Staphylococcal α-toxin induces a higher T cell proliferation and interleukin-31 in atopic dermatitis.

Abstract:

BACKGROUND:Patients with atopic dermatitis (AD) are frequently colonized with α-toxin-producing Staphylococcus aureus which is in turn positively correlated with the severity of eczema. METHODS:IN this study we addressed T cell proliferation and T cell as well as monocyte cytokine secretion upon α-toxin stimulation in peripheral blood mononuclear cells (PBMCs) from AD patients compared to healthy controls. RESULTS:We found that α-toxin stimulation of PBMCs markedly enhanced T cell proliferation both in patients with AD and healthy controls and was significantly increased in AD patients compared to healthy controls. PBMCs of AD patients secreted significantly more IL-31 compared to those of healthy controls upon α-toxin and SEB stimulation. Moreover, α-toxin stimulation yielded an increase in T cell (IL-2, IL-9, IL-10 and IFN-γ) as well as monocyte (IL-1β and TNF-α) cytokine secretion. CONCLUSION:Our results could partly explain how skin colonization and infection with S. aureus can contribute to chronic skin inflammation and pruritus in AD.

authors

Niebuhr M,Mamerow D,Heratizadeh A,Satzger I,Werfel T

doi

10.1159/000323905

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

412-5

issue

4

eissn

1018-2438

issn

1423-0097

pii

000323905

journal_volume

156

pub_type

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