Abstract:
BACKGROUND:Lactobacillus casei is a nonpathogenic gram-positive bacterium widely used in dairy products and has been shown to enhance the cellular immunity of the host. METHODS:To examine the inhibitory effect of L. casei on IgE production, splenocytes obtained from ovalbumin (OVA)-primed BALB/c mice were restimulated in vitro with the same antigen in the presence of heat-killed L. casei. The effect of this bacterium on T helper (Th) phenotype development was also examined with naive T cells from OVA-specific T cell receptor-transgenic mice. RESULTS:L. casei induced IFN-gamma, but inhibited IL-4 and IL-5 secretion, and markedly suppressed total and antigen-specific IgE secretion by OVA-stimulated splenocytes. The inhibitory effect of L. casei on IgE, IL-4, and IL-5 production was partially abrogated by addition of neutralizing antibody to IFN-gamma. Augmented IL-12 production was also observed in the cell cultures containing L. casei, and anti-IL-12 monoclonal antibody completely restored the IgE, IL-4, and IL-5 production to the control levels. The IL-12 augmentation by L. casei was macrophage-dependent. The Th cell development assay showed the ability of L. casei to induce Th1 development preferentially. This effect was also completely blocked by anti-IL-12 antibody. CONCLUSIONS:This is the first demonstration that a nonpathogenic microorganism, L. casei, can inhibit antigen-induced IgE production through induction of IL-12 secretion by macrophages. The findings suggest a potential use of this organism in preventing IgE-mediated allergy.
journal_name
Int Arch Allergy Immunoljournal_title
International archives of allergy and immunologyauthors
Shida K,Makino K,Morishita A,Takamizawa K,Hachimura S,Ametani A,Sato T,Kumagai Y,Habu S,Kaminogawa Sdoi
10.1159/000069458subject
Has Abstractpub_date
1998-04-01 00:00:00pages
278-87issue
4eissn
1018-2438issn
1423-0097pii
iaa15278journal_volume
115pub_type
杂志文章abstract::The causal association between cow's milk allergy (CMA) and constipation is not well established. Some guidelines describe constipation as a possible symptom of CMA, while others do not mention it. We conducted a literature review and found 10 prospective clinical trials. In all of them, an oral food challenge was per...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章,评审
doi:10.1159/000362365
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:A new lateral flow test (LFT) for office use provides information about sensitisation to common allergens. Concordance between LFT and skin-prick test (SPT) has not been assessed in epidemiological studies. The aim of this study is to determine LFT-SPT concordance in this field. METHODS:Plasma samples (n = ...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000288291
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:Recombinant allergens are preferred over natural allergen extracts in measuring antibodies. We tested the use of recombinant variants of the major mouse allergen Mus m 1 in detection of mouse-specific antibodies in sera of laboratory animal workers and children. METHODS:Six recombinant major urinary protein...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000106318
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:The aetiology of chronic urticaria is heterogeneous. Physical urticaria (PU) is estimated at around 35%, autoimmune urticaria (AIU) at 25% and chronic idiopathic urticaria (CIU) at 35% of all chronic urticaria cases. METHODS:Differences in clinical and laboratory parameters among AIU, PU and CIU groups were...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000103995
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Natural rubber latex proteins have been implicated in severe allergy in individuals exposed to latex products, particularly health care workers. Until recently, only crude antigens were available to study the immune response in these patients. In recent years a number of relevant allergens have been purified...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000024279
更新日期:1999-12-01 00:00:00
abstract::In the classical Pavlovian conditioning paradigm, a stimulus that unconditionally elicits a physiological response is repeatedly paired with a neutral stimulus that does not elicit that same response. Eventually, the neutral stimulus becomes a conditioned stimulus in that it elicits the physiological response in the a...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章,评审
doi:10.1159/000236811
更新日期:1994-10-01 00:00:00
abstract:BACKGROUND:A role of bacterial superantigens in several chronic inflammatory diseases has previously been proposed. Many of these diseases are associated with an imbalance of the T helper cell subsets and their cytokine production. METHODS:Peripheral blood mononuclear cells from healthy donors were incubated with vari...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000024320
更新日期:2000-03-01 00:00:00
abstract:BACKGROUND:The lymphocyte transformation test (LTT) is used for in vitro diagnosis of drug hypersensitivity reactions. While its specificity is over 90%, sensitivity is limited and depends on the type of reaction, drug and possibly time interval between the event and analysis. Removal of regulatory T cells (Treg/CD25(h...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000358491
更新日期:2014-01-01 00:00:00
abstract::Profilins are ubiquitous proteins, present in all eukaryotic cells and identified as allergens in pollen, latex and plant foods. The highly conserved structure justifies the cross-reactive nature of IgE antibodies against plant profilins and their designation as pan-allergens. Primary sensitization to profilin seems t...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章,评审
doi:10.1159/000321178
更新日期:2011-01-01 00:00:00
abstract::The aim of this study was to investigate whether repeated exposure to subclinical doses of cat allergens, not inducing asthma symptoms, could affect eosinophil cationic protein (ECP) levels in bronchoalveolar lavage (BAL) or in peripheral blood, without the appearance of clinical symptoms. Twelve patients with mild as...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000024234
更新日期:1999-10-01 00:00:00
abstract::Elevated levels of ovine reaginic antibody were induced by immunization with Ascaris suum antigens. The PCA activity of this antibody persisted in the skin of sheep for 20 days and was abolished by heating to 56 degrees C, suggesting that it was immunoglobulin E. Attempts to isolate IgE from this hyperimmune serum by ...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000236479
更新日期:1993-01-01 00:00:00
abstract::A high-dose, accelerated escalation schedule during subcutaneous allergen-specific immunotherapy (AIT) is safe and well-tolerated in adults. However, there are no data in children and adolescents. The aim of the present trial was to assess safety and tolerability of an accelerated dose escalation schedule of an AIT wi...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000512561
更新日期:2021-01-27 00:00:00
abstract:INTRODUCTION:Penicillins and cephalosporins are the most frequent causes of hypersensitivity reactions (HRs) to drugs in children. Among cephalosporins for intravenous use, ceftriaxone (CT) is the most frequently prescribed in Italy. The aims of this study were to evaluate the diagnostic methods for CT hypersensitivity...
journal_title:International archives of allergy and immunology
pub_type: 新闻
doi:10.1159/000495302
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Cow's milk (CM) allergy is the second most common food allergy developed during infancy in Japan. To identify predictors of persistent CM allergy, we investigated the tolerance acquisition rate based on an oral food challenge in children under 6 years of age, diagnosed with immediate-type CM allergy. METHOD...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000486311
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:In developed countries, increasing food allergy prevalence and concern regarding food allergies have been reported. Although the use of complementary and alternative medicine (CAM) for the treatment of allergic diseases has increased in some Western countries, the actual proportion and patterns of CAM use fo...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章,多中心研究
doi:10.1159/000338936
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Mugwort (Artemisia vulgaris) represents an important source of weed pollen allergens. The objectives of the present study were (i) to analyze the IgE binding profiles in a group of mugwort-allergic patients, (ii) to identify individual marker allergens crucial for the diagnosis of mugwort allergy and (iii) t...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000108134
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Wheat is known as the most widely consumed food all over the world. Although many types of wheat allergy have been recognized, their treatment still has a long way to go due to the complex pathogenesis. Oral immunotherapy (OIT) is under investigation for the treatment of wheat allergies. Previous studies hav...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000506945
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:In some subjects, specific foods trigger anaphylaxis when exercise follows ingestion (specific food-dependent exercise-induced anaphylaxis, FDEIAn). Skin test and/or RAST positivity to foods suggest an IgE-mediated pathogenic mechanism. Others suffer from anaphylaxis after all meals followed by exercise, reg...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000053825
更新日期:2001-07-01 00:00:00
abstract:BACKGROUND:Exposure to the house dust mite Blomia tropicalis is increasingly being implicated as a major risk factor for asthma exacerbations in sensitized individuals. The objective of this study is to clone and characterize B. Tropicalis allergens in order to better define their role in allergic asthma. METHODS:A la...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000068375
更新日期:2003-01-01 00:00:00
abstract::The inhibitory effects of a novel compound, 6-hydroxy-2-(4-sulfamoylbenzylamino)-4,5,7-trimethylbenzothiazo le hydrochloride (E6080) on IgE-mediated reactions in vitro and in vivo were determined in rhesus monkeys. E6080 inhibited both antigen- and anti-human IgE-induced leukotriene C4 generations from lung fragments ...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000236406
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND:Recent work indicates that subcutaneous specific immunotherapy induces specific T-cell anergy, a shift in the TH1/TH2 ratio, and antibody production in favor of IgG4. There are few data on sublingual immunotherapy (SLIT), especially in children. METHODS:We assessed the proliferation of peripheral blood mono...
journal_title:International archives of allergy and immunology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000083320
更新日期:2005-02-01 00:00:00
abstract::The present study has extended histochemical and functional investigations into rat mast cell heterogeneity using isolated mast cells from four connective tissue locations; the peritoneum, mesentery, lung and skin. On histological examination, mast cells from these locations displayed a range of phenotypes following f...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000236161
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:beta2-Adrenergic agonists play a pivotal role in the management of bronchial asthma. Although the major effect of short-acting beta2-agonists on the airway is relaxation of smooth muscles, they may also have several effects on surrounding immunomodulatory cells. METHODS:We examined whether widely used short...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000089516
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:Allergen molecule-based diagnosis has been suggested to facilitate the identification of disease-causing allergen sources and the prescription of allergen-specific immunotherapy (AIT). The aim of the current study was to compare allergen molecule-based IgE serology with allergen extract-based skin testing fo...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000477442
更新日期:2017-01-01 00:00:00
abstract::Antiphospholipid antibody syndrome (APS) is characterized by autoantibodies against negatively charged phospholipids in the serum, and clinically by multiple thromboses, thrombocytopenia, and recurrent fetal loss. The mechanism(s) by which the antibodies cause the clinical picture are not clear. We review the possible...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章,评审
doi:10.1159/000236883
更新日期:1995-01-01 00:00:00
abstract:BACKGROUND:Endogenous IL-17 is needed for the Ag sensitization that results in murine allergic asthma, a Th2-mediated disease. Here, we aimed to investigate the role IL-17 plays in the development of murine experimental allergic conjunctivitis (EC) which is also a Th2-mediated disease. METHODS:To induce EC, wild-type ...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000142043
更新日期:2008-01-01 00:00:00
abstract:INTRODUCTION:Pathologic accumulation and activation of mast cells and eosinophils are implicated in allergic and inflammatory diseases. Sialic acid-binding immunoglobulin-like lectin (Siglec)-8 is an inhibitory receptor selectively expressed on mast cells, eosinophils and, at a lower extent, basophils. When engaged wit...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000501637
更新日期:2019-01-01 00:00:00
abstract::IgE is a key mediator in allergic diseases. However, in strong contrast to other antibody isotypes, many details of the composition of the human IgE repertoire are poorly defined. The low levels of human IgE in the circulation and the rarity of IgE-producing B cells are important reasons for this lack of knowledge. In...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章,评审
doi:10.1159/000355947
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by the interplay between multiple genetic and environmental factors. The pathogenesis of AD remains incompletely understood. Treatment with topical steroids for chronic AD symptoms has severe side effects and so a new treatment is re...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000486958
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVE:To evaluate whether activated partial thromboplastin time (APTT) could be used in the laboratory diagnosis of hereditary or acquired angioedema (HAE or AAE) with and without C1 inhibitor (C1-INH) deficiency. METHODS:In a prospective investigation, APTT and other coagulation parameters were determined in 149 ...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000447695
更新日期:2016-01-01 00:00:00