Abstract:
:Because of the importance of cytokines in the regulation of allergic inflammation, we investigated the effects of SCF, IL-3, IL-5 and GM-CSF on immunological histamine release from sensitized human lung fragments as well as human leukocytes. SCF (0.2-20 ng/ml) caused a concentration-related enhancement of anti-IgE (1/100) induced histamine release from lung fragments reaching maximally 64% at 20 ng/ml. In contrast, enhancement produced by IL-5, IL-3 and GM-CSF (0.2-20 ng/ml) was quite marginal and reached at best around 20% at the higher concentration, IL-5 being slightly more effective than IL-3 and GM-CSF. Further, SCF potentiated histamine release whatever the level of immunological control whereas potentiation by IL-5 primarily occurred when the amount of histamine release induced by the immunological control ranged between 5 and 10%. SCF acted synergistically with IL-5, producing a greater enhancement of histamine release than the sum of each cytokine used alone. Both SCF and, to a lesser extent, IL-5 potentiated anti-IgE-mediated histamine release regardless of passive sensitization of lung fragments. Unlike what was observed with lung fragments, IL-3, GM-CSF and to a lesser extent IL-5, were potent enhancing agents of anti-IgE (1/2,000)-induced histamine release from leukocytes. Maximal enhancement produced by IL-3 (20 ng/ml), GM-CSF (2 ng/ml) and IL-5 (20 ng/ml) reached 92%, 78% and 61%, respectively. By contrast, SCF (0.2-20 ng/ml) was ineffective on human leukocytes.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Int Arch Allergy Immunoljournal_title
International archives of allergy and immunologyauthors
Louis R,Dowlati A,Weber T,Bury T,Corhay JL,Radermecker MFdoi
10.1159/000236798subject
Has Abstractpub_date
1994-09-01 00:00:00pages
18-25issue
1eissn
1018-2438issn
1423-0097journal_volume
105pub_type
杂志文章abstract:BACKGROUND:Recently, the high affinity receptor for IgE (Fc epsilonRI), which plays a major role in allergies, has been identified on a number of different antigen-presenting cell types, including human monocytes from atopic and nonatopic donors. In this report human monocytic cell lines were used to test for the expre...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000237621
更新日期:1997-08-01 00:00:00
abstract::Allergens present in the excretory/secretory (ES) products of adult Paragonimus ohirai were biochemically identified. Immunoblot analysis using sera from P. ohirai-infected rats revealed only two allergens to be major proteins in the ES products, with apparent molecular masses (M(r)) of 27 and 29 kD. As the ES product...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000064251
更新日期:2002-07-01 00:00:00
abstract::IL-13 is a relatively novel cytokine produced by activated T cells. IL-13 inhibits the production of proinflammatory cytokines and chemokines by activated monocytes, induces B cell proliferation and differentiation, including IgE production, and the expression of certain adhesion molecules on endothelial cells. All th...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章,评审
doi:10.1159/000236842
更新日期:1995-03-01 00:00:00
abstract:BACKGROUND:Recombinant allergens are preferred over natural allergen extracts in measuring antibodies. We tested the use of recombinant variants of the major mouse allergen Mus m 1 in detection of mouse-specific antibodies in sera of laboratory animal workers and children. METHODS:Six recombinant major urinary protein...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000106318
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:T cells are key regulators of immunologic disease parameters. However, their contribution to the process of tissue remodeling is ill defined. In the present study, we investigated gene expression of allergy-characteristic, IL-4-rich T cell cDNAs to monitor expression of genes that might participate in the pa...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000072139
更新日期:2003-08-01 00:00:00
abstract::In all mammalian species investigated so far, mast cells and basophils are the only cells that synthesize histamine and express plasma membrane receptors that bind IgE with high affinity (Fc epsilonRI). Human basophils and mast cells derive from distinct precursors that originate in the bone marrow and fetal liver and...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章,评审
doi:10.1159/000237670
更新日期:1997-11-01 00:00:00
abstract:BACKGROUND:15-Deoxy-Delta(12,14)-prostaglandin J2 (15d-PGJ2), a major prostanoid metabolized from prostaglandin D2 (PGD2), plays an important role in various biological processes including inflammatory responses. 15d-PGJ2 exerts its effects through two major receptors, chemoattractant receptor- homologous molecule expr...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000211377
更新日期:2009-01-01 00:00:00
abstract:INTRODUCTION:Penicillins and cephalosporins are the most frequent causes of hypersensitivity reactions (HRs) to drugs in children. Among cephalosporins for intravenous use, ceftriaxone (CT) is the most frequently prescribed in Italy. The aims of this study were to evaluate the diagnostic methods for CT hypersensitivity...
journal_title:International archives of allergy and immunology
pub_type: 新闻
doi:10.1159/000495302
更新日期:2019-01-01 00:00:00
abstract::For each medicinal product quality, safety and efficacy have to be proven to obtain a marketing authorisation. The national competent health authorities and the European Medicines Agency (EMEA) with support of the Heads of Medicines Agencies (HMA) work together to grant marketing authorisations for medicinal products....
journal_title:International archives of allergy and immunology
pub_type: 杂志文章,评审
doi:10.1159/000146074
更新日期:2008-01-01 00:00:00
abstract::For the identification and characterization of allergen grass group VI we performed two-dimensional immunoblotting of timothy grass pollen (Phleum pratense). Two intense 13-kD protein spots of pI 5.2 and 5.5 were found to be IgE reactive. By N-terminal microsequencing and amino acid analysis we identified them as Phl ...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000237117
更新日期:1995-09-01 00:00:00
abstract:BACKGROUND:We have previously shown that the allergic sensitization to ovalbumin does not represent a superantigen-like immune response. In gene-targeted mice (ΔD-iD) with a single modified Diversity gene segment (D(H)) of the immunoglobulin heavy chain, enriched for charged amino acids, the asthma phenotype in a murin...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000323527
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Sweating can worsen atopic dermatitis (AD). The purpose of this work was to study the associations between reactivity to autologous sweat and the clinical severity of AD as well as investigate the possible wheal-inducing factors of sweat. METHODS:Intracutaneous skin tests with autologous sweat were performe...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000447638
更新日期:2016-01-01 00:00:00
abstract::Mercuric chloride (HgCl(2)) has been proposed to be a mitogen for human blood lymphocytes in vitro. In our previous study, we demonstrated that HgCl(2) preferentially stimulates the CD4+ T cell subset to blast transformation and DNA synthesis and that the reaction is dependent on CD14+ accessory cells. In order to cha...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000024221
更新日期:1999-09-01 00:00:00
abstract:BACKGROUND AND AIM:Although still controversial, drug provocation tests (DPTs) are considered by many as the gold standard for diagnosis of drug hypersensitivity. No studies have addressed the opinion of patients submitted to DPT. We aimed to determine patient satisfaction with diagnostic DPT and their perception of it...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章,多中心研究
doi:10.1159/000323898
更新日期:2011-01-01 00:00:00
abstract::Psoriasis (Ps) is a chronic, immune-mediated, skin inflammatory disease affecting up to 3% of the population worldwide. Different environmental triggers initiate this complex multifactorial syndrome. Many individuals affected by Ps (6-26%) develop inflammatory disease in other organs, often in the joints as in psorias...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章,评审
doi:10.1159/000375401
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:In vivo, all blood vessels are lined by a single layer of flattened noncycling endothelial cells. We tested the hypothesis that the maintenance of such a quiescent endothelial monolayer depends on homotypic contacts between not yet defined growth-inhibitory molecules located at interendothelial junctions. M...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000024273
更新日期:1999-11-01 00:00:00
abstract:BACKGROUND:The human IgE response is associated with allergy and with host defence against parasitic worms. A response to Sm22.6, the dominant IgE antigen in adult Schistosoma mansoni worms, correlates with resistance to re-infection after treatment. Sm22.6 is one of a family of EF-hand containing parasite proteins wit...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000095997
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:We have previously shown that human monocyte-derived dendritic cells (moDCs) may participate in immune system-mediated hypercoagulable state through enhanced tissue factor (TF) expression and that the complement system may be involved in this process. OBJECTIVES:The aim of this study was to explore the role...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000496744
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Antiphospholipid antibodies (aPL) show great heterogeneity. Different phospholipids, with or without protein cofactor(s), and phospholipid binding proteins alone have been proposed as the target molecules for aPL. In order to determine the influence of phospholipid degradation products on the binding of aPL,...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000237426
更新日期:1997-01-01 00:00:00
abstract::Volumetric air sampling was performed at Corpus Christi, Tex., September 1987 to August 1989. Grass aeropollen during all of 1988 accounted for 15.3% of total pollen captured during two major peaks, one in May and another during September and October. The remaining grass pollen, about one-quarter of the total, was fou...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000236168
更新日期:1992-01-01 00:00:00
abstract:INTRODUCTION:Hereditary angioedema (HAE) with C1 inhibitor (C1-INH) deficiency is a rare autosomal dominant disease. Although the first symptoms can appear in childhood, the diagnosis's delay has a strong impact on the patient's quality of life. We analyzed clinical and laboratory characteristics and the drug therapy o...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000512944
更新日期:2021-01-28 00:00:00
abstract:BACKGROUND:The aim was to determine the clinical characteristics of patients with seasonal rhinitis (SR) and to disclose differences in the treatment of SR between an adult allergy clinic and other clinics over time. METHODS:A retrospective study was conducted based on clinical records of 774 out of 955 patients diagn...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000087360
更新日期:2005-09-01 00:00:00
abstract:BACKGROUND:Oxidants including reactive oxygen species have been indicated to play an important role in the pathogenesis of asthma. OBJECTIVE:We investigated oxidative status in patients with acute exacerbations of asthma and evaluated the therapeutic response using the D-ROM test which is simple to use and quick. MET...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000126064
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Pseudomonas aeruginosa phospholipase C (PLC) is a critical component in the pathogenesis of severe P. aeruginosa infections. However, P. aeruginosa can produce a hemolytic (PLC-H) as well as a nonhemolytic (PLC-N) variant, both having a MW of about 77 kD. In the past, studies did not distinguish between both...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000237441
更新日期:1997-02-01 00:00:00
abstract:BACKGROUND:Exhaled nitric oxide (NO) measurement at multiple exhalation flow rates allows calculation of flow-independent NO parameters: alveolar NO concentration, bronchial NO flux, bronchial diffusing capacity of NO and bronchial wall NO concentration. METHODS:In the present study, we measured the flow-independent N...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000155746
更新日期:2009-01-01 00:00:00
abstract::Nitric oxide (NO) is a potent biological mediator, and has a regulatory role in a wide variety of cellular and tissue functions. In the upper and lower airways, NO has been suggested to be involved in different functions with regulatory, protective, defensive or damaging effects. It is obvious that NO plays an importa...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章,评审
doi:10.1159/000324678
更新日期:2011-01-01 00:00:00
abstract::Many different mediators have been implicated in allergic responses and allergic diseases of the respiratory tract. The influence of several allergic inflammatory mediators on the ciliary activity has been well studied. However, ciliary responsiveness to platelet-activating factor (PAF) is yet to be established conclu...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000236681
更新日期:1994-07-01 00:00:00
abstract:BACKGROUND:Mercury causes in mouse strains of the H-2s haplotype an autoimmune syndrome with antibodies to the nucleolar protein fibrillarin and systemic immune complex (IC) deposits. Other strains, like BALB/C (H-2d), develop only IC deposits, and most strains are resistant. However, mercury activates the murine immun...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000023959
更新日期:1998-08-01 00:00:00
abstract:BACKGROUND:Allergic bronchopulmonary aspergillosis (ABPA) develops in the presence of predisposing conditions such as asthma and cystic fibrosis. Even ABPA accompanied by asthma is often complicated by chronic Pseudomonas aeruginosa or nontuberculous mycobacterial infection of the lower respiratory tract, rendering tre...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000507216
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:The cytokine transforming growth factor-beta(TGF-beta) has important regulatory roles in the immune system. To investigate the role of intact TGF-beta signaling during the contact hypersensitivity (CHS) response to a respiratory allergen, we exposed Smad3-/- mice to topical trimellitic anhydride (TMA). METH...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000236006
更新日期:2010-01-01 00:00:00