Relevant B cell epitopes in allergic disease.

abstract：:The role of CD8+ T cells in the regulation of IgE was investigated by in vivo CD8+ T-cell depletion. Following intraperitoneal immunization with ovalbumin (OVA), OVA-specific T cell responses were first detected in the draining lymph nodes (LN) and subsequently in the spleen. In vitro depletion of LN CD8+ cells reduce...

journal_title：International archives of allergy and immunology

authors： Holmes BJ,MacAry PA,Kemeny DM

更新日期：1997-05-01 00:00:00

abstract：BACKGROUND:Exposure and sensitization to indoor allergens have been associated with the development of asthma and other allergic diseases in many parts of the world. It is important to establish the degree of exposure, and to evaluate whether allergen control measures are effective in a particular area. METHODS:Concen...

journal_title：International archives of allergy and immunology

authors： Tobias KR,Ferriani VP,Chapman MD,Arruda LK

更新日期：2004-04-01 00:00:00

abstract：BACKGROUND:Over the past years, dust of green coffee beans has become known to be a relevant cause for occupational type I allergies. Up to now, allergy diagnostics is based on native green coffee bean extract which exhibits insufficient specificity due to interfering substances as well as batch-to-batch variations. No...

journal_title：International archives of allergy and immunology

authors： Manavski N,Peters U,Brettschneider R,Oldenburg M,Baur X,Bittner C

更新日期：2012-01-01 00:00:00

abstract：:We studied the effect of NZ-107 in a number of animal models of anaphylactic bronchoconstriction. In conscious guinea pigs, pretreated with indomethacin, pyrilamine and propranolol, passively sensitized with heterologous anti serum, NZ-107 in doses of 10-30 mg/kg per os inhibited the aerosolized antigen-induced cough ...

journal_title：International archives of allergy and immunology

authors： Iwama T,Shikada K,Yamamoto A,Sakashita M,Hibi M,Tanaka S

更新日期：1992-01-01 00:00:00

abstract：:Ever since the realization that T lymphocytes are key players in the defense against pathogens and tumors, a major aim of immunologists has been to understand the relationship between the functional and migratory properties of antigen-specific T cells. The current paradigm proposes that T cells follow organ-specific t...

journal_title：International archives of allergy and immunology

authors： Iparraguirre A,Weninger W

更新日期：2003-12-01 00:00:00

abstract：BACKGROUND:IgE-mediated hypersensitivity to latex has been recognized as an increasing health problem with far-reaching consequences for patients, regarding both their occupational situation and safety in medical care. Therefore, a correct diagnosis of natural rubber latex (NRL) allergy is essential. The purpose of the...

journal_title：International archives of allergy and immunology

authors： Kütting B,Weber B,Brehler R

更新日期：2001-11-01 00:00:00

abstract：:A peptide B3144, derived after peptic tryptic digestion of alpha-gliadin and corresponding to residues 3-56 from the coeliac-activating domain I, was previously used to produce monoclonal antibodies. A dot immunobinding assay was developed using these antibodies to detect gluten in wheat, rye, barley and oats. The lim...

journal_title：International archives of allergy and immunology

authors： Ellis HJ,Doyle AP,Day P,Wieser H,Ciclitira PJ

更新日期：1994-07-01 00:00:00

abstract：:Psoriasis (Ps) is a chronic, immune-mediated, skin inflammatory disease affecting up to 3% of the population worldwide. Different environmental triggers initiate this complex multifactorial syndrome. Many individuals affected by Ps (6-26%) develop inflammatory disease in other organs, often in the joints as in psorias...

journal_title：International archives of allergy and immunology

authors： Khmaladze Ia,Nandakumar KS,Holmdahl R

更新日期：2015-01-01 00:00:00

abstract：:Bed bugs may cause mild to severe cutaneous reactions. We studied the ability of bed bug salivary extract (SGE) to induce inflammatory reactions responsible for cutaneous manifestations and found that SGE stimulated the production of several potent chemokines and cytokines from macrophages. Chemokines induced by SGE i...

journal_title：International archives of allergy and immunology

authors： Goddard J,Hasenkampf N,Edwards KT,de Shazo R,Embers ME

更新日期：2013-01-01 00:00:00

abstract：:The inhibitory effects of a novel compound, 6-hydroxy-2-(4-sulfamoylbenzylamino)-4,5,7-trimethylbenzothiazo le hydrochloride (E6080) on IgE-mediated reactions in vitro and in vivo were determined in rhesus monkeys. E6080 inhibited both antigen- and anti-human IgE-induced leukotriene C4 generations from lung fragments ...

journal_title：International archives of allergy and immunology

authors： Katayama S,Sakuma Y,Abe S,Tsunoda H,Yamatsu I,Katayama K

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND:Recombinant dog allergens, rCan f 1 and rCan f 2, and their antibodies are good tools for the characterization of dog allergens in order to develop modern therapeutic and preventive methods for dog allergy. METHODS:In this study, cDNA was synthesized from the mRNA of dog salivary glands and cloned into the ...

journal_title：International archives of allergy and immunology

authors： Kamata Y,Miyanomae A,Nakayama E,Miyanomae T,Tajima T,Hoshi H

更新日期：2007-01-01 00:00:00

abstract：:In contrast to mast cells and basophils, the high affinity IgE receptor (FcepsilonRI) on antigen-presenting cells (APC) shows structural and functional differences. It consists only of a minimal structure of one alpha- and two gamma-chains and enables APC to efficiently take up and present antigen in IgE-mediated dela...

journal_title：International archives of allergy and immunology

authors： Kraft S,Katoh N,Novak N,Koch S,Bieber T

更新日期：2001-01-01 00:00:00

abstract：:We describe an HLA-B8, DR3-positive patient with localized morphea after silicone gel breast implantation for cosmetic reasons. We believe that this case suggests that a genetic background, i.e. HLA-B8, DR3 haplotype, is involved in the autoimmune response to silicone. ...

journal_title：International archives of allergy and immunology

authors： Di Lorenzo G,Mansueto P,Melluso M,Sangiorgi GB,Cigna D,Candore G,Caruso C

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:Lactobacillus casei is a nonpathogenic gram-positive bacterium widely used in dairy products and has been shown to enhance the cellular immunity of the host. METHODS:To examine the inhibitory effect of L. casei on IgE production, splenocytes obtained from ovalbumin (OVA)-primed BALB/c mice were restimulated...

journal_title：International archives of allergy and immunology

authors： Shida K,Makino K,Morishita A,Takamizawa K,Hachimura S,Ametani A,Sato T,Kumagai Y,Habu S,Kaminogawa S

更新日期：1998-04-01 00:00:00

abstract：BACKGROUND:Orange allergens are virtually unknown, in spite of the large consumption of this fruit. Germin-like proteins, together with vicilins and legumins, form the cupin superfamily of plant proteins, which includes many seed allergens. METHODS:Twenty-nine patients with allergy to oranges were studied. A major IgE...

journal_title：International archives of allergy and immunology

authors： Ahrazem O,Ibáñez MD,López-Torrejón G,Sánchez-Monge R,Sastre J,Lombardero M,Barber D,Salcedo G

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Accumulating evidence indicates that eotaxin is the primary mediator of tissue eosinophilia. In the present study, we analyzed the mechanisms of eotaxin generation by Th1-/Th2-derived cytokines in vitro. METHODS:Human dermal fibroblasts, human umbilical vein endothelial cells and A549 human bronchial epithe...

journal_title：International archives of allergy and immunology

authors： Miyamasu M,Misaki Y,Yamaguchi M,Yamamoto K,Morita Y,Matsushima K,Nakajima T,Hirai K

更新日期：2000-05-01 00:00:00

abstract：BACKGROUND:Previously we have shown that intranasal administration of ovalbumin (OVA) together with cholera toxin (CT) abrogates nasal tolerance to OVA, resulting in the induction of specific IgE antibody (Ab) responses, and that intraperitoneal injection of OVA coupled with liposomes (OVA-liposomes) induces a selectiv...

journal_title：International archives of allergy and immunology

authors： Yoshikawa T,Uchida T,Naito S,Horino A,Taneichi M,Kato H,Komuro K,Nakano Y,Mori M,Nishinohara S,Chiba J,Kurata T,Tamura S

更新日期：2000-02-01 00:00:00

abstract：BACKGROUND:The presence of autoantibodies reacting with the high affinity IgE receptor (FcepsilonRIalpha) usually indicates a more severe form of chronic urticaria (CU). Previously, we showed an increased lymphocyte reactivity in CU patients; however, the relation between enhanced cellular immunity and the presence of ...

journal_title：International archives of allergy and immunology

authors： Hidvégi B,Nagy E,Szabó T,Temesvári E,Marschalkó M,Kárpáti S,Horváth A,Gergely P

更新日期：2003-10-01 00:00:00

abstract：:Mast cell hyperplasia is found in different pathologies such as chronic inflammatory processes, fibrotic disorders, wound healing or neoplastic tissue transformation. The functional significance of the accumulation of mast cells in these processes is largely unknown. It is now established that bone marrow-derived mast...

journal_title：International archives of allergy and immunology

authors： Bischoff SC,Sellge G

更新日期：2002-02-01 00:00:00

abstract：BACKGROUND:The aim was to determine the clinical characteristics of patients with seasonal rhinitis (SR) and to disclose differences in the treatment of SR between an adult allergy clinic and other clinics over time. METHODS:A retrospective study was conducted based on clinical records of 774 out of 955 patients diagn...

journal_title：International archives of allergy and immunology

authors： Bozkurt B,Karakaya G,Kalyoncu AF

更新日期：2005-09-01 00:00:00

abstract：BACKGROUND:Subcutaneous immunotherapy for respiratory allergy has shown a long lasting efficacy after its discontinuation, whereas evidence in the case of sublingual immunotherapy (SLIT) is weak. This retrospective study evaluates whether SLIT exerts a long-lasting effect and whether it relates to its duration. METHOD...

journal_title：International archives of allergy and immunology

authors： Marogna M,Bruno M,Massolo A,Falagiani P

更新日期：2007-01-01 00:00:00

abstract：:Patients with atopic dermatitis (AD) are frequently colonized with Staphylococcus aureus strains secreting exotoxins such as the staphylococcal enterotoxin B (SEB) and A (SEA). Nonetheless the role of SEB and SEA in AD is yet unknown. We analyzed the responsiveness of peripheral blood mononuclear cells (PBMCs) and iso...

journal_title：International archives of allergy and immunology

authors： König B,Neuber K,König W

更新日期：1995-02-01 00:00:00

abstract：:CD95 (APO-1) is a member of the TNF/nerve growth factor receptor superfamily, which is expressed on the surface of different types of cells. Cross-linking of CD95 leads to the induction of apoptosis. This may be of importance in many physiological systems, but seems to play a special role for the maintenance of immuno...

journal_title：International archives of allergy and immunology

authors： Lechner H,Amort M,Steger MM,Maczek C,Grubeck-Loebenstein B

更新日期：1996-07-01 00:00:00

abstract：BACKGROUND:The fractional concentration of exhaled nitric oxide (FeNO) is a surrogate biomarker for Th2-dependent bronchial inflammation. The present study investigated whether FeNO may characterize allergic rhinitis (AR) patients. METHODS:A total of 553 AR patients (497 males, mean age 28.8 years) were evaluated. Tho...

journal_title：International archives of allergy and immunology

authors： Ciprandi G,Gallo F,Ricciardolo FL,Cirillo I

更新日期：2017-01-01 00:00:00

abstract：:Partially purified commercial phospholipase D (PLD) was fractionated by dye-ligand affinity chromatography and nondenaturing polyacrylamide gel electrophoresis (PAGE). Active material migrated as three bands on SDS-PAGE. The two higher-abundance species were shown to have identical N-terminal sequences, while the thir...

journal_title：International archives of allergy and immunology

authors： Dinh TT,McClure GD,Kennerly DA

更新日期：1995-05-01 00:00:00

abstract：BACKGROUND:A negative association has been observed between infections and allergy in several studies. The aim of the present study was to examine whether tuberculosis and leprosy patients have more or fewer allergies than healthy individuals. METHOD:Sera from tuberculosis patients, leprosy patients and healthy contro...

journal_title：International archives of allergy and immunology

authors： Ellertsen LK,Wiker HG,Egeberg NT,Hetland G

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND:Recombinant allergens are preferred over natural allergen extracts in measuring antibodies. We tested the use of recombinant variants of the major mouse allergen Mus m 1 in detection of mouse-specific antibodies in sera of laboratory animal workers and children. METHODS:Six recombinant major urinary protein...

journal_title：International archives of allergy and immunology

authors： Krop EJ,Matsui EC,Sharrow SD,Stone MJ,Gerber P,van der Zee JS,Chapman MD,Aalberse RC

更新日期：2007-01-01 00:00:00

abstract：:Because of the importance of cytokines in the regulation of allergic inflammation, we investigated the effects of SCF, IL-3, IL-5 and GM-CSF on immunological histamine release from sensitized human lung fragments as well as human leukocytes. SCF (0.2-20 ng/ml) caused a concentration-related enhancement of anti-IgE (1/...

journal_title：International archives of allergy and immunology

authors： Louis R,Dowlati A,Weber T,Bury T,Corhay JL,Radermecker MF

更新日期：1994-09-01 00:00:00

abstract：BACKGROUND:The coexistence of asthma and allergic rhinitis (AR) and its distinct association with obesity have been reported. However, few studies have differentiated the two types of AR, i.e., perennial (PAR) and seasonal AR (SAR), with regard to their associations with asthma and obesity. The aim of this study was to...

journal_title：International archives of allergy and immunology

authors： Matsumoto M,Konno S,Kimura H,Takei N,Kimura H,Shimizu K,Goudarzi H,Suzuki M,Hashino S,Nishimura M

更新日期：2018-01-01 00:00:00

abstract：:Nonspecific hyperreactivity to a number of physical, chemical and pharmacological agents in a common characteristics of allergic subjects, which is strictly related to the inflammatory events consequent to an allergic reaction. Hyperosmolar stimulus has previously been shown to cause an inflammatory response inducing ...

journal_title：International archives of allergy and immunology

authors： Ciprandi G,Buscaglia S,Pesce G,Lotti R,Rolando M,Bagnasco M,Canonica GW

更新日期：1994-05-01 00:00:00