Superantigen-induced T cell death by apoptosis: analysis on a single cell level and effect of IFN-gamma and IL-4 treatment.

abstract：BACKGROUND:Mouse models have been established mirroring key features of human bronchial asthma including airway hyperresponsiveness (AHR). Acute airway obstruction in response to an allergen challenge, however, remains to be demonstrated in these models. OBJECTIVE:A mouse model of allergic lung inflammation was employ...

journal_title：International archives of allergy and immunology

authors： Neuhaus-Steinmetz U,Glaab T,Daser A,Braun A,Lommatzsch M,Herz U,Kips J,Alarie Y,Renz H

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND:Sweating can worsen atopic dermatitis (AD). The purpose of this work was to study the associations between reactivity to autologous sweat and the clinical severity of AD as well as investigate the possible wheal-inducing factors of sweat. METHODS:Intracutaneous skin tests with autologous sweat were performe...

journal_title：International archives of allergy and immunology

authors： Ilves T,Virolainen A,Harvima IT

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:2-Arachidonoylglycerol (2-AG), an endogenous ligand for the cannabinoid receptors (CB1 and CB2), has been shown to exhibit a variety of cannabimimetic activities in vitro and in vivo. Recently, we found that human eosinophilic leukemia EoL-1 cells and human peripheral blood eosinophils express the CB2 recept...

journal_title：International archives of allergy and immunology

authors： Kishimoto S,Oka S,Gokoh M,Sugiura T

更新日期：2006-01-01 00:00:00

abstract：:In studies designed to optimize the production and detection of anti-ovalbumin (anti-Oa) IgE in Ham/ICR mice, a range of doses of both Oa and pertussis toxin as the IgE adjuvant was explored. As determined by 48-hour passive cutaneous anaphylaxis (PCA) tests, the highest titre of anti-Oa IgE was obtained in a three-in...

journal_title：International archives of allergy and immunology

authors： Lindsay DS,Parton R,Wardlaw AC

更新日期：1994-11-01 00:00:00

abstract：BACKGROUND:It has been reported that protein tyrosine phosphorylation is essential for cytokine production in mouse Th1 cells but not in Th2 cells. However, little is known about the difference of signal transduction between human antigen-specific Th1 and Th2 cell clones. METHODS:Purified protein derivative-specific T...

journal_title：International archives of allergy and immunology

authors： Minoguchi K,Yamashita N,Oda N,Takeno M,Kaneoka H,Sakane T

更新日期：1999-01-01 00:00:00

abstract：:Antibody response after immunization with surface-coupled ovalbumin (OVA) of liposomes was investigated in mice. OVA was coupled to the surface of liposome via amino groups using glutaraldehyde. OVA-liposome conjugate induced a significant anti-OVA IgG antibody production in mice. However, no IgE antibody production s...

journal_title：International archives of allergy and immunology

authors： Naito S,Horino A,Nakayama M,Nakano Y,Nagai T,Mizuguchi J,Komuro K,Uchida T

更新日期：1996-03-01 00:00:00

abstract：BACKGROUND:Little is known about the relation between allergic rhinitis severity and airborne pollen in combination with air pollutants. OBJECTIVE:To model the risk of suffering from severe seasonal allergic rhinitis (SAR) as a function of both pollen count and air pollution levels in a large nationwide sample of pati...

journal_title：International archives of allergy and immunology

authors： Annesi-Maesano I,Rouve S,Desqueyroux H,Jankovski R,Klossek JM,Thibaudon M,Demoly P,Didier A

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:In some subjects, specific foods trigger anaphylaxis when exercise follows ingestion (specific food-dependent exercise-induced anaphylaxis, FDEIAn). Skin test and/or RAST positivity to foods suggest an IgE-mediated pathogenic mechanism. Others suffer from anaphylaxis after all meals followed by exercise, reg...

journal_title：International archives of allergy and immunology

authors： Romano A,Di Fonso M,Giuffreda F,Papa G,Artesani MC,Viola M,Venuti A,Palmieri V,Zeppilli P

更新日期：2001-07-01 00:00:00

abstract：BACKGROUND:The aetiological factors underlying the worldwide increase in the prevalence of asthma and the international patterns of the prevalence of asthma are not well understood. This has led to consideration of factors such as fetomaternal health which may programme the initial susceptibility to allergic sensitisat...

journal_title：International archives of allergy and immunology

authors： Beasley R,Leadbitter P,Pearce N,Crane J

更新日期：1999-02-01 00:00:00

abstract：BACKGROUND:Anti-inflammatory therapy is a logical approach to slowing the inevitable lung function deterioration in cystic fibrosis (CF) patients. This study's aim was to evaluate inflammatory markers and disease progression in paediatric CF patients chronically treated with azithromycin or low-dose prednisolone. METH...

journal_title：International archives of allergy and immunology

authors： Shmarina G,Pukhalsky A,Avakian L,Semykin S,Pukhalskaya D,Alioshkin V

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Previously we have shown that intranasal administration of ovalbumin (OVA) together with cholera toxin (CT) abrogates nasal tolerance to OVA, resulting in the induction of specific IgE antibody (Ab) responses, and that intraperitoneal injection of OVA coupled with liposomes (OVA-liposomes) induces a selectiv...

journal_title：International archives of allergy and immunology

authors： Yoshikawa T,Uchida T,Naito S,Horino A,Taneichi M,Kato H,Komuro K,Nakano Y,Mori M,Nishinohara S,Chiba J,Kurata T,Tamura S

更新日期：2000-02-01 00:00:00

abstract：BACKGROUND:Exposure to the house dust mite Blomia tropicalis is increasingly being implicated as a major risk factor for asthma exacerbations in sensitized individuals. The objective of this study is to clone and characterize B. Tropicalis allergens in order to better define their role in allergic asthma. METHODS:A la...

journal_title：International archives of allergy and immunology

authors： Flores I,Mora C,Rivera E,Donnelly R,Montealegre F

更新日期：2003-01-01 00:00:00

abstract：:Corticosteroid-resistant (CR) asthma is associated with disease chronicity, a more frequent family history of asthma and impaired in vitro and in vivo responsiveness of peripheral blood mononuclear cells to the suppressive effects of glucocorticoids. CR asthma is associated with normal suppression of the hypothalamic-...

journal_title：International archives of allergy and immunology

authors： Lane SJ,Lee TH

更新日期：1997-05-01 00:00:00

abstract：BACKGROUND:The human IgE response is associated with allergy and with host defence against parasitic worms. A response to Sm22.6, the dominant IgE antigen in adult Schistosoma mansoni worms, correlates with resistance to re-infection after treatment. Sm22.6 is one of a family of EF-hand containing parasite proteins wit...

journal_title：International archives of allergy and immunology

authors： Fitzsimmons CM,McBeath R,Joseph S,Jones FM,Walter K,Hoffmann KF,Kariuki HC,Mwatha JK,Kimani G,Kabatereine NB,Vennervald BJ,Ouma JH,Dunne DW

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:We reported on the constitutive interferon-gamma receptor (IFN-gammaR) expression on eosinophils. But signal transduction through IFN-gammaR on eosinophils remains to be elucidated. In this study, we examined the involvement of the Jak/Stat pathway in the signaling of eosinophils after IFN-gammaR conjugation...

journal_title：International archives of allergy and immunology

authors： Ochiai K,Ishihara C,Tomioka H

更新日期：1999-02-01 00:00:00

abstract：BACKGROUND:Serum-derived hyaluronan (HA)-associated proteins (SHAPs), the heavy chains of inter-α-trypsin inhibitor, covalently bind to HA to form the SHAP-HA complex. The SHAP-HA complex is involved in the pathophysiology of inflammatory diseases, including rheumatoid arthritis. We investigated whether this complex is...

journal_title：International archives of allergy and immunology

authors： Zhu L,Zhuo L,Kimata K,Yamaguchi E,Watanabe H,Aronica MA,Hascall VC,Baba K

更新日期：2010-01-01 00:00:00

abstract：:Thioredoxin (TRX) is a redox-active protein that regulates reactive oxidative metabolism and plays a crucial role in the antioxidant system in regulating the reduction/oxidation balance by scavenging reactive oxygen species, which is implicated in the mechanism of asthma. As for the mechanisms by which TRX exerts its ...

journal_title：International archives of allergy and immunology

authors： Ito W,Kobayashi N,Takeda M,Ueki S,Kayaba H,Nakamura H,Yodoi J,Chihara J

更新日期：2011-01-01 00:00:00

abstract：:The allergic pig can be used as a large-animal model for studies of allergic reactions in the airways and the role of eosinophils in such reactions. To measure the activation of eosinophils, the release of eosinophil-derived cationic proteins can be used. The purpose of this study was to isolate and characterize catio...

journal_title：International archives of allergy and immunology

authors： Fornhem C,Peterson CG,Alving K

更新日期：1996-06-01 00:00:00

abstract：BACKGROUND:Orange allergens are virtually unknown, in spite of the large consumption of this fruit. Germin-like proteins, together with vicilins and legumins, form the cupin superfamily of plant proteins, which includes many seed allergens. METHODS:Twenty-nine patients with allergy to oranges were studied. A major IgE...

journal_title：International archives of allergy and immunology

authors： Ahrazem O,Ibáñez MD,López-Torrejón G,Sánchez-Monge R,Sastre J,Lombardero M,Barber D,Salcedo G

更新日期：2006-01-01 00:00:00

abstract：:Long-term birth cohort studies are essential to understanding the life course and childhood predictors of allergy and the complex interplay between genes and the environment (including lifestyle and socioeconomic determinants). Over 100 cohorts focusing on asthma and allergy have been initiated in the world over the p...

journal_title：International archives of allergy and immunology

authors： Bousquet J,Anto J,Sunyer J,Nieuwenhuijsen M,Vrijheid M,Keil T,MeDALL Study Group.,CHICOS Study Group.,ENRIECO Study Group.,GA²LEN Study Group.

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Pseudomonas aeruginosa phospholipase C (PLC) is a critical component in the pathogenesis of severe P. aeruginosa infections. However, P. aeruginosa can produce a hemolytic (PLC-H) as well as a nonhemolytic (PLC-N) variant, both having a MW of about 77 kD. In the past, studies did not distinguish between both...

journal_title：International archives of allergy and immunology

authors： König B,Vasil ML,König W

更新日期：1997-02-01 00:00:00

abstract：:Besides stem cell factor (SCF), additional fibroblast-derived mast cell growth factors have previously been described. Since keratinocytes have also been shown to produce SCF, we have studied the ability of culture supernatants from the human HaCaT keratinocyte cell line to induce SCF-independent mast cell differentia...

journal_title：International archives of allergy and immunology

authors： Welker P,Grabbe J,Czarnetzki BM

更新日期：1995-05-01 00:00:00

abstract：:Eosinophils used to be thought of as regulators of allergic inflammation, but there is now evidence to the contrary; eosinophils have been found to be the major effector cells responsible for the late asthmatic response (LAR), airway hyperresponsiveness (AHR) and, at least in part, airway remodeling by releasing leuko...

journal_title：International archives of allergy and immunology

authors： Matsumoto K,Saito H

更新日期：2001-08-01 00:00:00

abstract：:We studied the effect of NZ-107 in a number of animal models of anaphylactic bronchoconstriction. In conscious guinea pigs, pretreated with indomethacin, pyrilamine and propranolol, passively sensitized with heterologous anti serum, NZ-107 in doses of 10-30 mg/kg per os inhibited the aerosolized antigen-induced cough ...

journal_title：International archives of allergy and immunology

authors： Iwama T,Shikada K,Yamamoto A,Sakashita M,Hibi M,Tanaka S

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:Japanese cedar pollinosis (JCPsis) is an immunoglobulin E-mediated type I allergy caused by exposure to Japanese cedar pollen (JCP). Blood thymus and activation-regulated chemokine (TARC) levels are well known as an objective parameter for disease severity for several allergic disorders. The present study ai...

journal_title：International archives of allergy and immunology

authors： Xiao JZ,Kondo S,Takahashi N,Odamaki T,Iwabuchi N,Miyaji K,Iwatsuki K,Enomoto T

更新日期：2007-01-01 00:00:00

abstract：:At an international hereditary angioedema (HAE) expert meeting, results from a survey were used to guide discussion on how best to advise patients on self-administering intravenous C1 esterase inhibitor therapy. Treatment differences across Europe were highlighted, together with the practicalities of self-administrati...

journal_title：International archives of allergy and immunology

authors： Symons C,Rossi O,Magerl M,Andritschke K

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Recent work indicates that subcutaneous specific immunotherapy induces specific T-cell anergy, a shift in the TH1/TH2 ratio, and antibody production in favor of IgG4. There are few data on sublingual immunotherapy (SLIT), especially in children. METHODS:We assessed the proliferation of peripheral blood mono...

journal_title：International archives of allergy and immunology

authors： Rolinck-Werninghaus C,Kopp M,Liebke C,Lange J,Wahn U,Niggemann B

更新日期：2005-02-01 00:00:00

abstract：BACKGROUND:Grape allergy is considered rare; grape lipid transfer protein (LTP; Vit v 1), an endochitinase and a thaumatin-like protein (TLP) have been reported as grape allergens. A considerable number of patients have referred to our department for severe reactions to grapes, and several IgE binding proteins were det...

journal_title：International archives of allergy and immunology

authors： Vassilopoulou E,Zuidmeer L,Akkerdaas J,Tassios I,Rigby NR,Mills EN,van Ree R,Saxoni-Papageorgiou P,Papadopoulos NG

更新日期：2007-01-01 00:00:00

abstract：:IgE responsiveness to Dermatophagoides farinae body extract was compared by immunoblotting among four groups of mite-sensitive asthmatic children: group I aged 0-3, group II aged 4-7, group III aged 8-11 and group IV aged 12-15. In the group I subjects, the 15-kD component was bound by 88% of sera and strongly by 56% ...

journal_title：International archives of allergy and immunology

authors： Shibasaki M,Isoyama S,Takita H

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND:Air pollution is frequently proposed as a potential cause of the increased incidence of allergy in industrialised countries. Our objective was to investigate the impact of the major gaseous air pollutants on grass pollen allergens. METHODS:Timothy grass pollen was exposed to ozone (O(3)), nitrogen dioxide (...

journal_title：International archives of allergy and immunology

authors： Rogerieux F,Godfrin D,Sénéchal H,Motta AC,Marlière M,Peltre G,Lacroix G

更新日期：2007-01-01 00:00:00