Abstract:
BACKGROUND:Anti-inflammatory therapy is a logical approach to slowing the inevitable lung function deterioration in cystic fibrosis (CF) patients. This study's aim was to evaluate inflammatory markers and disease progression in paediatric CF patients chronically treated with azithromycin or low-dose prednisolone. METHODS:The study included 204 patients with CF and 100 healthy controls; 102 CF patients were treated with basic therapy only (without anti-inflammatory treatment; WAT), and 102 individuals received basic therapy along with azithromycin (n = 59) or low-dose prednisolone (n = 43). The median duration of therapy was 24 months (range 12-82) with azithromycin and 31 months (range 12-180) with prednisolone. A cross-sectional analysis of plasma and sputum biomarkers was performed. RESULTS:Compared with the healthy controls, the WAT group showed elevated IFN-γ, IL-10 (total), and TGFβ1 concentrations, and decreased TNFα (total) and adrenocorticotropic hormone (ACTH) levels (all p < 0.05). Plasma TNFα (total) concentrations in azithromycin/prednisolone patients were significantly higher than those in WAT patients and similar to those of healthy children. In contrast, IL-10 (total) levels were significantly decreased in azithromycin/prednisolone-treated patients compared with WAT patients. Children from the azithromycin group demonstrated ACTH levels similar to those of healthy controls. Azithromycin-treated patients showed a significantly reduced rate of CF-related liver disease and a significantly increased incidence of glucose metabolism disturbances. CONCLUSIONS:Steady-state anti-inflammatory treatments may have a sustained immunomodulatory action at systemic and local levels in CF patients. Further investigations are needed to assess the effects of supportive azithromycin therapy on the hypothalamic-pituitary-adrenal axis and the incidence of non-pulmonary CF complications.
journal_name
Int Arch Allergy Immunoljournal_title
International archives of allergy and immunologyauthors
Shmarina G,Pukhalsky A,Avakian L,Semykin S,Pukhalskaya D,Alioshkin Vdoi
10.1159/000453451subject
Has Abstractpub_date
2017-01-01 00:00:00pages
45-54issue
1eissn
1018-2438issn
1423-0097pii
000453451journal_volume
172pub_type
杂志文章abstract:BACKGROUND:The production of house dust mite (HDM) allergen products for allergy immunotherapy has traditionally been based on purified mite bodies or whole-mite culture, which are quite different source materials with a limited possibility for adjusting the chemical composition. The SQ HDM SLIT-tablet is a fast-dissol...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000444016
更新日期:2016-01-01 00:00:00
abstract::T cells are central regulators and mediators of allergic sensitisation and disease. The house dust mite allergens are a biochemically diverse group of proteins which are present in extracts and the environment in a wide range of concentrations. Here the importance of ascertaining the contribution of the different alle...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章,评审
doi:10.1159/000023824
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND:The coexistence of asthma and allergic rhinitis (AR) and its distinct association with obesity have been reported. However, few studies have differentiated the two types of AR, i.e., perennial (PAR) and seasonal AR (SAR), with regard to their associations with asthma and obesity. The aim of this study was to...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000488329
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:15-Deoxy-Delta(12,14)-prostaglandin J2 (15d-PGJ2), a major prostanoid metabolized from prostaglandin D2 (PGD2), plays an important role in various biological processes including inflammatory responses. 15d-PGJ2 exerts its effects through two major receptors, chemoattractant receptor- homologous molecule expr...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000211377
更新日期:2009-01-01 00:00:00
abstract::Human foamy virus (HFV) is a recently characterized member of the retrovirus subfamily Spumaretrovirinae. HFV has a complex structure: it encodes the classical three retroviral structural genes gag, pol and env, but also possesses additional regulatory, so-called bel sequences. Foamy viruses have been discussed occasi...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000236350
更新日期:1992-01-01 00:00:00
abstract::The present study has extended histochemical and functional investigations into rat mast cell heterogeneity using isolated mast cells from four connective tissue locations; the peritoneum, mesentery, lung and skin. On histological examination, mast cells from these locations displayed a range of phenotypes following f...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000236161
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:omega-5 gliadin is a major allergen in exercise-induced wheat allergy (EIWA), but it is also implicated in immediate-type reactions to wheat. An ImmunoCAP assay to measure omega-5 gliadin-specific IgE has become available. This study aimed to evaluate this new biological test in wheat allergy diagnosis and t...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000176309
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Recent work indicates that subcutaneous specific immunotherapy induces specific T-cell anergy, a shift in the TH1/TH2 ratio, and antibody production in favor of IgG4. There are few data on sublingual immunotherapy (SLIT), especially in children. METHODS:We assessed the proliferation of peripheral blood mono...
journal_title:International archives of allergy and immunology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000083320
更新日期:2005-02-01 00:00:00
abstract:BACKGROUND:Cow's milk (CM) allergy is the second most common food allergy developed during infancy in Japan. To identify predictors of persistent CM allergy, we investigated the tolerance acquisition rate based on an oral food challenge in children under 6 years of age, diagnosed with immediate-type CM allergy. METHOD...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000486311
更新日期:2018-01-01 00:00:00
abstract::Two cDNA clones named P9* and P1* of 794 and 631 bp, respectively, were isolated from a lambda ZAP cDNA expression library using Parietaria judaica (Pj) pollen-specific IgE antibodies from a pool of sera (n = 23) of patients allergic to Pj. Sequence analysis showed open reading frames of 176 and 138 amino acids. Both ...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000237479
更新日期:1997-04-01 00:00:00
abstract:INTRODUCTION:Penicillins and cephalosporins are the most frequent causes of hypersensitivity reactions (HRs) to drugs in children. Among cephalosporins for intravenous use, ceftriaxone (CT) is the most frequently prescribed in Italy. The aims of this study were to evaluate the diagnostic methods for CT hypersensitivity...
journal_title:International archives of allergy and immunology
pub_type: 新闻
doi:10.1159/000495302
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND/AIMS:The antioxidant properties of vitamin C and E are considered to be important for their anti-inflammatory activity. Recently, antioxidant resveratrol was found to suppress neopterin production and tryptophan degradation in mitogen-treated human peripheral blood mononuclear cells. METHODS:In this study, ...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000096438
更新日期:2007-01-01 00:00:00
abstract::Delayed drug allergy reactions (DDAR) are potentially fatal. Certain human leukocyte antigen (HLA) alleles have been associated with delayed allergy reactions following the administration of particular drugs. Examples are HLA-B*57:01 (abacavir), HLA-B*15:02/HLA-A*31:01 (carbamazepine), and HLA-B*58:01 (allopurinol). B...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章,评审
doi:10.1159/000448217
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Volatile monoisocyanates are formed through thermal degradation when products containing polyurethane are heated. Repeated exposure to diisocyanates, such as toluene diisocyanate (TDI) are a well-known cause of occupational asthma. However, although monoisocyanates are abundant in occupational settings, ther...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000222675
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:A subset of drug-intolerant patients show a marked propensity to react to several chemically unrelated antibacterial drugs. This condition is termed multiple drug allergy syndrome (MDAS). The pathogenesis of MDAS is still unclear. A possible mechanism is that a nonspecific patient-related factor leading to d...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000071486
更新日期:2003-07-01 00:00:00
abstract:BACKGROUND:Atopic dermatitis (AD) and food allergy (FA) are common childhood diseases, which may either be interrelated or be the result of skin barrier disruption and gut mucosal dysbiosis. Although some evidence suggests the efficacy of emollients and synbiotics, there is no conclusive evidence on the use of these in...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章,随机对照试验
doi:10.1159/000501636
更新日期:2019-01-01 00:00:00
abstract::Human mononuclear leukocytes (MNL), probably OKT4-positive T cells, produced an eosinophil chemotactic factor (ECF) when they were cocultured with irradiated BALL-1, a B cell lymphoma line. Treatment of MNL, with anti-IL-2 antibody failed to suppress BALL-1-induced ECF production. Periodate-lysine-paraformaldehyde-fix...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000236736
更新日期:1994-01-01 00:00:00
abstract:BACKGROUND:IgE mediates immediate-type hypersensitivity reactions responsible for various allergic symptoms. It is secreted by IgE-producing plasma cells, which differentiate from B cells expressing membrane-bound IgE (mIgE) on their surface. The epsilon-chain of human mIgE contains a membrane-anchoring peptide and an ...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000063860
更新日期:2002-08-01 00:00:00
abstract:BACKGROUND:Recombinant allergens are preferred over natural allergen extracts in measuring antibodies. We tested the use of recombinant variants of the major mouse allergen Mus m 1 in detection of mouse-specific antibodies in sera of laboratory animal workers and children. METHODS:Six recombinant major urinary protein...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000106318
更新日期:2007-01-01 00:00:00
abstract::Eosinophils participate in the inflammatory response seen in allergy and helminthic infestation. Their release of granule-bound cationic proteins may play a role in these diseases. Therefore, we investigated mechanisms involved in the release of eosinophil cationic protein (ECP). Serum-opsonized zymosan was phagocytos...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000023891
更新日期:1998-02-01 00:00:00
abstract:BACKGROUND:The fractional concentration of exhaled nitric oxide (FeNO) is a surrogate biomarker for Th2-dependent bronchial inflammation. The present study investigated whether FeNO may characterize allergic rhinitis (AR) patients. METHODS:A total of 553 AR patients (497 males, mean age 28.8 years) were evaluated. Tho...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000456548
更新日期:2017-01-01 00:00:00
abstract::The aim of this study was to assess the relevance of immunoinflammatory markers on the response to short acting beta(2)-agonist in acute asthma exacerbation. Thus, we measured serum eosinophil cationic protein (ECP) levels and sIL-2R at acute exacerbation in 52 adult patients with atopic asthma, and assessed forced ex...
journal_title:International archives of allergy and immunology
pub_type: 临床试验,杂志文章
doi:10.1159/000057748
更新日期:2002-04-01 00:00:00
abstract:BACKGROUND:Lactobacillus casei is a nonpathogenic gram-positive bacterium widely used in dairy products and has been shown to enhance the cellular immunity of the host. METHODS:To examine the inhibitory effect of L. casei on IgE production, splenocytes obtained from ovalbumin (OVA)-primed BALB/c mice were restimulated...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000069458
更新日期:1998-04-01 00:00:00
abstract::Human colostrum and a high molecular weight colostrum fraction (HMWF; > 14,000 D) prevented the adhesion of localized adherent (LA+) O111:H-enteropathogenic Escherichia coli (EPEC) to HeLa cells. This effect was abolished after absorption with an O111:H-LA + EPEC strain, but absorption with a LA- strain of same seroty...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000236645
更新日期:1994-01-01 00:00:00
abstract:BACKGROUND:Loss-of-function mutations of the filaggrin (FLG) gene cause an impaired skin barrier and increase the risk of atopic dermatitis. Interestingly, FLG mutations have also been found to be associated with a high risk of peanut allergy. OBJECTIVE:We investigated the association of FLG mutations with self-report...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000345949
更新日期:2013-01-01 00:00:00
abstract::Because of the importance of cytokines in the regulation of allergic inflammation, we investigated the effects of SCF, IL-3, IL-5 and GM-CSF on immunological histamine release from sensitized human lung fragments as well as human leukocytes. SCF (0.2-20 ng/ml) caused a concentration-related enhancement of anti-IgE (1/...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000236798
更新日期:1994-09-01 00:00:00
abstract:BACKGROUND:Previous studies have shown a negative association between ACP1 *B/*C genotype and total IgE level. ACP1 (acid phosphatase locus 1) is a polymorphic phosphotyrosine phosphatase that interacts with IL4-RA and is involved in T cell receptor signaling. METHODS:In the present paper, we have studied the relation...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000107466
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Proton pump inhibitors (PPIs) can trigger immediate-type hypersensitivity reactions (HSRs). Three main patterns of cross-reactivity have been identified: reactions to a single PPI, selective cross-reactions, and cross-reactions with all PPIs. Several hypotheses have been advanced, but no consensus has been r...
journal_title:International archives of allergy and immunology
pub_type:
doi:10.1159/000493581
更新日期:2019-01-01 00:00:00
abstract::Olive pollen is one of the most important causes of seasonal respiratory allergy in Mediterranean countries, where this tree is intensely cultivated. Among the high number of protein allergens detected in this pollen, 8 - Ole e 1 to Ole e 8 - have been isolated and characterized. Ole e 1 is the most frequent sensitizi...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章,评审
doi:10.1159/000053815
更新日期:2001-07-01 00:00:00
abstract:BACKGROUND:Little information is available on eosinophil activation and the cytokine profile in virus-induced acute exacerbation of bronchial asthma; therefore, we examined the effects of treatments that included systemic corticosteroids on serum eosinophil cationic protein (ECP) and 17 cytokines/chemokines in rhinovir...
journal_title:International archives of allergy and immunology
pub_type: 临床试验,杂志文章
doi:10.1159/000327434
更新日期:2011-01-01 00:00:00