Prolonged antigen exposure ameliorates airway inflammation but not remodeling in a mouse model of bronchial asthma.

abstract：:Adhesion molecules of microvascular endothelial cells play a key role in the inflammatory processes involved in nonallergic sinusitis. We investigated the cytokine-regulated expression of intercellular adhesion molecule-1 (ICAM-1), E-selectin and vascular cell adhesion molecule-1 (VCAM-1), and the effect of dexamethas...

journal_title：International archives of allergy and immunology

authors： Yamamoto Y,Ikeda K,Watanabe M,Shimomura A,Suzuki H,Oshima T,Imamura Y,Ohuchi K,Takasaka T

更新日期：1998-09-01 00:00:00

abstract：BACKGROUND:Penicillium chrysogenum (Penicillium notatum) is a prevalent airborne Penicillium species. A 34-kD major IgE-reacting component from P. chrysogenum has been identified as an alkaline serine protease (Pen ch 13, also known as Pen n 13 before) by immunoblot and N-terminal amino acid sequence analysis. METHODS...

journal_title：International archives of allergy and immunology

authors： Chou H,Lai HY,Tam MF,Chou MY,Wang SR,Han SH,Shen HD

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Grape allergy is considered rare; grape lipid transfer protein (LTP; Vit v 1), an endochitinase and a thaumatin-like protein (TLP) have been reported as grape allergens. A considerable number of patients have referred to our department for severe reactions to grapes, and several IgE binding proteins were det...

journal_title：International archives of allergy and immunology

authors： Vassilopoulou E,Zuidmeer L,Akkerdaas J,Tassios I,Rigby NR,Mills EN,van Ree R,Saxoni-Papageorgiou P,Papadopoulos NG

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Activated eosinophils are thought to play an important role in allergic inflammation. Prior reports suggest that eosinophils have receptors recognizing IgA, IgG and IgE; however, little is known regarding the direct effects of antigens and antigen-specific immunoglobulins on the functions of eosinophils. ME...

journal_title：International archives of allergy and immunology

authors： Muraki M,Gleich GJ,Kita H

更新日期：2011-01-01 00:00:00

abstract：:Anti-cyclic citrullinated peptide antibodies (anti-CCP) are a new diagnostic marker for rheumatoid arthritis (RA), which shows a specificity of 97% and a sensitivity of 81% in the second generation assay. About 61% of RA patients express HLA-DRB1*0401. In a cohort of patients with RA we investigated whether the expres...

journal_title：International archives of allergy and immunology

authors： Senkpiehl I,Marget M,Wedler M,Jenisch S,Georgi J,Kabelitz D,Steinmann J

更新日期：2005-08-01 00:00:00

abstract：:A peptide B3144, derived after peptic tryptic digestion of alpha-gliadin and corresponding to residues 3-56 from the coeliac-activating domain I, was previously used to produce monoclonal antibodies. A dot immunobinding assay was developed using these antibodies to detect gluten in wheat, rye, barley and oats. The lim...

journal_title：International archives of allergy and immunology

authors： Ellis HJ,Doyle AP,Day P,Wieser H,Ciclitira PJ

更新日期：1994-07-01 00:00:00

abstract：BACKGROUND:Cannabinoid (CB) 2 is expressed on immune and inflammatory cells. Identification of 2-arachidonyl glycerol (2-AG) and anandamide as endogenous CB2 ligands has allowed investigations of the roles of CB2 and its endogenous ligand system in inflammatory cells. However, the roles of this receptor-ligand system i...

journal_title：International archives of allergy and immunology

authors： Mimura T,Oka S,Koshimoto H,Ueda Y,Watanabe Y,Sugiura T

更新日期：2012-01-01 00:00:00

abstract：:Drug hypersensitivity reactions (DHR) are clinically and functionally heterogeneous. Different subclassifications based on timing of symptom appearance or type of immune mechanism have been proposed. Here, we show that the mode of action of drugs leading to immune/inflammatory cell stimulation is a further decisive fa...

journal_title：International archives of allergy and immunology

authors： Pichler WJ,Hausmann O

更新日期：2016-01-01 00:00:00

abstract：:The allergic pig can be used as a large-animal model for studies of allergic reactions in the airways and the role of eosinophils in such reactions. To measure the activation of eosinophils, the release of eosinophil-derived cationic proteins can be used. The purpose of this study was to isolate and characterize catio...

journal_title：International archives of allergy and immunology

authors： Fornhem C,Peterson CG,Alving K

更新日期：1996-06-01 00:00:00

abstract：BACKGROUND:Lactation is associated with an inhibited hypothalamic-pituitary-adrenal axis response to physical and psychological stress in women and female rats. However, suckling also improved mood and calmness in nonatopic lactating women. Relaxation by humor reduced allergen-induced skin wheal responses, while variou...

journal_title：International archives of allergy and immunology

authors： Kimata H

更新日期：2003-12-01 00:00:00

abstract：BACKGROUND:Depression and smoking contribute to the prognosis of autoimmune rheumatoid arthritis (RA). Advanced glycation end products (AGEs) are also detected in RA patients. This study correlates RA in patients with various levels of depression and a history of smoking through the detection of antibodies against AGEs...

journal_title：International archives of allergy and immunology

authors： Alouffi S,Sherwani S,Al-Mogbel MS,Sherwani MKA,Ali Khan MW

更新日期：2018-01-01 00:00:00

abstract：:Long-term birth cohort studies are essential to understanding the life course and childhood predictors of allergy and the complex interplay between genes and the environment (including lifestyle and socioeconomic determinants). Over 100 cohorts focusing on asthma and allergy have been initiated in the world over the p...

journal_title：International archives of allergy and immunology

authors： Bousquet J,Anto J,Sunyer J,Nieuwenhuijsen M,Vrijheid M,Keil T,MeDALL Study Group.,CHICOS Study Group.,ENRIECO Study Group.,GA²LEN Study Group.

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Over the past years, dust of green coffee beans has become known to be a relevant cause for occupational type I allergies. Up to now, allergy diagnostics is based on native green coffee bean extract which exhibits insufficient specificity due to interfering substances as well as batch-to-batch variations. No...

journal_title：International archives of allergy and immunology

authors： Manavski N,Peters U,Brettschneider R,Oldenburg M,Baur X,Bittner C

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Shellfish hypersensitivity is amongst the most common food allergies. The major shellfish allergen was identified as tropomyosin. Here, we investigated the immediate hypersensitivity responses, IgE and cell-mediated immune response in mice sensitized with recombinant shrimp tropomyosin. METHODS:Shrimp tropo...

journal_title：International archives of allergy and immunology

authors： Leung PS,Lee YS,Tang CY,Kung WY,Chuang YH,Chiang BL,Fung MC,Chu KH

更新日期：2008-01-01 00:00:00

abstract：INTRODUCTION:One of the most frequent abnormalities of B cells in common variable immunodeficiency (CVID) is reduced number of class-switched memory B cells, suggesting an impaired germinal center response. Therefore, due to its pivotal role in regulating the development of humoral immunity, the objective of this study...

journal_title：International archives of allergy and immunology

authors： Kasahara TM,Bento CAM,Gupta S

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Adoptive transfer of helper T (Th) cells conferred a late asthmatic response upon antigen challenge. A possible production of a contractile activity for bronchial smooth muscle (BSM) by activated Th cells was examined. METHOD:Murine Th clones were stimulated with immobilized anti-CD3 antibody in the presenc...

journal_title：International archives of allergy and immunology

authors： Abe A,Koyama S,Ohtomo T,Kitamura N,Kaminuma O,Mori A

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Sensitivity to the mite Blomia tropicalis is related to asthma in tropical climates, but correlates of sensitivity to B. tropicalis and its relationship to Dermatophagoides pteronyssinus sensitivity have not been widely examined in families with asthma. The main objective of this study was to determine preva...

journal_title：International archives of allergy and immunology

authors： Manolio TA,Barnes KC,Naidu RP,Levett PN,Beaty TH,Wilson AF

更新日期：2003-06-01 00:00:00

abstract：BACKGROUND:Eosinophils develop from bone marrow (BM) progenitors, and interleukin-5 (IL-5) and eotaxin may act in expansion and mobilisation of BM eosinophils in asthma. METHODS:We have examined phenotypic changes as CD34+ cells develop to the eosinophil lineage in vitro, and have evaluated BM eosinophils from asthmat...

journal_title：International archives of allergy and immunology

authors： Robinson DS,North J,Zeibecoglou K,Ying S,Meng Q,Rankin S,Hamid Q,Tavernier J,Kay AB

更新日期：1999-02-01 00:00:00

abstract：:Eosinophils are pleiotropic multi-functional leukocytes involved in initiation and propagation of diverse inflammatory responses. Recent studies examining eosinophil biology have focused on delineating the molecular basis of FIP1L1/PDGRFalpha-fusion gene induced HES, the molecular steps involved in eosinophil recruitm...

journal_title：International archives of allergy and immunology

authors： Hogan SP

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:To understand how the high-affinity IgE receptor (FcepsilonRI) communicates with downstream effectors, we focused on exploring the functional importance of the FcepsilonRI-mediated formation and localization of a signaling complex that contains the hematopoietic cell-specific scaffolding protein linker for a...

journal_title：International archives of allergy and immunology

authors： Rivera J,Arudchandran R,Gonzalez-Espinosa C,Manetz TS,Xirasagar S

更新日期：2001-01-01 00:00:00

abstract：:Accumulation and activation of eosinophils in tissue are critical events in the allergic inflammatory response and adhesion molecules play important roles in this process. We previously demonstrated that human eosinophils expressed a nuclear receptor, peroxisome proliferator-activated receptor gamma (PPARgamma), and t...

journal_title：International archives of allergy and immunology

authors： Hirasawa H,Chiba T,Ueki S,Kamada Y,Ito W,Takeda M,Fujita M,Kato H,Kayaba H,Chihara J

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:The cysteinyl leukotrienes (CysLTs) mediate their biological actions through two receptors: CysLT(1) receptor and CysLT(2) receptor. OBJECTIVE:This study was undertaken to examine the direct effects of CysLTs on eosinophils, such as chemotaxis and degranulation, focusing on CysLT(1). METHODS:Eosinophils we...

journal_title：International archives of allergy and immunology

authors： Ohshima N,Nagase H,Koshino T,Miyamasu M,Yamaguchi M,Hirai K,Yamamoto K,Fujisawa T,Nakagawa N,Kishikawa K,Morita Y

更新日期：2002-09-01 00:00:00

abstract：:We describe an HLA-B8, DR3-positive patient with localized morphea after silicone gel breast implantation for cosmetic reasons. We believe that this case suggests that a genetic background, i.e. HLA-B8, DR3 haplotype, is involved in the autoimmune response to silicone. ...

journal_title：International archives of allergy and immunology

authors： Di Lorenzo G,Mansueto P,Melluso M,Sangiorgi GB,Cigna D,Candore G,Caruso C

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:Recombinant allergens are preferred over natural allergen extracts in measuring antibodies. We tested the use of recombinant variants of the major mouse allergen Mus m 1 in detection of mouse-specific antibodies in sera of laboratory animal workers and children. METHODS:Six recombinant major urinary protein...

journal_title：International archives of allergy and immunology

authors： Krop EJ,Matsui EC,Sharrow SD,Stone MJ,Gerber P,van der Zee JS,Chapman MD,Aalberse RC

更新日期：2007-01-01 00:00:00

abstract：INTRODUCTION:Hereditary angioedema (HAE) with C1 inhibitor (C1-INH) deficiency is a rare autosomal dominant disease. Although the first symptoms can appear in childhood, the diagnosis's delay has a strong impact on the patient's quality of life. We analyzed clinical and laboratory characteristics and the drug therapy o...

journal_title：International archives of allergy and immunology

authors： Araújo-Simões J,Boanova AGP,Constantino-Silva RN,Fragnan NTML,Pinto JA,Minafra FG,Gonçalves RF,Valle SRD,Alonso MLO,Dortas SD,Goudouris ES,Rêgo-Silva AM,Marques MM,Serpa FS,Chong-Neto HJ,Nelson RF,Mansour E,Moreira IF,

更新日期：2021-01-28 00:00:00

abstract：:Human colostrum and a high molecular weight colostrum fraction (HMWF; > 14,000 D) prevented the adhesion of localized adherent (LA+) O111:H-enteropathogenic Escherichia coli (EPEC) to HeLa cells. This effect was abolished after absorption with an O111:H-LA + EPEC strain, but absorption with a LA- strain of same seroty...

journal_title：International archives of allergy and immunology

authors： Camara LM,Carbonare SB,Silva ML,Carneiro-Sampaio MM

更新日期：1994-01-01 00:00:00

abstract：:Many different mediators have been implicated in allergic responses and allergic diseases of the respiratory tract. The influence of several allergic inflammatory mediators on the ciliary activity has been well studied. However, ciliary responsiveness to platelet-activating factor (PAF) is yet to be established conclu...

journal_title：International archives of allergy and immunology

authors： Ohashi Y,Ohno Y,Sugiura Y,Okamoto H,Tanaka A,Kakinoki Y,Sakamoto H,Hayashi M,Nakai Y

更新日期：1994-07-01 00:00:00

abstract：:Besides stem cell factor (SCF), additional fibroblast-derived mast cell growth factors have previously been described. Since keratinocytes have also been shown to produce SCF, we have studied the ability of culture supernatants from the human HaCaT keratinocyte cell line to induce SCF-independent mast cell differentia...

journal_title：International archives of allergy and immunology

authors： Welker P,Grabbe J,Czarnetzki BM

更新日期：1995-05-01 00:00:00

abstract：:The low responsiveness of contact sensitivity (CS) in sensitized and challenged mice was induced by using hapten-amino acid derivatives. Subcutaneous injection of trinitrophenyl (TNP)-lysine or oxazolone-glycine inhibited ear swelling responses in mice that received rechallenge. The inhibitory effect was long-lasting ...

journal_title：International archives of allergy and immunology

authors： Satoh T,Yokozeki H,Katayama I,Nishioka K

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND:Chronic rhinosinusitis (CRS) is a multifaceted disease with a significant genetic component. The importance of taste receptor signaling has recently been highlighted in CRS; single nucleotide polymorphisms (SNPs) of bitter tastant-responsive G-protein-coupled receptors have been linked with CRS and with alte...

journal_title：International archives of allergy and immunology

authors： Purnell PR,Addicks BL,Zalzal HG,Shapiro S,Wen S,Ramadan HH,Setola V,Siderovski DP

更新日期：2019-01-01 00:00:00