Abstract:
:Endogenous peroxidase has been reported in rat peritoneal mast cells and granules. Mast cell granules have also been shown to avidly bind exogenous eosinophil peroxidase. To examine the possibility that contaminating eosinophil peroxidase contributes to the reported rat mast cell peroxidase activity, mast cells were increasingly purified over sequential Percoll gradients. Such repeated centrifugations did not affect the histamine content of the cells or the secretory activity of cells, but the small increases in mast cell purity significantly reduced the specific activity of peroxidase; the remaining peroxidase activity of the mast cell fraction was in a range that could easily be accounted for by a small extent of contamination with eosinophils. An upper limit of 0.3 ng peroxidase/10(6) mast cells was determined from these measurements, ten times less than the values previously reported. When isolated mast cells were deliberately contaminated with soluble eosinophil peroxidase followed by granule isolation, the granules showed increased peroxidase activity, confirming the ability of mast cell granules to bind exogenous peroxidase.
journal_name
Int Arch Allergy Immunoljournal_title
International archives of allergy and immunologyauthors
Rickard A,Lagunoff Ddoi
10.1159/000236655subject
Has Abstractpub_date
1994-01-01 00:00:00pages
365-9issue
4eissn
1018-2438issn
1423-0097journal_volume
103pub_type
杂志文章abstract::Fibroblast-derived growth factors like SCF are able to upregulate the expression of mast cell characteristics in human multilineage hematopoietic progenitor cells. Other factors, like GM-CSF, have been reported to inhibit this process, probably by the competitive recruitment of cells not belonging to the mast cell lin...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000237574
更新日期:1997-05-01 00:00:00
abstract::The inhibitory effects of a novel compound, 6-hydroxy-2-(4-sulfamoylbenzylamino)-4,5,7-trimethylbenzothiazo le hydrochloride (E6080) on IgE-mediated reactions in vitro and in vivo were determined in rhesus monkeys. E6080 inhibited both antigen- and anti-human IgE-induced leukotriene C4 generations from lung fragments ...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000236406
更新日期:1993-01-01 00:00:00
abstract::At an international hereditary angioedema (HAE) expert meeting, results from a survey were used to guide discussion on how best to advise patients on self-administering intravenous C1 esterase inhibitor therapy. Treatment differences across Europe were highlighted, together with the practicalities of self-administrati...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000351236
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Recently, the relationship between antigen contact via skin (skin sensitization) and the development of food allergies has gained increasing attention. However, few studies have examined the effects of skin sensitization on healthy skin. OBJECTIVE:To examine the effect of sensitization in healthy skin on Ig...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000511239
更新日期:2020-11-11 00:00:00
abstract:INTRODUCTION:Venom immunotherapy (VIT) is considered to be the gold-standard treatment for patients with Hymenoptera venom allergy. Data regarding VIT in bee venom (BV) allergic patients are scarce. AIM:The aim of this study was to evaluate the outcome of VIT in patients with exclusive BV allergy and to try to define ...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000500957
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND/AIMS:The antioxidant properties of vitamin C and E are considered to be important for their anti-inflammatory activity. Recently, antioxidant resveratrol was found to suppress neopterin production and tryptophan degradation in mitogen-treated human peripheral blood mononuclear cells. METHODS:In this study, ...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000096438
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Reactive oxygen species (ROS) and eosinophilic granule proteins such as eosinophil-derived neurotoxin (EDN) are known to damage bronchial tissue and cause airway hyperresponsiveness (AHR) in asthma. Hepatocyte growth factor (HGF) regulates various biological activities and is known to be a multifunctional fa...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000144041
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:A negative association has been observed between infections and allergy in several studies. The aim of the present study was to examine whether tuberculosis and leprosy patients have more or fewer allergies than healthy individuals. METHOD:Sera from tuberculosis patients, leprosy patients and healthy contro...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000088722
更新日期:2005-11-01 00:00:00
abstract:BACKGROUND:Numerous strategies have been proposed for the treatment of peanut allergies, but despite the steady advancement in our understanding of atopic immune responses and the increasing number of deaths each year from peanut anaphylaxis, there is still no safe, effective, specific therapy for the peanut-sensitive ...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000053672
更新日期:2001-01-01 00:00:00
abstract::Antibodies to specific autoantigens are serological hallmarks of systemic autoimmune diseases. These autoantibodies are thought to represent a consequence of immune dysregulation in these conditions, and, in part, have been shown to be involved in their pathologic consequences. However, the mechanisms that lead to the...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章,评审
doi:10.1159/000024422
更新日期:2000-09-01 00:00:00
abstract:BACKGROUND:Specific immunotherapy for respiratory allergy, a seasonal disease, significantly reduces the inflammatory process, attenuating the clinical symptoms. The mechanism for the clinical beneficial effect of immunotherapy has not yet been clarified. Melatonin shows a circadian and seasonal variation and together ...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000049498
更新日期:2001-09-01 00:00:00
abstract::Oxatomide (OXA), a histamine H1 receptor antagonist, is effective in the treatment of patients with allergic rhinitis, some allergic skin disorders, and bronchial asthma. We have characterized the effect of OXA on the immunologic release of preformed (histamine and tryptase) and de novo synthesized mediators (leukotri...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000237340
更新日期:1996-09-01 00:00:00
abstract::Factors are discussed as potential diagnostic parameters of atopic disorders. The amounts of sCD23 in sera from newborn children (n = 4,329) were determined by radioimmunoassay with monoclonal antibodies specific for CD23. The sCD23 levels ranged between 0 and 81.5 ng/ml of CD23-specific mAb. Furthermore, the sera of ...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000236346
更新日期:1992-01-01 00:00:00
abstract::Hypersensitivity pneumonitis remains an important industrial disease in mushroom workers. It has a significant morbidity, and early diagnosis and removal from exposure to the antigen are critically important in its management. Recently, several new allergens have been described, particularly those from mushroom specie...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章,评审
doi:10.1159/000083298
更新日期:2005-01-01 00:00:00
abstract::Reversible airway obstruction and airway inflammation following allergen exposure represent crucial pathophysiological features of allergic asthma. In order to investigate these events, bronchial-specific challenge is commonly employed although it may be complicated and may not be free of possible risks. Therefore, we...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000237461
更新日期:1997-03-01 00:00:00
abstract::Chlorhexidine is a commonly used antiseptic and disinfectant in the health-care setting. Its usage has increased in recent years with intensive campaigns and infection control guidelines to combat hospital-acquired infections. As a result, patients and health-care workers (HCW) are exposed to increasing chlorhexidine ...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000431358
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Prostaglandin D(2) (PGD(2)), a major prostanoid produced by activated mast cells, has long been implicated in allergic diseases. PGD(2) demonstrates its effects through two G-protein-coupled receptors, DP and CRTH2. The PGD(2)/CRTH2 system mediates chemotaxis of eosinophils, basophils, and Th2 cells, which a...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000095436
更新日期:2006-01-01 00:00:00
abstract::Thymulin is a nonapeptide hormone isolated from the thymus gland. It has immunomodulatory effects which have not yet been well defined. Its major actions have been shown to be on T-cells and their immature precursors. In this study, thymulin was tested in vitro for its effect on the release of IL-1 alpha, IL-2, IL-6 a...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000236509
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND:In naive rodents, repeated exposure to aerosolized antigen induces suppression of the Th2 response to the antigen. We hypothesized that more prolonged exposure of established asthma model to antigen aerosols may downregulate asthmatic phenotype. METHODS:After establishing an ovalbumin (OVA)-induced asthma m...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000049503
更新日期:2001-10-01 00:00:00
abstract:BACKGROUND:Environmental factors play an important role in asthma morbidity, although the contribution of individual pollutants or pollens in exacerbating asthma is not completely elucidated. Despite the evidence of importance of the hornbeam pollen in inducing allergic sensitization, its role in provoking asthma exace...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000322177
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Although common variable immunodeficiency (CVID) is associated with sinopulmonary disease, there are no previous systematic evaluations comparing computed tomographic (CT) sinus imaging with immunoglobulin measurements in patients with this condition. METHODS:We performed a retrospective review by a blinded...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000260088
更新日期:2010-01-01 00:00:00
abstract::Contact sensitivity to para-phenylenediamine (PPD) is a frequent delayed-type hypersensitivity resulting in contact dermatitis. The aim of the present study, conducted in 16 patients allergic to PPD (as assessed by a positive patch test), was to get better insight into the mechanism of T-cell activation in PPD contact...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000236573
更新日期:1993-01-01 00:00:00
abstract::Serum antibodies reactive with streptococcal cell wall peptidoglycan (PG) and its peptide subunit (synthetic tetra-D-alanine) were measured by enzyme-linked immunosorbent assay (ELISA) in patients with rheumatoid arthritis (RA), juvenile rheumatoid arthritis (JRA), osteoarthritis and acute rheumatic fever (RF) compare...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000236137
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:Most patients with chronic spontaneous urticaria (CSU) exhibit recurrent angioedema. As of yet, the pathogenesis of angioedema in CSU is largely unclear, especially when angioedema occurs in patients who do not develop wheals. Over the past years, we and others have repeatedly observed that patients with rec...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000371421
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Reports on oral immunotherapy (OIT) for anaphylactic food allergy are lacking. We investigated the efficacy and safety of peanut OIT for anaphylactic patients. METHODS:We enrolled 22 peanut anaphylactic patients who underwent OIT between 2011 and 2013, all of whom demonstrated anaphylaxis during a baseline ...
journal_title:International archives of allergy and immunology
pub_type: 临床试验,杂志文章
doi:10.1159/000486310
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Patients with atopic dermatitis (AD) are frequently colonized with α-toxin-producing Staphylococcus aureus which is in turn positively correlated with the severity of eczema. METHODS:IN this study we addressed T cell proliferation and T cell as well as monocyte cytokine secretion upon α-toxin stimulation in...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000323905
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Animal models are used to mimic human asthma, however, not all models replicate the major characteristics of the human disease. Spontaneous development of asthma with hallmark features similar to humans has been documented to occur with relative frequency in only one animal species, the cat. We hypothesized ...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000080654
更新日期:2004-10-01 00:00:00
abstract::It has been well documented that environmental factors such as antigen-presenting cells and related cytokines can affect the development of T-helper cells. The purpose of this study was to investigate the role of different antigen-presenting cells on T-cell development. Ovalbumin (OVA) combined with complete Freud's a...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000237394
更新日期:1996-12-01 00:00:00
abstract::Bronchial asthma is characterized by infiltration of the respiratory tracts by eosinophils. A wide variety of adhesion molecules expressed by eosinophils have been proposed to be involved in binding of eosinophils to the vascular endothelium and subsequent transmigration from the circulation to the airways, while litt...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000237722
更新日期:1997-10-01 00:00:00
abstract::Oral immunotherapy (OIT) is a significant focus of treatment of food allergy. OIT appears to be effective in inducing desensitization, however, patients receiving OIT frequently developmild/moderate symptoms during the therapy. It has not been clearly established whether the clinical tolerance induced by OIT resembles...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章,评审
doi:10.1159/000361025
更新日期:2014-01-01 00:00:00