. Cross-reactivity among LTP allergens leads to the so-called 'LTP syndrome'. METHODS:Eight adul...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000265539

    authors: Palacin A,Bartra J,Muñoz R,Diaz-Perales A,Valero A,Salcedo G

    更新日期:2010-01-01 00:00:00

  • Can the use of HEPA cleaners in homes of asthmatic children and adolescents sensitized to cat and dog allergens decrease bronchial hyperresponsiveness and allergen contents in solid dust?

    abstract:BACKGROUND:Exposure and sensitization to pet allergens are associated with allergic asthma in children. Conflicting data have emerged regarding the potential benefit of air cleaners with respect to a reduction of indoor pet allergens and bronchial hyperresponsiveness (BHR). METHODS:In a randomized controlled trial 36 ...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章,随机对照试验

    doi:10.1159/000151502

    authors: Sulser C,Schulz G,Wagner P,Sommerfeld C,Keil T,Reich A,Wahn U,Lau S

    更新日期:2009-01-01 00:00:00

  • Greater Real-Life Diagnostic Efficacy of Allergen Molecule-Based Diagnosis for Prescription of Immunotherapy in an Area with Multiple Pollen Exposure.

    abstract:BACKGROUND:Allergen molecule-based diagnosis has been suggested to facilitate the identification of disease-causing allergen sources and the prescription of allergen-specific immunotherapy (AIT). The aim of the current study was to compare allergen molecule-based IgE serology with allergen extract-based skin testing fo...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000477442

    authors: Saltabayeva U,Garib V,Morenko M,Rosenson R,Ispayeva Z,Gatauova M,Zulus L,Karaulov A,Gastager F,Valenta R

    更新日期:2017-01-01 00:00:00

  • Is the effect of prenatal paracetamol exposure on wheezing in preschool children modified by asthma in the mother?

    abstract:BACKGROUND:There seems to be an association between paracetamol consumption during late pregnancy and the prevalence of wheezing in infancy and childhood. The aim of the present study is to determine whether the aforementioned association is modified by the presence of asthma in the mother. METHODS:A total of 1,741 ch...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000176304

    authors: Garcia-Marcos L,Sanchez-Solis M,Perez-Fernandez V,Pastor-Vivero MD,Mondejar-Lopez P,Valverde-Molina J

    更新日期:2009-01-01 00:00:00

  • Is enhanced fetal growth a risk factor for the development of atopy or asthma?

    abstract:BACKGROUND:The aetiological factors underlying the worldwide increase in the prevalence of asthma and the international patterns of the prevalence of asthma are not well understood. This has led to consideration of factors such as fetomaternal health which may programme the initial susceptibility to allergic sensitisat...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000024149

    authors: Beasley R,Leadbitter P,Pearce N,Crane J

    更新日期:1999-02-01 00:00:00

  • Interferon-gamma increases CD62L expression on human eosinophils.

    abstract:BACKGROUND:L-selectin (CD62L) and Mac-1 (CD11b/CD18) play a crucial role in the infiltration of eosinophils. However, changes in CD62L and CD11b expression on eosinophils after stimulation with cytokines were little studied. METHODS:Eosinophils in peripheral blood of healthy volunteers were purified and cultured with ...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000053590

    authors: Momose T,Okubo Y,Horie S,Takashi S,Tsukadaira A,Suzuki J,Isobe M,Sekiguchi M

    更新日期:1999-01-01 00:00:00

  • Tyk2 is essential for IFN-alpha-induced gene expression in mast cells.

    abstract::Mast cells are recognized not only as the major effector cells of type I hypersensitivity reactions but also as an important player of innate immune response against bacterial infection. Type I IFNs are also involved in the response against bacterial infection. However, the role of type I IFNs and their associated Jan...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000077789

    authors: Mori Y,Hirose K,Suzuki K,Nakajima H,Seto Y,Ikeda K,Shimoda K,Nakayama K,Saito Y,Iwamoto I

    更新日期:2004-06-01 00:00:00

  • Food-dependent exercise-induced anaphylaxis: clinical and laboratory findings in 54 subjects.

    abstract:BACKGROUND:In some subjects, specific foods trigger anaphylaxis when exercise follows ingestion (specific food-dependent exercise-induced anaphylaxis, FDEIAn). Skin test and/or RAST positivity to foods suggest an IgE-mediated pathogenic mechanism. Others suffer from anaphylaxis after all meals followed by exercise, reg...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000053825

    authors: Romano A,Di Fonso M,Giuffreda F,Papa G,Artesani MC,Viola M,Venuti A,Palmieri V,Zeppilli P

    更新日期:2001-07-01 00:00:00

  • Skin Care and Synbiotics for Prevention of Atopic Dermatitis or Food Allergy in Newborn Infants: A 2 × 2 Factorial, Randomized, Non-Treatment Controlled Trial.

    abstract:BACKGROUND:Atopic dermatitis (AD) and food allergy (FA) are common childhood diseases, which may either be interrelated or be the result of skin barrier disruption and gut mucosal dysbiosis. Although some evidence suggests the efficacy of emollients and synbiotics, there is no conclusive evidence on the use of these in...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章,随机对照试验

    doi:10.1159/000501636

    authors: Dissanayake E,Tani Y,Nagai K,Sahara M,Mitsuishi C,Togawa Y,Suzuki Y,Nakano T,Yamaide F,Ohno H,Shimojo N

    更新日期:2019-01-01 00:00:00