Down-regulation of murine contact sensitivity by hapten-amino acid derivatives.

abstract：BACKGROUND:Japanese cedar pollinosis (JCPsis) is an immunoglobulin E-mediated type I allergy caused by exposure to Japanese cedar pollen (JCP). Blood thymus and activation-regulated chemokine (TARC) levels are well known as an objective parameter for disease severity for several allergic disorders. The present study ai...

journal_title：International archives of allergy and immunology

authors： Xiao JZ,Kondo S,Takahashi N,Odamaki T,Iwabuchi N,Miyaji K,Iwatsuki K,Enomoto T

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:There is no information whether galectin-9 (a novel eosinophil chemoattractant) was associated with pathogenesis of eosinophilic disorders. METHODS:We assessed the expression of galectin-9 with imunostaining and in situ hybridization both in the lesion of angiolymphoid hyperplasia with eosinophilia, and per...

journal_title：International archives of allergy and immunology

authors： Saita N,Goto E,Yamamoto T,Cho I,Tsumori K,Kohrogi H,Maruo K,Ono T,Takeya M,Kashio Y,Nakamura K,Hirashima M

更新日期：2002-05-01 00:00:00

abstract：:It is unclear what actually induces eosinophil degranulation in vivo. We examined eosinophil cationic protein (ECP) release from normal human eosinophils (Eos) in response to C3a and C5a. C3a and C5a induced remarkable ECP release when Eos were preincubated with cytochalasin B. ECP release induced by C3a or C5a was gr...

journal_title：International archives of allergy and immunology

authors： Takafuji S,Tadokoro K,Ito K,Dahinden CA

更新日期：1994-01-01 00:00:00

abstract：:Allergens from the pollen of Parthenium hysterophorus (American feverfew), responsible for high incidence of allergic rhinitis, were found by immunoprint analysis to be localized on the surface of the pollen grains. The allergens were released very rapidly when extracted in vitro. The allergenic activity of the rapid ...

journal_title：International archives of allergy and immunology

authors： Gupta N,Sriramarao P,Kori R,Rao PV

更新日期：1995-08-01 00:00:00

abstract：:The participation of platelets in the protection against larval Taenia taeniaeformis was studied. CB-17 SCID mice, susceptible to T. taeniaeformis, were protected against a challenge infection with T. taeniaeformis by the passive transfer of platelets from T. taeniaeformis-infected normal CB-17 mice, resistant to T. t...

journal_title：International archives of allergy and immunology

authors： Kakuda T,Ooi HK,Oku Y,Kamiya M

更新日期：1996-03-01 00:00:00

abstract：:Human colostrum and a high molecular weight colostrum fraction (HMWF; > 14,000 D) prevented the adhesion of localized adherent (LA+) O111:H-enteropathogenic Escherichia coli (EPEC) to HeLa cells. This effect was abolished after absorption with an O111:H-LA + EPEC strain, but absorption with a LA- strain of same seroty...

journal_title：International archives of allergy and immunology

authors： Camara LM,Carbonare SB,Silva ML,Carneiro-Sampaio MM

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND:Respiratory syncytial virus (RSV) infection in infants with Th2 predisposition is thought to increase the risk of allergic sensitization, recurrent wheezing, and bronchial asthma during childhood. We attempted to clarify the molecular mechanisms by which Th1/Th2 predisposition in the host alters RSV infectio...

journal_title：International archives of allergy and immunology

authors： Yamada Y,Matsumoto K,Hashimoto N,Saikusa M,Homma T,Yoshihara S,Saito H

更新日期：2011-01-01 00:00:00

abstract：:Aerosolized monoclonal antibodies (mAbs) specific for T-cell receptors (TCR) were used to manipulate T-cell function in airways of ovalbumin (OVA)-sensitized and -challenged mice with airway hyperresponsiveness (AHR). The inhaled mAbs were found to be effective at low doses, had little or no systemic effect and specif...

journal_title：International archives of allergy and immunology

authors： Lahn M,Kanehiro A,Hahn YS,Wands JM,Aydintug MK,O'Brien RL,Gelfand EW,Born WK

更新日期：2004-05-01 00:00:00

abstract：:Accumulation and activation of eosinophils in tissue are critical events in the allergic inflammatory response and adhesion molecules play important roles in this process. We previously demonstrated that human eosinophils expressed a nuclear receptor, peroxisome proliferator-activated receptor gamma (PPARgamma), and t...

journal_title：International archives of allergy and immunology

authors： Hirasawa H,Chiba T,Ueki S,Kamada Y,Ito W,Takeda M,Fujita M,Kato H,Kayaba H,Chihara J

更新日期：2008-01-01 00:00:00

abstract：AIM:To investigate the potential risk factors in patients who have experienced anaphylaxis from drugs. METHOD:The study included 281 adult patients (median age 40 years; 76.5% female) who experienced immediate types of hypersensitivity reaction to a drug. The patients were divided into an anaphylaxis group and a nonan...

journal_title：International archives of allergy and immunology

authors： Demir S,Erdenen F,Gelincik A,Unal D,Olgac M,Coskun R,Colakoglu B,Buyukozturk S

更新日期：2019-01-01 00:00:00

abstract：:Toll-like receptors have a critical role in innate immunity and host defence. However their role in allergic disease has not been studied in great detail. The presence of these receptors on mast cells opens up new possibilities concerning the role of Toll-like receptors in the pathogenesis of asthma and atopic dermati...

journal_title：International archives of allergy and immunology

authors： Marshall JS,McCurdy JD,Olynych T

更新日期：2003-10-01 00:00:00

abstract：:Bed bugs may cause mild to severe cutaneous reactions. We studied the ability of bed bug salivary extract (SGE) to induce inflammatory reactions responsible for cutaneous manifestations and found that SGE stimulated the production of several potent chemokines and cytokines from macrophages. Chemokines induced by SGE i...

journal_title：International archives of allergy and immunology

authors： Goddard J,Hasenkampf N,Edwards KT,de Shazo R,Embers ME

更新日期：2013-01-01 00:00:00

abstract：:Eosinophils are pleiotropic multi-functional leukocytes involved in initiation and propagation of diverse inflammatory responses. Recent studies examining eosinophil biology have focused on delineating the molecular basis of FIP1L1/PDGRFalpha-fusion gene induced HES, the molecular steps involved in eosinophil recruitm...

journal_title：International archives of allergy and immunology

authors： Hogan SP

更新日期：2007-01-01 00:00:00

abstract：:Recently, the induction of T cell anergy has been considered as a sophisticated form of immunotherapy. However, the multiplicity of T cell allergen epitopes discourages the practical use of this method. Since orally administered antigen proteins are digested to peptides and absorbed into the circulation, oral administ...

journal_title：International archives of allergy and immunology

authors： Suko M,Mori A,Ito K,Okudaira H

更新日期：1995-05-01 00:00:00

abstract：:A 20mer peptide representing the N-terminus of a major allergen, Alt a I, of Alternaria alternata was synthesized and examined for its antibody binding and antibody induction activities. Alt a I peptide-BSA conjugate reacted with both human IgE and rabbit anti-Alt a I IgG in ELISA, albeit the binding of the peptide to...

journal_title：International archives of allergy and immunology

authors： Zhang L,Curran IH,Muradia G,De Vouge MW,Rode H,Vijay HM

更新日期：1995-11-01 00:00:00

abstract：:The present study has extended histochemical and functional investigations into rat mast cell heterogeneity using isolated mast cells from four connective tissue locations; the peritoneum, mesentery, lung and skin. On histological examination, mast cells from these locations displayed a range of phenotypes following f...

journal_title：International archives of allergy and immunology

authors： Tainsh KR,Pearce FL

更新日期：1992-01-01 00:00:00

abstract：:Peritoneal mast cells of Syrian hamsters release histamine to the action of concanavalin A (Con A) in dose-dependent fashion. The rate of release was very rapid in the first seconds of cell activation and completed in 60 s after the challenge. Morphological changes concomitant to the lectin treatment, followed by elec...

journal_title：International archives of allergy and immunology

authors： Wyczolkowska J,Rydzynski K,Prouvost-Danon A

更新日期：1992-01-01 00:00:00

abstract：:T cells are central regulators and mediators of allergic sensitisation and disease. The house dust mite allergens are a biochemically diverse group of proteins which are present in extracts and the environment in a wide range of concentrations. Here the importance of ascertaining the contribution of the different alle...

journal_title：International archives of allergy and immunology

authors： Thomas WR,Smith W,Hales BJ

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND:The clinical significance and efficacy of treating patients who have immunoglobulin (Ig) G subclass deficiency and/or antibody deficiency with Ig-replacement therapy has been debated. There are no clear guidelines to recommend intravenous gammaglobulin (IgIV) in these patients as there are few published stud...

journal_title：International archives of allergy and immunology

authors： Abdou NI,Greenwell CA,Mehta R,Narra M,Hester JD,Halsey JF

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Although allergy to local anesthetics (LA) is rare, patients often report unwanted reactions after their administration. A history of anaphylaxis or an atypical reaction related to LA is an indication for typing a safe anesthetic for future surgical or dental procedures. AIM:The aim of the study was to dete...

journal_title：International archives of allergy and immunology

authors： Specjalski K,Kita-Milczarska K,Jassem E

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Subcutaneous immunotherapy for respiratory allergy has shown a long lasting efficacy after its discontinuation, whereas evidence in the case of sublingual immunotherapy (SLIT) is weak. This retrospective study evaluates whether SLIT exerts a long-lasting effect and whether it relates to its duration. METHOD...

journal_title：International archives of allergy and immunology

authors： Marogna M,Bruno M,Massolo A,Falagiani P

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Chronic rhinosinusitis (CRS) is a multifaceted disease with a significant genetic component. The importance of taste receptor signaling has recently been highlighted in CRS; single nucleotide polymorphisms (SNPs) of bitter tastant-responsive G-protein-coupled receptors have been linked with CRS and with alte...

journal_title：International archives of allergy and immunology

authors： Purnell PR,Addicks BL,Zalzal HG,Shapiro S,Wen S,Ramadan HH,Setola V,Siderovski DP

更新日期：2019-01-01 00:00:00

abstract：:The present study was designed to determine if depletion of the complement system in the circulation with cobra venom factor (CVF) prevented the cellular infiltration in a guinea pig model of asthma. Guinea pigs were sensitized with ovalbumin (OA) alone or OA with complete Freund's adjuvant. Animals were pretreated wi...

journal_title：International archives of allergy and immunology

authors： Regal JF,Fraser DG

更新日期：1996-02-01 00:00:00

abstract：:The last decade has seen the rapid development of research investigating the mechanisms of apoptosis in a variety of experimental systems. Among the multitude of changes observed in apoptotic cells, chromatin cleavage is considered a biochemical hallmark of apoptosis. Chromatin fragmentation is an enzymatic process wh...

journal_title：International archives of allergy and immunology

authors： Zhivotovsky B,Wade D,Nicotera P,Orrenius S

更新日期：1994-12-01 00:00:00

abstract：BACKGROUND:Cytosolic phospholipase A2 (cPLA2) plays a key role in the development of late-phase anaphylaxis. L-Glutamine (Gln), a nonessential amino acid, has anti-inflammatory activity via inhibiting cPLA2. METHODS:We used a penicillin-induced murine model of anaphylaxis, and late-phase anaphylaxis was quantified by ...

journal_title：International archives of allergy and immunology

authors： Kim HK,Song CH,Bae YS,Im SY,Lee HK

更新日期：2016-01-01 00:00:00

abstract：:The objective of this study was to investigate the role of progesterone in modulating electrophysiological responses to antigenic challenge that are reflective of immune functions in uterine and jejunal mucosae. In the rat-Trichinella spiralis, host-parasite system, an enteric infection with a microscopic nematode sen...

journal_title：International archives of allergy and immunology

authors： Harari Y,Castro GA

更新日期：1995-10-01 00:00:00

abstract：:The allergic pig can be used as a large-animal model for studies of allergic reactions in the airways and the role of eosinophils in such reactions. To measure the activation of eosinophils, the release of eosinophil-derived cationic proteins can be used. The purpose of this study was to isolate and characterize catio...

journal_title：International archives of allergy and immunology

authors： Fornhem C,Peterson CG,Alving K

更新日期：1996-06-01 00:00:00

abstract：:Fourteen Brown-Norway rats were pretreated with physiological saline (n = 7) or 500 micrograms Sephadex (n = 7) intratracheally. 24 h later, a bronchial provocation test was performed under pentobarbital anaesthesia using increasing doses of acetylcholine aerosol and the degree of bronchospasm was measured using a mod...

journal_title：International archives of allergy and immunology

authors： Kubin R,Deschl U,Linssen M,Wilhelms OH

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:Cat allergens are ubiquitous because the clothing of cat owners constitutes an important source of distribution of Fel d 1 in cat-free environments. Since Fel d 1 can adhere to a variety of surfaces, we sought to verify if human hair belonging to individuals with or without a cat at home might represent a re...

journal_title：International archives of allergy and immunology

authors： Liccardi G,Barber D,Russo M,D'Amato M,D'Amato G

更新日期：2005-06-01 00:00:00

abstract：BACKGROUND:To elucidate the usefulness of antigen-specific immunotherapy based on oral vaccination with an edible part of the plant, we examined the effect of transgenic (Tg) rice seeds expressing an immunodominant fragment of the group 1 antigen of Dermatophagoides pteronyssinus (Der p 1) on a murine model of asthma. ...

journal_title：International archives of allergy and immunology

authors： Suzuki K,Kaminuma O,Yang L,Motoi Y,Takai T,Ichikawa S,Okumura K,Ogawa H,Mori A,Takaiwa F,Hiroi T

更新日期：2009-01-01 00:00:00