当前位置： SCI文献检索 > INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY期刊下所有文献 > Effect of Th1/Th2 cytokine pretreatment on RSV-induced gene expression in airway epithelial cells.

Effect of Th1/Th2 cytokine pretreatment on RSV-induced gene expression in airway epithelial cells.

Abstract：

BACKGROUND:Respiratory syncytial virus (RSV) infection in infants with Th2 predisposition is thought to increase the risk of allergic sensitization, recurrent wheezing, and bronchial asthma during childhood. We attempted to clarify the molecular mechanisms by which Th1/Th2 predisposition in the host alters RSV infection and facilitates airway inflammation. METHODS:A549 human airway epithelial cells were inoculated with live or UV-treated RSV after pretreatment with either a combination of tumor necrosis factor (TNF)-α and interferon-γ (Th1-primed) or a combination of TNF-α and interleukin-4 (Th2-primed) for 48 h. The gene and protein expression profiles of RSV-infected A549 cells were examined. RESULTS:GeneChip analysis indicated that, at 96 h after inoculation with RSV, the expression of 62 genes was specifically enhanced (more than 2-fold by normalized data) in Th2-primed cells compared to that in unprimed or Th1-primed cells. An increase in mRNA and protein levels of monocyte chemoattractant protein (MCP)-1/CCL2 among those 62 genes was confirmed by real-time PCR and cytometric bead assay, respectively. RSV replication was markedly diminished in Th1-primed airway epithelial cells but not in Th2-primed cells, which was presumably caused at least in part by the early induction of antiviral genes. CONCLUSIONS:These results suggest that Th1/Th2 predisposition in the host prior to RSV infection critically regulates inflammatory reactions in the airways through alteration of gene expression, and that MCP-1/CCL2 plays an important role in the pathogenesis of severe RSV infection and the subsequent development of asthma in Th2-predisposed hosts.

journal_name

Int Arch Allergy Immunol

journal_title

International archives of allergy and immunology

authors

Yamada Y,Matsumoto K,Hashimoto N,Saikusa M,Homma T,Yoshihara S,Saito H

doi

10.1159/000321105

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

185-94

issue

3

eissn

1018-2438

issn

1423-0097

pii

000321105

journal_volume

154

pub_type

杂志文章

相关文献

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY文献大全
  • Histamine augments VCAM-1 expression on IL-4- and TNF-alpha-stimulated human umbilical vein endothelial cells.

    abstract：:Interaction between vascular cell adhesion molecule-1 (VCAM-1) on endothelial cells and CD49d molecules on eosinophils is thought to mediate the selective infiltration of eosinophils into inflamed tissues in allergic disease. IL-4 and TNF-alpha are associated with allergic conditions, and they have been shown to selec...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000237357

    authors： Saito H,Shimizu H,Mita H,Maeda Y,Akiyama K

    更新日期：1996-10-01 00:00:00

  • IgE-mediated sensitization to mould allergens among patients with allergic respiratory diseases in a desert environment.

    abstract：BACKGROUND:The importance of fungal allergens in the development of allergic diseases in a desert environment is uncertain. This study evaluated the prevalence of IgE sensitization to moulds among patients with allergic respiratory diseases in Kuwait - a desert country. METHODS:A total of 810 patients (male:female rat...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000024343

    authors： Ezeamuzie CI,Al-Ali S,Khan M,Hijazi Z,Dowaisan A,Thomson MS,Georgi J

    更新日期：2000-04-01 00:00:00

  • Probiotics have a different immunomodulatory potential in vitro versus ex vivo upon oral administration in children with food allergy.

    abstract：BACKGROUND:Previous studies suggest that administration of probiotics in vitro can stimulate regulatory and Th1 immune responses. We studied both the in vitro immunological effects of probiotics and the ex vivo immunological effects after oral administration of probiotics in children with food allergy, a Th2-mediated d...

    journal_title：International archives of allergy and immunology

    pub_type： 临床试验,杂志文章

    doi：10.1159/000099467

    authors： Flinterman AE,Knol EF,van Ieperen-van Dijk AG,Timmerman HM,Knulst AC,Bruijnzeel-Koomen CA,Pasmans SG,van Hoffen E

    更新日期：2007-01-01 00:00:00

  • Expression and effects of IL-33 and ST2 in allergic bronchial asthma: IL-33 induces eotaxin production in lung fibroblasts.

    abstract：BACKGROUND:Interleukin (IL)-33, a new member of the IL-1 cytokine family, has been recognized as a key cytokine that enhances T helper 2-balanced immune regulation through its receptor ST2; however, the function and relationship of the IL-33 and ST2 pathways in bronchial asthma are still unclear. We investigated the ce...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000327259

    authors： Kurokawa M,Matsukura S,Kawaguchi M,Ieki K,Suzuki S,Odaka M,Watanabe S,Homma T,Sato M,Yamaguchi M,Takeuchi H,Adachi M

    更新日期：2011-01-01 00:00:00

  • The role of immune response to Staphylococcus aureus superantigens and disease severity in relation to the sensitivity to tacrolimus in atopic dermatitis.

    abstract：BACKGROUND:Staphylococcus aureus-producing superantigens (SAgs), such as staphylococcal enterotoxin B (SEB) or toxic shock syndrome toxin-1 (TSST-1), are frequently observed in atopic dermatitis (AD). However, little has been done to establish the association of immune responses to SAgs and the therapeutic response to ...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000095298

    authors： Fukushima H,Hirano T,Shibayama N,Miwa K,Ito T,Saito M,Sumida H,Oyake S,Tsuboi R,Oka K

    更新日期：2006-01-01 00:00:00

  • Development of transgenic rice expressing mite antigen for a new concept of immunotherapy.

    abstract：BACKGROUND:To elucidate the usefulness of antigen-specific immunotherapy based on oral vaccination with an edible part of the plant, we examined the effect of transgenic (Tg) rice seeds expressing an immunodominant fragment of the group 1 antigen of Dermatophagoides pteronyssinus (Der p 1) on a murine model of asthma. ...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000210649

    authors： Suzuki K,Kaminuma O,Yang L,Motoi Y,Takai T,Ichikawa S,Okumura K,Ogawa H,Mori A,Takaiwa F,Hiroi T

    更新日期：2009-01-01 00:00:00

  • Lack of cross-reactivity between casein and gliadin in sera from coeliac disease patients.

    abstract：BACKGROUND:While searching for antigliadin and anticasein antibodies in sera from coeliac patients we investigated more than 20 persons suffering from this enteropathy. In some of sera, we registered antibodies against gliadin and in parallel the appearance of anticasein antibodies. A high percentage of glutamic acid h...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000024003

    authors： Paranos S,Nikolic G

    更新日期：1998-10-01 00:00:00

  • Effects of Migration on Allergic Diseases.

    abstract：:Studies in migrant populations provide vital opportunities to investigate the role of environmental factors in the pathogenesis of allergic disorders. Differences in allergy prevalence have been observed between migrants and native-born subjects living in the same geographical location. Immigrants who migrate from les...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章,评审

    doi：10.1159/000494129

    authors： Tham EH,Loo EXL,Zhu Y,Shek LP

    更新日期：2019-01-01 00:00:00

  • Hypersensitivity reactions to contrast media: prevalence, risk factors and the role of skin tests in diagnosis--a cross-sectional survey.

    abstract：BACKGROUND:Hypersensitivity to contrast media (CMs) may be common and serious. AIM:To evaluate the prevalence of CM hypersensitivity, risk factors associated with it and the role of skin testing in its diagnosis. METHODS:A structured questionnaire was administered to patients who underwent computed tomography during ...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000320760

    authors： Goksel O,Aydın O,Atasoy C,Akyar S,Demirel YS,Misirligil Z,Bavbek S

    更新日期：2011-01-01 00:00:00

  • The spectrum of olive pollen allergens.

    abstract：:Olive pollen is one of the most important causes of seasonal respiratory allergy in Mediterranean countries, where this tree is intensely cultivated. Among the high number of protein allergens detected in this pollen, 8 - Ole e 1 to Ole e 8 - have been isolated and characterized. Ole e 1 is the most frequent sensitizi...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章,评审

    doi：10.1159/000053815

    authors： Rodríguez R,Villalba M,Monsalve RI,Batanero E

    更新日期：2001-07-01 00:00:00

  • Specificities of IgE, IgG and IgA antibodies to ovalbumin. Comparison of binding activities to denatured ovalbumin or ovalbumin fragments of IgE antibodies with those of IgG or IgA antibodies.

    abstract：:We studied the binding activities of IgE, IgG and IgA antibodies in patients with allergy to hen's egg white against two different ovalbumin (OVA) preparations, which were physically or chemically denatured OVA and enzyme-digested OVA fragments. The binding activities of IgE antibodies to these OVA preparations with t...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000236602

    authors： Honma K,Kohno Y,Saito K,Shimojo N,Tsunoo H,Niimi H

    更新日期：1994-01-01 00:00:00

  • Aerosolized anti-T-cell-receptor antibodies are effective against airway inflammation and hyperreactivity.

    abstract：:Aerosolized monoclonal antibodies (mAbs) specific for T-cell receptors (TCR) were used to manipulate T-cell function in airways of ovalbumin (OVA)-sensitized and -challenged mice with airway hyperresponsiveness (AHR). The inhaled mAbs were found to be effective at low doses, had little or no systemic effect and specif...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000077533

    authors： Lahn M,Kanehiro A,Hahn YS,Wands JM,Aydintug MK,O'Brien RL,Gelfand EW,Born WK

    更新日期：2004-05-01 00:00:00

  • Kinetic analysis of pepsin digestion of chicken egg white ovomucoid and allergenic potential of pepsin fragments.

    abstract：BACKGROUND:The allergenic potential of chicken egg white ovomucoid (OVM) is thought to depend on its stability to heat treatment and digestion. Pepsin-digested fragments have been speculated to continue to exert an allergenic potential. OVM was digested in simulated gastric fluid (SGF) to examine the reactivity of the ...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000082581

    authors： Takagi K,Teshima R,Okunuki H,Itoh S,Kawasaki N,Kawanishi T,Hayakawa T,Kohno Y,Urisu A,Sawada J

    更新日期：2005-01-01 00:00:00

  • The negative predictive value of typing safe local anesthetics.

    abstract：BACKGROUND:Although allergy to local anesthetics (LA) is rare, patients often report unwanted reactions after their administration. A history of anaphylaxis or an atypical reaction related to LA is an indication for typing a safe anesthetic for future surgical or dental procedures. AIM:The aim of the study was to dete...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000350763

    authors： Specjalski K,Kita-Milczarska K,Jassem E

    更新日期：2013-01-01 00:00:00

  • Recombinant fusion proteins assembling Der p 1 and Der p 2 allergens from Dermatophagoides pteronyssinus.

    abstract：BACKGROUND:Fusion proteins assembling multiple allergens can be engineered by recombinant DNA technologies in order to produce tools for diagnostic and immunotherapeutic purposes. Herein, we developed and characterized chimeras assembling Der p 1 and Der p 2 allergens as potential candidate vaccines against house dust ...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000312631

    authors： Bussières L,Bordas-Le Floch V,Bulder I,Chabre H,Nony E,Lautrette A,Berrouet C,Nguefeu Y,Horiot S,Baron-Bodo V,Van Overtvelt L,De Conti AM,Schlegel A,Maguet N,Mouz N,Lemoine P,Batard T,Moingeon P

    更新日期：2010-01-01 00:00:00

  • Different reactivity to recombinant Aspergillus fumigatus allergen I/a in patients with atopic dermatitis or allergic asthma sensitised to Aspergillus fumigatus.

    abstract：:We report a clinical study comparing the skin test reactivity to recombinant Aspergillus fumigatus allergen 1 (rAsp fI/a) in patients with atopic dermatitis and A. fumigatus sensitisation (n = 15), A. fumigatus-allergic patients with asthma (n = 10) and healthy control subjects (n = 10). All patients sensitised to A. ...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000237123

    authors： Disch R,Menz G,Blaser K,Crameri R

    更新日期：1995-09-01 00:00:00

  • Successful pregnancy in a Churg-Strauss syndrome patient with a history of intrauterine fetal death.

    abstract：:Allergic granulomatosis and angiitis was first reported as a disease entity separate from polyarteritis nodosa in 1951 by Churg and Strauss. It is characterized by bronchial asthma, eosinophilia, and vasculitis and is especially rare in women of reproductive age, though, when present, may be associated with fetal mort...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000237140

    authors： Ogasawara M,Kajiura S,Inagaki H,Sasa H,Aoki K,Yagami Y

    更新日期：1995-10-01 00:00:00

  • Characterization of candidate anti-allergic probiotic strains in a model of th2-skewed human peripheral blood mononuclear cells.

    abstract：BACKGROUND:Pre-clinical and clinical studies have evaluated the efficacy of probiotics in allergy. However, predictive in vitro systems for rational strain selection are still missing. METHODS:We developed a novel in vitro screening system for the characterization of probiotics with anti-allergic potential. In this mo...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000343703

    authors： Holvoet S,Zuercher AW,Julien-Javaux F,Perrot M,Mercenier A

    更新日期：2013-01-01 00:00:00

  • Genetic and environmental influences on airway inflammation in asthma.

    abstract：:The clear recognition that asthma has an inflammatory basis has led to a search for genetic and environmental causes. Genetic linkage studies provide evidence for allelic association between polymorphic markers of interleukin-9 on chromosome 5 and a principal component of the allergic phenotype, log IgE. Further studi...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章,评审

    doi：10.1159/000236921

    authors： Holgate ST,Church MK,Howarth PH,Morton EN,Frew AJ,Djukanović R

    更新日期：1995-05-01 00:00:00

  • Regulation of surface FcepsilonRI expression on human eosinophils by IL-4 and IgE.

    abstract：BACKGROUND:Recent studies have demonstrated that eosinophils from allergic patients express low levels of FcepsilonRI on their surface, but the regulatory mechanisms of eosinophil surface FcepsilonRI expression are not fully understood. We investigated whether IL-4 and IgE, which are reported to regulate surface Fcepsi...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000053782

    authors： Iikura M,Yamaguchi M,Hirai K,Miyamasu M,Yamada H,Nakajima T,Fujisawa T,Ra C,Morita Y,Yamamoto K

    更新日期：2001-04-01 00:00:00

  • The activation of the JAK2/STAT5 pathway is commonly involved in signaling through the human IL-5 receptor.

    abstract：:The JAK (Janus kinase) family of protein tyrosine kinases and the STATs (signal transducers and activators of transcription) have been shown to be activated in response to a number of cytokines and growth factors. In this study, we evaluated the activation of JAK/STAT pathway upon human interleukin-5 (hIL-5) stimulati...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000237712

    authors： Ogata N,Kikuchi Y,Kouro T,Tomonaga M,Takatsu K

    更新日期：1997-10-01 00:00:00

  • Variability of Ole e 9 allergen in olive pollen extracts: relevance of minor allergens in immunotherapy treatments.

    abstract：BACKGROUND:Clustered severe adverse reactions to immunotherapy with olive pollen extracts have been occasionally reported in areas where olive trees are extensively grown. Allergic patients from these areas, in addition to the major olive pollen allergen Ole e 1, frequently recognize a recently described allergen, Ole ...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000092532

    authors： Duffort O,Palomares O,Lombardero M,Villalba M,Barber D,Rodríguez R,Polo F

    更新日期：2006-01-01 00:00:00

  • Peptide specificity, HLA class II restriction, and T-cell subsets of the T-cell clones specific to either Cry j 1 or Cry j 2, the major allergens of Japanese cedar (Cryptomeria japonica) pollen.

    abstract：BACKGROUND:Cry j 1 and Cry j 2 are thought to be the major allergens of Japanese cedar pollen. HLA class II types capable of presenting T-cell epitopes in both allergens and their role in induction of T-cell subsets are not well known. METHODS:CD4+ T (Th)-cell clones (TCCs) specific to either Cry j 1 or Cry j 2 were g...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000024194

    authors： Sone T,Morikubo K,Shimizu K,Komiyama N,Tsunoo H,Kino K

    更新日期：1999-07-01 00:00:00

  • Effect of ibudilast, a novel antiasthmatic agent, on anaphylactic bronchoconstriction: predominant involvement of endogenous slow reacting substance of anaphylaxis.

    abstract：:The effect of ibudilast on anaphylactic bronchoconstriction was studied in guinea pigs sensitized actively with ovalbumin (OA). Animals were treated with indomethacin, tripelennamine and propranolol prior to the antigen challenge. Anaphylactic bronchoconstriction was prevented by ibudilast (1-4 mg/kg i.v. and 5-20 mg/...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000236460

    authors： Ohashi M,Uno T,Nishino K

    更新日期：1993-01-01 00:00:00

  • Immunologic effects of omalizumab in children with severe refractory atopic dermatitis: a randomized, placebo-controlled clinical trial.

    abstract：BACKGROUND:Severe refractory atopic dermatitis (AD) is a chronic, debilitating condition that is associated with elevated serum immunoglobulin E (IgE) levels. Thymic stromal lymphopoietin (TSLP), thymus and activation-regulated chemokine (TARC) and OX40 ligand (OX40L) are important immunologic factors involved in the p...

    journal_title：International archives of allergy and immunology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1159/000350486

    authors： Iyengar SR,Hoyte EG,Loza A,Bonaccorso S,Chiang D,Umetsu DT,Nadeau KC

    更新日期：2013-01-01 00:00:00

  • Heterogeneity of pollen proteins within individual Betula pendula trees.

    abstract：:To determine the variation of antigenic water soluble proteins in white birch (Betula pendula) pollen, extracts of pollen from different sides of individual trees were analyzed by isoelectric focusing (IEF), crossed immunoelectrophoresis, and crossed radioimmunoelectrophoresis. IgE-antibody-binding patterns were also ...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000237184

    authors： Hjelmroos M,Schumacher MJ,Van Hage-Hamsten M

    更新日期：1995-12-01 00:00:00

  • Iris protein antibodies in serum of patients with juvenile rheumatoid arthritis and uveitis.

    abstract：:Homogenates of bovine iris were fractionated by gel filtration chromatography, and the column-eluted proteins were probed with pooled sera obtained from patients with pauciarticular juvenile rheumatoid arthritis (JRA). The serum pool prepared from patients with pauciarticular JRA and a history of anterior uveitis, but...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000236431

    authors： Hunt DW,Petty RE,Millar F

    更新日期：1993-01-01 00:00:00

  • Detection of Dermatophagoides farinae in the dust of air conditioning filters.

    abstract：BACKGROUND:The allergenic dust mite species Dermatophagoides pteronyssinus and Dermatophagoides farinae generally inhabit warm moist environments. This study tested the hypothesis that these allergenic species may thrive in air conditioner filters. METHODS:A year-long investigation of the dust mite population densitie...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000102619

    authors： Liu Z,Bai Y,Ji K,Liu X,Cai C,Yu H,Li M,Bao Y,Lian Y,Gao B

    更新日期：2007-01-01 00:00:00

  • Unexpected functions of FcepsilonRI on antigen-presenting cells.

    abstract：:In contrast to mast cells and basophils, the high affinity IgE receptor (FcepsilonRI) on antigen-presenting cells (APC) shows structural and functional differences. It consists only of a minimal structure of one alpha- and two gamma-chains and enables APC to efficiently take up and present antigen in IgE-mediated dela...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章,评审

    doi：10.1159/000053662

    authors： Kraft S,Katoh N,Novak N,Koch S,Bieber T

    更新日期：2001-01-01 00:00:00

  • Different kinds of antigen-presenting cells exert different effects on T-helper cells development.

    abstract：:It has been well documented that environmental factors such as antigen-presenting cells and related cytokines can affect the development of T-helper cells. The purpose of this study was to investigate the role of different antigen-presenting cells on T-cell development. Ovalbumin (OVA) combined with complete Freud's a...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000237394

    authors： Chuang YH,Chiang BL,Chou CC,Hsieh KH

    更新日期：1996-12-01 00:00:00