Abstract：
BACKGROUND:Although common variable immunodeficiency (CVID) is associated with sinopulmonary disease, there are no previous systematic evaluations comparing computed tomographic (CT) sinus imaging with immunoglobulin measurements in patients with this condition. METHODS:We performed a retrospective review by a blinded observer using the Lund-Mackay numerical scoring scale as well as a visual scale for remodeling changes in the paranasal sinus bone on CT scans in CVID patients. RESULTS:The sinus CT scans of 19 subjects (9 males, 10 females; median age at diagnosis 34 years) are described. There was an inverse relationship between serum IgM and sinus mucosal thickening as described by the Lund-Mackay scale (R = -0.6398; p = 0.0032). Osteitis of the paranasal sinus bone was almost exclusively found in patients with a reduced serum IgM level of less than 25 mg/dl (p = 0.0074). CONCLUSION:This is the first study to show that sinus mucosal thickening on CT in patients with CVID is inversely related to serum IgM levels.
journal_name
Int Arch Allergy Immunoljournal_title
International archives of allergy and immunologyauthors
Hagan JB,Park MA,Kita H,Campeau NGdoi
10.1159/000260088subject
Has Abstractpub_date
2010-01-01 00:00:00pages
81-6issue
1eissn
1018-2438issn
1423-0097pii
000260088journal_volume
152pub_type
杂志文章abstract：BACKGROUND:A new lateral flow test (LFT) for office use provides information about sensitisation to common allergens. Concordance between LFT and skin-prick test (SPT) has not been assessed in epidemiological studies. The aim of this study is to determine LFT-SPT concordance in this field. METHODS:Plasma samples (n = ...
journal_title：International archives of allergy and immunology
pub_type： 杂志文章
doi：10.1159/000288291
更新日期：2010-01-01 00:00:00
abstract：:We studied the binding activities of IgE, IgG and IgA antibodies in patients with allergy to hen's egg white against two different ovalbumin (OVA) preparations, which were physically or chemically denatured OVA and enzyme-digested OVA fragments. The binding activities of IgE antibodies to these OVA preparations with t...
journal_title：International archives of allergy and immunology
pub_type： 杂志文章
doi：10.1159/000236602
更新日期：1994-01-01 00:00:00
abstract：BACKGROUND:Jellyfish stings cause painful, papular-urticarial eruptions due to the immediate allergic, acute toxic and persistent inflammatory responses. In spite of many marine accidents and their economic impact, modes of first-aid treatment remain conventional and specific allergen and medical treatment are not yet ...
journal_title：International archives of allergy and immunology
pub_type： 杂志文章
doi：10.1159/000434721
更新日期：2015-01-01 00:00:00
abstract：:Kimura disease is a rare disorder of unknown etiology, characterized by the presence of benign subcutaneous granuloma, marked peripheral blood eosinophilia and elevation of the immunglobulin E (IgE) serum level. Here, we present a case of a 12-year-old boy with Kimura disease who had a history of repeated severe influ...
journal_title：International archives of allergy and immunology
pub_type： 杂志文章
doi：10.1159/000337777
更新日期：2012-01-01 00:00:00
abstract：:Ever since the realization that T lymphocytes are key players in the defense against pathogens and tumors, a major aim of immunologists has been to understand the relationship between the functional and migratory properties of antigen-specific T cells. The current paradigm proposes that T cells follow organ-specific t...
journal_title：International archives of allergy and immunology
pub_type： 杂志文章,评审
doi：10.1159/000074896
更新日期：2003-12-01 00:00:00
abstract：BACKGROUND:The importance of fungal allergens in the development of allergic diseases in a desert environment is uncertain. This study evaluated the prevalence of IgE sensitization to moulds among patients with allergic respiratory diseases in Kuwait - a desert country. METHODS:A total of 810 patients (male:female rat...
journal_title：International archives of allergy and immunology
pub_type： 杂志文章
doi：10.1159/000024343
更新日期：2000-04-01 00:00:00
abstract：BACKGROUND:The cytokine transforming growth factor-beta(TGF-beta) has important regulatory roles in the immune system. To investigate the role of intact TGF-beta signaling during the contact hypersensitivity (CHS) response to a respiratory allergen, we exposed Smad3-/- mice to topical trimellitic anhydride (TMA). METH...
journal_title：International archives of allergy and immunology
pub_type： 杂志文章
doi：10.1159/000236006
更新日期：2010-01-01 00:00:00
abstract：BACKGROUND:Little is known about the relation between allergic rhinitis severity and airborne pollen in combination with air pollutants. OBJECTIVE:To model the risk of suffering from severe seasonal allergic rhinitis (SAR) as a function of both pollen count and air pollution levels in a large nationwide sample of pati...
journal_title：International archives of allergy and immunology
pub_type： 杂志文章
doi：10.1159/000332964
更新日期：2012-01-01 00:00:00
abstract：BACKGROUND:Patients with chronic urticaria (CU) in the UK could be referred to health care professionals (HCPs) with diverse specialties using different guidelines. The aims of the present study were to determine which CU guidelines HCPs in the UK use, which tests they use for the diagnosis of CU, and how they manage C...
journal_title：International archives of allergy and immunology
pub_type： 杂志文章
doi：10.1159/000430442
更新日期：2015-01-01 00:00:00
abstract：:Mast cells are recognized not only as the major effector cells of type I hypersensitivity reactions but also as an important player of innate immune response against bacterial infection. Type I IFNs are also involved in the response against bacterial infection. However, the role of type I IFNs and their associated Jan...
journal_title：International archives of allergy and immunology
pub_type： 杂志文章
doi：10.1159/000077789
更新日期：2004-06-01 00:00:00
abstract：:Patients with atopic dermatitis (AD) are frequently colonized with Staphylococcus aureus strains secreting exotoxins such as the staphylococcal enterotoxin B (SEB) and A (SEA). Nonetheless the role of SEB and SEA in AD is yet unknown. We analyzed the responsiveness of peripheral blood mononuclear cells (PBMCs) and iso...
journal_title：International archives of allergy and immunology
pub_type： 杂志文章
doi：10.1159/000236832
更新日期：1995-02-01 00:00:00
abstract：BACKGROUND:Matrix metalloproteinase (MMP)-2, MMP-9 and MMP-13 can degrade type IV collagen which is the major component of the basement membrane zone (BMZ). In bullous pemphigoid (BP), the separation occurs within the BMZ. OBJECTIVE:To evaluate the involvement of MMPs in the pathogenesis of BP, we examined the express...
journal_title：International archives of allergy and immunology
pub_type： 杂志文章
doi：10.1159/000090385
更新日期：2006-01-01 00:00:00
abstract：BACKGROUND:Epidemiological data on food allergy are scarce in African countries. We studied the prevalence of food sensitization in Ghanaian schoolchildren. METHODS:Children (5-16 years; n = 1,714) from 9 Ghanaian schools were given parental consent to participate in the study. Adverse reactions and food consumption w...
journal_title：International archives of allergy and immunology
pub_type： 杂志文章
doi：10.1159/000318704
更新日期：2011-01-01 00:00:00
abstract：:The perchloric-acid-soluble Bacille bilié de Calmette-Guérin (BCG) antigen (BCG-P) was investigated for the diagnosis of tuberculosis. Monoclonal antibodies against BCG-P were produced. After SDS-PAGE, silver staining and immunoblotting were done. Pathological specimens of pulmonary tuberculosis, BCG organism itself a...
journal_title：International archives of allergy and immunology
pub_type： 杂志文章
doi：10.1159/000236476
更新日期：1993-01-01 00:00:00
abstract：:In the present study, we investigated the role of resident peritoneal cells as well as the mediators involved in the eosinophil migration induced by large volumes of physiological saline. Two consecutive intraperitoneal injections of saline given 48 h apart, induced a selective recruitment of eosinophils into the cavi...
journal_title：International archives of allergy and immunology
pub_type： 杂志文章
doi：10.1159/000236687
更新日期：1994-08-01 00:00:00
abstract：BACKGROUND:Recombinant allergens are preferred over natural allergen extracts in measuring antibodies. We tested the use of recombinant variants of the major mouse allergen Mus m 1 in detection of mouse-specific antibodies in sera of laboratory animal workers and children. METHODS:Six recombinant major urinary protein...
journal_title：International archives of allergy and immunology
pub_type： 杂志文章
doi：10.1159/000106318
更新日期：2007-01-01 00:00:00
abstract：BACKGROUND:Exposure to Aspergillus fumigatus allergens results in the sensitization and the development of allergic bronchopulmonary aspergillosis in susceptible individuals. Aspergillus antigen consists of a number of chemically diverse components and their cumulative or synergistic effect may result in disease. When ...
journal_title：International archives of allergy and immunology
pub_type： 杂志文章
doi：10.1159/000065882
更新日期：2002-10-01 00:00:00
abstract：BACKGROUND:Nasal polyps are a common health problem that can significantly impact the quality of life. OBJECTIVE:To analyze the impact of allergy and peripheral eosinophils (EOS) on the morbidity of chronic rhinosinusitis with nasal polyps (CRSwNP) in Northwest China. METHODS:A retrospective cohort of 323 patients wh...
journal_title：International archives of allergy and immunology
pub_type： 杂志文章
doi：10.1159/000497384
更新日期：2019-01-01 00:00:00
abstract：BACKGROUND:Allergic bronchopulmonary aspergillosis (ABPA) develops in the presence of predisposing conditions such as asthma and cystic fibrosis. Even ABPA accompanied by asthma is often complicated by chronic Pseudomonas aeruginosa or nontuberculous mycobacterial infection of the lower respiratory tract, rendering tre...
journal_title：International archives of allergy and immunology
pub_type： 杂志文章
doi：10.1159/000507216
更新日期：2020-01-01 00:00:00
abstract：BACKGROUND:The clinical significance and efficacy of treating patients who have immunoglobulin (Ig) G subclass deficiency and/or antibody deficiency with Ig-replacement therapy has been debated. There are no clear guidelines to recommend intravenous gammaglobulin (IgIV) in these patients as there are few published stud...
journal_title：International archives of allergy and immunology
pub_type： 临床试验,杂志文章
doi：10.1159/000199723
更新日期：2009-01-01 00:00:00
abstract：:The present study was designed to determine if depletion of the complement system in the circulation with cobra venom factor (CVF) prevented the cellular infiltration in a guinea pig model of asthma. Guinea pigs were sensitized with ovalbumin (OA) alone or OA with complete Freund's adjuvant. Animals were pretreated wi...
journal_title：International archives of allergy and immunology
pub_type： 杂志文章
doi：10.1159/000237214
更新日期：1996-02-01 00:00:00
abstract：:Homogenates of bovine iris were fractionated by gel filtration chromatography, and the column-eluted proteins were probed with pooled sera obtained from patients with pauciarticular juvenile rheumatoid arthritis (JRA). The serum pool prepared from patients with pauciarticular JRA and a history of anterior uveitis, but...
journal_title：International archives of allergy and immunology
pub_type： 杂志文章
doi：10.1159/000236431
更新日期：1993-01-01 00:00:00
abstract：BACKGROUND:The Notch signaling pathway plays an important role in regulating human immune function, but the relationship between allergic rhinitis (AR) and Notch signaling remains unclear. OBJECTIVE:To investigate the role of Notch signaling in the pathogenesis of AR and its regulation on Foxp3-Treg cells. METHOD:The...
journal_title：International archives of allergy and immunology
pub_type： 杂志文章
doi：10.1159/000493328
更新日期：2019-01-01 00:00:00
abstract：BACKGROUND:Pre-clinical and clinical studies have evaluated the efficacy of probiotics in allergy. However, predictive in vitro systems for rational strain selection are still missing. METHODS:We developed a novel in vitro screening system for the characterization of probiotics with anti-allergic potential. In this mo...
journal_title：International archives of allergy and immunology
pub_type： 杂志文章
doi：10.1159/000343703
更新日期：2013-01-01 00:00:00
abstract：:We studied the effect of NZ-107 in a number of animal models of anaphylactic bronchoconstriction. In conscious guinea pigs, pretreated with indomethacin, pyrilamine and propranolol, passively sensitized with heterologous anti serum, NZ-107 in doses of 10-30 mg/kg per os inhibited the aerosolized antigen-induced cough ...
journal_title：International archives of allergy and immunology
pub_type： 杂志文章
doi：10.1159/000236103
更新日期：1992-01-01 00:00:00
abstract：:A 73-year-old man developed organized pneumonia with severe right-sided eosinophilic pleural effusion (PE). CD69+ and HLA-DR+ eosinophils in PE were 90 and 31%, respectively, but were undetectable in peripheral blood (PB). CD4+, CD45RA+ (naive) and CD4+, CD45RO+ (memory) cells in PB, PE and bronchoalveolar lavage (BAL...
journal_title：International archives of allergy and immunology
pub_type： 杂志文章
doi：10.1159/000237368
更新日期：1996-10-01 00:00:00
abstract：BACKGROUND:The aim was to determine the clinical characteristics of patients with seasonal rhinitis (SR) and to disclose differences in the treatment of SR between an adult allergy clinic and other clinics over time. METHODS:A retrospective study was conducted based on clinical records of 774 out of 955 patients diagn...
journal_title：International archives of allergy and immunology
pub_type： 杂志文章
doi：10.1159/000087360
更新日期：2005-09-01 00:00:00
abstract：INTRODUCTION:The aim of this study was to evaluate the effectiveness of specific immunotherapy (SIT) management with allergoids in children with allergic asthma by monitoring changes in clinical parameters and inflammatory markers in exhaled breath. METHODS:The study population included 43 patients (24 males) of 6-14 ...
journal_title：International archives of allergy and immunology
pub_type： 杂志文章
doi：10.1159/000368832
更新日期：2014-01-01 00:00:00
abstract：BACKGROUND:The cervical sympathetic trunk-submandibular gland (CST-SMG) axis plays an important role in inflammation. An immunoregulatory heptapeptide, submandibular gland peptide T (SGP-T), was isolated from submandibular glands, and several of its biological activities have been identified. RESULTS:SGP-T reduced sho...
journal_title：International archives of allergy and immunology
pub_type： 杂志文章
doi：10.1159/000237594
更新日期：1997-05-01 00:00:00
abstract：BACKGROUND:Transforming growth factor-β1 (TGF-β1)-in-duced proliferation of airway smooth muscle cells plays critical roles in the development of airway remodeling. Six1 (sine oculis homeobox homolog 1) has been demonstrated to be involved in airway inflammation and remodeling in asthmatic mice. OBJECTIVES:The aim of ...
journal_title：International archives of allergy and immunology
pub_type： 杂志文章
doi：10.1159/000505064
更新日期：2020-01-01 00:00:00
