Abstract：
BACKGROUND:Endogenous IL-17 is needed for the Ag sensitization that results in murine allergic asthma, a Th2-mediated disease. Here, we aimed to investigate the role IL-17 plays in the development of murine experimental allergic conjunctivitis (EC) which is also a Th2-mediated disease. METHODS:To induce EC, wild-type (WT) and IL-17-deficient (IL-17 KO) mice on the BALB/c and C57BL/6 backgrounds were immunized with ragweed (RW) in alum and challenged with RW in eye drops. Alternatively, EC was induced by adoptively transferring RW-primed splenocytes followed by challenge with RW-containing eye drops. Twenty-four hours after the RW challenge, the conjunctivas and spleens were harvested for histological analyses and cytokine assays, respectively. RESULTS:The WT and IL-17 KO mice on both backgrounds did not differ in terms of the severity of actively induced EC, as evaluated by the conjunctival eosinophil infiltration. They also did not differ with regard to the phenotypes of the inflammatory cells infiltrating the conjunctivas, although primed IL-17 KO splenocytes stimulated in vitro with RW extract did produce significantly higher amounts of IL-4, IL-13 and IFN-gamma than WT splenocytes. Reciprocal adoptive transfer experiments also demonstrated that the IL-17 from both the donor splenocytes and the recipient mice is not involved in the development of EC. CONCLUSIONS:Endogenous IL-17 does not appear to play a significant role in the development of EC.
journal_name
Int Arch Allergy Immunoljournal_title
International archives of allergy and immunologyauthors
Fukushima A,Sumi T,Ishida W,Yamada J,Iwakura Y,Ueno Hdoi
10.1159/000142043subject
Has Abstractpub_date
2008-01-01 00:00:00pages
206-12issue
3eissn
1018-2438issn
1423-0097pii
000142043journal_volume
147pub_type
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journal_title：International archives of allergy and immunology
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journal_title：International archives of allergy and immunology
pub_type： 杂志文章
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journal_title：International archives of allergy and immunology
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journal_title：International archives of allergy and immunology
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journal_title：International archives of allergy and immunology
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pub_type： 杂志文章
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pub_type： 杂志文章,随机对照试验
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journal_title：International archives of allergy and immunology
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journal_title：International archives of allergy and immunology
pub_type： 杂志文章
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journal_title：International archives of allergy and immunology
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journal_title：International archives of allergy and immunology
pub_type： 杂志文章
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journal_title：International archives of allergy and immunology
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journal_title：International archives of allergy and immunology
pub_type： 杂志文章
doi：10.1159/000073719
更新日期：2003-10-01 00:00:00
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journal_title：International archives of allergy and immunology
pub_type： 杂志文章
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更新日期：1997-11-01 00:00:00
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journal_title：International archives of allergy and immunology
pub_type： 杂志文章
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journal_title：International archives of allergy and immunology
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pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：International archives of allergy and immunology
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journal_title：International archives of allergy and immunology
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journal_title：International archives of allergy and immunology
pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：International archives of allergy and immunology
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journal_title：International archives of allergy and immunology
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pub_type： 杂志文章,随机对照试验
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journal_title：International archives of allergy and immunology
pub_type： 杂志文章
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pub_type： 杂志文章
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