Abstract:
:Antibody response after immunization with surface-coupled ovalbumin (OVA) of liposomes was investigated in mice. OVA was coupled to the surface of liposome via amino groups using glutaraldehyde. OVA-liposome conjugate induced a significant anti-OVA IgG antibody production in mice. However, no IgE antibody production specific for OVA was observed. Immunization with OVA-liposome induced IgE-specific unresponsiveness even after the subsequent challenge with OVA adsorbed with with aluminium hydroxide (OVA-alum), which induces a high level of IgE antibody production. Furthermore, following the primary immunization with OVA-alum, a secondary challenge with OVA-liposome boosted anti-OVA IgG but not anti-OVA IgE antibody production. These results show the potential of the antigen-liposome conjugate for the development of a vaccine with the least allergic reaction and also for the application of immunotherapy.
journal_name
Int Arch Allergy Immunoljournal_title
International archives of allergy and immunologyauthors
Naito S,Horino A,Nakayama M,Nakano Y,Nagai T,Mizuguchi J,Komuro K,Uchida Tdoi
10.1159/000237241subject
Has Abstractpub_date
1996-03-01 00:00:00pages
223-8issue
3eissn
1018-2438issn
1423-0097journal_volume
109pub_type
杂志文章abstract::It is unclear what actually induces eosinophil degranulation in vivo. We examined eosinophil cationic protein (ECP) release from normal human eosinophils (Eos) in response to C3a and C5a. C3a and C5a induced remarkable ECP release when Eos were preincubated with cytochalasin B. ECP release induced by C3a or C5a was gr...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000236743
更新日期:1994-01-01 00:00:00
abstract::A case of anaphylaxis following a bite from a Siberian hamster (SH; Phodopus sungorus) is described. Skin prick tests with hair, urine and salivary gland extracts from SH were positive, while the tests were negative for hair extracts from other rodents. IgE immunoblotting with the patient serum revealed 3 IgE-binding ...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000324956
更新日期:2012-01-01 00:00:00
abstract::Long-term birth cohort studies are essential to understanding the life course and childhood predictors of allergy and the complex interplay between genes and the environment (including lifestyle and socioeconomic determinants). Over 100 cohorts focusing on asthma and allergy have been initiated in the world over the p...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章,评审
doi:10.1159/000343018
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Cat allergens are ubiquitous because the clothing of cat owners constitutes an important source of distribution of Fel d 1 in cat-free environments. Since Fel d 1 can adhere to a variety of surfaces, we sought to verify if human hair belonging to individuals with or without a cat at home might represent a re...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000085793
更新日期:2005-06-01 00:00:00
abstract:BACKGROUND:Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by the interplay between multiple genetic and environmental factors. The pathogenesis of AD remains incompletely understood. Treatment with topical steroids for chronic AD symptoms has severe side effects and so a new treatment is re...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000486958
更新日期:2018-01-01 00:00:00
abstract::The clear recognition that asthma has an inflammatory basis has led to a search for genetic and environmental causes. Genetic linkage studies provide evidence for allelic association between polymorphic markers of interleukin-9 on chromosome 5 and a principal component of the allergic phenotype, log IgE. Further studi...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章,评审
doi:10.1159/000236921
更新日期:1995-05-01 00:00:00
abstract::Studies in migrant populations provide vital opportunities to investigate the role of environmental factors in the pathogenesis of allergic disorders. Differences in allergy prevalence have been observed between migrants and native-born subjects living in the same geographical location. Immigrants who migrate from les...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章,评审
doi:10.1159/000494129
更新日期:2019-01-01 00:00:00
abstract::Bronchial asthma is characterized by infiltration of the respiratory tracts by eosinophils. A wide variety of adhesion molecules expressed by eosinophils have been proposed to be involved in binding of eosinophils to the vascular endothelium and subsequent transmigration from the circulation to the airways, while litt...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000237722
更新日期:1997-10-01 00:00:00
abstract::Transforming growth factor-beta 1 (TGF-beta(1)) is a key regulator of immune tolerance. TGF-beta(1) controls T lymphocyte activation and is involved in the immunosuppressive function and generation of regulatory T lymphocytes. Connective tissue growth factor (CTGF) has an essential role in the formation of connective ...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000137284
更新日期:2008-01-01 00:00:00
abstract::The time course of the development of airway hyperresponsiveness (AHR) to inhaled acetylcholine (ACh) and the associated inflammatory cell recovery in bronchoalveolar lavage fluid (BAL) in actively sensitised Brown-Norway rats was studied following challenge with inhaled ovalbumin (OA). IgE for OA was detected in seru...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000236340
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:Antiphospholipid antibodies (aPL) show great heterogeneity. Different phospholipids, with or without protein cofactor(s), and phospholipid binding proteins alone have been proposed as the target molecules for aPL. In order to determine the influence of phospholipid degradation products on the binding of aPL,...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000237426
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND:Hypersensitivity to contrast media (CMs) may be common and serious. AIM:To evaluate the prevalence of CM hypersensitivity, risk factors associated with it and the role of skin testing in its diagnosis. METHODS:A structured questionnaire was administered to patients who underwent computed tomography during ...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000320760
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Pseudomonas aeruginosa phospholipase C (PLC) is a critical component in the pathogenesis of severe P. aeruginosa infections. However, P. aeruginosa can produce a hemolytic (PLC-H) as well as a nonhemolytic (PLC-N) variant, both having a MW of about 77 kD. In the past, studies did not distinguish between both...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000237441
更新日期:1997-02-01 00:00:00
abstract:INTRODUCTION:Venom immunotherapy (VIT) is considered to be the gold-standard treatment for patients with Hymenoptera venom allergy. Data regarding VIT in bee venom (BV) allergic patients are scarce. AIM:The aim of this study was to evaluate the outcome of VIT in patients with exclusive BV allergy and to try to define ...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000500957
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:The association between staphylococcal enterotoxins and atopic dermatitis (AD) is well characterized. We aim to evaluate the association between sensitization to staphylococcal enterotoxin A (SEA) and/or B (SEB) and the development of allergic airway disease. METHODS:Two hundred and seventy-four patients we...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000088868
更新日期:2005-12-01 00:00:00
abstract:BACKGROUND:Mast cell-released chemical mediators such as histamine, leukotriene (LT) C(4) and prostaglandin (PG) D(2) lead to the onset of allergic disorders. ATP provided from glycolysis is essential for histamine release and LTC(4) secretion from mast cells upon Fc epsilon RI cross-linking, indicating that glucose is...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000312122
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:A number of different molecules are known to be involved in the signal pathway to release histamine from mast cells, among which arachidonic acid (AA) is one of the key mediators. On the other hand, we found that the application of compound 48/80, a typical histamine liberator, generated superoxide in mast c...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000070216
更新日期:2003-04-01 00:00:00
abstract::We investigated the effects of KW-4679, an antiallergic drug, on the development of bronchial hyperresponsiveness, airway inflammation and early and late asthmatic responses following aerosol antigen challenge in guinea pigs actively sensitized by the inhalation of aerosolized ovalbumin. Pretreatment with KW-4679 (10 ...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000237312
更新日期:1996-05-01 00:00:00
abstract::A quantitative determination of the inflammatory mediators was performed and correlated with complaints and the measurement of the inflammatory cells in nasal secretions of 18 seasonal allergic rhinitis patients (group 1) outside the pollen season and 40 symptomatic patients (group 2) with seasonal allergic rhinitis d...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000236855
更新日期:1995-03-01 00:00:00
abstract::Volumetric air sampling was performed at Corpus Christi, Tex., September 1987 to August 1989. Grass aeropollen during all of 1988 accounted for 15.3% of total pollen captured during two major peaks, one in May and another during September and October. The remaining grass pollen, about one-quarter of the total, was fou...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000236168
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:Mast cell tryptase has recently been reported to be involved in atherosclerotic plaque destabilization. However, the results of these reports are conflicting. METHODS:The aim of this study was to characterize the role of tryptase as a prognostic marker of patient cardiovascular complexity in acute coronary ...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000360164
更新日期:2014-01-01 00:00:00
abstract::We have systematically investigated the capacity of highly purified human peripheral CD8+ T cells to produce interleukin (IL)-4 and interferon (IFN)-gamma when triggered by different stimuli. CD8+ T cells were isolated from peripheral blood by positive selection to > 99% purity and stimulated with one of three differe...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000237030
更新日期:1995-05-01 00:00:00
abstract::We carried out a cross-sectional chronobiological investigation on blood histamine, thyroid histamine and thyroid mast cell number in Wistar rats. Daily, blood histamine varied from 0.38 +/- 0.01 (12.00 h) to 0.60 +/- 0.01 mg/g wet weight (20.00 h) and thyroid histamine from 21.2 +/- 1.19 (04.00 h) to 38.3 +/- 1.54 mg...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000236788
更新日期:1994-12-01 00:00:00
abstract:BACKGROUND:Protease-activated receptors (PARs) are a unique class of G-protein-coupled receptors, which are activated by proteolytic cleavage of the amino terminus of the receptor itself. Although expression of the PAR1, which is typically activated by thrombin, on human eosinophils has been demonstrated, no effect of ...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000080037
更新日期:2004-09-01 00:00:00
abstract::CD95 (APO-1) is a member of the TNF/nerve growth factor receptor superfamily, which is expressed on the surface of different types of cells. Cross-linking of CD95 leads to the induction of apoptosis. This may be of importance in many physiological systems, but seems to play a special role for the maintenance of immuno...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000237293
更新日期:1996-07-01 00:00:00
abstract::Asthmatic individuals in the general population appear to be susceptible to disease exacerbation during summertime 'smog' episodes (ambient air pollution containing other pollutants in addition to ozone). Although controlled exposure to ozone causes acute decrements in lung function, asthmatic subjects are only margin...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章,评审
doi:10.1159/000236989
更新日期:1995-05-01 00:00:00
abstract:BACKGROUND:The coexistence of asthma and allergic rhinitis (AR) and its distinct association with obesity have been reported. However, few studies have differentiated the two types of AR, i.e., perennial (PAR) and seasonal AR (SAR), with regard to their associations with asthma and obesity. The aim of this study was to...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000488329
更新日期:2018-01-01 00:00:00
abstract::Anti-cyclic citrullinated peptide antibodies (anti-CCP) are a new diagnostic marker for rheumatoid arthritis (RA), which shows a specificity of 97% and a sensitivity of 81% in the second generation assay. About 61% of RA patients express HLA-DRB1*0401. In a cohort of patients with RA we investigated whether the expres...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000086463
更新日期:2005-08-01 00:00:00
abstract:BACKGROUND:Matrix metalloproteinase (MMP)-2, MMP-9 and MMP-13 can degrade type IV collagen which is the major component of the basement membrane zone (BMZ). In bullous pemphigoid (BP), the separation occurs within the BMZ. OBJECTIVE:To evaluate the involvement of MMPs in the pathogenesis of BP, we examined the express...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000090385
更新日期:2006-01-01 00:00:00
abstract::In murines, interleukins (IL) 3, 4, 9, and 10, nerve growth factor, and stem cell factor induce or promote growth and differentiation of mast cells (MC). Increased stimulation and synergy was observed when combinations of cytokines were used. In man, no growth factor for human MCs had been identified until recently, w...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000236767
更新日期:1994-11-01 00:00:00