Abstract:
BACKGROUND:Evidence regarding sublingual immunotherapy (SLIT) efficacy and its good safety profile has been demonstrated with pollen and house dust mite (HDM) allergens in the treatment of airway allergies. In addition, the use of grass pollen presents a SLIT disease-modifying treatment for respiratory allergies. OBJECTIVES:The aim of this study was to demonstrate the efficacy of HDM-based SLIT in mouse models of allergic airway inflammation and to gain insights into the involved local immunological mechanisms. METHODS:Balb/c mice were sensitized/challenged with Dermatophagoides farinae (Der f) extract and underwent Der f-SLIT in prophylactic and therapeutic settings. The SLIT efficacy was assessed using lung function measurements, analysis of local inflammatory responses by bronchoalveolar lavage cell differentiation and lung histology. Humoral and cellular responses were monitored by ELISA, cytokine bead array and flow cytometry analyses. RESULTS:In a prophylactic setting, Der f-SLIT with 12 development units per dose reduced the eosinophil-dominated inflammatory response in the lung paralleled by a marked reduction in airway hyperresponsiveness. Local Th2 responses were prevented as demonstrated by significantly lower levels of IL-5 and IL-13. Additionally, SLIT-treated mice revealed a lower proportion of CD4-CD8- x03B3;δ cells and a higher frequency of CD8+CD25+IFNx03B3;+ T cells in the lungs compared to sham-treated mice. In a therapeutic setting, Der f-SLIT also resulted in reduced inflammatory responses in the lung. CONCLUSION:The efficacy of Der f-SLIT was demonstrated in prophylactic and therapeutic conditions using experimental mouse models of HDM-induced airway inflammation. A potential role of a so far underestimated lymphocyte subpopulation was also indicated.
journal_name
Int Arch Allergy Immunoljournal_title
International archives of allergy and immunologyauthors
Hagner S,Rask C,Brimnes J,Andersen PS,Raifer H,Renz H,Garn Hdoi
10.1159/000446155subject
Has Abstractpub_date
2016-01-01 00:00:00pages
22-34issue
1eissn
1018-2438issn
1423-0097pii
000446155journal_volume
170pub_type
杂志文章abstract::A peptide B3144, derived after peptic tryptic digestion of alpha-gliadin and corresponding to residues 3-56 from the coeliac-activating domain I, was previously used to produce monoclonal antibodies. A dot immunobinding assay was developed using these antibodies to detect gluten in wheat, rye, barley and oats. The lim...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000236683
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journal_title:International archives of allergy and immunology
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doi:10.1159/000236681
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journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000236770
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journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000095290
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journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000236536
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journal_title:International archives of allergy and immunology
pub_type: 杂志文章
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更新日期:2013-01-01 00:00:00
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journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000237554
更新日期:1997-05-01 00:00:00
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journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000236204
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journal_title:International archives of allergy and immunology
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journal_title:International archives of allergy and immunology
pub_type: 杂志文章
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abstract:BACKGROUND:Volatile monoisocyanates are formed through thermal degradation when products containing polyurethane are heated. Repeated exposure to diisocyanates, such as toluene diisocyanate (TDI) are a well-known cause of occupational asthma. However, although monoisocyanates are abundant in occupational settings, ther...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000222675
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:The importance of fungal allergens in the development of allergic diseases in a desert environment is uncertain. This study evaluated the prevalence of IgE sensitization to moulds among patients with allergic respiratory diseases in Kuwait - a desert country. METHODS:A total of 810 patients (male:female rat...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000024343
更新日期:2000-04-01 00:00:00
abstract::Human mononuclear leukocytes (MNL), probably OKT4-positive T cells, produced an eosinophil chemotactic factor (ECF) when they were cocultured with irradiated BALL-1, a B cell lymphoma line. Treatment of MNL, with anti-IL-2 antibody failed to suppress BALL-1-induced ECF production. Periodate-lysine-paraformaldehyde-fix...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000236736
更新日期:1994-01-01 00:00:00
abstract:INTRODUCTION:Hereditary angioedema (HAE) with C1 inhibitor (C1-INH) deficiency is a rare autosomal dominant disease. Although the first symptoms can appear in childhood, the diagnosis's delay has a strong impact on the patient's quality of life. We analyzed clinical and laboratory characteristics and the drug therapy o...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000512944
更新日期:2021-01-28 00:00:00
abstract:BACKGROUND:The so-called 'latex-fruit syndrome' is a well-documented phenomenon in cross-reactive allergies. By contrast, there is a lack of information about allergy to exotic fruits in patients with a predominant pollen sensitization. Since the ubiquitous protein profilin has been identified as an allergen in natural...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000059400
更新日期:2002-06-01 00:00:00
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journal_title:International archives of allergy and immunology
pub_type: 杂志文章,随机对照试验
doi:10.1159/000356328
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:beta2-Adrenergic agonists play a pivotal role in the management of bronchial asthma. Although the major effect of short-acting beta2-agonists on the airway is relaxation of smooth muscles, they may also have several effects on surrounding immunomodulatory cells. METHODS:We examined whether widely used short...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000089516
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:The high-affinity IgE receptor, FcepsilonRI, is unresponsive on mast cells and basophils from people in several populations through an unknown mechanism. Similarly, FcepsilonRI-positive basophils from 'nonreleasers' are IgE-unresponsive and are deficient in the tyrosine kinase Syk. OBJECTIVE:To test the hyp...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000087355
更新日期:2005-09-01 00:00:00
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journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000106318
更新日期:2007-01-01 00:00:00
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journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000355333
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journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000095997
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journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000144041
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:A role of bacterial superantigens in several chronic inflammatory diseases has previously been proposed. Many of these diseases are associated with an imbalance of the T helper cell subsets and their cytokine production. METHODS:Peripheral blood mononuclear cells from healthy donors were incubated with vari...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000024320
更新日期:2000-03-01 00:00:00
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journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000288291
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:Previous studies have indicated that colitis increases intestinal permeability to food antigens. This condition also generates an immunoreactive milieu in the gut, which may exacerbate or counteract allergy reactions. This, along with the fact that both colitis and allergy are being codiagnosed more frequent...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000353596
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Omalizumab, an anti-immunoglobulin E (IgE) monoclonal antibody, inhibits the binding of circulating IgE to mast cells and basophils, resulting in fewer episodes of airway inflammation, asthma symptoms and exacerbations in patients with severe allergic asthma. Treatment of patients with asthma using omalizuma...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000442668
更新日期:2015-01-01 00:00:00
abstract::Eosinophils are pleiotropic multi-functional leukocytes involved in initiation and propagation of diverse inflammatory responses. Recent studies examining eosinophil biology have focused on delineating the molecular basis of FIP1L1/PDGRFalpha-fusion gene induced HES, the molecular steps involved in eosinophil recruitm...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章,评审
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更新日期:2007-01-01 00:00:00
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journal_title:International archives of allergy and immunology
pub_type: 杂志文章
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更新日期:2016-01-01 00:00:00
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journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000236884
更新日期:1995-01-01 00:00:00
abstract:BACKGROUND AND AIM:Although still controversial, drug provocation tests (DPTs) are considered by many as the gold standard for diagnosis of drug hypersensitivity. No studies have addressed the opinion of patients submitted to DPT. We aimed to determine patient satisfaction with diagnostic DPT and their perception of it...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章,多中心研究
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更新日期:2011-01-01 00:00:00