Involvement of the endogenous cannabinoid 2 ligand 2-arachidonyl glycerol in allergic inflammation.

abstract：BACKGROUND:The lymphocyte transformation test (LTT) is used for in vitro diagnosis of drug hypersensitivity reactions. While its specificity is over 90%, sensitivity is limited and depends on the type of reaction, drug and possibly time interval between the event and analysis. Removal of regulatory T cells (Treg/CD25(h...

journal_title：International archives of allergy and immunology

authors： Srinoulprasert Y,Pichler WJ

更新日期：2014-01-01 00:00:00

abstract：:Interaction between vascular cell adhesion molecule-1 (VCAM-1) on endothelial cells and CD49d molecules on eosinophils is thought to mediate the selective infiltration of eosinophils into inflamed tissues in allergic disease. IL-4 and TNF-alpha are associated with allergic conditions, and they have been shown to selec...

journal_title：International archives of allergy and immunology

authors： Saito H,Shimizu H,Mita H,Maeda Y,Akiyama K

更新日期：1996-10-01 00:00:00

abstract：BACKGROUND:The aim was to determine the clinical characteristics of patients with seasonal rhinitis (SR) and to disclose differences in the treatment of SR between an adult allergy clinic and other clinics over time. METHODS:A retrospective study was conducted based on clinical records of 774 out of 955 patients diagn...

journal_title：International archives of allergy and immunology

authors： Bozkurt B,Karakaya G,Kalyoncu AF

更新日期：2005-09-01 00:00:00

abstract：BACKGROUND:Asthma is a major health problem worldwide, and the morbidity and mortality caused by asthma are on the rise. Corticosteroid therapies for asthma treatment frequently induce many side effects. Therefore, the development of new medicines that have both high efficacy and fewer side effects has been a scientifi...

journal_title：International archives of allergy and immunology

authors： Lim YJ,Na HS,Yun YS,Choi IS,Oh JS,Rhee JH,Cho BH,Lee HC

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Serum-derived hyaluronan (HA)-associated proteins (SHAPs), the heavy chains of inter-α-trypsin inhibitor, covalently bind to HA to form the SHAP-HA complex. The SHAP-HA complex is involved in the pathophysiology of inflammatory diseases, including rheumatoid arthritis. We investigated whether this complex is...

journal_title：International archives of allergy and immunology

authors： Zhu L,Zhuo L,Kimata K,Yamaguchi E,Watanabe H,Aronica MA,Hascall VC,Baba K

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:T(H)2 inflammation and bronchial smooth muscle cell (BSMC) hyperplasia are characteristic features of asthma, but whether these phenomena are linked remains unknown. This study aims to define the effect of the T(H)2 cytokines IL-4 and IL-13 on human BSMC proliferation when administered alone or in combinatio...

journal_title：International archives of allergy and immunology

authors： Bossé Y,Thompson C,Audette K,Stankova J,Rola-Pleszczynski M

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:In vivo, all blood vessels are lined by a single layer of flattened noncycling endothelial cells. We tested the hypothesis that the maintenance of such a quiescent endothelial monolayer depends on homotypic contacts between not yet defined growth-inhibitory molecules located at interendothelial junctions. M...

journal_title：International archives of allergy and immunology

authors： Halama T,Staffler G,Hoch S,Stockinger H,Wolff K,Petzelbauer P

更新日期：1999-11-01 00:00:00

abstract：BACKGROUND:Mast cell tryptase has recently been reported to be involved in atherosclerotic plaque destabilization. However, the results of these reports are conflicting. METHODS:The aim of this study was to characterize the role of tryptase as a prognostic marker of patient cardiovascular complexity in acute coronary ...

journal_title：International archives of allergy and immunology

authors： Pastorello EA,Morici N,Farioli L,Di Biase M,Losappio LM,Nichelatti M,Lupica L,Schroeder JW,Stafylaraki C,Klugmann S

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Flavonoids exert antiallergic and antioxidant effects. We investigated the efficacy of enzymatically modified isoquercitrin (EMIQ), a flavonoid, to relieve symptoms of pollinosis. METHODS:In a parallel-group, double-blind placebo-controlled study design, 20 subjects with Japanese cedar pollinosis took two c...

journal_title：International archives of allergy and immunology

authors： Kawai M,Hirano T,Arimitsu J,Higa S,Kuwahara Y,Hagihara K,Shima Y,Narazaki M,Ogata A,Koyanagi M,Kai T,Shimizu R,Moriwaki M,Suzuki Y,Ogino S,Kawase I,Tanaka T

更新日期：2009-01-01 00:00:00

abstract：:Mercuric chloride (HgCl(2)) has been proposed to be a mitogen for human blood lymphocytes in vitro. In our previous study, we demonstrated that HgCl(2) preferentially stimulates the CD4+ T cell subset to blast transformation and DNA synthesis and that the reaction is dependent on CD14+ accessory cells. In order to cha...

journal_title：International archives of allergy and immunology

authors： Loftenius A,Ekstrand J,Möller E

更新日期：1999-09-01 00:00:00

abstract：:The 3-dimensional structure of an allergen defines the accessible parts on the surface of the molecule or epitopes that interact with antibodies. Mapping the antigenic determinants for IgE antibody binding has been pursued through strategies based on the use of overlapping synthetic peptides, recombinant allergenic fr...

journal_title：International archives of allergy and immunology

authors： Pomés A

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by the interplay between multiple genetic and environmental factors. The pathogenesis of AD remains incompletely understood. Treatment with topical steroids for chronic AD symptoms has severe side effects and so a new treatment is re...

journal_title：International archives of allergy and immunology

authors： Li Y,Yu H,Jin Y,Li M,Qu C

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Severe refractory atopic dermatitis (AD) is a chronic, debilitating condition that is associated with elevated serum immunoglobulin E (IgE) levels. Thymic stromal lymphopoietin (TSLP), thymus and activation-regulated chemokine (TARC) and OX40 ligand (OX40L) are important immunologic factors involved in the p...

journal_title：International archives of allergy and immunology

authors： Iyengar SR,Hoyte EG,Loza A,Bonaccorso S,Chiang D,Umetsu DT,Nadeau KC

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:It is important to understand that allergic rhinitis, whether seasonal or perennial, may be difficult to distinguish clinically from the nonallergic forms of rhinitis. OBJECTIVE:This study aimed to investigate the presence of local allergic rhinitis (LAR) in children who have allergic rhinitis symptoms in t...

journal_title：International archives of allergy and immunology

authors： Duman H,Bostanci I,Ozmen S,Dogru M

更新日期：2016-01-01 00:00:00

abstract：:Preferential eosinophil accumulation is characteristic of airway inflammation in asthma. Although little is known about its mechanism, the effect of a sialyl Lewis X analog on airway eosinophilia was examined in a guinea-pig model of asthma. Guinea-pigs were sensitized by repeated inhalation of ovalbumin. After a sing...

journal_title：International archives of allergy and immunology

authors： Sagara H,Ra C,Okada T,Shinohara S,Fukuda T,Okumura K,Makino S

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND:Reports on oral immunotherapy (OIT) for anaphylactic food allergy are lacking. We investigated the efficacy and safety of peanut OIT for anaphylactic patients. METHODS:We enrolled 22 peanut anaphylactic patients who underwent OIT between 2011 and 2013, all of whom demonstrated anaphylaxis during a baseline ...

journal_title：International archives of allergy and immunology

authors： Nagakura KI,Sato S,Yanagida N,Nishino M,Asaumi T,Ogura K,Ebisawa M

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Protective acquired immunity against helminths and allergic sensitisation are both characterised by high IgE antibody levels. Levels of IgE antibodies are naturally tightly regulated by several mechanisms including binding of the CD23 receptor. Following observations that helminth infections and allergic sen...

journal_title：International archives of allergy and immunology

authors： Rujeni N,Nausch N,Midzi N,Gwisai R,Mduluza T,Taylor DW,Mutapi F

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Cytosolic phospholipase A2 (cPLA2) plays a key role in the development of late-phase anaphylaxis. L-Glutamine (Gln), a nonessential amino acid, has anti-inflammatory activity via inhibiting cPLA2. METHODS:We used a penicillin-induced murine model of anaphylaxis, and late-phase anaphylaxis was quantified by ...

journal_title：International archives of allergy and immunology

authors： Kim HK,Song CH,Bae YS,Im SY,Lee HK

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Mountain cedar (Juniperus ashei) pollen commonly causes a winter time allergic rhinitis in the central USA. Jun a 1 is the dominant allergenic protein, but biologically active recombinant Jun a 1 has not been successfully expressed, despite numerous attempts with several expression systems. METHOD:Jun a 1 c...

journal_title：International archives of allergy and immunology

authors： Liu Z,Bhattacharyya S,Ning B,Midoro-Horiuti T,Czerwinski EW,Goldblum RM,Mort A,Kearney CM

更新日期：2010-01-01 00:00:00

abstract：:In contrast to mast cells and basophils, the high affinity IgE receptor (FcepsilonRI) on antigen-presenting cells (APC) shows structural and functional differences. It consists only of a minimal structure of one alpha- and two gamma-chains and enables APC to efficiently take up and present antigen in IgE-mediated dela...

journal_title：International archives of allergy and immunology

authors： Kraft S,Katoh N,Novak N,Koch S,Bieber T

更新日期：2001-01-01 00:00:00

abstract：:Recently, the induction of T cell anergy has been considered as a sophisticated form of immunotherapy. However, the multiplicity of T cell allergen epitopes discourages the practical use of this method. Since orally administered antigen proteins are digested to peptides and absorbed into the circulation, oral administ...

journal_title：International archives of allergy and immunology

authors： Suko M,Mori A,Ito K,Okudaira H

更新日期：1995-05-01 00:00:00

abstract：BACKGROUND:Helper T cells are involved in chronic eosinophilic inflammation. Control of cytokine production seems to be an effective management. METHODS:The effect of nonactin, SB203580, a p38 MAP kinase inhibitor, and JTE-711 on the cytokine production of allergen-specific T cell clones was determined. The effect of ...

journal_title：International archives of allergy and immunology

authors： Mori A,Okudaira H,Kobayashi N,Akiyama K

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:Hypersensitivity to contrast media (CMs) may be common and serious. AIM:To evaluate the prevalence of CM hypersensitivity, risk factors associated with it and the role of skin testing in its diagnosis. METHODS:A structured questionnaire was administered to patients who underwent computed tomography during ...

journal_title：International archives of allergy and immunology

authors： Goksel O,Aydın O,Atasoy C,Akyar S,Demirel YS,Misirligil Z,Bavbek S

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Segmental allergen challenge is a powerful tool to study inflammatory reactions in asthmatic airways. There is little information on the early events at 5 min and 4 h after allergen challenge with respect to the cell influx and the chemokine interleukin-8 (IL-8). METHODS:Seven mild to moderate allergic asth...

journal_title：International archives of allergy and immunology

authors： Nocker RE,Out TA,Weller FR,Mul EP,Jansen HM,van der Zee JS

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND:We showed previously that treatment with an agonistic anti-4-1BB Ab during the induction phase of murine experimental allergic conjunctivitis (EC) suppresses the development of this model disease. It was reported that 4-1BB promotes the expansion of regulatory T cells. Here we asked whether the suppression o...

journal_title：International archives of allergy and immunology

authors： Sumi T,Ishida W,Mittler RS,Yagita H,Taguchi O,Fukushima A

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Despite parallel increases in asthma and obesity prevalence, there is little data on obesity as a risk factor for atopy. The latter is an important phenotype in asthmatic patients. This study investigates the association between asthma traits, atopy and obesity-related markers in Chinese adolescents. METHOD...

journal_title：International archives of allergy and immunology

authors： Leung TF,Kong AP,Chan IH,Choi KC,Ho CS,Chan MH,So WY,Lam CW,Wong GW,Chan JC

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Patients with atopic dermatitis (AD) are frequently colonized with α-toxin-producing Staphylococcus aureus which is in turn positively correlated with the severity of eczema. METHODS:IN this study we addressed T cell proliferation and T cell as well as monocyte cytokine secretion upon α-toxin stimulation in...

journal_title：International archives of allergy and immunology

authors： Niebuhr M,Mamerow D,Heratizadeh A,Satzger I,Werfel T

更新日期：2011-01-01 00:00:00

abstract：:A high-dose, accelerated escalation schedule during subcutaneous allergen-specific immunotherapy (AIT) is safe and well-tolerated in adults. However, there are no data in children and adolescents. The aim of the present trial was to assess safety and tolerability of an accelerated dose escalation schedule of an AIT wi...

journal_title：International archives of allergy and immunology

authors： Bovermann X,Ricklefs I,Vogelberg C,Klimek L,Kopp MV

更新日期：2021-01-27 00:00:00

abstract：:Eosinophils may play an important role in the pathogenesis of airway remodeling in asthma through the production of various fibrogenic cytokines such as transforming growth factor-beta1 (TGF-beta1). Cysteinyl leukotrienes are also suggested to be involved in remodeling with their potential to induce proliferation of a...

journal_title：International archives of allergy and immunology

authors： Kato Y,Fujisawa T,Nishimori H,Katsumata H,Atsuta J,Iguchi K,Kamiya H

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Recently, the relationship between antigen contact via skin (skin sensitization) and the development of food allergies has gained increasing attention. However, few studies have examined the effects of skin sensitization on healthy skin. OBJECTIVE:To examine the effect of sensitization in healthy skin on Ig...

journal_title：International archives of allergy and immunology

authors： Koshiba R,Oba T,Fuwa A,Arai K,Sasaki N,Kitazawa G,Hattori M,Matsuda H,Yoshida T

更新日期：2020-11-11 00:00:00