Abstract:
:We studied the binding activities of IgE, IgG and IgA antibodies in patients with allergy to hen's egg white against two different ovalbumin (OVA) preparations, which were physically or chemically denatured OVA and enzyme-digested OVA fragments. The binding activities of IgE antibodies to these OVA preparations with those of IgG or IgA antibodies were compared. It was found that the binding activities of IgE antibodies to denatured OVA by treatment with dithiothreitol, urea or hydrochloric acid were similar to those of IgG or IgA antibodies. In contrast, the binding activities of IgE antibodies to heat-denatured OVA or by treatment with sodium hydroxide at pH 11.0 were different from those of IgG or IgA antibodies to these denatured OVA. Furthermore, we found that the binding activities of anti-OVA antibodies in sera from patients with allergy to hen's egg white against fragmented OVA were different between IgE antibodies and IgG or IgA antibodies. Thus, it can be concluded that IgE antibodies to OVA in sera from patients with allergy to egg white differ from IgG or IgA antibodies in respect to binding activities against different preparations of denatured or fragmented OVA, probably due to differences in fine specificities of these antibodies against OVA.
journal_name
Int Arch Allergy Immunoljournal_title
International archives of allergy and immunologyauthors
Honma K,Kohno Y,Saito K,Shimojo N,Tsunoo H,Niimi Hdoi
10.1159/000236602subject
Has Abstractpub_date
1994-01-01 00:00:00pages
28-35issue
1eissn
1018-2438issn
1423-0097journal_volume
103pub_type
杂志文章abstract::The modulatory role of hormones in the regulation of the immune response has been well documented. Here, we present some thoughts on how sex hormones affect immunity, particularly at mucosal sites. We further discuss the possible pitfalls and difficulties associated with analysis of the data. ...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章,评审
doi:10.1159/000236631
更新日期:1994-01-01 00:00:00
abstract::Immunological suppression is one of the important aspects which govern the regulation of the immune response. Clonal deletion, clonal anergy and the activity of suppressor cells were proposed as mechanisms leading to this phenomenon. In this review we provide evidence for the existence of suppressor (Ts) cells and the...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章,评审
doi:10.1159/000236379
更新日期:1993-01-01 00:00:00
abstract::In studies designed to optimize the production and detection of anti-ovalbumin (anti-Oa) IgE in Ham/ICR mice, a range of doses of both Oa and pertussis toxin as the IgE adjuvant was explored. As determined by 48-hour passive cutaneous anaphylaxis (PCA) tests, the highest titre of anti-Oa IgE was obtained in a three-in...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000236770
更新日期:1994-11-01 00:00:00
abstract::The downstream signaling components of high-affinity IgE receptor (FcepsilonRI) were studied using yeast two-hybrid screening of the cDNA library constructed from RBL-2H3 cells. The cytoplasmic part of the gamma-chain but not that of the beta-chain was found to interact with pyruvate kinase in the yeast. The in-vitro-...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000024183
更新日期:1999-06-01 00:00:00
abstract:BACKGROUND:Natural rubber latex proteins have been implicated in severe allergy in individuals exposed to latex products, particularly health care workers. Until recently, only crude antigens were available to study the immune response in these patients. In recent years a number of relevant allergens have been purified...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000024279
更新日期:1999-12-01 00:00:00
abstract:BACKGROUND:Protective acquired immunity against helminths and allergic sensitisation are both characterised by high IgE antibody levels. Levels of IgE antibodies are naturally tightly regulated by several mechanisms including binding of the CD23 receptor. Following observations that helminth infections and allergic sen...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000346545
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Recent work indicates that subcutaneous specific immunotherapy induces specific T-cell anergy, a shift in the TH1/TH2 ratio, and antibody production in favor of IgG4. There are few data on sublingual immunotherapy (SLIT), especially in children. METHODS:We assessed the proliferation of peripheral blood mono...
journal_title:International archives of allergy and immunology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000083320
更新日期:2005-02-01 00:00:00
abstract::IL-13 is a relatively novel cytokine produced by activated T cells. IL-13 inhibits the production of proinflammatory cytokines and chemokines by activated monocytes, induces B cell proliferation and differentiation, including IgE production, and the expression of certain adhesion molecules on endothelial cells. All th...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章,评审
doi:10.1159/000236842
更新日期:1995-03-01 00:00:00
abstract::Mast cells in the tongue of the bat (Artibeus lituratus) show a well-developed Golgi area and abundant mitochondria in the granule-free perinuclear cytoplasm. Rough endoplasmic reticulum profiles, free ribosomes, mitochondria, bundles of filaments and a great number of secretory granules are found throughout the remai...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000236416
更新日期:1993-01-01 00:00:00
abstract::Recent data suggest that stem cell factor (SCF or c-kit ligand, KL) is a major regulator of human mast cells (MCs). In the present study, MCs derived from the lung (n = 8), uterus (n = 14) and heart (n = 4) were analyzed for expression of c-kit receptor and for responses to recombinant SCF. MCs of all organs tested we...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000236568
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND:A negative association has been observed between infections and allergy in several studies. The aim of the present study was to examine whether tuberculosis and leprosy patients have more or fewer allergies than healthy individuals. METHOD:Sera from tuberculosis patients, leprosy patients and healthy contro...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000088722
更新日期:2005-11-01 00:00:00
abstract:BACKGROUND:Assessing high-sensitivity C-reactive protein (hs-CRP) in relation to allergic endpoints can shed light on both the mechanisms of allergic disease development and early non-communicable disease prevention. However, only a few epidemiological studies so far have investigated the relationship in children and a...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章,多中心研究
doi:10.1159/000497320
更新日期:2019-01-01 00:00:00
abstract::It has been well documented that environmental factors such as antigen-presenting cells and related cytokines can affect the development of T-helper cells. The purpose of this study was to investigate the role of different antigen-presenting cells on T-cell development. Ovalbumin (OVA) combined with complete Freud's a...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000237394
更新日期:1996-12-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to investigate lymphocyte adhesion to Kupffer cells as a component of an immune-mediated mechanism for halothane hepatitis. METHODS:Kupffer cells were isolated from guinea pigs exposed to 1.0% halothane/40% oxygen and cultured with various synthetic antigens (trifluoroacetyl-pr...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000237642
更新日期:1997-09-01 00:00:00
abstract:BACKGROUND:Nonsteroidal anti-inflammatory drugs (NSAIDS) are among the most common causes of drug hypersensitivity (HS) reactions. The diagnosis is based on a careful clinical history, and provocation tests are considered the gold standard for diagnosis. Skin tests have some value to study reactions to pyrazolones. Lab...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000452627
更新日期:2016-01-01 00:00:00
abstract::Oxatomide (OXA), a histamine H1 receptor antagonist, is effective in the treatment of patients with allergic rhinitis, some allergic skin disorders, and bronchial asthma. We have characterized the effect of OXA on the immunologic release of preformed (histamine and tryptase) and de novo synthesized mediators (leukotri...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000237340
更新日期:1996-09-01 00:00:00
abstract::We examined the capacity of interleukin-4 (IL) production from lymphocytes and basophils, isolated from the peripheral blood of allergic patients sensitive to house dust mite, after stimulation with mite extract. IL-4 production was measured by a sensitive bioassay based on coculture with CT.h4S (a human IL-4-responsi...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000237375
更新日期:1996-11-01 00:00:00
abstract:BACKGROUND:Chronic rhinosinusitis (CRS) is a multifaceted disease with a significant genetic component. The importance of taste receptor signaling has recently been highlighted in CRS; single nucleotide polymorphisms (SNPs) of bitter tastant-responsive G-protein-coupled receptors have been linked with CRS and with alte...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000499875
更新日期:2019-01-01 00:00:00
abstract::Epithelial cells line all cavities and surfaces throughout the body and play a substantial role in maintaining tissue homeostasis. Asthma and other atopic diseases are increasing worldwide and allergic disorders are hypothesized to be a consequence of a combination of dysregulation of the epithelial response towards e...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章,评审
doi:10.1159/000445833
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:We analyzed the T cell activation potency and the IgE-binding properties (allergenicity) of nine isoforms of Bet v 1, the major allergen of birch pollen. METHODS:The capacity of recombinant Bet v 1 isoforms to bind serum IgE from allergic patients was evaluated by immunoblot experiments and skin prick tests...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000237524
更新日期:1997-05-01 00:00:00
abstract::Interaction between vascular cell adhesion molecule-1 (VCAM-1) on endothelial cells and CD49d molecules on eosinophils is thought to mediate the selective infiltration of eosinophils into inflamed tissues in allergic disease. IL-4 and TNF-alpha are associated with allergic conditions, and they have been shown to selec...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000237357
更新日期:1996-10-01 00:00:00
abstract:BACKGROUND:It is assumed that the very late antigen-4 (VLA-4) plays a key role in selective migration and accumulation of eosinophils to the allergic inflammatory focus. The regulatory mechanism for VLA-4 expression is poorly understood, as is its relationship between other adhesion molecules. OBJECTIVE:The aim of the...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000053850
更新日期:2001-01-01 00:00:00
abstract::A peptide B3144, derived after peptic tryptic digestion of alpha-gliadin and corresponding to residues 3-56 from the coeliac-activating domain I, was previously used to produce monoclonal antibodies. A dot immunobinding assay was developed using these antibodies to detect gluten in wheat, rye, barley and oats. The lim...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000236683
更新日期:1994-07-01 00:00:00
abstract:BACKGROUND:Diethylhexyl phthalate (DEHP) and diisononyl phthalate (DINP), two commonly used plasticizers in flexible polyvinylchloride formulations, have potentially adverse effects on human health. However, the influence of these diphthalates on allergic responses remains unclear. In this study we examined the effects...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000078768
更新日期:2004-07-01 00:00:00
abstract::Based on in vitro findings with mouse mast cells and in vivo findings in mice, we report that dexamethasone or cyclosporin A can have at least three actions which interfere with the pathogenesis IgE-, mast-cell-, and cytokine-dependent inflammatory reactions: suppression of the IgE-dependent increase in tumor necrosis...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章,评审
doi:10.1159/000237015
更新日期:1995-05-01 00:00:00
abstract::Psoriasis (Ps) is a chronic, immune-mediated, skin inflammatory disease affecting up to 3% of the population worldwide. Different environmental triggers initiate this complex multifactorial syndrome. Many individuals affected by Ps (6-26%) develop inflammatory disease in other organs, often in the joints as in psorias...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章,评审
doi:10.1159/000375401
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:The so-called 'latex-fruit syndrome' is a well-documented phenomenon in cross-reactive allergies. By contrast, there is a lack of information about allergy to exotic fruits in patients with a predominant pollen sensitization. Since the ubiquitous protein profilin has been identified as an allergen in natural...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000059400
更新日期:2002-06-01 00:00:00
abstract::There is a great need to develop a method for making an accurate and reliable in vitro diagnosis of adverse hypersensitivity reactions to drugs. We measured the amount of sulfidoleukotriene (sLT) released from the peripheral blood leukocytes obtained from 25 patients who developed hypersensitivity reactions following ...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000237695
更新日期:1997-12-01 00:00:00
abstract::Preferential eosinophil accumulation is characteristic of airway inflammation in asthma. Although little is known about its mechanism, the effect of a sialyl Lewis X analog on airway eosinophilia was examined in a guinea-pig model of asthma. Guinea-pigs were sensitized by repeated inhalation of ovalbumin. After a sing...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000237412
更新日期:1996-01-01 00:00:00
abstract:BACKGROUND:Antiphospholipid antibodies (aPL) show great heterogeneity. Different phospholipids, with or without protein cofactor(s), and phospholipid binding proteins alone have been proposed as the target molecules for aPL. In order to determine the influence of phospholipid degradation products on the binding of aPL,...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000237426
更新日期:1997-01-01 00:00:00