CD44 expression on blood eosinophils is a novel marker of bronchial asthma.

Abstract:

:Bronchial asthma is characterized by infiltration of the respiratory tracts by eosinophils. A wide variety of adhesion molecules expressed by eosinophils have been proposed to be involved in binding of eosinophils to the vascular endothelium and subsequent transmigration from the circulation to the airways, while little is known about CD44 expression on eosinophils. We introduced a novel staining combination with which surface markers on eosinophils could be analyzed without purification prior to staining, and examined the expression of CD44 on eosinophils. Staining of eosinophils with anti-CD 16 and anti-VLA-4 mAbs enabled us to delineate eosinophils as VLA-4high CD 16- cells from any other leukocyte populations in the whole blood. CD44 was found to be constitutively expressed on resting eosinophils, and expression increased upon cytokine-mediated activation. In all bronchial asthma patients examined, CD44high eosinophils were enriched in sputum relative to peripheral blood, indicating that eosinophils in sputum were more activated than those in blood. By comparing the extent of CD44 expression on blood eosinophils from poorly controlled and well-controlled asthma patients, we unexpectedly found that the density of CD44 expression is higher on blood eosinophils from the well-controlled group. Thus, the extent of CD44 expression on blood eosinophils is a novel marker indicative of the mangement of bronchial asthma. Deterioration of the asthma management with a concomitant decrease in CD44 expression on peripheral eosinophils implies that CD44 may play an important role in facilitating the transmigration of activated, CD44high eosinophils from the circulation to the respiratory tracts.

authors

Sano K,Yamauchi K,Hoshi H,Honma M,Tamura G,Shirato K

doi

10.1159/000237722

subject

Has Abstract

pub_date

1997-10-01 00:00:00

pages

67-71

eissn

1018-2438

issn

1423-0097

journal_volume

114 Suppl 1

pub_type

杂志文章
  • The Challenges in the Follow-Up and Treatment of Brazilian Children with Hereditary Angioedema.

    abstract:INTRODUCTION:Hereditary angioedema (HAE) with C1 inhibitor (C1-INH) deficiency is a rare autosomal dominant disease. Although the first symptoms can appear in childhood, the diagnosis's delay has a strong impact on the patient's quality of life. We analyzed clinical and laboratory characteristics and the drug therapy o...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000512944

    authors: Araújo-Simões J,Boanova AGP,Constantino-Silva RN,Fragnan NTML,Pinto JA,Minafra FG,Gonçalves RF,Valle SRD,Alonso MLO,Dortas SD,Goudouris ES,Rêgo-Silva AM,Marques MM,Serpa FS,Chong-Neto HJ,Nelson RF,Mansour E,Moreira IF,

    更新日期:2021-01-28 00:00:00

  • Asthma: the role of low high-density-lipoprotein cholesterol in childhood and adolescence.

    abstract:BACKGROUND:Several studies have examined the relationship of asthma with serum dyslipidemia and reported positive, negative or no association. Most studies were limited by their cross-sectional design and the wide age range of the participants. In a cohort of children in Cyprus, we explored the association of asthma wi...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000368405

    authors: Yiallouros PK,Savva SC,Kolokotroni O,Dima K,Zerva A,Kouis P,Bousquet J,Middleton N

    更新日期:2014-01-01 00:00:00

  • Resting B cells are not antigen-presenting cells in the induction of oral tolerance of specific Th2 immune responses in mice.

    abstract:BACKGROUND:It has been shown that antigen presentation by resting B cells can induce tolerance to intravenously administered protein antigens, but the role of resting B cells in the induction of oral tolerance is unclear. METHODS:Mice continuously treated since birth with rabbit anti-mouse IgM serum for 5 weeks were d...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000024394

    authors: Peng HJ,Chang ZN,Kuo SW,Lee CC,Tzau YY

    更新日期:2000-07-01 00:00:00

  • Different reactivity to recombinant Aspergillus fumigatus allergen I/a in patients with atopic dermatitis or allergic asthma sensitised to Aspergillus fumigatus.

    abstract::We report a clinical study comparing the skin test reactivity to recombinant Aspergillus fumigatus allergen 1 (rAsp fI/a) in patients with atopic dermatitis and A. fumigatus sensitisation (n = 15), A. fumigatus-allergic patients with asthma (n = 10) and healthy control subjects (n = 10). All patients sensitised to A. ...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000237123

    authors: Disch R,Menz G,Blaser K,Crameri R

    更新日期:1995-09-01 00:00:00

  • The Gut Microbiome of Adults with Allergic Rhinitis Is Characterised by Reduced Diversity and an Altered Abundance of Key Microbial Taxa Compared to Controls.

    abstract:INTRODUCTION:Unique gut microbial colonisation patterns are associated with the onset of allergic disease in infants; however, there is insufficient evidence to determine if aberrant microbial composition patterns persist in adult allergic rhinitis (AR) sufferers. OBJECTIVE:To compare the gut microbiome composition be...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000510536

    authors: Watts AM,West NP,Zhang P,Smith PK,Cripps AW,Cox AJ

    更新日期:2021-01-01 00:00:00

  • Circadian patterns in histamine concentrations and mast cell number in the rat thyroid gland.

    abstract::We carried out a cross-sectional chronobiological investigation on blood histamine, thyroid histamine and thyroid mast cell number in Wistar rats. Daily, blood histamine varied from 0.38 +/- 0.01 (12.00 h) to 0.60 +/- 0.01 mg/g wet weight (20.00 h) and thyroid histamine from 21.2 +/- 1.19 (04.00 h) to 38.3 +/- 1.54 mg...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000236788

    authors: Catini C,Miliani A,Macchi C

    更新日期:1994-12-01 00:00:00

  • Specific activation of human mast cells by the ligand for c-kit: comparison between lung, uterus and heart mast cells.

    abstract::Recent data suggest that stem cell factor (SCF or c-kit ligand, KL) is a major regulator of human mast cells (MCs). In the present study, MCs derived from the lung (n = 8), uterus (n = 14) and heart (n = 4) were analyzed for expression of c-kit receptor and for responses to recombinant SCF. MCs of all organs tested we...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000236568

    authors: Sperr WR,Czerwenka K,Mundigler G,Müller MR,Semper H,Klappacher G,Glogar HD,Lechner K,Valent P

    更新日期:1993-01-01 00:00:00

  • Characterization of api g 1.0201, a new member of the Api g 1 family of celery allergens.

    abstract:BACKGROUND:The association of pollinosis with allergy to plant foods occurs in up to 70% of tree pollen-allergic patients. In recent years, some of the relevant cross-reacting proteins have been characterized at the molecular and immunological level. Api g 1 has been identified as the celery homologue of the major birc...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000024367

    authors: Hoffmann-Sommergruber K,Ferris R,Pec M,Radauer C,O'Riordain G,Laimer Da Camara Machado M,Scheiner O,Breiteneder H

    更新日期:2000-06-01 00:00:00

  • Bioavailability and allergoprotective capacity of milk-associated conjugated linoleic acid in a murine model of allergic airway inflammation.

    abstract:BACKGROUND:Cross-sectional epidemiological studies have demonstrated that farm milk from traditional farm settings possesses allergoprotective properties. Up to now, it has not been clarified which milk ingredient is responsible for protection against allergic diseases. As farm milk is rich in conjugated linoleic acids...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000358523

    authors: Böcking C,Harb H,Ege MJ,Zehethofer N,Fischer K,Krauß J,Holst O,Nüsing RM,Lindner B,von Mutius E,Renz H,Garn H,Pfefferle PI

    更新日期:2014-01-01 00:00:00

  • Analysis of IgE-binding factors (sCD23) within newborn sera.

    abstract::Factors are discussed as potential diagnostic parameters of atopic disorders. The amounts of sCD23 in sera from newborn children (n = 4,329) were determined by radioimmunoassay with monoclonal antibodies specific for CD23. The sCD23 levels ranged between 0 and 81.5 ng/ml of CD23-specific mAb. Furthermore, the sera of ...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000236346

    authors: Bujanowski-Weber J,Knöller I,Wahn U,König W

    更新日期:1992-01-01 00:00:00

  • Exposure to indoor allergens in homes of patients with asthma and/or rhinitis in southeast Brazil: effect of mattress and pillow covers on mite allergen levels.

    abstract:BACKGROUND:Exposure and sensitization to indoor allergens have been associated with the development of asthma and other allergic diseases in many parts of the world. It is important to establish the degree of exposure, and to evaluate whether allergen control measures are effective in a particular area. METHODS:Concen...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000077356

    authors: Tobias KR,Ferriani VP,Chapman MD,Arruda LK

    更新日期:2004-04-01 00:00:00

  • An odorant-binding protein as a new allergen from Siberian hamster (Phodopus sungorus).

    abstract::A case of anaphylaxis following a bite from a Siberian hamster (SH; Phodopus sungorus) is described. Skin prick tests with hair, urine and salivary gland extracts from SH were positive, while the tests were negative for hair extracts from other rodents. IgE immunoblotting with the patient serum revealed 3 IgE-binding ...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000324956

    authors: Torres JA,Pastor-Vargas C,de las Heras M,Vivanco F,Cuesta J,Sastre J

    更新日期:2012-01-01 00:00:00

  • Vitamin C and E suppress mitogen-stimulated peripheral blood mononuclear cells in vitro.

    abstract:BACKGROUND/AIMS:The antioxidant properties of vitamin C and E are considered to be important for their anti-inflammatory activity. Recently, antioxidant resveratrol was found to suppress neopterin production and tryptophan degradation in mitogen-treated human peripheral blood mononuclear cells. METHODS:In this study, ...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000096438

    authors: Winkler C,Schroecksnadel K,Schennach H,Fuchs D

    更新日期:2007-01-01 00:00:00

  • Unexpected functions of FcepsilonRI on antigen-presenting cells.

    abstract::In contrast to mast cells and basophils, the high affinity IgE receptor (FcepsilonRI) on antigen-presenting cells (APC) shows structural and functional differences. It consists only of a minimal structure of one alpha- and two gamma-chains and enables APC to efficiently take up and present antigen in IgE-mediated dela...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章,评审

    doi:10.1159/000053662

    authors: Kraft S,Katoh N,Novak N,Koch S,Bieber T

    更新日期:2001-01-01 00:00:00

  • Selective regulation of T cell IL-5 synthesis by OM-01, JTE-711 and p38 MAP kinase inhibitor: independent control of Th2 cytokines, IL-4 and IL-5.

    abstract:BACKGROUND:Helper T cells are involved in chronic eosinophilic inflammation. Control of cytokine production seems to be an effective management. METHODS:The effect of nonactin, SB203580, a p38 MAP kinase inhibitor, and JTE-711 on the cytokine production of allergen-specific T cell clones was determined. The effect of ...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000053702

    authors: Mori A,Okudaira H,Kobayashi N,Akiyama K

    更新日期:2001-01-01 00:00:00

  • House Dust Mite-Specific Sublingual Immunotherapy Prevents the Development of Allergic Inflammation in a Mouse Model of Experimental Asthma.

    abstract:BACKGROUND:Evidence regarding sublingual immunotherapy (SLIT) efficacy and its good safety profile has been demonstrated with pollen and house dust mite (HDM) allergens in the treatment of airway allergies. In addition, the use of grass pollen presents a SLIT disease-modifying treatment for respiratory allergies. OBJE...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000446155

    authors: Hagner S,Rask C,Brimnes J,Andersen PS,Raifer H,Renz H,Garn H

    更新日期:2016-01-01 00:00:00

  • Bed bug saliva causes release of monocytic inflammatory mediators: plausible cause of cutaneous bite reactions.

    abstract::Bed bugs may cause mild to severe cutaneous reactions. We studied the ability of bed bug salivary extract (SGE) to induce inflammatory reactions responsible for cutaneous manifestations and found that SGE stimulated the production of several potent chemokines and cytokines from macrophages. Chemokines induced by SGE i...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000345134

    authors: Goddard J,Hasenkampf N,Edwards KT,de Shazo R,Embers ME

    更新日期:2013-01-01 00:00:00

  • Repeated inhalation of low doses of cat allergen that do not induce clinical symptoms increases bronchial hyperresponsiveness and eosinophil cationic protein levels.

    abstract::The aim of this study was to investigate whether repeated exposure to subclinical doses of cat allergens, not inducing asthma symptoms, could affect eosinophil cationic protein (ECP) levels in bronchoalveolar lavage (BAL) or in peripheral blood, without the appearance of clinical symptoms. Twelve patients with mild as...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000024234

    authors: de Blay F,Krieger P,Spirlet F,Moreau L,Duvernelle C,Kassel O,Kopferschmitt MC,Gasser B,Demangeat C,Pauli G,Frossard N

    更新日期:1999-10-01 00:00:00

  • Sulfidoleukotriene release test (CAST) in hypersensitivity to nonsteroidal anti-inflammatory drugs.

    abstract::There is a great need to develop a method for making an accurate and reliable in vitro diagnosis of adverse hypersensitivity reactions to drugs. We measured the amount of sulfidoleukotriene (sLT) released from the peripheral blood leukocytes obtained from 25 patients who developed hypersensitivity reactions following ...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000237695

    authors: Kubota Y,Imayama S,Toshitani A,Miyahara H,Tanahashi T,Uemura Y,Koga T,Sugawara N,Kurimoto F,Hata K

    更新日期:1997-12-01 00:00:00

  • Evaluation of receptor expression on immune system cells in the peripheral blood of asthmatic children undergoing food challenges.

    abstract:BACKGROUND:The role of food allergens in the induction of allergic reactions in the airways is not completely understood. The aim of the present study was to evaluate fluorocytometric assays of the peripheral blood during food challenge tests in children with asthma and food allergy. PATIENTS AND METHODS:22 children w...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000226239

    authors: Krogulska A,Wasowska-Królikowska K,Polakowska E,Chrul S

    更新日期:2009-01-01 00:00:00

  • Inhibitory effects of human neutrophil functions by the 45-kD glycoprotein derived from the parasitic nematode Trichinella spiralis.

    abstract:AIM:We evaluated the effect of the 45-kD protein of Trichinella spiralis (gp45), purified by affinity chromatography, on random migration and chemotaxis, the oxidative metabolism of human neutrophils and on the CD11b upregulation induced by formyl-methionyl-leucyl-phenylalanine (f-MLP). METHODS:Donor neutrophils incub...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000024359

    authors: Bruschi F,Carulli G,Azzarà A,Homan W,Minnucci S,Rizzuti-Gullaci A,Sbrana S,Angiolini C

    更新日期:2000-05-01 00:00:00

  • Influence of genetic and environmental factors on surface expression and occupancy of IgE receptors and on histamine releasability of mast cells.

    abstract::The relationship between the IgE load on mast cells and their secretory capacity when challenged with anti-IgE was studied in peritoneal cells obtained from rats of three different strains, Hooded Lister (HL), Wistar Kyoto (WKY) and Sprague-Dawley (SD). IgE was determined cytofluorometrically after labelling with FITC...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000236849

    authors: Chen XJ,Enerbäck L

    更新日期:1995-03-01 00:00:00

  • Induction of Oral Tolerance by Pepsin-Digested Gliadin Retaining T Cell Reactivity in a Mouse Model of Wheat Allergy.

    abstract:BACKGROUND:Wheat is known as the most widely consumed food all over the world. Although many types of wheat allergy have been recognized, their treatment still has a long way to go due to the complex pathogenesis. Oral immunotherapy (OIT) is under investigation for the treatment of wheat allergies. Previous studies hav...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000506945

    authors: Li X,Miyakawa T,Takano T,Nakajima-Adachi H,Tanokura M,Hachimura S

    更新日期:2020-01-01 00:00:00

  • Suckling reduces allergic skin responses and plasma levels of neuropeptide and neurotrophin in lactating women with atopic eczema/dermatitis syndrome.

    abstract:BACKGROUND:Lactation is associated with an inhibited hypothalamic-pituitary-adrenal axis response to physical and psychological stress in women and female rats. However, suckling also improved mood and calmness in nonatopic lactating women. Relaxation by humor reduced allergen-induced skin wheal responses, while variou...

    journal_title:International archives of allergy and immunology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000074906

    authors: Kimata H

    更新日期:2003-12-01 00:00:00

  • Isolation and partial characterization of eosinophil granule proteins in rats--eosinophil cationic protein and major basic protein.

    abstract::Peritoneal eosinophilia was induced in rats using Ascaris suum extract as an antigen, and characteristics of granule proteins of eosinophils collected from the peritoneal cavity were investigated. Peritoneal eosinophilia was induced by injection of the antigen solution into the peritoneal cavity of the immunized rats ...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000237111

    authors: Watanabe M,Nittoh T,Suzuki T,Kitoh A,Mue S,Ohuchi K

    更新日期:1995-09-01 00:00:00

  • Coexistence of angioedema alone with impaired glucose tolerance.

    abstract:BACKGROUND:Most patients with chronic spontaneous urticaria (CSU) exhibit recurrent angioedema. As of yet, the pathogenesis of angioedema in CSU is largely unclear, especially when angioedema occurs in patients who do not develop wheals. Over the past years, we and others have repeatedly observed that patients with rec...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000371421

    authors: Rogala B,Bozek A,Glück J,Rymarczyk B,Jarzab J,Maurer M

    更新日期:2014-01-01 00:00:00

  • Long-term characteristics of hazelnut allergy in an adjuvant-free mouse model.

    abstract:BACKGROUND:Clinically it is recognized that tree nut allergies such as hazelnut allergy are not usually outgrown. Specific mechanisms underlying the persistence of such food allergies are incompletely understood. Here we studied the natural history and the long-term immune and clinical characteristics of hazelnut aller...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000283028

    authors: Gonipeta B,Parvataneni S,Paruchuri P,Gangur V

    更新日期:2010-01-01 00:00:00

  • Effects of conjunctival hyperosmolar challenge in allergic subjects and normal controls.

    abstract::Nonspecific hyperreactivity to a number of physical, chemical and pharmacological agents in a common characteristics of allergic subjects, which is strictly related to the inflammatory events consequent to an allergic reaction. Hyperosmolar stimulus has previously been shown to cause an inflammatory response inducing ...

    journal_title:International archives of allergy and immunology

    pub_type: 临床试验,杂志文章

    doi:10.1159/000236713

    authors: Ciprandi G,Buscaglia S,Pesce G,Lotti R,Rolando M,Bagnasco M,Canonica GW

    更新日期:1994-05-01 00:00:00

  • The role of immune response to Staphylococcus aureus superantigens and disease severity in relation to the sensitivity to tacrolimus in atopic dermatitis.

    abstract:BACKGROUND:Staphylococcus aureus-producing superantigens (SAgs), such as staphylococcal enterotoxin B (SEB) or toxic shock syndrome toxin-1 (TSST-1), are frequently observed in atopic dermatitis (AD). However, little has been done to establish the association of immune responses to SAgs and the therapeutic response to ...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000095298

    authors: Fukushima H,Hirano T,Shibayama N,Miwa K,Ito T,Saito M,Sumida H,Oyake S,Tsuboi R,Oka K

    更新日期:2006-01-01 00:00:00

  • Pathogenesis of spongiform encephalopathies: an update.

    abstract::In the last 40 years, the pathogenesis of transmissible spongiform encephalopathies of humans and animals have been the subject of exciting discoveries and also of passionate controversies. Although the human forms of these diseases are rare, the recent epidemics of bovine spongiform encephalopathy has most dramatical...

    journal_title:International archives of allergy and immunology

    pub_type: 历史文章,杂志文章,评审

    doi:10.1159/000237273

    authors: Aguzzi A

    更新日期:1996-06-01 00:00:00