Inflammatory markers and acid-base equilibrium in exhaled breath condensate of stable and unstable asthma patients.

abstract：:Mercuric chloride (HgCl(2)) has been proposed to be a mitogen for human blood lymphocytes in vitro. In our previous study, we demonstrated that HgCl(2) preferentially stimulates the CD4+ T cell subset to blast transformation and DNA synthesis and that the reaction is dependent on CD14+ accessory cells. In order to cha...

journal_title：International archives of allergy and immunology

authors： Loftenius A,Ekstrand J,Möller E

更新日期：1999-09-01 00:00:00

abstract：BACKGROUND:Aspirin-intolerant asthma (AIA) is a clinical syndrome characterized by acute bronchoconstriction following the ingestion of aspirin. Solute carrier family 22, member 2 (SLC22A2), also known as organic cation transporter 2 (OCT2), is predominantly expressed in the luminal membrane of airway epithelial cells ...

journal_title：International archives of allergy and immunology

authors： Park TJ,Kim JH,Bae JS,Park BL,Cheong HS,Chun JY,Lee JS,Kim JY,Pasaje CF,Cho SH,Uh ST,Kim MK,Choi IS,Koh IS,Park CS,Shin HD

更新日期：2011-01-01 00:00:00

abstract：:A case of anaphylaxis following a bite from a Siberian hamster (SH; Phodopus sungorus) is described. Skin prick tests with hair, urine and salivary gland extracts from SH were positive, while the tests were negative for hair extracts from other rodents. IgE immunoblotting with the patient serum revealed 3 IgE-binding ...

journal_title：International archives of allergy and immunology

authors： Torres JA,Pastor-Vargas C,de las Heras M,Vivanco F,Cuesta J,Sastre J

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Respiratory syncytial virus (RSV) infection in infants with Th2 predisposition is thought to increase the risk of allergic sensitization, recurrent wheezing, and bronchial asthma during childhood. We attempted to clarify the molecular mechanisms by which Th1/Th2 predisposition in the host alters RSV infectio...

journal_title：International archives of allergy and immunology

authors： Yamada Y,Matsumoto K,Hashimoto N,Saikusa M,Homma T,Yoshihara S,Saito H

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:A role of bacterial superantigens in several chronic inflammatory diseases has previously been proposed. Many of these diseases are associated with an imbalance of the T helper cell subsets and their cytokine production. METHODS:Peripheral blood mononuclear cells from healthy donors were incubated with vari...

journal_title：International archives of allergy and immunology

authors： Weber AK,Wahn U,Renz H

更新日期：2000-03-01 00:00:00

abstract：:Anti-cyclic citrullinated peptide antibodies (anti-CCP) are a new diagnostic marker for rheumatoid arthritis (RA), which shows a specificity of 97% and a sensitivity of 81% in the second generation assay. About 61% of RA patients express HLA-DRB1*0401. In a cohort of patients with RA we investigated whether the expres...

journal_title：International archives of allergy and immunology

authors： Senkpiehl I,Marget M,Wedler M,Jenisch S,Georgi J,Kabelitz D,Steinmann J

更新日期：2005-08-01 00:00:00

abstract：:There is a great need to develop a method for making an accurate and reliable in vitro diagnosis of adverse hypersensitivity reactions to drugs. We measured the amount of sulfidoleukotriene (sLT) released from the peripheral blood leukocytes obtained from 25 patients who developed hypersensitivity reactions following ...

journal_title：International archives of allergy and immunology

authors： Kubota Y,Imayama S,Toshitani A,Miyahara H,Tanahashi T,Uemura Y,Koga T,Sugawara N,Kurimoto F,Hata K

更新日期：1997-12-01 00:00:00

abstract：BACKGROUND:Five to twenty percent of healthy, nonasthmatic individuals exhibit airway hyperreactivity. Because cytokines are important intermediates in airway responses, we investigated the relationship between serum cytokines and airway responsiveness in a well-characterized population of pregnant women. METHODS:We a...

journal_title：International archives of allergy and immunology

authors： Tsunoda M,Litonjua AA,Kuniak MP,Weiss ST,Satoh T,Guevarra L,Tollerud DJ

更新日期：2003-02-01 00:00:00

abstract：BACKGROUND:A growing body of evidence suggests that proinflammatory cytokines play a role in allergic inflammation by attracting and activating inflammatory cells. In this study, we have investigated the relationship between interleukin-8 (IL-8) in nasal lavage fluid and the local activation of eosinophils and neutroph...

journal_title：International archives of allergy and immunology

authors： Jacobi HH,Poulsen LK,Reimert CM,Skov PS,Ulfgren AK,Jones I,Elfman LB,Malling HJ,Mygind N

更新日期：1998-05-01 00:00:00

abstract：:Thymulin is a nonapeptide hormone isolated from the thymus gland. It has immunomodulatory effects which have not yet been well defined. Its major actions have been shown to be on T-cells and their immature precursors. In this study, thymulin was tested in vitro for its effect on the release of IL-1 alpha, IL-2, IL-6 a...

journal_title：International archives of allergy and immunology

authors： Safieh-Garabedian B,Ahmed K,Khamashta MA,Taub NA,Hughes GR

更新日期：1993-01-01 00:00:00

abstract：:Sensitivity to strong odors has a broad differential diagnosis. A presentation is made of a 60-year-old man with lifelong mild allergic rhinitis and a superimposed 4-year history of sensitivity to smells. He had no response to medical treatments or allergic immunotherapy. His physical examination was unremarkable. Aft...

journal_title：International archives of allergy and immunology

authors： Myles IA

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Sensitivity to the mite Blomia tropicalis is related to asthma in tropical climates, but correlates of sensitivity to B. tropicalis and its relationship to Dermatophagoides pteronyssinus sensitivity have not been widely examined in families with asthma. The main objective of this study was to determine preva...

journal_title：International archives of allergy and immunology

authors： Manolio TA,Barnes KC,Naidu RP,Levett PN,Beaty TH,Wilson AF

更新日期：2003-06-01 00:00:00

abstract：INTRODUCTION:The aim of this study was to evaluate the effectiveness of specific immunotherapy (SIT) management with allergoids in children with allergic asthma by monitoring changes in clinical parameters and inflammatory markers in exhaled breath. METHODS:The study population included 43 patients (24 males) of 6-14 ...

journal_title：International archives of allergy and immunology

authors： Lozano J,Cruz MJ,Piquer M,Giner MT,Plaza AM

更新日期：2014-01-01 00:00:00

abstract：:Adhesion molecules of microvascular endothelial cells play a key role in the inflammatory processes involved in nonallergic sinusitis. We investigated the cytokine-regulated expression of intercellular adhesion molecule-1 (ICAM-1), E-selectin and vascular cell adhesion molecule-1 (VCAM-1), and the effect of dexamethas...

journal_title：International archives of allergy and immunology

authors： Yamamoto Y,Ikeda K,Watanabe M,Shimomura A,Suzuki H,Oshima T,Imamura Y,Ohuchi K,Takasaka T

更新日期：1998-09-01 00:00:00

abstract：:Preferential eosinophil accumulation is characteristic of airway inflammation in asthma. Although little is known about its mechanism, the effect of a sialyl Lewis X analog on airway eosinophilia was examined in a guinea-pig model of asthma. Guinea-pigs were sensitized by repeated inhalation of ovalbumin. After a sing...

journal_title：International archives of allergy and immunology

authors： Sagara H,Ra C,Okada T,Shinohara S,Fukuda T,Okumura K,Makino S

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND:Chronic granulomatous disease (CGD) is a rare genetic disorder characterized by failure of phagocytic leukocytes to destroy certain microbes. We present a study on CGD patients enrolled at a single medical center concerning the infectious and noninfectious complications and genetic properties of the disease....

journal_title：International archives of allergy and immunology

authors： Aygun D,Koker MY,Nepesov S,Koker N,van Leeuwen K,de Boer M,Kıykım A,Ozsoy S,Cokugras H,Kuijpers T,Roos D,Camcıoglu Y

更新日期：2020-01-01 00:00:00

abstract：:Antibody response after immunization with surface-coupled ovalbumin (OVA) of liposomes was investigated in mice. OVA was coupled to the surface of liposome via amino groups using glutaraldehyde. OVA-liposome conjugate induced a significant anti-OVA IgG antibody production in mice. However, no IgE antibody production s...

journal_title：International archives of allergy and immunology

authors： Naito S,Horino A,Nakayama M,Nakano Y,Nagai T,Mizuguchi J,Komuro K,Uchida T

更新日期：1996-03-01 00:00:00

abstract：:The downstream signaling components of high-affinity IgE receptor (FcepsilonRI) were studied using yeast two-hybrid screening of the cDNA library constructed from RBL-2H3 cells. The cytoplasmic part of the gamma-chain but not that of the beta-chain was found to interact with pyruvate kinase in the yeast. The in-vitro-...

journal_title：International archives of allergy and immunology

authors： Oak MH,Cheong H,Kim KM

更新日期：1999-06-01 00:00:00

abstract：BACKGROUND:Serum-derived hyaluronan (HA)-associated proteins (SHAPs), the heavy chains of inter-α-trypsin inhibitor, covalently bind to HA to form the SHAP-HA complex. The SHAP-HA complex is involved in the pathophysiology of inflammatory diseases, including rheumatoid arthritis. We investigated whether this complex is...

journal_title：International archives of allergy and immunology

authors： Zhu L,Zhuo L,Kimata K,Yamaguchi E,Watanabe H,Aronica MA,Hascall VC,Baba K

更新日期：2010-01-01 00:00:00

abstract：:Aerosolized monoclonal antibodies (mAbs) specific for T-cell receptors (TCR) were used to manipulate T-cell function in airways of ovalbumin (OVA)-sensitized and -challenged mice with airway hyperresponsiveness (AHR). The inhaled mAbs were found to be effective at low doses, had little or no systemic effect and specif...

journal_title：International archives of allergy and immunology

authors： Lahn M,Kanehiro A,Hahn YS,Wands JM,Aydintug MK,O'Brien RL,Gelfand EW,Born WK

更新日期：2004-05-01 00:00:00

abstract：BACKGROUND:The population of large parts of Africa, South America and travellers to these areas are at risk of yellow fever (YF) with a 50% mortality risk. Yellow fever vaccine (YFV) propagated in hens' eggs confers protection in 95% of the vaccinated. The rate of anaphylaxis for YFV ranges from 0.42 to 1.8/100,000 dos...

journal_title：International archives of allergy and immunology

authors： Rutkowski K,Ewan PW,Nasser SM

更新日期：2013-01-01 00:00:00

abstract：INTRODUCTION:Cow's milk protein allergy (CMA) is the most common type of food allergy in childhood and exclusion diet is a challenge for patients. OBJECTIVE:The study aim was to investigate the frequency of tolerance to baked foods containing milk and evaluate immediate skin prick test (SPT) and specific IgEs for diff...

journal_title：International archives of allergy and immunology

authors： Vilar LK,Araújo FA,Santos TP,Menezes TT,Cheik MF,Segundo GRS

更新日期：2020-10-14 00:00:00

abstract：:The clear recognition that asthma has an inflammatory basis has led to a search for genetic and environmental causes. Genetic linkage studies provide evidence for allelic association between polymorphic markers of interleukin-9 on chromosome 5 and a principal component of the allergic phenotype, log IgE. Further studi...

journal_title：International archives of allergy and immunology

authors： Holgate ST,Church MK,Howarth PH,Morton EN,Frew AJ,Djukanović R

更新日期：1995-05-01 00:00:00

abstract：BACKGROUND:Helicobacter pylori, the main cause of gastritis and peptic ulcer, has been associated with idiopathic chronic urticaria (ICU), an immunological skin disorder of unknown origin. Eosinophilic cationic protein (ECP) is a cytotoxic molecule secreted by the activated eosinophils involved in the pathogenesis of I...

journal_title：International archives of allergy and immunology

authors： Ojetti V,Armuzzi A,De Luca A,Nucera E,Franceschi F,Candelli M,Zannoni GF,Danese S,Di Caro S,Vastola M,Schiavino D,Gasbarrini G,Patriarca G,Pola P,Gasbarrini A

更新日期：2001-05-01 00:00:00

abstract：BACKGROUND:beta2-Adrenergic agonists play a pivotal role in the management of bronchial asthma. Although the major effect of short-acting beta2-agonists on the airway is relaxation of smooth muscles, they may also have several effects on surrounding immunomodulatory cells. METHODS:We examined whether widely used short...

journal_title：International archives of allergy and immunology

authors： Yasui K,Kobayashi N,Yamazaki T,Agematsu K,Matsuzaki S,Nakata S,Baba A

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:alpha-Melanocyte-stimulating hormone (alpha-MSH) is a neuropeptide that controls melanogenesis in pigmentary cells. In addition, its potent immunomodulatory activity has been recently described in cutaneous inflammatory disorders. However the mechanism of such pollen allergies remains to be elucidated. The p...

journal_title：International archives of allergy and immunology

authors： Hiramoto K,Hashimoto M,Orita K,Jikumaru M,Sato EF,Inoue M

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:The cysteinyl leukotrienes (CysLTs) mediate their biological actions through two receptors: CysLT(1) receptor and CysLT(2) receptor. OBJECTIVE:This study was undertaken to examine the direct effects of CysLTs on eosinophils, such as chemotaxis and degranulation, focusing on CysLT(1). METHODS:Eosinophils we...

journal_title：International archives of allergy and immunology

authors： Ohshima N,Nagase H,Koshino T,Miyamasu M,Yamaguchi M,Hirai K,Yamamoto K,Fujisawa T,Nakagawa N,Kishikawa K,Morita Y

更新日期：2002-09-01 00:00:00

abstract：BACKGROUND:Clustered severe adverse reactions to immunotherapy with olive pollen extracts have been occasionally reported in areas where olive trees are extensively grown. Allergic patients from these areas, in addition to the major olive pollen allergen Ole e 1, frequently recognize a recently described allergen, Ole ...

journal_title：International archives of allergy and immunology

authors： Duffort O,Palomares O,Lombardero M,Villalba M,Barber D,Rodríguez R,Polo F

更新日期：2006-01-01 00:00:00

abstract：AIM:We evaluated the effect of the 45-kD protein of Trichinella spiralis (gp45), purified by affinity chromatography, on random migration and chemotaxis, the oxidative metabolism of human neutrophils and on the CD11b upregulation induced by formyl-methionyl-leucyl-phenylalanine (f-MLP). METHODS:Donor neutrophils incub...

journal_title：International archives of allergy and immunology

authors： Bruschi F,Carulli G,Azzarà A,Homan W,Minnucci S,Rizzuti-Gullaci A,Sbrana S,Angiolini C

更新日期：2000-05-01 00:00:00

abstract：:Oral immunotherapy (OIT) is a significant focus of treatment of food allergy. OIT appears to be effective in inducing desensitization, however, patients receiving OIT frequently developmild/moderate symptoms during the therapy. It has not been clearly established whether the clinical tolerance induced by OIT resembles...

journal_title：International archives of allergy and immunology

authors： Sato S,Yanagida N,Ogura K,Imai T,Utsunomiya T,Iikura K,Goto M,Asaumi T,Okada Y,Koike Y,Syukuya A,Ebisawa M

更新日期：2014-01-01 00:00:00