Abstract：
INTRODUCTION:Cow's milk protein allergy (CMA) is the most common type of food allergy in childhood and exclusion diet is a challenge for patients. OBJECTIVE:The study aim was to investigate the frequency of tolerance to baked foods containing milk and evaluate immediate skin prick test (SPT) and specific IgEs for different cow's milk (CM) protein types as predictors of tolerance to baked foods containing milk for CMA patients. METHODS:A cross-sectional study was performed. Fifty-four CMA patients were enrolled and oral food challenge (OFC) was performed with baked product, 6 different milk SPTs and specific IgEs to CM, casein, α-lactalbumin, and β-lactoglobulin. RESULTS:Thirty-nine (72.2%) patients tolerated OFC with baked milk cupcake. CM-specific IgE and casein SPT showed statistical difference between positive and negative OFC groups. Probability curves for baked milk tolerance were created for specific CM IgE (Z = 2.542, p < 0.0110) and casein SPT (Z = 2.290, p < 0.0220) using logistic regression. CONCLUSIONS:The high percentage of patients able to tolerate baked goods enables an improvement in intake possibilities and quality of life of CMA patients and families. Specific CM IgE and casein SPT demonstrated to be useful predictors in relation to baked milk tolerance.
journal_name
Int Arch Allergy Immunoljournal_title
International archives of allergy and immunologyauthors
Vilar LK,Araújo FA,Santos TP,Menezes TT,Cheik MF,Segundo GRSdoi
10.1159/000511148subject
Has Abstractpub_date
2020-10-14 00:00:00pages
1-5eissn
1018-2438issn
1423-0097pii
000511148pub_type
新闻abstract：BACKGROUND:Helper T cells are involved in chronic eosinophilic inflammation. Control of cytokine production seems to be an effective management. METHODS:The effect of nonactin, SB203580, a p38 MAP kinase inhibitor, and JTE-711 on the cytokine production of allergen-specific T cell clones was determined. The effect of ...
journal_title：International archives of allergy and immunology
pub_type： 杂志文章
doi：10.1159/000053702
更新日期：2001-01-01 00:00:00
abstract：BACKGROUND:A growing body of evidence suggests that proinflammatory cytokines play a role in allergic inflammation by attracting and activating inflammatory cells. In this study, we have investigated the relationship between interleukin-8 (IL-8) in nasal lavage fluid and the local activation of eosinophils and neutroph...
journal_title：International archives of allergy and immunology
pub_type： 杂志文章
doi：10.1159/000023925
更新日期：1998-05-01 00:00:00
abstract：BACKGROUND:In patients showing multiple reactivity to seasonal airborne allergens, a skin prick test (SPT) with Parietaria pollen scores frequently negative, suggesting that profilin from Parietaria might not share IgE-binding epitopes with profilin from botanically unrelated airborne allergens. This study investigated...
journal_title：International archives of allergy and immunology
pub_type： 杂志文章
doi：10.1159/000076384
更新日期：2004-02-01 00:00:00
abstract：:T cells are central regulators and mediators of allergic sensitisation and disease. The house dust mite allergens are a biochemically diverse group of proteins which are present in extracts and the environment in a wide range of concentrations. Here the importance of ascertaining the contribution of the different alle...
journal_title：International archives of allergy and immunology
pub_type： 杂志文章,评审
doi：10.1159/000023824
更新日期：1998-01-01 00:00:00
abstract：:The clear recognition that asthma has an inflammatory basis has led to a search for genetic and environmental causes. Genetic linkage studies provide evidence for allelic association between polymorphic markers of interleukin-9 on chromosome 5 and a principal component of the allergic phenotype, log IgE. Further studi...
journal_title：International archives of allergy and immunology
pub_type： 杂志文章,评审
doi：10.1159/000236921
更新日期：1995-05-01 00:00:00
abstract：:Sensitivity to strong odors has a broad differential diagnosis. A presentation is made of a 60-year-old man with lifelong mild allergic rhinitis and a superimposed 4-year history of sensitivity to smells. He had no response to medical treatments or allergic immunotherapy. His physical examination was unremarkable. Aft...
journal_title：International archives of allergy and immunology
pub_type： 杂志文章
doi：10.1159/000316355
更新日期：2010-01-01 00:00:00
abstract：BACKGROUND:Exhaled nitric oxide (NO) measurement at multiple exhalation flow rates allows calculation of flow-independent NO parameters: alveolar NO concentration, bronchial NO flux, bronchial diffusing capacity of NO and bronchial wall NO concentration. METHODS:In the present study, we measured the flow-independent N...
journal_title：International archives of allergy and immunology
pub_type： 杂志文章
doi：10.1159/000155746
更新日期：2009-01-01 00:00:00
abstract：BACKGROUND:ADAM (a disintegrin and metalloprotease) family members, characterized by a metalloprotease and a disintegrin domain, are membrane-anchored glycoproteins involved in proteolysis and cell adhesion. ADAM8 might have an important role in allergic inflammation. It can cleave a variety of substrates and is a shed...
journal_title：International archives of allergy and immunology
pub_type： 杂志文章
doi：10.1159/000097359
更新日期：2007-01-01 00:00:00
abstract：:The downstream signaling components of high-affinity IgE receptor (FcepsilonRI) were studied using yeast two-hybrid screening of the cDNA library constructed from RBL-2H3 cells. The cytoplasmic part of the gamma-chain but not that of the beta-chain was found to interact with pyruvate kinase in the yeast. The in-vitro-...
journal_title：International archives of allergy and immunology
pub_type： 杂志文章
doi：10.1159/000024183
更新日期：1999-06-01 00:00:00
abstract：:A high-dose, accelerated escalation schedule during subcutaneous allergen-specific immunotherapy (AIT) is safe and well-tolerated in adults. However, there are no data in children and adolescents. The aim of the present trial was to assess safety and tolerability of an accelerated dose escalation schedule of an AIT wi...
journal_title：International archives of allergy and immunology
pub_type： 杂志文章
doi：10.1159/000512561
更新日期：2021-01-27 00:00:00
abstract：BACKGROUND:Kawasaki disease (KD) is an acute, systemic vasculitis in children, with an etiology that is not completely understood. It is assumed that the development of KD is mediated by an immunologic response. Several reports from East Asia have found a higher prevalence of atopic diseases among patients with KD, but...
journal_title：International archives of allergy and immunology
pub_type： 杂志文章
doi：10.1159/000447639
更新日期：2016-01-01 00:00:00
abstract：BACKGROUND:The clinical significance and efficacy of treating patients who have immunoglobulin (Ig) G subclass deficiency and/or antibody deficiency with Ig-replacement therapy has been debated. There are no clear guidelines to recommend intravenous gammaglobulin (IgIV) in these patients as there are few published stud...
journal_title：International archives of allergy and immunology
pub_type： 临床试验,杂志文章
doi：10.1159/000199723
更新日期：2009-01-01 00:00:00
abstract：BACKGROUND:The high-affinity IgE receptor, FcepsilonRI, is unresponsive on mast cells and basophils from people in several populations through an unknown mechanism. Similarly, FcepsilonRI-positive basophils from 'nonreleasers' are IgE-unresponsive and are deficient in the tyrosine kinase Syk. OBJECTIVE:To test the hyp...
journal_title：International archives of allergy and immunology
pub_type： 杂志文章
doi：10.1159/000087355
更新日期：2005-09-01 00:00:00
abstract：BACKGROUND:Sensitivity to the mite Blomia tropicalis is related to asthma in tropical climates, but correlates of sensitivity to B. tropicalis and its relationship to Dermatophagoides pteronyssinus sensitivity have not been widely examined in families with asthma. The main objective of this study was to determine preva...
journal_title：International archives of allergy and immunology
pub_type： 杂志文章
doi：10.1159/000070927
更新日期：2003-06-01 00:00:00
abstract：BACKGROUND:Exposure to Aspergillus fumigatus allergens results in the sensitization and the development of allergic bronchopulmonary aspergillosis in susceptible individuals. Aspergillus antigen consists of a number of chemically diverse components and their cumulative or synergistic effect may result in disease. When ...
journal_title：International archives of allergy and immunology
pub_type： 杂志文章
doi：10.1159/000065882
更新日期：2002-10-01 00:00:00
abstract：BACKGROUND:A subset of drug-intolerant patients show a marked propensity to react to several chemically unrelated antibacterial drugs. This condition is termed multiple drug allergy syndrome (MDAS). The pathogenesis of MDAS is still unclear. A possible mechanism is that a nonspecific patient-related factor leading to d...
journal_title：International archives of allergy and immunology
pub_type： 杂志文章
doi：10.1159/000071486
更新日期：2003-07-01 00:00:00
abstract：:We investigated the effects of KW-4679, an antiallergic drug, on the development of bronchial hyperresponsiveness, airway inflammation and early and late asthmatic responses following aerosol antigen challenge in guinea pigs actively sensitized by the inhalation of aerosolized ovalbumin. Pretreatment with KW-4679 (10 ...
journal_title：International archives of allergy and immunology
pub_type： 杂志文章
doi：10.1159/000237312
更新日期：1996-05-01 00:00:00
abstract：:Homogenates of bovine iris were fractionated by gel filtration chromatography, and the column-eluted proteins were probed with pooled sera obtained from patients with pauciarticular juvenile rheumatoid arthritis (JRA). The serum pool prepared from patients with pauciarticular JRA and a history of anterior uveitis, but...
journal_title：International archives of allergy and immunology
pub_type： 杂志文章
doi：10.1159/000236431
更新日期：1993-01-01 00:00:00
abstract：:Antiphospholipid antibody syndrome (APS) is characterized by autoantibodies against negatively charged phospholipids in the serum, and clinically by multiple thromboses, thrombocytopenia, and recurrent fetal loss. The mechanism(s) by which the antibodies cause the clinical picture are not clear. We review the possible...
journal_title：International archives of allergy and immunology
pub_type： 杂志文章,评审
doi：10.1159/000236883
更新日期：1995-01-01 00:00:00
abstract：BACKGROUND:Cross-sectional epidemiological studies have demonstrated that farm milk from traditional farm settings possesses allergoprotective properties. Up to now, it has not been clarified which milk ingredient is responsible for protection against allergic diseases. As farm milk is rich in conjugated linoleic acids...
journal_title：International archives of allergy and immunology
pub_type： 杂志文章
doi：10.1159/000358523
更新日期：2014-01-01 00:00:00
abstract：BACKGROUND:Studies comparing skin prick test (SPT) devices have revealed varying results in performance and there is little known about their use on children. METHODS:We performed 2 complementary studies to test the sensitivity, reproducibility and acceptability of commercially available SPT devices (Stallerpoint, Ant...
journal_title：International archives of allergy and immunology
pub_type： 杂志文章
doi：10.1159/000350788
更新日期：2013-01-01 00:00:00
abstract：BACKGROUND:Egg allergy is one of the most common food allergies in children. The standard therapy for egg allergy is strict avoidance. Yet, there is considerable clinical and scientific interest in primary or secondary prevention. A major drawback of oral tolerance (OT) induction protocols, however, is the possibility ...
journal_title：International archives of allergy and immunology
pub_type： 杂志文章
doi：10.1159/000363110
更新日期：2014-01-01 00:00:00
abstract：BACKGROUND:Nonsteroidal anti-inflammatory drugs (NSAIDS) are among the most common causes of drug hypersensitivity (HS) reactions. The diagnosis is based on a careful clinical history, and provocation tests are considered the gold standard for diagnosis. Skin tests have some value to study reactions to pyrazolones. Lab...
journal_title：International archives of allergy and immunology
pub_type： 杂志文章
doi：10.1159/000452627
更新日期：2016-01-01 00:00:00
abstract：:Mercuric chloride (HgCl(2)) has been proposed to be a mitogen for human blood lymphocytes in vitro. In our previous study, we demonstrated that HgCl(2) preferentially stimulates the CD4+ T cell subset to blast transformation and DNA synthesis and that the reaction is dependent on CD14+ accessory cells. In order to cha...
journal_title：International archives of allergy and immunology
pub_type： 杂志文章
doi：10.1159/000024221
更新日期：1999-09-01 00:00:00
abstract：BACKGROUND:Allergic conjunctivitis is characterized by itchy, watery and swollen eyes which occur in response to exposure to seasonal or environmental allergens. The early phase reaction of allergic conjunctivitis is primarily mediated by mast cell degranulation while the late phase reaction is driven by Th2 cells and ...
journal_title：International archives of allergy and immunology
pub_type： 杂志文章
doi：10.1159/000328769
更新日期：2012-01-01 00:00:00
abstract：:The modulatory role of hormones in the regulation of the immune response has been well documented. Here, we present some thoughts on how sex hormones affect immunity, particularly at mucosal sites. We further discuss the possible pitfalls and difficulties associated with analysis of the data. ...
journal_title：International archives of allergy and immunology
pub_type： 杂志文章,评审
doi：10.1159/000236631
更新日期：1994-01-01 00:00:00
abstract：BACKGROUND:Cry j 1 and Cry j 2 are thought to be the major allergens of Japanese cedar pollen. HLA class II types capable of presenting T-cell epitopes in both allergens and their role in induction of T-cell subsets are not well known. METHODS:CD4+ T (Th)-cell clones (TCCs) specific to either Cry j 1 or Cry j 2 were g...
journal_title：International archives of allergy and immunology
pub_type： 杂志文章
doi：10.1159/000024194
更新日期：1999-07-01 00:00:00
abstract：BACKGROUND:A number of different molecules are known to be involved in the signal pathway to release histamine from mast cells, among which arachidonic acid (AA) is one of the key mediators. On the other hand, we found that the application of compound 48/80, a typical histamine liberator, generated superoxide in mast c...
journal_title：International archives of allergy and immunology
pub_type： 杂志文章
doi：10.1159/000070216
更新日期：2003-04-01 00:00:00
abstract：BACKGROUND:The population of large parts of Africa, South America and travellers to these areas are at risk of yellow fever (YF) with a 50% mortality risk. Yellow fever vaccine (YFV) propagated in hens' eggs confers protection in 95% of the vaccinated. The rate of anaphylaxis for YFV ranges from 0.42 to 1.8/100,000 dos...
journal_title：International archives of allergy and immunology
pub_type： 杂志文章
doi：10.1159/000346350
更新日期：2013-01-01 00:00:00
abstract：BACKGROUND:Cytosolic phospholipase A2 (cPLA2) plays a key role in the development of late-phase anaphylaxis. L-Glutamine (Gln), a nonessential amino acid, has anti-inflammatory activity via inhibiting cPLA2. METHODS:We used a penicillin-induced murine model of anaphylaxis, and late-phase anaphylaxis was quantified by ...
journal_title：International archives of allergy and immunology
pub_type： 杂志文章
doi：10.1159/000452103
更新日期：2016-01-01 00:00:00
