Abstract:
:Delayed drug allergy reactions (DDAR) are potentially fatal. Certain human leukocyte antigen (HLA) alleles have been associated with delayed allergy reactions following the administration of particular drugs. Examples are HLA-B*57:01 (abacavir), HLA-B*15:02/HLA-A*31:01 (carbamazepine), and HLA-B*58:01 (allopurinol). Based on the identification of these associations, it may now be possible to prevent certain allergy reactions that were, until recently, considered unpredictable. In this review, we will focus on the pharmacogenetics of the best-studied associations between specific HLA alleles and delayed allergy reactions and describe the pathogenesis models proposed so far. Finally, we will evaluate the genetic screening strategies available and discuss the clinical relevance of a better understanding of the immunogenetics and mechanisms involved in DDAR.
journal_name
Int Arch Allergy Immunoljournal_title
International archives of allergy and immunologyauthors
Sousa-Pinto B,Correia C,Gomes L,Gil-Mata S,Araújo L,Correia O,Delgado Ldoi
10.1159/000448217subject
Has Abstractpub_date
2016-01-01 00:00:00pages
163-79issue
3eissn
1018-2438issn
1423-0097pii
000448217journal_volume
170pub_type
杂志文章,评审abstract:BACKGROUND:Chronic urticaria is associated with an immune dysregulation usually mediated by T lymphocytes. Recently, Th17 and Tc17 have been implicated in autoimmune diseases; however, their role in urticaria is not clear yet. METHODS:For the study we recruited 20 patients [10 of them had autoreactive chronic spontane...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000345401
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Loss-of-function mutations of the filaggrin (FLG) gene cause an impaired skin barrier and increase the risk of atopic dermatitis. Interestingly, FLG mutations have also been found to be associated with a high risk of peanut allergy. OBJECTIVE:We investigated the association of FLG mutations with self-report...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000345949
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Pre-clinical and clinical studies have evaluated the efficacy of probiotics in allergy. However, predictive in vitro systems for rational strain selection are still missing. METHODS:We developed a novel in vitro screening system for the characterization of probiotics with anti-allergic potential. In this mo...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000343703
更新日期:2013-01-01 00:00:00
abstract::Bed bugs may cause mild to severe cutaneous reactions. We studied the ability of bed bug salivary extract (SGE) to induce inflammatory reactions responsible for cutaneous manifestations and found that SGE stimulated the production of several potent chemokines and cytokines from macrophages. Chemokines induced by SGE i...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000345134
更新日期:2013-01-01 00:00:00
abstract::A case of anaphylaxis following a bite from a Siberian hamster (SH; Phodopus sungorus) is described. Skin prick tests with hair, urine and salivary gland extracts from SH were positive, while the tests were negative for hair extracts from other rodents. IgE immunoblotting with the patient serum revealed 3 IgE-binding ...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000324956
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:The population of large parts of Africa, South America and travellers to these areas are at risk of yellow fever (YF) with a 50% mortality risk. Yellow fever vaccine (YFV) propagated in hens' eggs confers protection in 95% of the vaccinated. The rate of anaphylaxis for YFV ranges from 0.42 to 1.8/100,000 dos...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000346350
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Sweating can worsen atopic dermatitis (AD). The purpose of this work was to study the associations between reactivity to autologous sweat and the clinical severity of AD as well as investigate the possible wheal-inducing factors of sweat. METHODS:Intracutaneous skin tests with autologous sweat were performe...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000447638
更新日期:2016-01-01 00:00:00
abstract::Epithelial cells line all cavities and surfaces throughout the body and play a substantial role in maintaining tissue homeostasis. Asthma and other atopic diseases are increasing worldwide and allergic disorders are hypothesized to be a consequence of a combination of dysregulation of the epithelial response towards e...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章,评审
doi:10.1159/000445833
更新日期:2016-01-01 00:00:00
abstract::Sera of 54 symptomatic workers showing sensitization to isocyanate-human serum albumin (HSA) conjugates were subjected to parallel enzyme allergosorbent test (EAST) and CAP measurements to determine IgE antibodies to diphenyl-methane diisocyanate-HSA, toluene diisocyanate-HSA and hexamethylene diisocyanate-HSA. Result...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000237325
更新日期:1996-08-01 00:00:00
abstract::Psoriasis (Ps) is a chronic, immune-mediated, skin inflammatory disease affecting up to 3% of the population worldwide. Different environmental triggers initiate this complex multifactorial syndrome. Many individuals affected by Ps (6-26%) develop inflammatory disease in other organs, often in the joints as in psorias...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章,评审
doi:10.1159/000375401
更新日期:2015-01-01 00:00:00
abstract::IL-3-dependent, murine mast cell lines derived from embryonic yolk sac precursors display a tumoricidal activity that is blocked by antibodies against tumor necrosis factor-alpha, indicating that this cytokine is the major mediator involved in the cytotoxic activity of the cultured mast cell lines. Further, cholera to...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000236179
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:The digestive system of Dermatophagoides farinae remains poorly documented. METHODS:In this study, a three-dimensional (3-D) model of the alimentary canal of D. farinae was built for the first time based on hematoxylin-eosin staining, 76 cross-sections of the adult mite and 3-D reconstruction technology. R...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000115890
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Nuclear factor (NF)-kappaB is a transcription factor known to regulate allergy-associated cytokine and chemokine production related to the induction of inflammation. I kappaB kinase beta (IKK beta), which is responsible for activation of the NF-kappaB pathway, may be an ideal molecular target to inhibit this...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000161579
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Nonsteroidal anti-inflammatory drugs (NSAIDS) are among the most common causes of drug hypersensitivity (HS) reactions. The diagnosis is based on a careful clinical history, and provocation tests are considered the gold standard for diagnosis. Skin tests have some value to study reactions to pyrazolones. Lab...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000452627
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Lactation is associated with an inhibited hypothalamic-pituitary-adrenal axis response to physical and psychological stress in women and female rats. However, suckling also improved mood and calmness in nonatopic lactating women. Relaxation by humor reduced allergen-induced skin wheal responses, while variou...
journal_title:International archives of allergy and immunology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000074906
更新日期:2003-12-01 00:00:00
abstract:BACKGROUND:T cells are key regulators of immunologic disease parameters. However, their contribution to the process of tissue remodeling is ill defined. In the present study, we investigated gene expression of allergy-characteristic, IL-4-rich T cell cDNAs to monitor expression of genes that might participate in the pa...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000072139
更新日期:2003-08-01 00:00:00
abstract::Two cDNA clones named P9* and P1* of 794 and 631 bp, respectively, were isolated from a lambda ZAP cDNA expression library using Parietaria judaica (Pj) pollen-specific IgE antibodies from a pool of sera (n = 23) of patients allergic to Pj. Sequence analysis showed open reading frames of 176 and 138 amino acids. Both ...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000237479
更新日期:1997-04-01 00:00:00
abstract::Nitric oxide (NO) is a potent biological mediator, and has a regulatory role in a wide variety of cellular and tissue functions. In the upper and lower airways, NO has been suggested to be involved in different functions with regulatory, protective, defensive or damaging effects. It is obvious that NO plays an importa...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章,评审
doi:10.1159/000324678
更新日期:2011-01-01 00:00:00
abstract::At an international hereditary angioedema (HAE) expert meeting, results from a survey were used to guide discussion on how best to advise patients on self-administering intravenous C1 esterase inhibitor therapy. Treatment differences across Europe were highlighted, together with the practicalities of self-administrati...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000351236
更新日期:2013-01-01 00:00:00
abstract::HIV-1 RNA has become the standard for monitoring antiretroviral therapies. Dogma predicts, however, that a viral protein like p24 should be at least as good a marker of HIV disease activity, provided that it is measured with sufficient sensitivity and accuracy. Simple modifications including use of a more efficient vi...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章,评审
doi:10.1159/000074552
更新日期:2003-11-01 00:00:00
abstract:BACKGROUND:Food allergy to wheat-derived foodstuffs is on the rise. Tri a 14, a wheat flour lipid transfer protein (LTP) allergen, has been described as a major allergen associated with baker's asthma and wheat food allergy. Cross-reactivity among LTP allergens leads to the so-called 'LTP syndrome'. METHODS:Eight adul...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000265539
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:Although common variable immunodeficiency (CVID) is associated with sinopulmonary disease, there are no previous systematic evaluations comparing computed tomographic (CT) sinus imaging with immunoglobulin measurements in patients with this condition. METHODS:We performed a retrospective review by a blinded...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000260088
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:It has been reported that protein tyrosine phosphorylation is essential for cytokine production in mouse Th1 cells but not in Th2 cells. However, little is known about the difference of signal transduction between human antigen-specific Th1 and Th2 cell clones. METHODS:Purified protein derivative-specific T...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000024028
更新日期:1999-01-01 00:00:00
abstract:BACKGROUND:Aspirin-intolerant asthma (AIA) is a clinical syndrome characterized by acute bronchoconstriction following the ingestion of aspirin. Solute carrier family 22, member 2 (SLC22A2), also known as organic cation transporter 2 (OCT2), is predominantly expressed in the luminal membrane of airway epithelial cells ...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000321267
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Prostaglandin D(2) (PGD(2)), a major prostanoid produced by activated mast cells, has long been implicated in allergic diseases. PGD(2) demonstrates its effects through two G-protein-coupled receptors, DP and CRTH2. The PGD(2)/CRTH2 system mediates chemotaxis of eosinophils, basophils, and Th2 cells, which a...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000095436
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:Five to twenty percent of healthy, nonasthmatic individuals exhibit airway hyperreactivity. Because cytokines are important intermediates in airway responses, we investigated the relationship between serum cytokines and airway responsiveness in a well-characterized population of pregnant women. METHODS:We a...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000069008
更新日期:2003-02-01 00:00:00
abstract:BACKGROUND:Severe refractory atopic dermatitis (AD) is a chronic, debilitating condition that is associated with elevated serum immunoglobulin E (IgE) levels. Thymic stromal lymphopoietin (TSLP), thymus and activation-regulated chemokine (TARC) and OX40 ligand (OX40L) are important immunologic factors involved in the p...
journal_title:International archives of allergy and immunology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000350486
更新日期:2013-01-01 00:00:00
abstract:AIM:To investigate the potential risk factors in patients who have experienced anaphylaxis from drugs. METHOD:The study included 281 adult patients (median age 40 years; 76.5% female) who experienced immediate types of hypersensitivity reaction to a drug. The patients were divided into an anaphylaxis group and a nonan...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000494130
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:The importance of fungal allergens in the development of allergic diseases in a desert environment is uncertain. This study evaluated the prevalence of IgE sensitization to moulds among patients with allergic respiratory diseases in Kuwait - a desert country. METHODS:A total of 810 patients (male:female rat...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000024343
更新日期:2000-04-01 00:00:00
abstract:BACKGROUND:15-Deoxy-Delta(12,14)-prostaglandin J2 (15d-PGJ2), a major prostanoid metabolized from prostaglandin D2 (PGD2), plays an important role in various biological processes including inflammatory responses. 15d-PGJ2 exerts its effects through two major receptors, chemoattractant receptor- homologous molecule expr...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000211377
更新日期:2009-01-01 00:00:00