当前位置： SCI文献检索 > INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY期刊下所有文献 > Regulatory T cells participate in 4-1BB-mediated suppression of experimental allergic conjunctivitis.

Regulatory T cells participate in 4-1BB-mediated suppression of experimental allergic conjunctivitis.

Abstract：

BACKGROUND:We showed previously that treatment with an agonistic anti-4-1BB Ab during the induction phase of murine experimental allergic conjunctivitis (EC) suppresses the development of this model disease. It was reported that 4-1BB promotes the expansion of regulatory T cells. Here we asked whether the suppression of EC by agonistic anti-4-1BB Ab treatment is mediated by regulatory T cells. METHODS:Neonatal BALB/c mice were thymectomized and intraperitoneally injected with anti-CD25 Ab. At 6 weeks of age, these mice were immunized with ragweed (RW) in alum. As a control, immunocompetent BALB/c mice were immunized. Ten days later, the mice were challenged with RW in eye drops and 24 h later, the conjunctivas and spleens were harvested for histological and flow-cytometric analyses, respectively. The agonistic anti-4-1BB Ab or control normal rat IgG was injected intraperitoneally during the induction phase of EC. RESULTS:With regard to immunocompetent mice, anti-4-1BB Ab treatment significantly suppressed the severity of EC as evaluated by conjunctival eosinophil numbers. In contrast, in thymectomized and anti-CD25 Ab-treated mice in which CD4+CD25+ regulatory T cells were efficiently depleted, anti-4-1BB Ab treatment did not affect the severity of EC. CONCLUSIONS:These results indicate that CD4+CD25+ regulatory T cells play a critical role in the suppression of EC by anti-4-1BB Ab treatment.

journal_name

Int Arch Allergy Immunol

journal_title

International archives of allergy and immunology

authors

Sumi T,Ishida W,Mittler RS,Yagita H,Taguchi O,Fukushima A

doi

10.1159/000170384

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

305-10

issue

4

eissn

1018-2438

issn

1423-0097

pii

000170384

journal_volume

148

pub_type

杂志文章

相关文献

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY文献大全
  • Elevated numbers of cells producing interleukin-5 and interleukin-10 in a boy with Kimura disease.

    abstract：:Kimura disease is a rare disorder of unknown etiology, characterized by the presence of benign subcutaneous granuloma, marked peripheral blood eosinophilia and elevation of the immunglobulin E (IgE) serum level. Here, we present a case of a 12-year-old boy with Kimura disease who had a history of repeated severe influ...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000337777

    authors： Hosoki K,Hirayama M,Kephart GM,Kita H,Nagao M,Uchizono H,Toyoda H,Senba Y,Imai Y,Komada Y,Ihara T,Fujisawa T

    更新日期：2012-01-01 00:00:00

  • Severe immediate allergic reactions to grapes: part of a lipid transfer protein-associated clinical syndrome.

    abstract：BACKGROUND:Grape allergy is considered rare; grape lipid transfer protein (LTP; Vit v 1), an endochitinase and a thaumatin-like protein (TLP) have been reported as grape allergens. A considerable number of patients have referred to our department for severe reactions to grapes, and several IgE binding proteins were det...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000098657

    authors： Vassilopoulou E,Zuidmeer L,Akkerdaas J,Tassios I,Rigby NR,Mills EN,van Ree R,Saxoni-Papageorgiou P,Papadopoulos NG

    更新日期：2007-01-01 00:00:00

  • Single Nucleotide Polymorphisms in Chemosensory Pathway Genes GNB3, TAS2R19, and TAS2R38 Are Associated with Chronic Rhinosinusitis.

    abstract：BACKGROUND:Chronic rhinosinusitis (CRS) is a multifaceted disease with a significant genetic component. The importance of taste receptor signaling has recently been highlighted in CRS; single nucleotide polymorphisms (SNPs) of bitter tastant-responsive G-protein-coupled receptors have been linked with CRS and with alte...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000499875

    authors： Purnell PR,Addicks BL,Zalzal HG,Shapiro S,Wen S,Ramadan HH,Setola V,Siderovski DP

    更新日期：2019-01-01 00:00:00

  • Verbascoside Alleviates Atopic Dermatitis-Like Symptoms in Mice via Its Potent Anti-Inflammatory Effect.

    abstract：BACKGROUND:Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by the interplay between multiple genetic and environmental factors. The pathogenesis of AD remains incompletely understood. Treatment with topical steroids for chronic AD symptoms has severe side effects and so a new treatment is re...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000486958

    authors： Li Y,Yu H,Jin Y,Li M,Qu C

    更新日期：2018-01-01 00:00:00

  • Effectiveness and Safety of Omalizumab in Patients with Allergic Bronchopulmonary Aspergillosis Complicated by Chronic Bacterial Infection in the Airways.

    abstract：BACKGROUND:Allergic bronchopulmonary aspergillosis (ABPA) develops in the presence of predisposing conditions such as asthma and cystic fibrosis. Even ABPA accompanied by asthma is often complicated by chronic Pseudomonas aeruginosa or nontuberculous mycobacterial infection of the lower respiratory tract, rendering tre...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000507216

    authors： Tomomatsu K,Oguma T,Baba T,Toyoshima M,Komase Y,Taniguchi M,Asano K,Japan ABPM Research Program.

    更新日期：2020-01-01 00:00:00

  • Allergic sensitization to common airborne allergens among adults in Estonia.

    abstract：BACKGROUND:Allergies and asthma exhibit a growing health problem in the world. Sparse data are available about the prevalence of allergic sensitization in Estonia and Eastern Europe as well. We studied the prevalence of allergic sensitization, the associations between respiratory symptoms and allergic sensitization, an...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000097027

    authors： Raukas-Kivioja A,Raukas ES,Meren M,Loit HM,Rönmark E,Lundbäck B

    更新日期：2007-01-01 00:00:00

  • Development of a monoclonal antibody-based sandwich ELISA for detection of the latex allergen Hev b 1.

    abstract：BACKGROUND:Natural rubber latex (NRL) products are complex mixtures consisting of different allergenic components. Among them, Hev b 1 belongs to the important and well-characterized ones. To quantify the relevant allergen Hev b 1 in NRL products, a two-site monoclonal antibody (mAb)-based assay was developed. METHODS...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000024449

    authors： Raulf-Heimsoth M,Sander I,Chen Z,Borowitzki G,Diewald K,van Kampen V,Baur X

    更新日期：2000-11-01 00:00:00

  • Grass pollen counts, air pollution levels and allergic rhinitis severity.

    abstract：BACKGROUND:Little is known about the relation between allergic rhinitis severity and airborne pollen in combination with air pollutants. OBJECTIVE:To model the risk of suffering from severe seasonal allergic rhinitis (SAR) as a function of both pollen count and air pollution levels in a large nationwide sample of pati...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000332964

    authors： Annesi-Maesano I,Rouve S,Desqueyroux H,Jankovski R,Klossek JM,Thibaudon M,Demoly P,Didier A

    更新日期：2012-01-01 00:00:00

  • Unexpected functions of FcepsilonRI on antigen-presenting cells.

    abstract：:In contrast to mast cells and basophils, the high affinity IgE receptor (FcepsilonRI) on antigen-presenting cells (APC) shows structural and functional differences. It consists only of a minimal structure of one alpha- and two gamma-chains and enables APC to efficiently take up and present antigen in IgE-mediated dela...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章,评审

    doi：10.1159/000053662

    authors： Kraft S,Katoh N,Novak N,Koch S,Bieber T

    更新日期：2001-01-01 00:00:00

  • Expression of lymphocytes Fc epsilon RII/CD23 in allergic children undergoing hyposensitization.

    abstract：:Owing to the proposed role of Fc epsilon RII/CD23 in allergic diseases, we analyzed the expression of this receptor on peripheral blood lymphocytes (pan-B, pan-T and CD4+ or CD8+ T cells) and its autoproteolytic product sCD23 in serum. This was done in 10 asthmatic children allergic to Dermatophagoides pteronyssinus (...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000236520

    authors： Gagro A,Rabatić S,Tresćec A,Dekaris D,Medar-Lasić M

    更新日期：1993-01-01 00:00:00

  • Pretreatment with low levels of FcεRI-crosslinking stimulation enhances basophil mediator release.

    abstract：BACKGROUND:Basophils and mast cells are important initiator/effector cells capable of rapidly responding to IgE-mediated stimulation, but the precise mechanisms regulating their functions in vivo have not been fully identified. In this study, we assessed whether low levels of antigen can modulate activation of basophil...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000350339

    authors： Koketsu R,Yamaguchi M,Suzukawa M,Tanaka Y,Tashimo H,Arai H,Nagase H,Matsumoto K,Saito H,Ra C,Yamamoto K,Ohta K

    更新日期：2013-01-01 00:00:00

  • Polarized Airway Epithelial Models for Immunological Co-Culture Studies.

    abstract：:Epithelial cells line all cavities and surfaces throughout the body and play a substantial role in maintaining tissue homeostasis. Asthma and other atopic diseases are increasing worldwide and allergic disorders are hypothesized to be a consequence of a combination of dysregulation of the epithelial response towards e...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章,评审

    doi：10.1159/000445833

    authors： Papazian D,Würtzen PA,Hansen SW

    更新日期：2016-01-01 00:00:00

  • The use of complementary and alternative medicine by pediatric food-allergic patients in Japan.

    abstract：BACKGROUND:In developed countries, increasing food allergy prevalence and concern regarding food allergies have been reported. Although the use of complementary and alternative medicine (CAM) for the treatment of allergic diseases has increased in some Western countries, the actual proportion and patterns of CAM use fo...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章,多中心研究

    doi：10.1159/000338936

    authors： Nakano T,Shimojo N,Okamoto Y,Ebisawa M,Kurihara K,Hoshioka A,Yamaguchi K,Ito K,Fujisawa T,Kameda M,Suehiro Y,Ogura H,Shibata R,Suzuki S,Takahashi Y,Ikeda M,Kohno Y

    更新日期：2012-01-01 00:00:00

  • Development of transgenic rice expressing mite antigen for a new concept of immunotherapy.

    abstract：BACKGROUND:To elucidate the usefulness of antigen-specific immunotherapy based on oral vaccination with an edible part of the plant, we examined the effect of transgenic (Tg) rice seeds expressing an immunodominant fragment of the group 1 antigen of Dermatophagoides pteronyssinus (Der p 1) on a murine model of asthma. ...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000210649

    authors： Suzuki K,Kaminuma O,Yang L,Motoi Y,Takai T,Ichikawa S,Okumura K,Ogawa H,Mori A,Takaiwa F,Hiroi T

    更新日期：2009-01-01 00:00:00

  • Vitamin C and E suppress mitogen-stimulated peripheral blood mononuclear cells in vitro.

    abstract：BACKGROUND/AIMS:The antioxidant properties of vitamin C and E are considered to be important for their anti-inflammatory activity. Recently, antioxidant resveratrol was found to suppress neopterin production and tryptophan degradation in mitogen-treated human peripheral blood mononuclear cells. METHODS:In this study, ...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000096438

    authors： Winkler C,Schroecksnadel K,Schennach H,Fuchs D

    更新日期：2007-01-01 00:00:00

  • Allergen-specific conjunctival challenge in asthma. An additional diagnostic tool to define sensitization.

    abstract：:Reversible airway obstruction and airway inflammation following allergen exposure represent crucial pathophysiological features of allergic asthma. In order to investigate these events, bronchial-specific challenge is commonly employed although it may be complicated and may not be free of possible risks. Therefore, we...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000237461

    authors： Ciprandi G,Buscaglia S,Scordamaglia A,Canonica GW

    更新日期：1997-03-01 00:00:00

  • Successful pregnancy in a Churg-Strauss syndrome patient with a history of intrauterine fetal death.

    abstract：:Allergic granulomatosis and angiitis was first reported as a disease entity separate from polyarteritis nodosa in 1951 by Churg and Strauss. It is characterized by bronchial asthma, eosinophilia, and vasculitis and is especially rare in women of reproductive age, though, when present, may be associated with fetal mort...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000237140

    authors： Ogasawara M,Kajiura S,Inagaki H,Sasa H,Aoki K,Yagami Y

    更新日期：1995-10-01 00:00:00

  • Mast cell hyperplasia: role of cytokines.

    abstract：:Mast cell hyperplasia is found in different pathologies such as chronic inflammatory processes, fibrotic disorders, wound healing or neoplastic tissue transformation. The functional significance of the accumulation of mast cells in these processes is largely unknown. It is now established that bone marrow-derived mast...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章,评审

    doi：10.1159/000048181

    authors： Bischoff SC,Sellge G

    更新日期：2002-02-01 00:00:00

  • Histamine augments VCAM-1 expression on IL-4- and TNF-alpha-stimulated human umbilical vein endothelial cells.

    abstract：:Interaction between vascular cell adhesion molecule-1 (VCAM-1) on endothelial cells and CD49d molecules on eosinophils is thought to mediate the selective infiltration of eosinophils into inflamed tissues in allergic disease. IL-4 and TNF-alpha are associated with allergic conditions, and they have been shown to selec...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000237357

    authors： Saito H,Shimizu H,Mita H,Maeda Y,Akiyama K

    更新日期：1996-10-01 00:00:00

  • Immediate Wheal Reactivity to Autologous Sweat in Atopic Dermatitis Is Associated with Clinical Severity, Serum Total and Specific IgE and Sweat Tryptase Activity.

    abstract：BACKGROUND:Sweating can worsen atopic dermatitis (AD). The purpose of this work was to study the associations between reactivity to autologous sweat and the clinical severity of AD as well as investigate the possible wheal-inducing factors of sweat. METHODS:Intracutaneous skin tests with autologous sweat were performe...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000447638

    authors： Ilves T,Virolainen A,Harvima IT

    更新日期：2016-01-01 00:00:00

  • Role of hemolytic and nonhemolytic phospholipase C from Pseudomonas aeruginosa for inflammatory mediator release from human granulocytes.

    abstract：BACKGROUND:Pseudomonas aeruginosa phospholipase C (PLC) is a critical component in the pathogenesis of severe P. aeruginosa infections. However, P. aeruginosa can produce a hemolytic (PLC-H) as well as a nonhemolytic (PLC-N) variant, both having a MW of about 77 kD. In the past, studies did not distinguish between both...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000237441

    authors： König B,Vasil ML,König W

    更新日期：1997-02-01 00:00:00

  • An experimental model of allergic asthma in cats sensitized to house dust mite or bermuda grass allergen.

    abstract：BACKGROUND:Animal models are used to mimic human asthma, however, not all models replicate the major characteristics of the human disease. Spontaneous development of asthma with hallmark features similar to humans has been documented to occur with relative frequency in only one animal species, the cat. We hypothesized ...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000080654

    authors： Norris Reinero CR,Decile KC,Berghaus RD,Williams KJ,Leutenegger CM,Walby WF,Schelegle ES,Hyde DM,Gershwin LJ

    更新日期：2004-10-01 00:00:00

  • The genotype determines the B cell response in mercury-treated mice.

    abstract：BACKGROUND:Mercury causes in mouse strains of the H-2s haplotype an autoimmune syndrome with antibodies to the nucleolar protein fibrillarin and systemic immune complex (IC) deposits. Other strains, like BALB/C (H-2d), develop only IC deposits, and most strains are resistant. However, mercury activates the murine immun...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000023959

    authors： Johansson U,Hansson-Georgiadis H,Hultman P

    更新日期：1998-08-01 00:00:00

  • Inhibitory effects of human neutrophil functions by the 45-kD glycoprotein derived from the parasitic nematode Trichinella spiralis.

    abstract：AIM:We evaluated the effect of the 45-kD protein of Trichinella spiralis (gp45), purified by affinity chromatography, on random migration and chemotaxis, the oxidative metabolism of human neutrophils and on the CD11b upregulation induced by formyl-methionyl-leucyl-phenylalanine (f-MLP). METHODS:Donor neutrophils incub...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000024359

    authors： Bruschi F,Carulli G,Azzarà A,Homan W,Minnucci S,Rizzuti-Gullaci A,Sbrana S,Angiolini C

    更新日期：2000-05-01 00:00:00

  • Accelerated Dose Escalation with 3 Injections of an Aluminum Hydroxide-Adsorbed Allergoid Preparation of 6 Grasses Is Safe for Children and Adolescents with Moderate to Severe Allergic Rhinitis.

    abstract：:A high-dose, accelerated escalation schedule during subcutaneous allergen-specific immunotherapy (AIT) is safe and well-tolerated in adults. However, there are no data in children and adolescents. The aim of the present trial was to assess safety and tolerability of an accelerated dose escalation schedule of an AIT wi...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000512561

    authors： Bovermann X,Ricklefs I,Vogelberg C,Klimek L,Kopp MV

    更新日期：2021-01-27 00:00:00

  • The importance of serine proteinases as aeroallergens associated with asthma.

    abstract：:Penicillium and Aspergillus species have been identified as prevalent indoor airborne fungi that are associated with extrinsic bronchial asthma. We have recently analyzed the IgE-binding components in 8 prevalent Penicillium and Aspergillus species (P. citrinum, P. notatum, P. oxalicum, P. brevicompactum, A. fumigatus...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章,评审

    doi：10.1159/000024202

    authors： Shen HD,Tam MF,Chou H,Han SH

    更新日期：1999-08-01 00:00:00

  • Purification and N-terminal sequence analysis of Streptomyces chromofuscus phospholipase D.

    abstract：:Partially purified commercial phospholipase D (PLD) was fractionated by dye-ligand affinity chromatography and nondenaturing polyacrylamide gel electrophoresis (PAGE). Active material migrated as three bands on SDS-PAGE. The two higher-abundance species were shown to have identical N-terminal sequences, while the thir...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000236934

    authors： Dinh TT,McClure GD,Kennerly DA

    更新日期：1995-05-01 00:00:00

  • Interleukin-5 plays a key role in mouse strain- dependent susceptibility to contact hypersensitivity through its effects on initiator B cells.

    abstract：BACKGROUND:Elicitation of contact hypersensitivity requires antigen-specific immunoglobulin M (IgM) antibodies that trigger recruitment of effector T cells to the local tissue. These antigen-specific IgM antibodies are produced by B-1-like 'initiator B cells'. In this study, we compared susceptibility to hapten-induced...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000350367

    authors： Itakura A,Ikutani M,Takatsu K,Kikuchi Y

    更新日期：2013-01-01 00:00:00

  • Sulfidoleukotriene release test (CAST) in hypersensitivity to nonsteroidal anti-inflammatory drugs.

    abstract：:There is a great need to develop a method for making an accurate and reliable in vitro diagnosis of adverse hypersensitivity reactions to drugs. We measured the amount of sulfidoleukotriene (sLT) released from the peripheral blood leukocytes obtained from 25 patients who developed hypersensitivity reactions following ...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000237695

    authors： Kubota Y,Imayama S,Toshitani A,Miyahara H,Tanahashi T,Uemura Y,Koga T,Sugawara N,Kurimoto F,Hata K

    更新日期：1997-12-01 00:00:00

  • Plant-expressed recombinant mountain cedar allergen Jun a 1 is allergenic and has limited pectate lyase activity.

    abstract：BACKGROUND:Mountain cedar (Juniperus ashei) pollen commonly causes a winter time allergic rhinitis in the central USA. Jun a 1 is the dominant allergenic protein, but biologically active recombinant Jun a 1 has not been successfully expressed, despite numerous attempts with several expression systems. METHOD:Jun a 1 c...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000316345

    authors： Liu Z,Bhattacharyya S,Ning B,Midoro-Horiuti T,Czerwinski EW,Goldblum RM,Mort A,Kearney CM

    更新日期：2010-01-01 00:00:00