Abstract:
BACKGROUND:Japanese cedar pollinosis (JCPsis) is an immunoglobulin E-mediated type I allergy caused by exposure to Japanese cedar pollen (JCP). Blood thymus and activation-regulated chemokine (TARC) levels are well known as an objective parameter for disease severity for several allergic disorders. The present study aims to evaluate the relationship between TARC levels and disease symptoms during the pollen season. METHODS:Analysis was performed of results of symptom scores and blood parameters obtained from 42 JCPsis patients who participated in a probiotic (Bifidobacterium longum BB536) intake trial in the JCP season of 2005 (January to April), using a randomized, double-blind, placebo-controlled design. RESULTS:Significant increases in plasma TARC levels were observed in subjects receiving placebo (p < 0.05 in February and p < 0.01 in March), but not in subjects receiving BB536. Increased plasma TARC levels were markedly greater in subjects who experienced severe symptoms and were thus excluded early from the intervention (placebo group: n = 8; BB536 group: n = 2). Significant differences were found in changes from baseline TARC levels in February and March between the subjects where treatment was terminated early and the remaining ones. Among the remaining subjects, significant positive correlations were found as regards changed values of TARC compared to baseline in March and April with symptom scores recorded in the pollen season. CONCLUSION:Changed values of blood TARC in the pollen season may offer promising parameters for assessing disease severity and monitoring treatment.
journal_name
Int Arch Allergy Immunoljournal_title
International archives of allergy and immunologyauthors
Xiao JZ,Kondo S,Takahashi N,Odamaki T,Iwabuchi N,Miyaji K,Iwatsuki K,Enomoto Tdoi
10.1159/000103223subject
Has Abstractpub_date
2007-01-01 00:00:00pages
123-7issue
2eissn
1018-2438issn
1423-0097pii
000103223journal_volume
144pub_type
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journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000078768
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journal_title:International archives of allergy and immunology
pub_type: 杂志文章
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journal_title:International archives of allergy and immunology
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journal_title:International archives of allergy and immunology
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journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000236655
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journal_title:International archives of allergy and immunology
pub_type: 杂志文章
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journal_title:International archives of allergy and immunology
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journal_title:International archives of allergy and immunology
pub_type: 杂志文章
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journal_title:International archives of allergy and immunology
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journal_title:International archives of allergy and immunology
pub_type: 杂志文章
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journal_title:International archives of allergy and immunology
pub_type: 杂志文章
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journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000236975
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journal_title:International archives of allergy and immunology
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journal_title:International archives of allergy and immunology
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pub_type: 杂志文章
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journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000236431
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journal_title:International archives of allergy and immunology
pub_type: 杂志文章,评审
doi:10.1159/000237015
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journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000236855
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journal_title:International archives of allergy and immunology
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journal_title:International archives of allergy and immunology
pub_type: 杂志文章,评审
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pub_type: 杂志文章,meta分析,评审
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更新日期:2011-01-01 00:00:00
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journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000350788
更新日期:2013-01-01 00:00:00
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journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000094177
更新日期:2006-01-01 00:00:00
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journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000499409
更新日期:2019-01-01 00:00:00
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journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000070435
更新日期:2003-05-01 00:00:00
abstract:BACKGROUND:The hemagglutinin (HA) of influenza viruses is one of the major targets of the humoral response. The role of serum antibody to HA in the protection against infection has been demonstrated by long-standing observation. In previous studies, we suggested that an epitope vaccine might be a new strategy against t...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000053869
更新日期:2002-03-01 00:00:00
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journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000236767
更新日期:1994-11-01 00:00:00
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journal_title:International archives of allergy and immunology
pub_type: 杂志文章,随机对照试验
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更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Epinephrine autoinjector (EAI) is prescribed to prevent a fatal outcome in the case of a repeated anaphylactic reactions. We wanted to determine how adult patients who received their first prescription as part of an urgent treatment of an anaphylactic reaction or at their family physician were instructed on ...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000513421
更新日期:2021-01-22 00:00:00