A functional study on CysLT(1) receptors in human eosinophils.

abstract：BACKGROUND:A new lateral flow test (LFT) for office use provides information about sensitisation to common allergens. Concordance between LFT and skin-prick test (SPT) has not been assessed in epidemiological studies. The aim of this study is to determine LFT-SPT concordance in this field. METHODS:Plasma samples (n = ...

journal_title：International archives of allergy and immunology

authors： Sanchez-Bahillo M,Garcia-Marcos L,Martinez-Torres AE,Perez-Fernandez V,Sanchez-Solis M

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Patients with atopic dermatitis (AD) are frequently colonized with α-toxin-producing Staphylococcus aureus which is in turn positively correlated with the severity of eczema. METHODS:IN this study we addressed T cell proliferation and T cell as well as monocyte cytokine secretion upon α-toxin stimulation in...

journal_title：International archives of allergy and immunology

authors： Niebuhr M,Mamerow D,Heratizadeh A,Satzger I,Werfel T

更新日期：2011-01-01 00:00:00

abstract：INTRODUCTION:One of the most frequent abnormalities of B cells in common variable immunodeficiency (CVID) is reduced number of class-switched memory B cells, suggesting an impaired germinal center response. Therefore, due to its pivotal role in regulating the development of humoral immunity, the objective of this study...

journal_title：International archives of allergy and immunology

authors： Kasahara TM,Bento CAM,Gupta S

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Transforming growth factor-β1 (TGF-β1)-in-duced proliferation of airway smooth muscle cells plays critical roles in the development of airway remodeling. Six1 (sine oculis homeobox homolog 1) has been demonstrated to be involved in airway inflammation and remodeling in asthmatic mice. OBJECTIVES:The aim of ...

journal_title：International archives of allergy and immunology

authors： Yang Z,Qu Z,Yi M,Lv Z,Wang Y,Shan Y,Ran N,Liu X

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:alpha-Melanocyte-stimulating hormone (alpha-MSH) is a neuropeptide that controls melanogenesis in pigmentary cells. In addition, its potent immunomodulatory activity has been recently described in cutaneous inflammatory disorders. However the mechanism of such pollen allergies remains to be elucidated. The p...

journal_title：International archives of allergy and immunology

authors： Hiramoto K,Hashimoto M,Orita K,Jikumaru M,Sato EF,Inoue M

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Reports on oral immunotherapy (OIT) for anaphylactic food allergy are lacking. We investigated the efficacy and safety of peanut OIT for anaphylactic patients. METHODS:We enrolled 22 peanut anaphylactic patients who underwent OIT between 2011 and 2013, all of whom demonstrated anaphylaxis during a baseline ...

journal_title：International archives of allergy and immunology

authors： Nagakura KI,Sato S,Yanagida N,Nishino M,Asaumi T,Ogura K,Ebisawa M

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Mouse models have been established mirroring key features of human bronchial asthma including airway hyperresponsiveness (AHR). Acute airway obstruction in response to an allergen challenge, however, remains to be demonstrated in these models. OBJECTIVE:A mouse model of allergic lung inflammation was employ...

journal_title：International archives of allergy and immunology

authors： Neuhaus-Steinmetz U,Glaab T,Daser A,Braun A,Lommatzsch M,Herz U,Kips J,Alarie Y,Renz H

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND:Animal models are used to mimic human asthma, however, not all models replicate the major characteristics of the human disease. Spontaneous development of asthma with hallmark features similar to humans has been documented to occur with relative frequency in only one animal species, the cat. We hypothesized ...

journal_title：International archives of allergy and immunology

authors： Norris Reinero CR,Decile KC,Berghaus RD,Williams KJ,Leutenegger CM,Walby WF,Schelegle ES,Hyde DM,Gershwin LJ

更新日期：2004-10-01 00:00:00

abstract：BACKGROUND:Secretory phospholipases A(2) (sPLA(2)) are an emerging class of mediators of inflammation. These enzymes are released in vivo in patients with systemic inflammatory diseases and allergic disorders. sPLA(2)s may activate inflammatory cells by both enzymatic and nonenzymatic mechanisms. The aim of this study ...

journal_title：International archives of allergy and immunology

authors： Triggiani M,Granata F,Petraroli A,Loffredo S,Frattini A,Staiano RI,Monaco G,Marone G

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Sweating can worsen atopic dermatitis (AD). The purpose of this work was to study the associations between reactivity to autologous sweat and the clinical severity of AD as well as investigate the possible wheal-inducing factors of sweat. METHODS:Intracutaneous skin tests with autologous sweat were performe...

journal_title：International archives of allergy and immunology

authors： Ilves T,Virolainen A,Harvima IT

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Patients with allergic rhinoconjunctivitis are susceptible to both nasal and ocular symptoms. The conjunctival provocation test (CPT) is an established diagnostic procedure used in allergic rhinoconjunctivitis, particularly to document a patient's current reactivity to allergens. To date, there are no intern...

journal_title：International archives of allergy and immunology

authors： Dogan S,Astvatsatourov A,Deserno TM,Bock F,Shah-Hosseini K,Michels A,Mösges R

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Staphylococcus aureus-producing superantigens (SAgs), such as staphylococcal enterotoxin B (SEB) or toxic shock syndrome toxin-1 (TSST-1), are frequently observed in atopic dermatitis (AD). However, little has been done to establish the association of immune responses to SAgs and the therapeutic response to ...

journal_title：International archives of allergy and immunology

authors： Fukushima H,Hirano T,Shibayama N,Miwa K,Ito T,Saito M,Sumida H,Oyake S,Tsuboi R,Oka K

更新日期：2006-01-01 00:00:00

abstract：:Interaction between vascular cell adhesion molecule-1 (VCAM-1) on endothelial cells and CD49d molecules on eosinophils is thought to mediate the selective infiltration of eosinophils into inflamed tissues in allergic disease. IL-4 and TNF-alpha are associated with allergic conditions, and they have been shown to selec...

journal_title：International archives of allergy and immunology

authors： Saito H,Shimizu H,Mita H,Maeda Y,Akiyama K

更新日期：1996-10-01 00:00:00

abstract：BACKGROUND:The classical clinical manifestation of untreated immunoglobulin deficiency comprises predominantly recurrent and complicated respiratory tract infections. Before the 1980s, little was known about the clinical manifestation of immunodeficiency in the general medical population, and also the availability of s...

journal_title：International archives of allergy and immunology

authors： Litzman J,Stikarovska D,Pikulova Z,Pavlik T,Pesak S,Thon V,Kuklinek P,Lokaj J

更新日期：2010-01-01 00:00:00

abstract：:Nitric oxide (NO) is a potent biological mediator, and has a regulatory role in a wide variety of cellular and tissue functions. In the upper and lower airways, NO has been suggested to be involved in different functions with regulatory, protective, defensive or damaging effects. It is obvious that NO plays an importa...

journal_title：International archives of allergy and immunology

authors： Sahin G,Klimek L,Mullol J,Hörmann K,Walther LE,Pfaar O

更新日期：2011-01-01 00:00:00

abstract：:For each medicinal product quality, safety and efficacy have to be proven to obtain a marketing authorisation. The national competent health authorities and the European Medicines Agency (EMEA) with support of the Heads of Medicines Agencies (HMA) work together to grant marketing authorisations for medicinal products....

journal_title：International archives of allergy and immunology

authors： Lorenz AR,Luttkopf D,Seitz R,Vieths S

更新日期：2008-01-01 00:00:00

abstract：INTRODUCTION:Venom immunotherapy (VIT) is considered to be the gold-standard treatment for patients with Hymenoptera venom allergy. Data regarding VIT in bee venom (BV) allergic patients are scarce. AIM:The aim of this study was to evaluate the outcome of VIT in patients with exclusive BV allergy and to try to define ...

journal_title：International archives of allergy and immunology

authors： Rosman Y,Nashef F,Cohen-Engler A,Meir-Shafrir K,Lachover-Roth I,Confino-Cohen R

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Evidence regarding sublingual immunotherapy (SLIT) efficacy and its good safety profile has been demonstrated with pollen and house dust mite (HDM) allergens in the treatment of airway allergies. In addition, the use of grass pollen presents a SLIT disease-modifying treatment for respiratory allergies. OBJE...

journal_title：International archives of allergy and immunology

authors： Hagner S,Rask C,Brimnes J,Andersen PS,Raifer H,Renz H,Garn H

更新日期：2016-01-01 00:00:00

abstract：:Various methods have been devised to assay eosinophil chemotaxis. In this review, we introduced a rapid and sensitive eosinophil chemotactic assay system based on eosinophil peroxidase (EPO) determination. Eosinophils were semipurified by dextran sedimentation followed by Percoll gradient centrifugation. Eosinophil mi...

journal_title：International archives of allergy and immunology

authors： Nagase H,Yamaguchi M,Jibiki S,Yamada H,Ohta K,Kawasaki H,Yoshie O,Yamamoto K,Morita Y,Hirai K

更新日期：2000-05-01 00:00:00

abstract：:For the identification and characterization of allergen grass group VI we performed two-dimensional immunoblotting of timothy grass pollen (Phleum pratense). Two intense 13-kD protein spots of pI 5.2 and 5.5 were found to be IgE reactive. By N-terminal microsequencing and amino acid analysis we identified them as Phl ...

journal_title：International archives of allergy and immunology

authors： Petersen A,Bufe A,Schlaak M,Becker WM

更新日期：1995-09-01 00:00:00

abstract：BACKGROUND:Mast cell tryptase has recently been reported to be involved in atherosclerotic plaque destabilization. However, the results of these reports are conflicting. METHODS:The aim of this study was to characterize the role of tryptase as a prognostic marker of patient cardiovascular complexity in acute coronary ...

journal_title：International archives of allergy and immunology

authors： Pastorello EA,Morici N,Farioli L,Di Biase M,Losappio LM,Nichelatti M,Lupica L,Schroeder JW,Stafylaraki C,Klugmann S

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Natural rubber latex proteins have been implicated in severe allergy in individuals exposed to latex products, particularly health care workers. Until recently, only crude antigens were available to study the immune response in these patients. In recent years a number of relevant allergens have been purified...

journal_title：International archives of allergy and immunology

authors： Johnson BD,Kurup VP,Sussman GL,Arif SA,Kelly KJ,Beezhold DH,Fink JN

更新日期：1999-12-01 00:00:00

abstract：BACKGROUND:In naive rodents, repeated exposure to aerosolized antigen induces suppression of the Th2 response to the antigen. We hypothesized that more prolonged exposure of established asthma model to antigen aerosols may downregulate asthmatic phenotype. METHODS:After establishing an ovalbumin (OVA)-induced asthma m...

journal_title：International archives of allergy and immunology

authors： Sakai K,Yokoyama A,Kohno N,Hamada H,Hiwada K

更新日期：2001-10-01 00:00:00

abstract：:A peptide B3144, derived after peptic tryptic digestion of alpha-gliadin and corresponding to residues 3-56 from the coeliac-activating domain I, was previously used to produce monoclonal antibodies. A dot immunobinding assay was developed using these antibodies to detect gluten in wheat, rye, barley and oats. The lim...

journal_title：International archives of allergy and immunology

authors： Ellis HJ,Doyle AP,Day P,Wieser H,Ciclitira PJ

更新日期：1994-07-01 00:00:00

abstract：BACKGROUND:Wheat is known as the most widely consumed food all over the world. Although many types of wheat allergy have been recognized, their treatment still has a long way to go due to the complex pathogenesis. Oral immunotherapy (OIT) is under investigation for the treatment of wheat allergies. Previous studies hav...

journal_title：International archives of allergy and immunology

authors： Li X,Miyakawa T,Takano T,Nakajima-Adachi H,Tanokura M,Hachimura S

更新日期：2020-01-01 00:00:00

abstract：:Two cDNA clones named P9* and P1* of 794 and 631 bp, respectively, were isolated from a lambda ZAP cDNA expression library using Parietaria judaica (Pj) pollen-specific IgE antibodies from a pool of sera (n = 23) of patients allergic to Pj. Sequence analysis showed open reading frames of 176 and 138 amino acids. Both ...

journal_title：International archives of allergy and immunology

authors： Duro G,Colombo P,Assunta Costa M,Izzo V,Porcasi R,Di Fiore R,Locorotondo G,Cocchiara R,Geraci D

更新日期：1997-04-01 00:00:00

abstract：:CD95 (APO-1) is a member of the TNF/nerve growth factor receptor superfamily, which is expressed on the surface of different types of cells. Cross-linking of CD95 leads to the induction of apoptosis. This may be of importance in many physiological systems, but seems to play a special role for the maintenance of immuno...

journal_title：International archives of allergy and immunology

authors： Lechner H,Amort M,Steger MM,Maczek C,Grubeck-Loebenstein B

更新日期：1996-07-01 00:00:00

abstract：BACKGROUND:The importance of fungal allergens in the development of allergic diseases in a desert environment is uncertain. This study evaluated the prevalence of IgE sensitization to moulds among patients with allergic respiratory diseases in Kuwait - a desert country. METHODS:A total of 810 patients (male:female rat...

journal_title：International archives of allergy and immunology

authors： Ezeamuzie CI,Al-Ali S,Khan M,Hijazi Z,Dowaisan A,Thomson MS,Georgi J

更新日期：2000-04-01 00:00:00

abstract：:It has been well documented that environmental factors such as antigen-presenting cells and related cytokines can affect the development of T-helper cells. The purpose of this study was to investigate the role of different antigen-presenting cells on T-cell development. Ovalbumin (OVA) combined with complete Freud's a...

journal_title：International archives of allergy and immunology

authors： Chuang YH,Chiang BL,Chou CC,Hsieh KH

更新日期：1996-12-01 00:00:00

abstract：BACKGROUND:Asthma, allergic conditions, and COPD overlap, but the effect of them and their combinations on disease severity, need for drugs, use of healthcare, and costs is poorly known. OBJECTIVE:To study how different allergic diseases co-occur in asthma and allergy patients and evaluate the use of medication well a...

journal_title：International archives of allergy and immunology

authors： Jantunen J,Haahtela T,Salimäki J,Linna M,Mäkelä M,Pelkonen A,Kauppi P

更新日期：2019-01-01 00:00:00