Abstract:
BACKGROUND:Animal models are used to mimic human asthma, however, not all models replicate the major characteristics of the human disease. Spontaneous development of asthma with hallmark features similar to humans has been documented to occur with relative frequency in only one animal species, the cat. We hypothesized that we could develop an experimental model of feline asthma using clinically relevant aeroallergens identified from cases of naturally developing feline asthma, and characterize immunologic, physiologic, and pathologic changes over 1 year. METHODS:House dust mite (HDMA) and Bermuda grass (BGA) allergen were selected by screening 10 privately owned pet cats with spontaneous asthma using a serum allergen-specific IgE ELISA. Parenteral sensitization and aerosol challenges were used to replicate the naturally developing disease in research cats. The asthmatic phenotype was characterized using intradermal skin testing, serum allergen-specific IgE ELISA, serum and bronchoalveolar lavage fluid (BALF) IgG and IgA ELISAs, airway hyperresponsiveness testing, BALF cytology, cytokine profiles using TaqMan PCR, and histopathologic evaluation. RESULTS:Sensitization with HDMA or BGA in cats led to allergen-specific IgE production, allergen-specific serum and BALF IgG and IgA production, airway hyperreactivity, airway eosinophilia, an acute T helper 2 cytokine profile in peripheral blood mononuclear cells and BALF cells, and histologic evidence of airway remodeling. CONCLUSIONS:Using clinically relevant aeroallergens to sensitize and challenge the cat provides an additional animal model to study the immunopathophysiologic mechanisms of allergic asthma. Chronic exposure to allergen in the cat leads to a variety of immunologic, physiologic, and pathologic changes that mimic the features seen in human asthma.
journal_name
Int Arch Allergy Immunoljournal_title
International archives of allergy and immunologyauthors
Norris Reinero CR,Decile KC,Berghaus RD,Williams KJ,Leutenegger CM,Walby WF,Schelegle ES,Hyde DM,Gershwin LJdoi
10.1159/000080654keywords:
subject
Has Abstractpub_date
2004-10-01 00:00:00pages
117-31issue
2eissn
1018-2438issn
1423-0097pii
80654journal_volume
135pub_type
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journal_title:International archives of allergy and immunology
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journal_title:International archives of allergy and immunology
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journal_title:International archives of allergy and immunology
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journal_title:International archives of allergy and immunology
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journal_title:International archives of allergy and immunology
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journal_title:International archives of allergy and immunology
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journal_title:International archives of allergy and immunology
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journal_title:International archives of allergy and immunology
pub_type: 临床试验,杂志文章
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journal_title:International archives of allergy and immunology
pub_type: 杂志文章
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journal_title:International archives of allergy and immunology
pub_type: 杂志文章
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journal_title:International archives of allergy and immunology
pub_type: 杂志文章
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journal_title:International archives of allergy and immunology
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pub_type: 杂志文章
doi:10.1159/000077356
更新日期:2004-04-01 00:00:00
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journal_title:International archives of allergy and immunology
pub_type: 杂志文章
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更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:Asthma, allergic conditions, and COPD overlap, but the effect of them and their combinations on disease severity, need for drugs, use of healthcare, and costs is poorly known. OBJECTIVE:To study how different allergic diseases co-occur in asthma and allergy patients and evaluate the use of medication well a...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000498861
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abstract:BACKGROUND:In patients showing multiple reactivity to seasonal airborne allergens, a skin prick test (SPT) with Parietaria pollen scores frequently negative, suggesting that profilin from Parietaria might not share IgE-binding epitopes with profilin from botanically unrelated airborne allergens. This study investigated...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
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journal_title:International archives of allergy and immunology
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journal_title:International archives of allergy and immunology
pub_type: 杂志文章
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journal_title:International archives of allergy and immunology
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journal_title:International archives of allergy and immunology
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abstract::Human foamy virus (HFV) is a recently characterized member of the retrovirus subfamily Spumaretrovirinae. HFV has a complex structure: it encodes the classical three retroviral structural genes gag, pol and env, but also possesses additional regulatory, so-called bel sequences. Foamy viruses have been discussed occasi...
journal_title:International archives of allergy and immunology
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journal_title:International archives of allergy and immunology
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更新日期:1998-01-01 00:00:00
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journal_title:International archives of allergy and immunology
pub_type: 杂志文章
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更新日期:1999-01-01 00:00:00
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journal_title:International archives of allergy and immunology
pub_type: 杂志文章
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更新日期:2013-01-01 00:00:00