Ovalbumin-liposome conjugate induces IgG but not IgE antibody production.

Abstract:

:Antibody response after immunization with surface-coupled ovalbumin (OVA) of liposomes was investigated in mice. OVA was coupled to the surface of liposome via amino groups using glutaraldehyde. OVA-liposome conjugate induced a significant anti-OVA IgG antibody production in mice. However, no IgE antibody production specific for OVA was observed. Immunization with OVA-liposome induced IgE-specific unresponsiveness even after the subsequent challenge with OVA adsorbed with with aluminium hydroxide (OVA-alum), which induces a high level of IgE antibody production. Furthermore, following the primary immunization with OVA-alum, a secondary challenge with OVA-liposome boosted anti-OVA IgG but not anti-OVA IgE antibody production. These results show the potential of the antigen-liposome conjugate for the development of a vaccine with the least allergic reaction and also for the application of immunotherapy.

authors

Naito S,Horino A,Nakayama M,Nakano Y,Nagai T,Mizuguchi J,Komuro K,Uchida T

doi

10.1159/000237241

subject

Has Abstract

pub_date

1996-03-01 00:00:00

pages

223-8

issue

3

eissn

1018-2438

issn

1423-0097

journal_volume

109

pub_type

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